Isopropoxyethanol

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  • Identifiers

    CAS number
    109-59-1

    Molecular formula
    C5H12O2

    SMILES
    CC(C)OCCO

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Ethereal 71.92%
    Alcoholic 69.53%
    Fruity 66.32%
    Fermented 60.73%
    Solvent 46.48%
    Winey 37.85%
    Pungent 35.08%
    Oily 34.94%
    Nutty 32.63%
    Malty 31.14%

     

    Flavor
    Alcoholic 46.35%
    Bitter 44.29%
    Fusel 34.41%
    Ether 32.76%
    Sweet 31.93%
    Musty 31.8%
    Ethereal 31.07%
    Fermented 30.26%
    Alcohol 28.76%
    Fruit 28.14%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    0.1

    pKa est.
    8.18 (weak base)

    Molecular weight
    104.15 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • -60 °C

    Boiling point

    • 285.8 °F at 760 mmHg (USCG, 1999)
    • 144 °C @ 743 MM HG
    • at 99kPa: 139.5-144.5 °C
    • 283 °F

    Flash point

    • 47.97 ˚C est.
    • 91.4 °F (USCG, 1999)
    • 33 °C
    • 92 °F (33 °C) OC
    • 44 °C c.c.
    • (oc) 92 °F

    Solubility expt.

    • Miscible (NIOSH, 2024)
    • SOL IN ALL PROP IN WATER, ALC, ETHER; SOL IN ACETONE
    • Solubility in water, g/100ml at 25 °C: 100
    • Miscible

  • Synonyms

    • 2-Isopropoxyethanol
    • 109-59-1
    • Isopropyl oxitol
    • Dowanal EiPAT
    • Isopropyl cellosolve
    • Ucar AC
    • ISOPROPOXYETHANOL
    • Isopropyl glycol
    • Ethylene glycol isopropyl ether
    • Ethanol, 2-isopropoxy-
    • Ethylene glycol monoisopropyl ether
    • Isopropylethanediol
    • Ethanol, 2-(1-methylethoxy)-
    • 2-propan-2-yloxyethanol
    • 2-(1-Methylethoxy)ethanol
    • Iso-propyl glycol ether
    • Dowanol EiPAT
    • Monoisopropyl ether of ethylene glycol
    • beta-Hydroxyethyl isopropyl ether
    • 2-Isopropoxy-ethanol
    • NSC 1259
    • Isopropylethylene glycol ether
    • HSDB 2831
    • 9L4RL5EKZC
    • .beta.-Hydroxyethyl isopropyl ether
    • Ethylene glycol, monoisopropyl ether
    • EINECS 203-685-6
    • 2-isopropyloxyethanol
    • BRN 1732184
    • DTXSID4047466
    • AI3-03871
    • Ethylene glycol monisopropyl ether
    • NSC-1259
    • 4-Methyl-3-oxa-1-pentanol
    • 2-[(1-methylethyl)oxy]ethanol
    • ISOPROPOXYETHANOL [HSDB]
    • DTXCID2027466
    • EC 203-685-6
    • 2-((1-METHYLETHYL)OXY)ETHANOL
    • Isopropylglycol
    • 2-isopropoxy ethanol
    • UNII-9L4RL5EKZC
    • 2isopropoxyethanol
    • EGiPE
    • MFCD00002866
    • Ethanol, 2isopropoxy
    • Isopropyl glycol ether
    • 2-(isopropyloxy)ethanol
    • 2-isopropoxy-1-ethanol
    • 2-Isopropoxyethanol, 99%
    • 2-Isopropoxyethanol; 98%
    • Ethanol, 2(1methylethoxy)
    • 2-(propan-2-yloxy)ethanol
    • Ethylene glycol monoisopropyl
    • 2-(1-Methoxyethoxy)-ethanol
    • 2-Isopropoxyethanol (ACGIH)
    • ETHANOL, 2-ISOPROPOXY
    • SCHEMBL165976
    • betaHydroxyethyl isopropyl ether
    • CHEMBL3187409
    • 2-(propan-2-yloxy)ethan-1-ol
    • NSC1259
    • WLN: Q2OY1 & 1
    • Tox21_301136
    • B-HYDROXYETHYL ISOPROPYL ETHER
    • AKOS000120277
    • NCGC00248303-01
    • NCGC00255035-01
    • CAS-109-59-1
    • LS-13096
    • E0110
    • NS00009373
    • EN300-20504
    • F93017
    • Q15632912
    • Z104478444
    • 203-685-6

