Khusimone

Overview IFRA Botanical Request a quote

  • Identifiers

    CAS number
    30557-76-7

    Molecular formula
    C14H20O

    SMILES
    CC1([C@H]2CC[C@@]3(C2)[C@@H](C1=C)CCC3=O)C

    Retention indicies (RI)

    • DB5: 1593.0

  • Odor profile

    Woody 86.18%
    Cedar 51.93%
    Camphoreous 46.12%
    Amber 40.64%
    Dry 39.49%
    Fresh 37.84%
    Herbal 37.32%
    Earthy 35.39%
    Vetiver 35.11%
    Spicy 35.08%

    Scent© AI

  • Properties

    XLogP3-AA
    2.6

    pKa est.
    9.13 (weak base)

    Molecular weight
    204.31 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point est.
    317°C

    Flash point est.
    116.64 ˚C

  • Synonyms

    • 12-nor-Zizaen-2-one
    • (3aR,6R,8aR)-7,7-Dimethyl-8-methylenehexahydro-1H-3a,6-methanoazulen-3(2H)-one
    • 30557-76-7

  • Applications

    Khusimone (CAS 30557-76-7) is a natural sesquiterpene ketone from vetiver oil, used primarily in perfumery to impart earthy-woody, slightly smoky warmth with strong tenacity, functioning as a long-lasting base-note fixative in fine fragrances (fougère, chypre, woody, oriental) and in cosmetics, soaps, detergents, candles, and air care; it deepens accords with patchouli, cedarwood, ambrox/amber, Iso E Super or citrus, improves substantivity on skin and textiles, helps mask technical off-odors in functional products, and is employed as a marker/analytical reference for vetiver oil quality control and adulteration screening by GC-MS, as well as in sensory/olfactory research and formula optimization, with usage typically aligned to IFRA guidance at low dosages to avoid overpowering impact.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 472.07
    methanol 616.48
    isopropanol 508.46
    water 4.52
    ethyl acetate 1297.02
    n-propanol 456.72
    acetone 1621.25
    n-butanol 437.4
    acetonitrile 1215.05
    DMF 2131.47
    toluene 1426.79
    isobutanol 313.2
    1,4-dioxane 2382.45
    methyl acetate 1094.47
    THF 4481.71
    2-butanone 1056.48
    n-pentanol 123.06
    sec-butanol 219.83
    n-hexane 12.45
    ethylene glycol 119.96
    NMP 1084.04
    cyclohexane 66.73
    DMSO 805.76
    n-butyl acetate 522.9
    n-octanol 80.49
    chloroform 3412.66
    n-propyl acetate 396.01
    acetic acid 458.81
    dichloromethane 2992.63
    cyclohexanone 1606.81
    propylene glycol 119.87
    isopropyl acetate 965.63
    DMAc 915.12
    2-ethoxyethanol 347.14
    isopentanol 376.95
    n-heptane 16.6
    ethyl formate 695.41
    1,2-dichloroethane 1770.05
    n-hexanol 223.96
    2-methoxyethanol 1081.22
    isobutyl acetate 286.34
    tetrachloromethane 415.19
    n-pentyl acetate 287.28
    transcutol 1636.87
    n-heptanol 108.74
    ethylbenzene 299.26
    MIBK 666.05
    2-propoxyethanol 745.82
    tert-butanol 507.31
    MTBE 593.02
    2-butoxyethanol 328.66
    propionic acid 405.37
    o-xylene 494.42
    formic acid 233.36
    diethyl ether 736.65
    m-xylene 797.75
    p-xylene 398.22
    chlorobenzene 1314.28
    dimethyl carbonate 668.17
    n-octane 7.31
    formamide 568.05
    cyclopentanone 2644.9
    2-pentanone 957.38
    anisole 763.23
    cyclopentyl methyl ether 1188.44
    gamma-butyrolactone 2775.3
    1-methoxy-2-propanol 887.79
    pyridine 2116.1
    3-pentanone 673.68
    furfural 1967.84
    n-dodecane 6.52
    diethylene glycol 553.11
    diisopropyl ether 237.9
    tert-amyl alcohol 222.58
    acetylacetone 1542.96
    n-hexadecane 8.22
    acetophenone 564.31
    methyl propionate 982.55
    isopentyl acetate 504.53
    trichloroethylene 3434.04
    n-nonanol 82.37
    cyclohexanol 429.94
    benzyl alcohol 422.47
    2-ethylhexanol 125.46
    isooctanol 99.86
    dipropyl ether 226.31
    1,2-dichlorobenzene 1021.31
    ethyl lactate 177.64
    propylene carbonate 1180.47
    n-methylformamide 1139.1
    2-pentanol 256.66
    n-pentane 26.16
    1-propoxy-2-propanol 445.64
    1-methoxy-2-propyl acetate 851.15
    2-(2-methoxypropoxy) propanol 302.42
    mesitylene 392.76
    ε-caprolactone 1245.71
    p-cymene 144.28
    epichlorohydrin 3223.1
    1,1,1-trichloroethane 1708.11
    2-aminoethanol 221.21
    morpholine-4-carbaldehyde 1607.23
    sulfolane 1565.0
    2,2,4-trimethylpentane 15.68
    2-methyltetrahydrofuran 1589.82
    n-hexyl acetate 356.14
    isooctane 21.6
    2-(2-butoxyethoxy)ethanol 432.45
    sec-butyl acetate 321.97
    tert-butyl acetate 884.28
    decalin 30.82
    glycerin 231.47
    diglyme 1078.71
    acrylic acid 397.8
    isopropyl myristate 145.72
    n-butyric acid 712.0
    acetyl acetate 934.27
    di(2-ethylhexyl) phthalate 142.8
    ethyl propionate 441.68
    nitromethane 1738.63
    1,2-diethoxyethane 580.54
    benzonitrile 937.34
    trioctyl phosphate 93.26
    1-bromopropane 669.52
    gamma-valerolactone 2750.03
    n-decanol 59.34
    triethyl phosphate 161.12
    4-methyl-2-pentanol 183.41
    propionitrile 946.2
    vinylene carbonate 1249.13
    1,1,2-trichlorotrifluoroethane 874.93
    DMS 592.93
    cumene 165.26
    2-octanol 64.95
    2-hexanone 324.17
    octyl acetate 162.4
    limonene 160.19
    1,2-dimethoxyethane 886.83
    ethyl orthosilicate 153.25
    tributyl phosphate 128.18
    diacetone alcohol 632.01
    N,N-dimethylaniline 338.21
    acrylonitrile 1256.48
    aniline 1013.23
    1,3-propanediol 475.17
    bromobenzene 1495.22
    dibromomethane 1546.08
    1,1,2,2-tetrachloroethane 2004.36
    2-methyl-cyclohexyl acetate 257.89
    tetrabutyl urea 153.75
    diisobutyl methanol 112.29
    2-phenylethanol 469.36
    styrene 400.93
    dioctyl adipate 193.21
    dimethyl sulfate 782.0
    ethyl butyrate 353.08
    methyl lactate 396.28
    butyl lactate 211.16
    diethyl carbonate 258.48
    propanediol butyl ether 220.32
    triethyl orthoformate 241.33
    p-tert-butyltoluene 156.59
    methyl 4-tert-butylbenzoate 405.25
    morpholine 2108.28
    tert-butylamine 276.63
    n-dodecanol 44.48
    dimethoxymethane 1840.01
    ethylene carbonate 1068.29
    cyrene 313.07
    2-ethoxyethyl acetate 619.2
    2-ethylhexyl acetate 348.36
    1,2,4-trichlorobenzene 1039.06
    4-methylpyridine 1979.63
    dibutyl ether 147.02
    2,6-dimethyl-4-heptanol 112.29
    DEF 788.2
    dimethyl isosorbide 746.33
    tetrachloroethylene 1192.37
    eugenol 352.94
    triacetin 409.16
    span 80 226.89
    1,4-butanediol 97.9
    1,1-dichloroethane 1814.47
    2-methyl-1-pentanol 126.56
    methyl formate 1065.48
    2-methyl-1-butanol 245.09
    n-decane 11.34
    butyronitrile 832.21
    3,7-dimethyl-1-octanol 115.83
    1-chlorooctane 72.39
    1-chlorotetradecane 30.36
    n-nonane 9.35
    undecane 8.37
    tert-butylcyclohexane 25.97
    cyclooctane 22.8
    cyclopentanol 529.73
    tetrahydropyran 1776.9
    tert-amyl methyl ether 275.89
    2,5,8-trioxanonane 578.14
    1-hexene 68.78
    2-isopropoxyethanol 241.72
    2,2,2-trifluoroethanol 323.21
    methyl butyrate 489.23

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Vetiver 84238-29-9 Vetiveria zizanioides Stapf, fam. Poaceae (Gramineae) 1.0%
Santolina insularis (Italy) 1b hydrodistilled Santolina insularis L., fam. Asteraceae (Compositae) 0.3%
Siparuna guianensis stem wood Siparuna guianensis Aublet, fam. Monimiaceae 1.7%
Vetiver (Haiti) 84238-29-9 Vetiveria zizanioides Stapf, fam. Poaceae (Gramineae) 1.8%