Jwh-018

Overview IFRA Request a quote

  • Identifiers

    CAS number
    209414-07-3

    Molecular formula
    C24H23NO

    SMILES
    CCCCCN1C=C(C2=CC=CC=C21)C(=O)C3=CC=CC4=CC=CC=C43

  • Odor profile

    Fragrance
    Floral 53.59%
    Neroli 41.79%
    Grape 40.02%
    Fruity 36.57%
    Animal 36.21%
    Orange 31.97%
    Sweet 29.2%
    Balsamic 27.2%
    Fresh 25.25%
    Citrus 24.7%

     

    Flavor
    Bitter 74.36%
    Nitrile 19.69%
    Very strong 19.28%
    Lovage 19.27%
    Cedarleaf 19.1%
    Indole 19.04%
    Heather 18.58%
    Odorless 18.25%
    Broom 18.19%
    Genet 18.18%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    6.3

    pKa est.
    6.87 (neutral)

    Molecular weight
    341.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    630°C

    Melting point expt.

    • 54-60 °C

    Flash point

    • 249.27 ˚C est.

  • Synonyms

    • 1-Pentyl-3-(1-naphthoyl)indole
    • 209414-07-3
    • JWH-018
    • JWH 018
    • Naphthalen-1-yl-(1-pentylindol-3-yl)methanone
    • 1-pentyl-3-(1-naphthoyl)-indole
    • AM-678
    • JWH018
    • 1-Pentyl-3-(1-naphthoyl) indole
    • DEA No. 7118
    • AM 678
    • naphthalen-1-yl(1-pentyl-1H-indol-3-yl)methanone
    • HSDB 7998
    • Methanone, 1-naphthalenyl(1-pentyl-1H-indol-3-yl)-
    • CHEMBL561013
    • DTXSID10175117
    • AM678
    • UNII-G391998J57
    • J770.893I
    • G391998J57
    • 1-Naphthalenyl(1-pentyl-1H-indol-3-yl)methanone; AM 678; AM-678; JWH-018; N-Pentyl-3-(1-naphthoyl)indole
    • GTPL9706
    • SCHEMBL1707018
    • DTXCID1097608
    • JWH-018, 1mg/ml in Methanol
    • CHEBI:185787
    • BCP27424
    • QGC74444
    • JWH-018, 0.1mg/ml in Methanol
    • BDBM50353747
    • AKOS005145577
    • CCG-208715
    • DS-3151
    • FP26827
    • NCGC00386566-01
    • DB-003103
    • A4549
    • NS00010391
    • Naphthaten-1-yl-(1-pentylindol-3-yl)methanone
    • 10.14272/JDNLPKCAXICMBW-UHFFFAOYSA-N.1
    • Q419020
    • doi:10.14272/JDNLPKCAXICMBW-UHFFFAOYSA-N.1
    • Naphthalen-1-yl-(10pentyl-1H-indol-3-yl)methanone
    • JWH-018,1-Ii>>u-3-(1-YA(1/4)xo pound>>u)ssAssa
    • JWH-018 ((Naphthalen-1-yl)(1-pentylindol-3-yl)methanone)
    • 1-Naphthalenyl(1-pentyl-1H-indol-3-yl)methanone;1-Pentyl-3-(1-naphthoyl)indole
    • JWH-018 ((Naphthalen-1-yl)(1-pentylindol-3-yl)methanone) 0.1 mg/ml in Acetonitrile
    • JWH-018 ((Naphthalen-1-yl)(1-pentylindol-3-yl)methanone) 1.0 mg/ml in Acetonitrile

  • Applications

    Jwh-018, CAS 209414-07-3, is primarily used in scientific research on the cannabinoid system as a CB1/CB2 receptor agonist, supporting pharmacology studies to evaluate biological activity, selectivity, and mechanism of action; in analytical and forensic settings, it serves as a reference standard or sample for developing and calibrating GC-MS/LC-MS methods to detect and quantify cannabinoids; in academic and research laboratories it aids structure-activity relationship work and receptor profiling; due to its controlled status and regulatory restrictions, it is not approved for consumer, medical, or commercial applications and use is limited by local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 48.91
    methanol 50.49
    isopropanol 20.46
    water 0.03
    ethyl acetate 120.21
    n-propanol 55.79
    acetone 161.62
    n-butanol 56.81
    acetonitrile 42.6
    DMF 400.96
    toluene 149.58
    isobutanol 46.92
    1,4-dioxane 226.13
    methyl acetate 147.4
    THF 404.74
    2-butanone 194.73
    n-pentanol 43.55
    sec-butanol 35.18
    n-hexane 3.66
    ethylene glycol 7.2
    NMP 341.91
    cyclohexane 8.39
    DMSO 96.65
    n-butyl acetate 90.72
    n-octanol 11.94
    chloroform 808.76
    n-propyl acetate 91.99
    acetic acid 74.11
    dichloromethane 1118.44
    cyclohexanone 313.31
    propylene glycol 10.05
    isopropyl acetate 85.93
    DMAc 414.2
    2-ethoxyethanol 81.13
    isopentanol 58.76
    n-heptane 2.31
    ethyl formate 72.41
    1,2-dichloroethane 700.72
    n-hexanol 37.23
    2-methoxyethanol 117.53
    isobutyl acetate 81.29
    tetrachloromethane 37.78
    n-pentyl acetate 73.62
    transcutol 301.74
    n-heptanol 20.45
    ethylbenzene 57.74
    MIBK 92.91
    2-propoxyethanol 102.85
    tert-butanol 20.69
    MTBE 53.93
    2-butoxyethanol 64.61
    propionic acid 61.54
    o-xylene 52.35
    formic acid 25.75
    diethyl ether 100.67
    m-xylene 56.9
    p-xylene 72.62
    chlorobenzene 260.87
    dimethyl carbonate 105.17
    n-octane 1.62
    formamide 60.8
    cyclopentanone 365.46
    2-pentanone 140.93
    anisole 128.82
    cyclopentyl methyl ether 139.54
    gamma-butyrolactone 322.58
    1-methoxy-2-propanol 75.3
    pyridine 424.64
    3-pentanone 143.24
    furfural 312.27
    n-dodecane 1.45
    diethylene glycol 56.62
    diisopropyl ether 21.67
    tert-amyl alcohol 30.13
    acetylacetone 197.58
    n-hexadecane 1.74
    acetophenone 124.88
    methyl propionate 138.94
    isopentyl acetate 101.05
    trichloroethylene 1252.26
    n-nonanol 13.98
    cyclohexanol 60.12
    benzyl alcohol 105.24
    2-ethylhexanol 28.44
    isooctanol 20.96
    dipropyl ether 40.35
    1,2-dichlorobenzene 218.82
    ethyl lactate 38.01
    propylene carbonate 167.1
    n-methylformamide 111.25
    2-pentanol 29.22
    n-pentane 3.16
    1-propoxy-2-propanol 53.39
    1-methoxy-2-propyl acetate 113.15
    2-(2-methoxypropoxy) propanol 64.98
    mesitylene 23.25
    ε-caprolactone 241.02
    p-cymene 22.18
    epichlorohydrin 731.13
    1,1,1-trichloroethane 257.21
    2-aminoethanol 23.81
    morpholine-4-carbaldehyde 295.24
    sulfolane 266.79
    2,2,4-trimethylpentane 3.06
    2-methyltetrahydrofuran 219.35
    n-hexyl acetate 66.22
    isooctane 1.67
    2-(2-butoxyethoxy)ethanol 86.8
    sec-butyl acetate 73.12
    tert-butyl acetate 76.8
    decalin 6.14
    glycerin 19.61
    diglyme 213.09
    acrylic acid 71.03
    isopropyl myristate 26.91
    n-butyric acid 96.41
    acetyl acetate 85.8
    di(2-ethylhexyl) phthalate 37.48
    ethyl propionate 83.88
    nitromethane 183.48
    1,2-diethoxyethane 123.53
    benzonitrile 120.3
    trioctyl phosphate 19.09
    1-bromopropane 231.53
    gamma-valerolactone 465.15
    n-decanol 10.54
    triethyl phosphate 37.87
    4-methyl-2-pentanol 23.14
    propionitrile 70.83
    vinylene carbonate 184.11
    1,1,2-trichlorotrifluoroethane 244.09
    DMS 121.99
    cumene 31.05
    2-octanol 13.06
    2-hexanone 107.44
    octyl acetate 33.52
    limonene 29.15
    1,2-dimethoxyethane 192.06
    ethyl orthosilicate 38.21
    tributyl phosphate 27.16
    diacetone alcohol 76.06
    N,N-dimethylaniline 65.69
    acrylonitrile 112.44
    aniline 152.33
    1,3-propanediol 42.26
    bromobenzene 282.02
    dibromomethane 548.94
    1,1,2,2-tetrachloroethane 748.85
    2-methyl-cyclohexyl acetate 69.62
    tetrabutyl urea 41.06
    diisobutyl methanol 16.49
    2-phenylethanol 85.14
    styrene 88.0
    dioctyl adipate 49.27
    dimethyl sulfate 133.12
    ethyl butyrate 70.48
    methyl lactate 51.11
    butyl lactate 48.9
    diethyl carbonate 50.04
    propanediol butyl ether 35.13
    triethyl orthoformate 50.0
    p-tert-butyltoluene 17.32
    methyl 4-tert-butylbenzoate 72.27
    morpholine 266.29
    tert-butylamine 14.19
    n-dodecanol 8.61
    dimethoxymethane 226.87
    ethylene carbonate 138.19
    cyrene 80.61
    2-ethoxyethyl acetate 143.05
    2-ethylhexyl acetate 82.33
    1,2,4-trichlorobenzene 266.27
    4-methylpyridine 318.71
    dibutyl ether 32.58
    2,6-dimethyl-4-heptanol 16.49
    DEF 205.89
    dimethyl isosorbide 138.12
    tetrachloroethylene 453.75
    eugenol 79.48
    triacetin 75.31
    span 80 47.34
    1,4-butanediol 16.75
    1,1-dichloroethane 334.79
    2-methyl-1-pentanol 58.03
    methyl formate 88.27
    2-methyl-1-butanol 65.64
    n-decane 2.29
    butyronitrile 71.83
    3,7-dimethyl-1-octanol 17.91
    1-chlorooctane 15.06
    1-chlorotetradecane 6.86
    n-nonane 1.89
    undecane 1.74
    tert-butylcyclohexane 4.56
    cyclooctane 2.02
    cyclopentanol 58.2
    tetrahydropyran 222.99
    tert-amyl methyl ether 51.31
    2,5,8-trioxanonane 129.53
    1-hexene 31.15
    2-isopropoxyethanol 63.04
    2,2,2-trifluoroethanol 32.44
    methyl butyrate 114.25

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction