Isoferulic Acid

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  • Identifiers

    CAS number
    537-73-5

    Molecular formula
    C10H10O4

    SMILES
    COC1=C(C=C(C=C1)/C=C/C(=O)O)O

    Safety labels

    Irritant
    Irritant

  • Properties

    XLogP3-AA
    1.5

    Molecular weight
    194.18 g/mol

    Melting point expt.

    • 228 - 233 °C

    Boiling point

    • 409.00 to 411.00 °C. @ 760.00 mm Hg

  • Synonyms

    • Isoferulic acid
    • 3-Hydroxy-4-methoxycinnamic acid
    • 537-73-5
    • Hesperetic acid
    • (2E)-3-(3-hydroxy-4-methoxyphenyl)prop-2-enoic acid
    • 3-(3-Hydroxy-4-methoxyphenyl)-2-propenoic acid
    • XSQ2K2G7MC
    • (E)-3-(3-hydroxy-4-methoxyphenyl)prop-2-enoic acid
    • NSC-51987
    • CHEBI:27794
    • DTXSID80862148
    • RefChem:39780
    • DTXCID50810954
    • 208-676-0
    • 25522-33-2
    • trans-Isoferulic acid
    • 3-(3-Hydroxy-4-methoxyphenyl)acrylic acid
    • (E)-3-(3-hydroxy-4-methoxyphenyl)acrylic acid
    • 2-Propenoic acid, 3-(3-hydroxy-4-methoxyphenyl)-
    • MFCD00004391
    • Isoferulate
    • (E)-3'-Hydroxy-4'-methoxycinnamic acid
    • Cinnamic acid, 3-hydroxy-4-methoxy-
    • trans-3-Hydroxy-4-methoxycinnamic acid
    • CHEMBL233295
    • (E)-3-(3-hydroxy-4-methoxy-phenyl)-acrylic acid
    • 3-Hydroxy-4-methoxycinnamic acid (isoferulic acid)
    • cis-Isoferulic acid
    • 3-Hydroxy-4-methoxycinnamate
    • Hesperetinic acid
    • 3-hydroxy-4-methoxy-cinnamic acid
    • UNII-XSQ2K2G7MC
    • Hesperetate
    • Isoferulasaure
    • isoferrulic acid
    • iso-ferulic acid
    • Hesperetic acid;
    • rans-3-(3-Hydroxy-4-methoxyphenyl)acrylic acid; trans-3-Hydroxy-4-methoxycinnamic acid; Hesperetic acid; trans-Isoferulic acid
    • EINECS 208-676-0
    • EINECS 247-071-6
    • NSC 51987
    • BRN 2212760
    • bmse000618
    • 4-10-00-01777 (Beilstein Handbook Reference)
    • MLS000563054
    • SCHEMBL249041
    • 3-hydroxy-4-methoxy-Cinnamate
    • 4-O-METHYLCAFFEIC ACID
    • 3-Hydroxy-4-methoxycinnamic acid, predominantly trans
    • GTPL7980
    • orb1304884
    • SCHEMBL29574481
    • HY-N0761A
    • 3-Hydroxy-4-methoxycinnamic-acid
    • 2-Propenoic acid, 3-(3-hydroxy-4-methoxyphenyl)-, (2E)-
    • DTXSID901314847
    • HMS2268G06
    • ABA52233
    • BB_NC-03267
    • HY-N0761
    • MSK40364
    • NSC51987
    • STR05122
    • BBL036268
    • BDBM50241245
    • EBC-69057
    • s3764
    • SBB042817
    • STL186177
    • AKOS000141174
    • CCG-266533
    • CS-W020120
    • DB07109
    • FH24260
    • 3-Hydroxy-4-Methoxycinnamic Acid,Trans
    • NCGC00247490-01
    • NCGC00247490-02
    • AC-34927
    • LS-13768
    • MS-11465
    • SMR001215828
    • ST098721
    • SY013717
    • SY290434
    • trans-Isoferulic acid, analytical standard
    • 3-(3-hydroxy-4-methoxyphenyl)-2-Propenoate
    • H0524
    • NS00014666
    • EN300-50983
    • (E)-3-(3-hydroxy-4-methoxyphenyl)acrylicacid
    • EN300-331979
    • G77265
    • 537H735
    • F554593
    • F791625
    • Q27096447
    • (2E)-3-(3-HYDROXY-4-METHOXYPHENYL)ACRYLIC ACID
    • (E)-3-(3-hydroxy-4-methoxy-phenyl)prop-2-enoic acid
    • Z2693271860
    • (2E)-3-(3-Hydroxy-4-methoxyphenyl)-2-propenoic acid #
    • 3-Hydroxy-4-methoxycinnamic acid, predominantly trans, 97%
    • ISOFERULIC ACID (CONSTITUENT OF BLACK COHOSH) [DSC]
    • 4FE
    • 25522-33-2

  • Applications

    Isoferulic acid (CAS 537-73-5) is used as a versatile building block and functional additive across several industries: in perfumery it serves as an odorant and can function as a fixative; in cosmetics and personal care it is evaluated for antioxidant activity and as a stabilizer to protect formulations from oxidation and photodegradation; as an intermediate in organic synthesis it supports pharmaceutical and specialty chemical manufacturing; in polymer and coating applications it acts as a phenolic modifier and antioxidant/UV-stabilizer to enhance durability and aging resistance; and in coatings and inks it may contribute to oxidative stability and compatibility with bio-based polymers.

    gpt-5-nano

1 3

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction