Isofucosterol

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  • Identifiers

    CAS number
    481-14-1

    Molecular formula
    C29H48O

    SMILES
    C/C=C(/CC[C@@H](C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C)\C(C)C

    Safety labels

  • Odor profile

    Fragrance
    Woody 83.0%
    Sandalwood 54.98%
    Balsamic 45.61%
    Amber 39.24%
    Sweet 37.88%
    Spicy 37.61%
    Waxy 37.5%
    Dry 36.35%
    Oily 33.82%
    Herbal 33.44%

     

    Flavor
    Woody 55.07%
    Wood 45.5%
    Herb 39.17%
    Spice 36.25%
    Herbal 35.78%
    Waxy 25.67%
    Balsam 24.53%
    Terpene 24.05%
    Citrus 23.48%
    Balsamic 23.2%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    8.9

    pKa est.
    7.88 (neutral)

    Molecular weight
    412.7 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    501°C

    Flash point

    • 218.27 ˚C est.

  • Synonyms

    • Isofucosterol
    • delta5-Avenasterol
    • Delta 5-avenasterol
    • 481-14-1
    • 18472-36-1
    • (24Z)-Ethylidenecholesterol
    • delta5-Avenosterol
    • 24Z-ethylidene-cholest-5-en-3beta-ol
    • S4UL5AI3R2
    • (Z)-24-Ethylidenecholesterol
    • (Z)-Stigmasta-5,24(28)-dien-3beta-ol
    • (Z)-24-Ethylcholesta-5,24(28)-dien-3beta-ol
    • (24Z)-24-Ethylcholesta-5,24(28)-dien-3beta-ol
    • Stigmasta-5,24(28)-dien-3-ol, (3.beta.,24Z)-
    • Delta5-Avenasterol (E/Z mixture)
    • Z ?5-Avenasterol
    • 29-Isofucosterol
    • (3S,8S,9S,10R,13R,14S,17R)-17-((R,E)-5-Isopropylhept-5-en-2-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol
    • (3S,8S,9S,10R,13R,14S,17R)-17-[(Z,1R)-4-isopropyl-1-methyl-hex-4-enyl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
    • CS4PB4FQQ7
    • Stigmasta-5,24(28)-dien-3beta-ol, (Z)-
    • Stigmasta-5,24(28)-dien-3-ol, (3beta)-
    • Stigmasta-5,24(28)-dien-3.beta.-ol, (E)-
    • Stigmasta-5,24(28)-dien-3-ol, (3.beta.,24E)-
    • UNII-S4UL5AI3R2
    • MFCD28016319
    • 5-Cholesten-24(28)-ethylidene-3beta-ol
    • (3beta)-stigmasta-5,24(28)-dien-3-ol
    • 24(E)-Ethylidenecholest-5-en-3.beta.-ol
    • 24(Z)-Ethylidenecholest-5-en-3beta-ol
    • Stigmasta-5,24(28)-dien-3.beta.-ol, (Z)-
    • Stigmasta-5-cis,24(28)-dien-3beta-ol
    • UNII-CS4PB4FQQ7
    • | currency5-?Avenasterol
    • (24Z)-stigmasta-5,24(28)-dien-3beta-ol
    • 24-Ethylcholesta-5,24(28)Z-dien-3beta-ol
    • Stigmasta-5,24(28)-dien-3-ol, (3beta,24Z)-
    • CHEMBL1836654
    • SCHEMBL13833056
    • CHEBI:28604
    • HY-N4103A
    • DTXSID50904509
    • OSELKOCHBMDKEJ-WGMIZEQOSA-N
    • LMST01040145
    • MFCD00037543
    • MSK001404
    • FS-7603
    • MSK001404-100M
    • MSK001404-1000M
    • (Z)-Stigmasta-5,24(28)-dien-3b-ol
    • DA-52428
    • FD165751
    • FF145236
    • (24Z)-Stigmasta-5,24(28)-dien-3-ol
    • (3b,24Z)-Stigmasta-5,24(28)-dien-3-ol
    • C08821
    • (3beta,24Z)-stigmasta-5,24(28)-dien-3-ol
    • (24Z)-Stigmasta-5,24(24~1~)-dien-3beta-ol
    • 24(Z)-ETHYLIDENECHOLEST-5-EN-3.BETA.-OL
    • 605F673
    • (3.beta.,24Z)-Stigmasta-5,24(28)-dien-3-ol
    • delta5-Avenosterol Solution in Methanol, 1000ug/mL
    • delta5-Avenosterol Solution in Methanol, 100ug/mL
    • STIGMASTA-5-CIS,24(28)-DIEN-3.BETA.-OL
    • (Z)-STIGMASTA-5,24(28)-DIEN-3.BETA.-OL
    • Q27288596
    • 24-ETHYLCHOLESTA-5,24(28)Z-DIEN-3.BETA.-OL
    • (Z)-24-ETHYLCHOLESTA-5,24(28)-DIEN-3.BETA.-OL
    • (24Z)-24-ETHYLCHOLESTA-5,24(28)-DIEN-3.BETA.-OL
    • 24(Z)-stigmasta-5,24(24<sup>1</sup>)-dien-3beta-ol
    • 18472-36-1

  • Applications

    Isofucosterol (CAS 481-14-1) is a plant-based sterol derived from natural sources and commonly used as a biobased building block or intermediate in the synthesis of steroidal compounds for pharmaceuticals and specialty chemicals. In cosmetics and personal care, it serves as a skin-conditioning agent and emollient derived from sterols, helping to support the skin’s lipid structure and improve formulation stability in creams and lotions. In industrial manufacturing, it can function as a building block for sterol-derived compounds or as a biobased additive to modulate formulation properties and processing. In research and development, it is used as a reference standard and a substrate for analytical methods and derivatization studies.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 12.82
    methanol 2.47
    isopropanol 10.38
    water 0.03
    ethyl acetate 22.62
    n-propanol 16.6
    acetone 17.45
    n-butanol 24.33
    acetonitrile 2.09
    DMF 10.11
    toluene 58.69
    isobutanol 13.77
    1,4-dioxane 48.4
    methyl acetate 9.75
    THF 79.62
    2-butanone 22.54
    n-pentanol 14.63
    sec-butanol 7.98
    n-hexane 3.12
    ethylene glycol 0.31
    NMP 20.84
    cyclohexane 6.94
    DMSO 5.35
    n-butyl acetate 32.39
    n-octanol 11.7
    chloroform 62.69
    n-propyl acetate 17.49
    acetic acid 4.79
    dichloromethane 34.43
    cyclohexanone 45.73
    propylene glycol 0.79
    isopropyl acetate 29.92
    DMAc 25.5
    2-ethoxyethanol 17.22
    isopentanol 24.8
    n-heptane 4.76
    ethyl formate 5.43
    1,2-dichloroethane 23.49
    n-hexanol 23.9
    2-methoxyethanol 16.03
    isobutyl acetate 21.6
    tetrachloromethane 13.01
    n-pentyl acetate 35.05
    transcutol 134.1
    n-heptanol 19.44
    ethylbenzene 20.12
    MIBK 32.57
    2-propoxyethanol 49.12
    tert-butanol 9.98
    MTBE 23.52
    2-butoxyethanol 40.18
    propionic acid 4.89
    o-xylene 26.86
    formic acid 1.06
    diethyl ether 38.35
    m-xylene 38.71
    p-xylene 20.21
    chlorobenzene 31.88
    dimethyl carbonate 7.15
    n-octane 1.27
    formamide 1.6
    cyclopentanone 37.88
    2-pentanone 31.54
    anisole 35.92
    cyclopentyl methyl ether 46.21
    gamma-butyrolactone 23.92
    1-methoxy-2-propanol 21.89
    pyridine 41.57
    3-pentanone 24.77
    furfural 20.82
    n-dodecane 0.69
    diethylene glycol 11.52
    diisopropyl ether 16.17
    tert-amyl alcohol 7.52
    acetylacetone 31.37
    n-hexadecane 0.87
    acetophenone 27.0
    methyl propionate 17.74
    isopentyl acetate 44.57
    trichloroethylene 47.58
    n-nonanol 15.36
    cyclohexanol 16.77
    benzyl alcohol 17.59
    2-ethylhexanol 20.7
    isooctanol 19.06
    dipropyl ether 37.45
    1,2-dichlorobenzene 28.97
    ethyl lactate 7.79
    propylene carbonate 14.49
    n-methylformamide 3.19
    2-pentanol 14.11
    n-pentane 4.44
    1-propoxy-2-propanol 42.56
    1-methoxy-2-propyl acetate 56.92
    2-(2-methoxypropoxy) propanol 37.4
    mesitylene 22.53
    ε-caprolactone 39.55
    p-cymene 18.48
    epichlorohydrin 36.75
    1,1,1-trichloroethane 26.65
    2-aminoethanol 1.77
    morpholine-4-carbaldehyde 33.11
    sulfolane 21.79
    2,2,4-trimethylpentane 2.41
    2-methyltetrahydrofuran 40.44
    n-hexyl acetate 34.18
    isooctane 2.68
    2-(2-butoxyethoxy)ethanol 52.9
    sec-butyl acetate 20.14
    tert-butyl acetate 38.99
    decalin 3.9
    glycerin 1.84
    diglyme 89.79
    acrylic acid 3.07
    isopropyl myristate 15.99
    n-butyric acid 18.94
    acetyl acetate 17.03
    di(2-ethylhexyl) phthalate 17.95
    ethyl propionate 18.25
    nitromethane 6.35
    1,2-diethoxyethane 51.07
    benzonitrile 14.25
    trioctyl phosphate 11.59
    1-bromopropane 24.55
    gamma-valerolactone 59.95
    n-decanol 10.02
    triethyl phosphate 17.16
    4-methyl-2-pentanol 15.1
    propionitrile 6.75
    vinylene carbonate 14.89
    1,1,2-trichlorotrifluoroethane 18.01
    DMS 17.73
    cumene 14.42
    2-octanol 10.46
    2-hexanone 21.12
    octyl acetate 17.66
    limonene 21.15
    1,2-dimethoxyethane 36.34
    ethyl orthosilicate 22.22
    tributyl phosphate 11.54
    diacetone alcohol 27.12
    N,N-dimethylaniline 26.55
    acrylonitrile 4.97
    aniline 29.54
    1,3-propanediol 7.53
    bromobenzene 41.43
    dibromomethane 29.73
    1,1,2,2-tetrachloroethane 39.19
    2-methyl-cyclohexyl acetate 32.66
    tetrabutyl urea 17.49
    diisobutyl methanol 15.49
    2-phenylethanol 32.27
    styrene 20.46
    dioctyl adipate 22.78
    dimethyl sulfate 9.43
    ethyl butyrate 29.99
    methyl lactate 6.61
    butyl lactate 22.88
    diethyl carbonate 17.54
    propanediol butyl ether 18.08
    triethyl orthoformate 34.54
    p-tert-butyltoluene 17.93
    methyl 4-tert-butylbenzoate 41.13
    morpholine 47.22
    tert-butylamine 8.83
    n-dodecanol 6.5
    dimethoxymethane 31.01
    ethylene carbonate 14.6
    cyrene 25.23
    2-ethoxyethyl acetate 51.46
    2-ethylhexyl acetate 39.16
    1,2,4-trichlorobenzene 36.04
    4-methylpyridine 41.93
    dibutyl ether 18.19
    2,6-dimethyl-4-heptanol 15.49
    DEF 24.18
    dimethyl isosorbide 61.42
    tetrachloroethylene 28.54
    eugenol 37.67
    triacetin 34.27
    span 80 29.66
    1,4-butanediol 2.32
    1,1-dichloroethane 21.67
    2-methyl-1-pentanol 16.59
    methyl formate 2.37
    2-methyl-1-butanol 18.8
    n-decane 1.86
    butyronitrile 11.43
    3,7-dimethyl-1-octanol 15.64
    1-chlorooctane 8.43
    1-chlorotetradecane 2.57
    n-nonane 1.52
    undecane 1.07
    tert-butylcyclohexane 3.41
    cyclooctane 3.19
    cyclopentanol 9.88
    tetrahydropyran 60.99
    tert-amyl methyl ether 17.32
    2,5,8-trioxanonane 55.82
    1-hexene 9.41
    2-isopropoxyethanol 18.21
    2,2,2-trifluoroethanol 2.37
    methyl butyrate 17.86

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction