Kaempferol-7,4'-dimethyl ether

Overview IFRA Request a quote

  • Identifiers

    CAS number
    15486-33-6

    Molecular formula
    C17H14O6

    SMILES
    COC1=CC=C(C=C1)C2=C(C(=O)C3=C(C=C(C=C3O2)OC)O)O

    Safety labels

  • Odor profile

    Fragrance
    Phenolic 56.64%
    Sweet 47.97%
    Vanilla 42.6%
    Fruity 41.14%
    Spicy 34.42%
    Burnt 33.71%
    Smoky 30.82%
    Powdery 29.89%
    Balsamic 29.85%
    Medicinal 27.74%

     

    Flavor
    Bitter 90.57%
    Parsley 20.79%
    Eugenol 20.17%
    Sweet-like 20.07%
    Bland 19.96%
    Lovage 19.91%
    Cedarleaf 19.9%
    Odorless 19.69%
    Ethyl benzoate 19.33%
    Very strong 19.17%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    2.5

    pKa est.
    9.16 (weak base)

    Molecular weight
    314.29 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    870°C

    Flash point

    • 211.32 ˚C est.

  • Synonyms

    • 15486-33-6
    • kaempferol-7,4'-dimethyl ether
    • 3,5-Dihydroxy-7-methoxy-2-(4-methoxyphenyl)-4-benzopyrone
    • DTXSID70165751
    • RefChem:1087959
    • DTXCID6088242
    • 239-513-1
    • 3,5-Dihydroxy-4',7-dimethoxyflavone
    • 3,5-Dihydroxy-7-methoxy-2-(4-methoxyphenyl)-4H-chromen-4-one
    • Kaempferol 7,4'-dimethyl ether
    • 3,5-Dihydroxy-7,4'-dimethoxyflavone
    • 3,5-dihydroxy-7-methoxy-2-(4-methoxyphenyl)chromen-4-one
    • 7,4'-dimethylkaempferol
    • kaempferol 4',7-dimethyl ether
    • 3,5-DIHYDROXY-7-METHOXY-2-(4-METHOXY-PHENYL)-CHROMEN-4-ONE
    • C17H14O6
    • MFCD00017441
    • Y4D3RA49HD
    • 4',7-DIMETHYLKAEMPFEROL
    • 3,5-dihydroxy-7-methoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
    • 4H-1-Benzopyran-4-one, 3,5-dihydroxy-7-methoxy-2-(4-methoxyphenyl)-
    • EINECS 239-513-1
    • UNII-Y4D3RA49HD
    • SCHEMBL748643
    • 4'-O,7-O-Dimethylkaempferol
    • orb1297134
    • CHEMBL3527009
    • 4',7-DIMETHOXYKAEMPFEROL
    • 7,4'-DIMETHOXYKAEMPFEROL
    • CHEBI:146145
    • HY-N1789
    • 7,4'-DI-O-METHYLKAEMPFEROL
    • 3,5-Dihydroxy-4'7-dimethoxyflavone
    • LMPK12112595
    • AKOS015999073
    • EBC-616615
    • FK65584
    • FS-10419
    • DB-043245
    • CS-0017643
    • NS00025030
    • G12070
    • DIHYDROXY-4',7-DIMETHOXYFLAVONE, 3,5-
    • FLAVONE, 3,5-DIHYDROXY-4',7-DIMETHOXY-
    • 3,5-Dihydroxy-7-methoxy-2-(4-methoxyphenyl)-4H-chromen-4-one #
    • 15486-33-6

  • Applications

    Kaempferol-7,4'-dimethyl ether (CAS 15486-33-6) is used in cosmetics and personal care as an antioxidant active ingredient and stabilizer; in coatings and polymers, it can serve as an antioxidant/stabilizer additive to improve durability and color retention under light exposure; in industrial manufacturing, it functions as a building block and intermediate for the synthesis of more complex flavonoid derivatives; in pharmaceutical and biotech research, it is commonly evaluated as a starting material for flavonoid synthesis and structure-activity relationship (SAR) studies in laboratory settings.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.23
    methanol 0.2
    isopropanol 0.32
    water 0.0
    ethyl acetate 1.06
    n-propanol 0.43
    acetone 1.59
    n-butanol 0.38
    acetonitrile 0.54
    DMF 7.87
    toluene 0.17
    isobutanol 0.38
    1,4-dioxane 2.78
    methyl acetate 1.69
    THF 18.69
    2-butanone 3.22
    n-pentanol 0.3
    sec-butanol 0.56
    n-hexane 0.01
    ethylene glycol 0.26
    NMP 11.9
    cyclohexane 0.02
    DMSO 52.28
    n-butyl acetate 1.42
    n-octanol 0.25
    chloroform 1.27
    n-propyl acetate 0.95
    acetic acid 1.31
    dichloromethane 1.68
    cyclohexanone 4.11
    propylene glycol 0.36
    isopropyl acetate 0.93
    DMAc 20.79
    2-ethoxyethanol 2.22
    isopentanol 0.56
    n-heptane 0.02
    ethyl formate 0.61
    1,2-dichloroethane 1.93
    n-hexanol 0.35
    2-methoxyethanol 4.71
    isobutyl acetate 0.57
    tetrachloromethane 0.1
    n-pentyl acetate 0.77
    transcutol 10.26
    n-heptanol 0.31
    ethylbenzene 0.14
    MIBK 1.18
    2-propoxyethanol 3.95
    tert-butanol 0.83
    MTBE 0.89
    2-butoxyethanol 2.0
    propionic acid 0.9
    o-xylene 0.22
    formic acid 0.56
    diethyl ether 0.53
    m-xylene 0.13
    p-xylene 0.24
    chlorobenzene 0.31
    dimethyl carbonate 1.31
    n-octane 0.01
    formamide 1.46
    cyclopentanone 8.84
    2-pentanone 1.49
    anisole 0.86
    cyclopentyl methyl ether 2.09
    gamma-butyrolactone 9.01
    1-methoxy-2-propanol 3.63
    pyridine 2.58
    3-pentanone 1.59
    furfural 6.39
    n-dodecane 0.02
    diethylene glycol 3.54
    diisopropyl ether 0.17
    tert-amyl alcohol 1.07
    acetylacetone 2.94
    n-hexadecane 0.02
    acetophenone 1.47
    methyl propionate 1.64
    isopentyl acetate 1.78
    trichloroethylene 4.34
    n-nonanol 0.34
    cyclohexanol 0.6
    benzyl alcohol 0.75
    2-ethylhexanol 0.48
    isooctanol 0.38
    dipropyl ether 0.81
    1,2-dichlorobenzene 0.53
    ethyl lactate 1.12
    propylene carbonate 2.18
    n-methylformamide 1.64
    2-pentanol 0.31
    n-pentane 0.01
    1-propoxy-2-propanol 2.84
    1-methoxy-2-propyl acetate 3.51
    2-(2-methoxypropoxy) propanol 4.24
    mesitylene 0.1
    ε-caprolactone 3.51
    p-cymene 0.32
    epichlorohydrin 15.01
    1,1,1-trichloroethane 0.83
    2-aminoethanol 0.49
    morpholine-4-carbaldehyde 9.66
    sulfolane 27.61
    2,2,4-trimethylpentane 0.02
    2-methyltetrahydrofuran 3.86
    n-hexyl acetate 0.96
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 3.91
    sec-butyl acetate 0.78
    tert-butyl acetate 1.79
    decalin 0.03
    glycerin 1.89
    diglyme 10.24
    acrylic acid 1.17
    isopropyl myristate 0.63
    n-butyric acid 0.97
    acetyl acetate 0.78
    di(2-ethylhexyl) phthalate 0.88
    ethyl propionate 1.22
    nitromethane 5.61
    1,2-diethoxyethane 2.25
    benzonitrile 0.74
    trioctyl phosphate 0.58
    1-bromopropane 0.59
    gamma-valerolactone 12.29
    n-decanol 0.27
    triethyl phosphate 1.65
    4-methyl-2-pentanol 0.3
    propionitrile 0.8
    vinylene carbonate 1.56
    1,1,2-trichlorotrifluoroethane 10.47
    DMS 2.04
    cumene 0.16
    2-octanol 0.21
    2-hexanone 1.46
    octyl acetate 0.72
    limonene 0.47
    1,2-dimethoxyethane 6.99
    ethyl orthosilicate 1.39
    tributyl phosphate 0.92
    diacetone alcohol 3.78
    N,N-dimethylaniline 0.88
    acrylonitrile 1.42
    aniline 0.7
    1,3-propanediol 1.0
    bromobenzene 0.27
    dibromomethane 0.73
    1,1,2,2-tetrachloroethane 3.72
    2-methyl-cyclohexyl acetate 1.65
    tetrabutyl urea 1.6
    diisobutyl methanol 0.44
    2-phenylethanol 1.07
    styrene 0.14
    dioctyl adipate 1.34
    dimethyl sulfate 5.89
    ethyl butyrate 1.51
    methyl lactate 2.12
    butyl lactate 1.21
    diethyl carbonate 1.23
    propanediol butyl ether 1.24
    triethyl orthoformate 1.71
    p-tert-butyltoluene 0.29
    methyl 4-tert-butylbenzoate 2.52
    morpholine 4.65
    tert-butylamine 0.31
    n-dodecanol 0.22
    dimethoxymethane 4.27
    ethylene carbonate 1.17
    cyrene 4.06
    2-ethoxyethyl acetate 1.99
    2-ethylhexyl acetate 1.39
    1,2,4-trichlorobenzene 1.01
    4-methylpyridine 1.59
    dibutyl ether 0.65
    2,6-dimethyl-4-heptanol 0.44
    DEF 3.02
    dimethyl isosorbide 9.46
    tetrachloroethylene 1.62
    eugenol 2.52
    triacetin 2.02
    span 80 2.0
    1,4-butanediol 0.26
    1,1-dichloroethane 0.68
    2-methyl-1-pentanol 0.53
    methyl formate 1.24
    2-methyl-1-butanol 0.55
    n-decane 0.02
    butyronitrile 0.52
    3,7-dimethyl-1-octanol 0.44
    1-chlorooctane 0.17
    1-chlorotetradecane 0.09
    n-nonane 0.02
    undecane 0.02
    tert-butylcyclohexane 0.03
    cyclooctane 0.01
    cyclopentanol 1.0
    tetrahydropyran 1.67
    tert-amyl methyl ether 1.13
    2,5,8-trioxanonane 7.79
    1-hexene 0.08
    2-isopropoxyethanol 1.57
    2,2,2-trifluoroethanol 0.76
    methyl butyrate 1.61

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction