Karahanaenol

Overview IFRA Botanical Request a quote

  • Identifiers

    CAS number
    68224-52-2

    Molecular formula
    C10H18O

    SMILES
    CC1=CCC(C(CC1)O)(C)C

  • Odor profile

    Herbal 76.09%
    Camphoreous 61.74%
    Woody 60.83%
    Mint 60.31%
    Earthy 59.32%
    Sweet 49.03%
    Spicy 48.13%
    Citrus 47.34%
    Fresh 46.14%
    Musty 44.95%

    Scent© AI

  • Properties

    XLogP3-AA
    2.2

    Molecular weight
    154.25 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately slow

    Boiling point est.
    219°C

    Flash point est.
    85.04 ˚C

  • Synonyms

    • Karahanaenol
    • 2,2,5-trimethylcyclohept-4-en-1-ol

  • Applications

    Karahanaenol (CAS 68224-52-2) is a hop-derived secondary metabolite recognized as a contributor to green, resinous, herbal “hoppy” notes; in practice, it is applied in the flavors and fragrances industry to create, boost, and fine-tune beer/hop top notes in non-alcoholic and low-alcohol beers, malt beverages, bitters, herbal soft drinks, and in perfumery with green-bitter facets; in brewing science, karahanaenol is commonly used as a marker and reference standard for GC–MS/LC–MS quantification in hops, hop extracts, and beers, assisting varietal/source authentication, tracking oxidation/aging, studying dry-hopping mechanisms, optimizing processes, and improving aroma stability; in analytical chemistry, it serves as a calibration and internal/external standard, for matrix spike/recovery checks and method development, and supports metabolomics and chemotaxonomy of hop-related botanicals; in R&D, the compound acts as a precursor/scaffold for semi-synthetic derivatives to probe structure–odor relationships, oxidation pathways and photostability, as well as microencapsulation or carrier-based delivery strategies to control aroma release in dry formats, and it is explored at a screening level for biological properties (e.g., antioxidant or antimicrobial potential) to inform safety assessment and QSAR modeling without implying therapeutic use; additionally, it is a useful teaching sample for extraction, purification of natural products, and stereochemical separations in food and flavor chemistry.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 706.79
    methanol 537.99
    isopropanol 786.08
    water 2.27
    ethyl acetate 596.39
    n-propanol 657.41
    acetone 563.45
    n-butanol 613.31
    acetonitrile 467.86
    DMF 579.22
    toluene 285.71
    isobutanol 523.82
    1,4-dioxane 935.44
    methyl acetate 576.32
    THF 1134.03
    2-butanone 625.44
    n-pentanol 374.72
    sec-butanol 629.81
    n-hexane 106.45
    ethylene glycol 121.47
    NMP 313.19
    cyclohexane 109.63
    DMSO 375.29
    n-butyl acetate 501.64
    n-octanol 356.3
    chloroform 1036.74
    n-propyl acetate 322.05
    acetic acid 270.13
    dichloromethane 679.55
    cyclohexanone 513.01
    propylene glycol 264.64
    isopropyl acetate 413.62
    DMAc 494.36
    2-ethoxyethanol 479.97
    isopentanol 548.15
    n-heptane 104.06
    ethyl formate 296.71
    1,2-dichloroethane 422.54
    n-hexanol 662.43
    2-methoxyethanol 652.98
    isobutyl acetate 267.7
    tetrachloromethane 261.38
    n-pentyl acetate 316.27
    transcutol 1252.47
    n-heptanol 377.47
    ethylbenzene 189.79
    MIBK 385.41
    2-propoxyethanol 818.17
    tert-butanol 875.06
    MTBE 775.47
    2-butoxyethanol 532.2
    propionic acid 351.92
    o-xylene 209.5
    formic acid 94.79
    diethyl ether 617.94
    m-xylene 243.83
    p-xylene 246.73
    chlorobenzene 287.94
    dimethyl carbonate 170.79
    n-octane 53.26
    formamide 145.04
    cyclopentanone 594.58
    2-pentanone 484.45
    anisole 377.02
    cyclopentyl methyl ether 499.87
    gamma-butyrolactone 533.24
    1-methoxy-2-propanol 691.23
    pyridine 479.7
    3-pentanone 352.76
    furfural 468.83
    n-dodecane 43.06
    diethylene glycol 455.87
    diisopropyl ether 260.29
    tert-amyl alcohol 650.47
    acetylacetone 449.08
    n-hexadecane 47.97
    acetophenone 268.55
    methyl propionate 390.11
    isopentyl acetate 465.43
    trichloroethylene 717.13
    n-nonanol 298.73
    cyclohexanol 370.61
    benzyl alcohol 252.25
    2-ethylhexanol 369.86
    isooctanol 311.14
    dipropyl ether 411.37
    1,2-dichlorobenzene 276.03
    ethyl lactate 176.83
    propylene carbonate 360.68
    n-methylformamide 302.79
    2-pentanol 488.27
    n-pentane 113.32
    1-propoxy-2-propanol 613.67
    1-methoxy-2-propyl acetate 444.4
    2-(2-methoxypropoxy) propanol 395.41
    mesitylene 181.62
    ε-caprolactone 447.48
    p-cymene 158.05
    epichlorohydrin 630.17
    1,1,1-trichloroethane 612.85
    2-aminoethanol 316.3
    morpholine-4-carbaldehyde 518.4
    sulfolane 463.04
    2,2,4-trimethylpentane 70.1
    2-methyltetrahydrofuran 711.04
    n-hexyl acetate 453.3
    isooctane 81.9
    2-(2-butoxyethoxy)ethanol 573.42
    sec-butyl acetate 264.19
    tert-butyl acetate 468.91
    decalin 76.16
    glycerin 272.81
    diglyme 876.22
    acrylic acid 239.58
    isopropyl myristate 197.93
    n-butyric acid 507.19
    acetyl acetate 287.43
    di(2-ethylhexyl) phthalate 159.11
    ethyl propionate 297.48
    nitromethane 444.18
    1,2-diethoxyethane 522.08
    benzonitrile 307.55
    trioctyl phosphate 135.02
    1-bromopropane 423.71
    gamma-valerolactone 677.53
    n-decanol 222.22
    triethyl phosphate 145.88
    4-methyl-2-pentanol 355.75
    propionitrile 500.79
    vinylene carbonate 339.96
    1,1,2-trichlorotrifluoroethane 424.88
    DMS 258.58
    cumene 161.5
    2-octanol 261.94
    2-hexanone 355.76
    octyl acetate 236.86
    limonene 213.99
    1,2-dimethoxyethane 707.76
    ethyl orthosilicate 158.47
    tributyl phosphate 150.79
    diacetone alcohol 473.95
    N,N-dimethylaniline 243.57
    acrylonitrile 456.3
    aniline 306.65
    1,3-propanediol 406.26
    bromobenzene 311.93
    dibromomethane 520.45
    1,1,2,2-tetrachloroethane 628.7
    2-methyl-cyclohexyl acetate 252.21
    tetrabutyl urea 168.78
    diisobutyl methanol 246.63
    2-phenylethanol 350.72
    styrene 209.65
    dioctyl adipate 206.09
    dimethyl sulfate 205.66
    ethyl butyrate 334.66
    methyl lactate 224.61
    butyl lactate 245.56
    diethyl carbonate 211.95
    propanediol butyl ether 448.05
    triethyl orthoformate 239.24
    p-tert-butyltoluene 176.85
    methyl 4-tert-butylbenzoate 329.56
    morpholine 875.52
    tert-butylamine 635.77
    n-dodecanol 168.3
    dimethoxymethane 482.58
    ethylene carbonate 294.79
    cyrene 259.08
    2-ethoxyethyl acetate 383.38
    2-ethylhexyl acetate 352.1
    1,2,4-trichlorobenzene 302.98
    4-methylpyridine 476.02
    dibutyl ether 347.54
    2,6-dimethyl-4-heptanol 246.63
    DEF 386.2
    dimethyl isosorbide 493.54
    tetrachloroethylene 409.35
    eugenol 308.63
    triacetin 326.76
    span 80 363.58
    1,4-butanediol 182.44
    1,1-dichloroethane 614.91
    2-methyl-1-pentanol 333.93
    methyl formate 215.35
    2-methyl-1-butanol 484.82
    n-decane 70.47
    butyronitrile 525.44
    3,7-dimethyl-1-octanol 319.47
    1-chlorooctane 213.66
    1-chlorotetradecane 93.38
    n-nonane 68.74
    undecane 53.69
    tert-butylcyclohexane 95.12
    cyclooctane 52.77
    cyclopentanol 392.16
    tetrahydropyran 767.78
    tert-amyl methyl ether 457.67
    2,5,8-trioxanonane 552.13
    1-hexene 297.72
    2-isopropoxyethanol 402.02
    2,2,2-trifluoroethanol 127.02
    methyl butyrate 344.96

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Cypress 8013-86-3 Cupressus sempervirens L. (C. fastigiata DC), fam. Cupressaceae 0.35%