Isopropyl Palmitate

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  • Identifiers

    CAS number
    142-91-6

    Molecular formula
    C19H38O2

    SMILES
    CCCCCCCCCCCCCCCC(=O)OC(C)C

  • Odor profile

    Fatty 76.01%
    Waxy 74.54%
    Oily 67.03%
    Creamy 39.6%
    Fruity 34.16%
    Dairy 31.93%
    Sweet 31.2%
    Milky 26.42%
    Soapy 25.4%
    Odorless 24.91%

    Scent© AI

  • Properties

    XLogP3-AA
    8.2

    Molecular weight
    298.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • 13.5 °C
    • 13 - 14 °C

    Boiling point

    • 160 °C at 2 mm Hg
    • 342.00 °C. @ 760.00 mm Hg

    Flash point est.
    150.32 ˚C

    Solubility expt.

    • Very soluble in acetone, benzene, ether, ethanol
    • Soluble in 4 parts 90% alcohol; soluble in mineral and fixed oils

  • Synonyms

    • ISOPROPYL PALMITATE
    • 142-91-6
    • Isopropyl hexadecanoate
    • Hexadecanoic acid, 1-methylethyl ester
    • Isopalm
    • Emerest 2316
    • Wickenol 111
    • Deltyl
    • Isopal
    • Propal
    • Deltyl prime
    • Tegester isopalm
    • Ja-fa ippkessco
    • Sinnoester PIT
    • Crodamol IPP
    • Plymouth IPP
    • Starfol IPP
    • Unimate IPP
    • Kessco IPP
    • Emcol-IP
    • Isopropyl n-hexadecanoate
    • Nikkol IPP
    • Stepan D-70
    • Palmitic acid, isopropyl ester
    • 1-Methylethyl hexadecanoate
    • Estol 103
    • Usaf ke-5
    • JA-FA Ipp
    • Kessco isopropyl palmitate
    • Hexadecanoic acid, isopropyl ester
    • propan-2-yl hexadecanoate
    • Hariol ipp
    • Palmitic Acid Isopropyl Ester
    • NSC 69169
    • Estol 1517
    • HSDB 2647
    • Tegosoft P
    • Liponate IPP
    • UNII-8CRQ2TH63M
    • EINECS 205-571-1
    • Lexol IPP
    • 8CRQ2TH63M
    • MFCD00008993
    • NSC-69169
    • BRN 1786567
    • CHEBI:84262
    • 2-propyl hexadecanoate
    • AI3-05733
    • Isopropyl palmitate (NF)
    • Isopropyl palmitate [NF]
    • DTXSID9027104
    • EC 205-571-1
    • 4-02-00-01167 (Beilstein Handbook Reference)
    • Isopropyl ester of hexadecanoic acid
    • NCGC00164128-01
    • WE(2:0(1Me)/16:0)
    • DTXCID507104
    • ISOPROPYL PALMITATE (II)
    • ISOPROPYL PALMITATE [II]
    • ISOPROPYL PALMITATE (MART.)
    • ISOPROPYL PALMITATE [MART.]
    • ISOPROPYL PALMITATE (USP-RS)
    • ISOPROPYL PALMITATE [USP-RS]
    • ISOPROPYL PALMITATE (EP IMPURITY)
    • ISOPROPYL PALMITATE [EP IMPURITY]
    • CAS-142-91-6
    • ISOPROPYL PALMITATE (EP MONOGRAPH)
    • ISOPROPYL PALMITATE [EP MONOGRAPH]
    • iso-propylpalmitate
    • isopropyl-palmitate
    • Hexadecanoic acid 1-methylethyl ester
    • ISOPROPYLPALMITATE
    • Radia 7200
    • 1-methylethyl hexandecanoate
    • SCHEMBL7743
    • Palmitic acid-isopropyl ester
    • Isopropyl palmitate, >=90%
    • CHEMBL139055
    • Hexadecanoic acid isopropyl ester
    • MSK1642
    • Hexadecanoic acid, 1-methyl ester
    • ISOPROPYL PALMITATE [HSDB]
    • WLN: 15VOY1 & 1
    • ISOPROPYL PALMITATE [VANDF]
    • NSC69169
    • Tox21_112085
    • Tox21_202558
    • ISOPROPYL PALMITATE [WHO-DD]
    • LMFA07010675
    • AKOS015902011
    • Tox21_112085_1
    • 1ST1642
    • CS-W012142
    • HY-W011426
    • NCGC00164128-02
    • NCGC00260107-01
    • BS-15396
    • Hexadecanoic acidisopropyl n-hexadecanoate
    • MSK1642-1000
    • Isopropyl palmitate, technical grade, 90%
    • DB-042654
    • NS00009869
    • P0005
    • 1-Methylethyl ester1-methylethyl hexandecanoate
    • 1ST1642-1000
    • D04632
    • SBI-0654057.0001
    • SR-01000944752
    • Isopropyl palmitate Solution in Acetone, 1000?g/mL
    • Q2631777
    • SR-01000944752-1
    • BRD-K30758549-001-01-8
    • Isopropyl palmitate Solution in Acetone, 1000mug/mL
    • Isopropyl hexadecanoate, European Pharmacopoeia (EP) Reference Standard
    • Isopropyl palmitate, United States Pharmacopeia (USP) Reference Standard
    • Isopropyl palmitate, Pharmaceutical Secondary Standard; Certified Reference Material
    • 205-571-1

  • Applications

    Isopropyl palmitate (IPP, CAS 142-91-6) is the ester of isopropanol and palmitic acid that enjoys broad acceptance in personal-care products because it leaves a silky, dry, fast-spreading feel on the skin, so it is widely employed as an emollient, fragrance carrier and skin-penetration enhancer in creams, lotions, lipsticks, foundations, sunscreens and makeup removers; in pharmaceuticals it functions as a solubilizing excipient for poorly soluble actives, boosts dermal bioavailability and acts as a low-friction vehicle in soft-gel formulations; industrially it serves as a biolubricant, mold-release agent, cold-flex additive for PVC, printing-ink solvent, and oily carrier in pesticide emulsions and polishes, taking advantage of its oxidative stability, low volatility and favorable eco-tox profile; IPP also helps control viscosity, prevents sedimentation and imparts surface gloss while remaining odorless, non-sensitizing and compliant with FDA, EU and ASEAN Cosmetic Directive requirements, fitting modern demands for environmentally benign, high-performance ingredients.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 470.03
    methanol 371.43
    isopropanol 737.33
    water 0.05
    ethyl acetate 2370.96
    n-propanol 687.1
    acetone 1848.92
    n-butanol 846.2
    acetonitrile 701.35
    DMF 1980.96
    toluene 944.77
    isobutanol 782.16
    1,4-dioxane 1975.1
    methyl acetate 1380.51
    THF 4126.34
    2-butanone 2102.33
    n-pentanol 562.01
    sec-butanol 908.4
    n-hexane 550.18
    ethylene glycol 22.73
    NMP 3285.73
    cyclohexane 1859.19
    DMSO 1704.66
    n-butyl acetate 2297.46
    n-octanol 548.14
    chloroform 4550.07
    n-propyl acetate 2298.52
    acetic acid 556.78
    dichloromethane 4577.62
    cyclohexanone 5406.83
    propylene glycol 89.93
    isopropyl acetate 2076.62
    DMAc 2565.33
    2-ethoxyethanol 759.2
    isopentanol 1028.76
    n-heptane 408.17
    ethyl formate 920.43
    1,2-dichloroethane 3411.62
    n-hexanol 581.43
    2-methoxyethanol 934.61
    isobutyl acetate 1526.63
    tetrachloromethane 1177.62
    n-pentyl acetate 2438.4
    transcutol 3088.92
    n-heptanol 458.64
    ethylbenzene 659.89
    MIBK 1919.81
    2-propoxyethanol 932.99
    tert-butanol 1187.89
    MTBE 2200.8
    2-butoxyethanol 913.93
    propionic acid 701.17
    o-xylene 780.08
    formic acid 68.92
    diethyl ether 1920.27
    m-xylene 706.67
    p-xylene 1020.92
    chlorobenzene 1547.64
    dimethyl carbonate 382.29
    n-octane 159.45
    formamide 158.9
    cyclopentanone 4355.49
    2-pentanone 2371.26
    anisole 1080.36
    cyclopentyl methyl ether 3082.3
    gamma-butyrolactone 3712.87
    1-methoxy-2-propanol 1108.8
    pyridine 2187.56
    3-pentanone 1864.15
    furfural 2112.13
    n-dodecane 81.17
    diethylene glycol 295.35
    diisopropyl ether 942.36
    tert-amyl alcohol 1280.83
    acetylacetone 2280.23
    n-hexadecane 104.37
    acetophenone 1243.35
    methyl propionate 1506.74
    isopentyl acetate 2217.27
    trichloroethylene 4785.17
    n-nonanol 533.03
    cyclohexanol 1821.62
    benzyl alcohol 609.82
    2-ethylhexanol 737.81
    isooctanol 519.84
    dipropyl ether 1756.01
    1,2-dichlorobenzene 1679.22
    ethyl lactate 573.11
    propylene carbonate 2172.09
    n-methylformamide 641.86
    2-pentanol 850.28
    n-pentane 333.03
    1-propoxy-2-propanol 1121.05
    1-methoxy-2-propyl acetate 1676.85
    2-(2-methoxypropoxy) propanol 766.23
    mesitylene 570.22
    ε-caprolactone 3963.88
    p-cymene 510.84
    epichlorohydrin 3525.52
    1,1,1-trichloroethane 4055.96
    2-aminoethanol 126.49
    morpholine-4-carbaldehyde 2368.47
    sulfolane 4557.72
    2,2,4-trimethylpentane 227.23
    2-methyltetrahydrofuran 3978.47
    n-hexyl acetate 2441.75
    isooctane 141.2
    2-(2-butoxyethoxy)ethanol 1068.23
    sec-butyl acetate 1837.66
    tert-butyl acetate 2483.66
    decalin 497.09
    glycerin 121.52
    diglyme 2376.71
    acrylic acid 390.49
    isopropyl myristate 824.25
    n-butyric acid 1856.77
    acetyl acetate 1254.06
    di(2-ethylhexyl) phthalate 497.81
    ethyl propionate 1986.02
    nitromethane 1372.39
    1,2-diethoxyethane 2011.21
    benzonitrile 1105.09
    trioctyl phosphate 420.64
    1-bromopropane 2492.51
    gamma-valerolactone 4512.65
    n-decanol 344.76
    triethyl phosphate 804.3
    4-methyl-2-pentanol 578.41
    propionitrile 939.41
    vinylene carbonate 1525.42
    1,1,2-trichlorotrifluoroethane 1807.89
    DMS 1137.56
    cumene 474.33
    2-octanol 512.81
    2-hexanone 1918.41
    octyl acetate 947.68
    limonene 1138.79
    1,2-dimethoxyethane 2359.71
    ethyl orthosilicate 800.4
    tributyl phosphate 601.32
    diacetone alcohol 1600.07
    N,N-dimethylaniline 801.81
    acrylonitrile 828.41
    aniline 849.02
    1,3-propanediol 326.13
    bromobenzene 1914.21
    dibromomethane 3352.26
    1,1,2,2-tetrachloroethane 4739.18
    2-methyl-cyclohexyl acetate 1489.74
    tetrabutyl urea 863.31
    diisobutyl methanol 538.97
    2-phenylethanol 597.4
    styrene 803.49
    dioctyl adipate 1112.68
    dimethyl sulfate 762.14
    ethyl butyrate 2137.68
    methyl lactate 440.15
    butyl lactate 1158.7
    diethyl carbonate 1038.15
    propanediol butyl ether 675.8
    triethyl orthoformate 1453.41
    p-tert-butyltoluene 477.84
    methyl 4-tert-butylbenzoate 1197.25
    morpholine 2788.98
    tert-butylamine 925.29
    n-dodecanol 252.99
    dimethoxymethane 1183.23
    ethylene carbonate 1619.37
    cyrene 762.06
    2-ethoxyethyl acetate 1883.43
    2-ethylhexyl acetate 1926.24
    1,2,4-trichlorobenzene 1866.62
    4-methylpyridine 2347.95
    dibutyl ether 1894.95
    2,6-dimethyl-4-heptanol 538.97
    DEF 2779.8
    dimethyl isosorbide 1659.92
    tetrachloroethylene 3081.99
    eugenol 807.92
    triacetin 1753.27
    span 80 889.04
    1,4-butanediol 135.53
    1,1-dichloroethane 3392.08
    2-methyl-1-pentanol 685.13
    methyl formate 422.03
    2-methyl-1-butanol 922.34
    n-decane 199.32
    butyronitrile 1312.18
    3,7-dimethyl-1-octanol 659.66
    1-chlorooctane 869.03
    1-chlorotetradecane 270.8
    n-nonane 209.1
    undecane 116.04
    tert-butylcyclohexane 366.19
    cyclooctane 424.1
    cyclopentanol 1657.58
    tetrahydropyran 4027.69
    tert-amyl methyl ether 1847.97
    2,5,8-trioxanonane 1291.53
    1-hexene 1097.1
    2-isopropoxyethanol 760.03
    2,2,2-trifluoroethanol 234.13
    methyl butyrate 2752.59

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Melittis melissophyllum Melittis melissophylum L., ssp. albida Guss, fam. Lamiaceae (Labiatae) 1.25%
Datura flower headspace (Japan) Datura candida (Pers.), fam. Solanaceae 0.16%