  • Applications

    Isopropoxyethanol (CAS 109-59-1) is a versatile solvent used widely in industrial formulations, particularly in coatings and inks to dissolve resin systems and improve film formation. It also serves as a cleaning and degreasing solvent in manufacturing, including electronics, automotive, and metal finishing, helping prepare surfaces prior to coating or bonding. In addition, it is found in general purpose and industrial cleaning products such as degreasers and cleaning solvents. In polymer processing, it can act as a co-solvent or processing aid to dissolve and blend polymer components. It may be used as a co-solvent or processing aid in cosmetic and personal care formulations, depending on regulatory requirements and formulation needs.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 492.54
    methanol 831.14
    isopropanol 317.19
    water 41.93
    ethyl acetate 82.74
    n-propanol 353.23
    acetone 150.06
    n-butanol 275.28
    acetonitrile 141.1
    DMF 298.59
    toluene 27.6
    isobutanol 204.19
    1,4-dioxane 229.37
    methyl acetate 114.8
    THF 263.34
    2-butanone 109.96
    n-pentanol 141.75
    sec-butanol 248.5
    n-hexane 20.2
    ethylene glycol 335.11
    NMP 252.91
    cyclohexane 26.41
    DMSO 334.46
    n-butyl acetate 65.78
    n-octanol 74.17
    chloroform 239.04
    n-propyl acetate 42.6
    acetic acid 406.81
    dichloromethane 200.48
    cyclohexanone 154.46
    propylene glycol 332.97
    isopropyl acetate 40.32
    DMAc 223.09
    2-ethoxyethanol 213.07
    isopentanol 144.07
    n-heptane 25.03
    ethyl formate 90.63
    1,2-dichloroethane 103.59
    n-hexanol 172.98
    2-methoxyethanol 482.39
    isobutyl acetate 30.35
    tetrachloromethane 68.39
    n-pentyl acetate 44.77
    transcutol 317.45
    n-heptanol 70.13
    ethylbenzene 16.57
    MIBK 38.01
    2-propoxyethanol 255.53
    tert-butanol 282.96
    MTBE 109.5
    2-butoxyethanol 118.65
    propionic acid 260.17
    o-xylene 29.13
    formic acid 305.73
    diethyl ether 104.97
    m-xylene 23.88
    p-xylene 23.08
    chlorobenzene 51.67
    dimethyl carbonate 26.56
    n-octane 8.09
    formamide 178.83
    cyclopentanone 173.46
    2-pentanone 71.26
    anisole 48.36
    cyclopentyl methyl ether 94.55
    gamma-butyrolactone 194.27
    1-methoxy-2-propanol 264.16
    pyridine 115.2
    3-pentanone 56.27
    furfural 203.86
    n-dodecane 7.16
    diethylene glycol 304.07
    diisopropyl ether 21.72
    tert-amyl alcohol 210.47
    acetylacetone 66.09
    n-hexadecane 7.58
    acetophenone 46.83
    methyl propionate 76.91
    isopentyl acetate 53.37
    trichloroethylene 173.84
    n-nonanol 61.37
    cyclohexanol 172.55
    benzyl alcohol 74.44
    2-ethylhexanol 80.26
    isooctanol 50.26
    dipropyl ether 66.59
    1,2-dichlorobenzene 51.35
    ethyl lactate 54.35
    propylene carbonate 102.73
    n-methylformamide 208.96
    2-pentanol 130.85
    n-pentane 25.35
    1-propoxy-2-propanol 167.88
    1-methoxy-2-propyl acetate 71.86
    2-(2-methoxypropoxy) propanol 105.59
    mesitylene 17.02
    ε-caprolactone 132.66
    p-cymene 25.09
    epichlorohydrin 169.14
    1,1,1-trichloroethane 98.96
    2-aminoethanol 410.88
    morpholine-4-carbaldehyde 257.71
    sulfolane 240.18
    2,2,4-trimethylpentane 13.23
    2-methyltetrahydrofuran 182.49
    n-hexyl acetate 70.35
    isooctane 7.58
    2-(2-butoxyethoxy)ethanol 133.24
    sec-butyl acetate 28.76
    tert-butyl acetate 44.18
    decalin 11.29
    glycerin 395.13
    diglyme 210.46
    acrylic acid 240.42
    isopropyl myristate 31.35
    n-butyric acid 211.84
    acetyl acetate 53.73
    di(2-ethylhexyl) phthalate 41.51
    ethyl propionate 39.26
    nitromethane 237.67
    1,2-diethoxyethane 77.73
    benzonitrile 71.6
    trioctyl phosphate 33.03
    1-bromopropane 82.03
    gamma-valerolactone 226.55
    n-decanol 45.06
    triethyl phosphate 36.16
    4-methyl-2-pentanol 52.03
    propionitrile 122.33
    vinylene carbonate 98.45
    1,1,2-trichlorotrifluoroethane 242.53
    DMS 49.58
    cumene 17.47
    2-octanol 45.81
    2-hexanone 50.65
    octyl acetate 43.18
    limonene 43.3
    1,2-dimethoxyethane 203.5
    ethyl orthosilicate 36.79
    tributyl phosphate 37.24
    diacetone alcohol 92.22
    N,N-dimethylaniline 40.76
    acrylonitrile 139.91
    aniline 83.23
    1,3-propanediol 375.52
    bromobenzene 38.8
    dibromomethane 141.13
    1,1,2,2-tetrachloroethane 159.73
    2-methyl-cyclohexyl acetate 49.84
    tetrabutyl urea 47.8
    diisobutyl methanol 42.89
    2-phenylethanol 73.48
    styrene 21.78
    dioctyl adipate 49.39
    dimethyl sulfate 56.71
    ethyl butyrate 48.92
    methyl lactate 88.79
    butyl lactate 59.88
    diethyl carbonate 35.86
    propanediol butyl ether 130.69
    triethyl orthoformate 44.2
    p-tert-butyltoluene 26.71
    methyl 4-tert-butylbenzoate 61.84
    morpholine 291.37
    tert-butylamine 163.39
    n-dodecanol 34.98
    dimethoxymethane 115.84
    ethylene carbonate 77.11
    cyrene 90.09
    2-ethoxyethyl acetate 55.77
    2-ethylhexyl acetate 43.46
    1,2,4-trichlorobenzene 66.86
    4-methylpyridine 102.35
    dibutyl ether 49.19
    2,6-dimethyl-4-heptanol 42.89
    DEF 111.13
    dimethyl isosorbide 127.07
    tetrachloroethylene 133.65
    eugenol 75.55
    triacetin 74.43
    span 80 108.1
    1,4-butanediol 160.01
    1,1-dichloroethane 115.21
    2-methyl-1-pentanol 93.22
    methyl formate 127.91
    2-methyl-1-butanol 160.56
    n-decane 11.49
    butyronitrile 117.33
    3,7-dimethyl-1-octanol 64.48
    1-chlorooctane 35.47
    1-chlorotetradecane 15.4
    n-nonane 12.02
    undecane 8.6
    tert-butylcyclohexane 12.9
    cyclooctane 8.9
    cyclopentanol 214.07
    tetrahydropyran 179.89
    tert-amyl methyl ether 80.61
    2,5,8-trioxanonane 161.74
    1-hexene 46.37
    2-isopropoxyethanol 120.99
    2,2,2-trifluoroethanol 137.34
    methyl butyrate 56.7

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction