Isostearamidopropyl morpholine

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  • Identifiers

    CAS number
    72300-23-3

    Molecular formula
    C25H50N2O2

    SMILES
    CC(C)CCCCCCCCCCCCCCC(=O)NCCCN1CCOCC1

    Safety labels

  • Odor profile

    Fragrance
    Fishy 39.57%
    Odorless 34.25%
    Savory 33.96%
    Meaty 32.98%
    Waxy 32.01%
    Animal 31.03%
    Cooling 30.1%
    Oily 24.23%
    Fatty 23.0%
    Cheesy 21.02%

     

    Flavor
    Bland 33.43%
    Mild 28.95%
    Odorless 27.71%
    Fatty 25.07%
    Faint 23.51%
    Slightly waxy 21.88%
    Delicate 20.76%
    Bay oil 20.37%
    Waxy 20.31%
    Cedarleaf 19.87%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    7.7

    pKa est.
    8.08 (weak base)

    Molecular weight
    410.7 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    545°C

    Flash point

    • 224.07 ˚C est.

  • Synonyms

    • isostearamidopropyl morpholine
    • 72300-23-3
    • U7190A9Q1L
    • UNII-U7190A9Q1L
    • N-(3-(4-Morpholinyl)propyl)isooctadecanamide
    • Isooctadecanamide, N-(3-(4-morpholinyl)propyl)-
    • Isostearamidopropyl morpholine [INCI]
    • RefChem:201319
    • 16-methyl-N-(3-morpholin-4-ylpropyl)heptadecanamide
    • SCHEMBL28277522
    • LJWPCXCFOGGBFK-UHFFFAOYSA-N
    • Q27290776
    • 72300-23-3

  • Applications

    Isostearamidopropyl morpholine (CAS 72300-23-3) is commonly used as a nonionic surfactant and emulsifier in formulations for cosmetics and personal care, where it can function as a cleansing agent and conditioning component. It is also employed in household cleaning products as a surfactant/emulsifier to aid wetting, debris dispersion, and formulation stability. In industrial manufacturing, it can serve as a processing aid and wetting/dispersion agent in lubricant formulations, metalworking fluids, and polymer processing. In coatings and inks, it acts as a wetting and dispersing additive to improve pigment dispersion and surface leveling. In polymers and plastics, it may be used to improve compatibility and as a processing aid in emulsion polymerization and related formulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 8.66
    methanol 13.6
    isopropanol 5.96
    water 0.4
    ethyl acetate 32.68
    n-propanol 11.08
    acetone 21.75
    n-butanol 12.73
    acetonitrile 7.17
    DMF 35.24
    toluene 18.77
    isobutanol 11.6
    1,4-dioxane 38.34
    methyl acetate 23.86
    THF 82.01
    2-butanone 35.53
    n-pentanol 12.61
    sec-butanol 12.07
    n-hexane 2.44
    ethylene glycol 2.01
    NMP 154.39
    cyclohexane 9.03
    DMSO 60.75
    n-butyl acetate 43.76
    n-octanol 16.72
    chloroform 187.07
    n-propyl acetate 43.04
    acetic acid 48.0
    dichloromethane 157.08
    cyclohexanone 120.81
    propylene glycol 4.47
    isopropyl acetate 34.27
    DMAc 119.61
    2-ethoxyethanol 34.5
    isopentanol 16.85
    n-heptane 2.87
    ethyl formate 23.97
    1,2-dichloroethane 79.92
    n-hexanol 11.28
    2-methoxyethanol 29.84
    isobutyl acetate 34.79
    tetrachloromethane 45.45
    n-pentyl acetate 66.4
    transcutol 195.96
    n-heptanol 17.22
    ethylbenzene 11.35
    MIBK 31.85
    2-propoxyethanol 35.48
    tert-butanol 10.79
    MTBE 16.84
    2-butoxyethanol 52.55
    propionic acid 29.09
    o-xylene 20.91
    formic acid 20.2
    diethyl ether 12.97
    m-xylene 16.44
    p-xylene 16.87
    chlorobenzene 35.29
    dimethyl carbonate 13.13
    n-octane 1.65
    formamide 23.34
    cyclopentanone 108.63
    2-pentanone 33.63
    anisole 20.97
    cyclopentyl methyl ether 54.78
    gamma-butyrolactone 117.31
    1-methoxy-2-propanol 28.71
    pyridine 46.82
    3-pentanone 35.63
    furfural 107.43
    n-dodecane 1.14
    diethylene glycol 19.45
    diisopropyl ether 8.37
    tert-amyl alcohol 19.16
    acetylacetone 49.22
    n-hexadecane 1.33
    acetophenone 41.95
    methyl propionate 29.55
    isopentyl acetate 50.32
    trichloroethylene 183.18
    n-nonanol 17.61
    cyclohexanol 34.37
    benzyl alcohol 22.66
    2-ethylhexanol 15.8
    isooctanol 18.37
    dipropyl ether 19.7
    1,2-dichlorobenzene 49.08
    ethyl lactate 27.17
    propylene carbonate 84.99
    n-methylformamide 19.76
    2-pentanol 10.55
    n-pentane 1.86
    1-propoxy-2-propanol 37.62
    1-methoxy-2-propyl acetate 55.08
    2-(2-methoxypropoxy) propanol 55.24
    mesitylene 13.08
    ε-caprolactone 124.46
    p-cymene 13.56
    epichlorohydrin 109.52
    1,1,1-trichloroethane 93.85
    2-aminoethanol 6.91
    morpholine-4-carbaldehyde 90.87
    sulfolane 207.48
    2,2,4-trimethylpentane 3.74
    2-methyltetrahydrofuran 64.83
    n-hexyl acetate 57.37
    isooctane 1.5
    2-(2-butoxyethoxy)ethanol 66.82
    sec-butyl acetate 37.29
    tert-butyl acetate 47.91
    decalin 4.62
    glycerin 11.8
    diglyme 152.84
    acrylic acid 25.33
    isopropyl myristate 18.45
    n-butyric acid 52.57
    acetyl acetate 34.07
    di(2-ethylhexyl) phthalate 27.2
    ethyl propionate 35.17
    nitromethane 58.7
    1,2-diethoxyethane 52.92
    benzonitrile 25.02
    trioctyl phosphate 17.4
    1-bromopropane 34.94
    gamma-valerolactone 158.95
    n-decanol 10.87
    triethyl phosphate 38.38
    4-methyl-2-pentanol 10.41
    propionitrile 9.43
    vinylene carbonate 67.58
    1,1,2-trichlorotrifluoroethane 137.04
    DMS 35.26
    cumene 10.89
    2-octanol 12.92
    2-hexanone 35.47
    octyl acetate 24.92
    limonene 20.55
    1,2-dimethoxyethane 54.64
    ethyl orthosilicate 38.3
    tributyl phosphate 25.06
    diacetone alcohol 49.56
    N,N-dimethylaniline 19.97
    acrylonitrile 11.35
    aniline 23.72
    1,3-propanediol 12.94
    bromobenzene 38.19
    dibromomethane 93.55
    1,1,2,2-tetrachloroethane 178.69
    2-methyl-cyclohexyl acetate 52.51
    tetrabutyl urea 33.35
    diisobutyl methanol 10.72
    2-phenylethanol 23.12
    styrene 11.81
    dioctyl adipate 39.81
    dimethyl sulfate 45.05
    ethyl butyrate 48.03
    methyl lactate 21.39
    butyl lactate 52.19
    diethyl carbonate 29.86
    propanediol butyl ether 41.67
    triethyl orthoformate 49.11
    p-tert-butyltoluene 12.03
    methyl 4-tert-butylbenzoate 63.35
    morpholine 54.63
    tert-butylamine 7.64
    n-dodecanol 7.31
    dimethoxymethane 24.12
    ethylene carbonate 59.56
    cyrene 66.09
    2-ethoxyethyl acetate 83.79
    2-ethylhexyl acetate 47.23
    1,2,4-trichlorobenzene 67.05
    4-methylpyridine 40.93
    dibutyl ether 23.45
    2,6-dimethyl-4-heptanol 10.72
    DEF 53.9
    dimethyl isosorbide 104.84
    tetrachloroethylene 133.7
    eugenol 52.32
    triacetin 88.73
    span 80 46.83
    1,4-butanediol 6.77
    1,1-dichloroethane 58.73
    2-methyl-1-pentanol 18.17
    methyl formate 16.4
    2-methyl-1-butanol 18.97
    n-decane 2.53
    butyronitrile 12.58
    3,7-dimethyl-1-octanol 17.95
    1-chlorooctane 14.17
    1-chlorotetradecane 4.23
    n-nonane 2.24
    undecane 1.58
    tert-butylcyclohexane 3.42
    cyclooctane 3.23
    cyclopentanol 29.28
    tetrahydropyran 50.04
    tert-amyl methyl ether 26.6
    2,5,8-trioxanonane 87.49
    1-hexene 7.36
    2-isopropoxyethanol 30.95
    2,2,2-trifluoroethanol 34.05
    methyl butyrate 49.36

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction