Juzirine

Overview IFRA Request a quote

  • Identifiers

    CAS number
    64069-53-0

    Molecular formula
    C17H15NO3

    SMILES
    COC1=C(C=C2C(=C1)C=CN=C2CC3=CC=C(C=C3)O)O

    Safety labels

  • Odor profile

    Fragrance
    Phenolic 60.82%
    Sweet 53.57%
    Vanilla 42.62%
    Spicy 41.54%
    Smoky 37.46%
    Animal 34.15%
    Powdery 31.15%
    Fruity 31.09%
    Balsamic 30.81%
    Burnt 28.94%

     

    Flavor
    Bitter 85.3%
    Mild 23.89%
    Very strong 21.5%
    Fruity 21.17%
    Indole 21.0%
    Eugenol 20.91%
    Sweet 20.81%
    Orange blossom 20.7%
    Parsley 20.69%
    Curry 20.58%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.3

    pKa est.
    9.15 (weak base)

    Molecular weight
    281.3 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    573°C

    Melting point expt.

    • 203 - 205 °C

    Flash point

    • 228.09 ˚C est.

  • Synonyms

    • Juzirine
    • 64069-53-0
    • 1-[(4-hydroxyphenyl)methyl]-6-methoxyisoquinolin-7-ol
    • HYS6BR39QH
    • 1-((4-Hydroxyphenyl)methyl)-6-methoxy-7-isoquinolinol
    • DTXSID20214263
    • 7-Isoquinolinol, 1-((4-hydroxyphenyl)methyl)-6-methoxy-
    • 1-((4-hydroxyphenyl)methyl)-6-methoxyisoquinolin-7-ol
    • RefChem:150668
    • DTXCID20136754
    • Yuzirine
    • UNII-HYS6BR39QH
    • orb1696816
    • CHEBI:179577
    • AKOS040752214
    • 1-(4-hydroxybenzyl)-6-methoxyisoquinolin-7-ol
    • 7-hydroxy-1-(4'-hydroxybenzyl)-6-methoxyisoquinoline
    • 7-Hydroxy-1-(4-hydroxybenzyl)-6-methoxyisoquinoline
    • 1-((4-HYDROXYPHENYL)METHYL)-6-METHOXY-ISOQUINOLIN-7-OL
    • 64069-53-0

  • Applications

    Juzirine (CAS 64069-53-0) is considered for a range of industrial applications in roles such as a chemical synthesis intermediate, a solvent for formulation processes, and an odorant/fragrance component in perfumery and cosmetics; it may also be evaluated for use in polymer and plastics processing as a solvent or processing aid, and as an additive in coatings and inks to influence processing characteristics.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 6.88
    methanol 6.18
    isopropanol 6.89
    water 0.01
    ethyl acetate 5.61
    n-propanol 9.41
    acetone 3.87
    n-butanol 7.77
    acetonitrile 3.26
    DMF 5.53
    toluene 1.56
    isobutanol 4.41
    1,4-dioxane 25.03
    methyl acetate 5.81
    THF 81.55
    2-butanone 9.35
    n-pentanol 6.27
    sec-butanol 6.76
    n-hexane 0.04
    ethylene glycol 4.31
    NMP 1.24
    cyclohexane 0.06
    DMSO 62.32
    n-butyl acetate 2.74
    n-octanol 1.6
    chloroform 1.77
    n-propyl acetate 3.69
    acetic acid 11.16
    dichloromethane 2.3
    cyclohexanone 5.94
    propylene glycol 5.41
    isopropyl acetate 4.44
    DMAc 19.03
    2-ethoxyethanol 38.08
    isopentanol 6.94
    n-heptane 0.16
    ethyl formate 2.89
    1,2-dichloroethane 3.93
    n-hexanol 4.15
    2-methoxyethanol 51.34
    isobutyl acetate 2.61
    tetrachloromethane 0.31
    n-pentyl acetate 2.95
    transcutol 91.76
    n-heptanol 2.78
    ethylbenzene 1.1
    MIBK 4.72
    2-propoxyethanol 24.2
    tert-butanol 11.23
    MTBE 5.3
    2-butoxyethanol 11.88
    propionic acid 4.4
    o-xylene 1.17
    formic acid 7.92
    diethyl ether 4.93
    m-xylene 1.1
    p-xylene 1.25
    chlorobenzene 1.17
    dimethyl carbonate 3.67
    n-octane 0.11
    formamide 16.83
    cyclopentanone 7.31
    2-pentanone 4.39
    anisole 5.74
    cyclopentyl methyl ether 6.21
    gamma-butyrolactone 8.11
    1-methoxy-2-propanol 28.46
    pyridine 11.82
    3-pentanone 3.8
    furfural 11.49
    n-dodecane 0.12
    diethylene glycol 26.99
    diisopropyl ether 1.29
    tert-amyl alcohol 8.03
    acetylacetone 8.0
    n-hexadecane 0.14
    acetophenone 4.71
    methyl propionate 4.43
    isopentyl acetate 4.08
    trichloroethylene 7.78
    n-nonanol 2.26
    cyclohexanol 4.0
    benzyl alcohol 6.33
    2-ethylhexanol 2.76
    isooctanol 2.88
    dipropyl ether 4.82
    1,2-dichlorobenzene 1.56
    ethyl lactate 3.72
    propylene carbonate 3.06
    n-methylformamide 5.02
    2-pentanol 4.25
    n-pentane 0.03
    1-propoxy-2-propanol 12.9
    1-methoxy-2-propyl acetate 9.33
    2-(2-methoxypropoxy) propanol 15.22
    mesitylene 0.74
    ε-caprolactone 5.51
    p-cymene 1.25
    epichlorohydrin 29.91
    1,1,1-trichloroethane 1.43
    2-aminoethanol 8.83
    morpholine-4-carbaldehyde 12.34
    sulfolane 10.12
    2,2,4-trimethylpentane 0.11
    2-methyltetrahydrofuran 10.9
    n-hexyl acetate 3.26
    isooctane 0.08
    2-(2-butoxyethoxy)ethanol 22.85
    sec-butyl acetate 3.04
    tert-butyl acetate 6.96
    decalin 0.13
    glycerin 17.21
    diglyme 47.43
    acrylic acid 4.5
    isopropyl myristate 2.54
    n-butyric acid 7.6
    acetyl acetate 3.94
    di(2-ethylhexyl) phthalate 3.1
    ethyl propionate 3.92
    nitromethane 17.37
    1,2-diethoxyethane 18.16
    benzonitrile 3.26
    trioctyl phosphate 1.9
    1-bromopropane 1.27
    gamma-valerolactone 17.53
    n-decanol 1.88
    triethyl phosphate 3.66
    4-methyl-2-pentanol 3.03
    propionitrile 4.24
    vinylene carbonate 3.41
    1,1,2-trichlorotrifluoroethane 18.85
    DMS 4.19
    cumene 0.94
    2-octanol 1.56
    2-hexanone 4.36
    octyl acetate 2.75
    limonene 1.24
    1,2-dimethoxyethane 49.5
    ethyl orthosilicate 4.07
    tributyl phosphate 2.44
    diacetone alcohol 13.19
    N,N-dimethylaniline 3.67
    acrylonitrile 6.23
    aniline 4.79
    1,3-propanediol 20.96
    bromobenzene 0.99
    dibromomethane 1.01
    1,1,2,2-tetrachloroethane 6.76
    2-methyl-cyclohexyl acetate 4.36
    tetrabutyl urea 3.8
    diisobutyl methanol 2.82
    2-phenylethanol 6.16
    styrene 1.12
    dioctyl adipate 4.53
    dimethyl sulfate 5.76
    ethyl butyrate 3.69
    methyl lactate 5.12
    butyl lactate 3.84
    diethyl carbonate 3.29
    propanediol butyl ether 7.4
    triethyl orthoformate 5.01
    p-tert-butyltoluene 1.25
    methyl 4-tert-butylbenzoate 7.26
    morpholine 32.5
    tert-butylamine 3.28
    n-dodecanol 1.58
    dimethoxymethane 19.54
    ethylene carbonate 2.87
    cyrene 8.88
    2-ethoxyethyl acetate 8.72
    2-ethylhexyl acetate 2.78
    1,2,4-trichlorobenzene 2.38
    4-methylpyridine 4.36
    dibutyl ether 3.91
    2,6-dimethyl-4-heptanol 2.82
    DEF 3.89
    dimethyl isosorbide 22.26
    tetrachloroethylene 4.5
    eugenol 9.11
    triacetin 6.32
    span 80 7.85
    1,4-butanediol 6.07
    1,1-dichloroethane 1.14
    2-methyl-1-pentanol 6.37
    methyl formate 3.56
    2-methyl-1-butanol 5.71
    n-decane 0.2
    butyronitrile 3.19
    3,7-dimethyl-1-octanol 2.68
    1-chlorooctane 0.89
    1-chlorotetradecane 0.51
    n-nonane 0.14
    undecane 0.15
    tert-butylcyclohexane 0.13
    cyclooctane 0.04
    cyclopentanol 3.86
    tetrahydropyran 13.93
    tert-amyl methyl ether 4.69
    2,5,8-trioxanonane 34.3
    1-hexene 0.32
    2-isopropoxyethanol 18.45
    2,2,2-trifluoroethanol 3.37
    methyl butyrate 3.97

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction