Ipriflavone

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  • Identifiers

    CAS number
    35212-22-7

    Molecular formula
    C18H16O3

    SMILES
    CC(C)OC1=CC2=C(C=C1)C(=O)C(=CO2)C3=CC=CC=C3

    Safety labels

  • Odor profile

    Fragrance
    Sweet 50.19%
    Fruity 44.11%
    Phenolic 37.91%
    Floral 37.28%
    Herbal 34.05%
    Animal 30.99%
    Spicy 28.71%
    Powdery 27.75%
    Balsamic 27.67%
    Aromatic 26.98%

     

    Flavor
    Bitter 88.85%
    Parsley 19.16%
    Cedarleaf 19.05%
    Lovage 18.95%
    Herbal 18.95%
    Butyric 18.73%
    Broom 18.65%
    Tarragon 18.61%
    Heather 18.57%
    Aniseed 18.48%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    4.0

    pKa est.
    7.12 (neutral)

    Molecular weight
    280.3 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    424°C

    Melting point expt.

    • 115 - 117 °C

    Flash point

    • 178.54 ˚C est.

  • Synonyms

    • ipriflavone
    • 35212-22-7
    • Osten
    • Yambolap
    • 7-Isopropoxyisoflavone
    • Ipriflavona
    • Ipriflavonum
    • Ostivone
    • 7-(1-Methylethoxy)-3-phenyl-4H-1-benzopyran-4-one
    • 3-phenyl-7-(propan-2-yloxy)-4H-chromen-4-one
    • DTXSID5040679
    • 80BJ7WN25Z
    • NSC-755888
    • DTXCID3020679
    • CHEBI:31719
    • RefChem:923535
    • M05BX01
    • 7-(1-Methylethyl)oxy-3-phenyl-4H-chromen-4-one
    • Osteofix
    • 7-Isopropoxy-3-phenyl-4H-1-benzopyran-4-one
    • Iprosten
    • Osteoquine
    • 7-isopropoxy-3-phenyl-4H-chromen-4-one
    • 3-phenyl-7-propan-2-yloxychromen-4-one
    • Ipriflavone [INN:JAN]
    • Osten (TN)
    • FL-113
    • Osteochin
    • TC 80
    • FL 113
    • MFCD00221719
    • MLS000069470
    • 7-isopropyloxy-isoflavone
    • SMR000059060
    • 4H-1-Benzopyran-4-one, 7-(1-methylethoxy)-3-phenyl-
    • NCGC00024094-04
    • Quinogin
    • Ipriflavone (Osteofix)
    • Iprivone
    • Ipriflavonum [INN-Latin]
    • Ipriflavona [INN-Spanish]
    • CAS-35212-22-7
    • CCRIS 1920
    • BRN 4754346
    • UNII-80BJ7WN25Z
    • Ipriflavon
    • Ipriflavone RS
    • (Ipriflavone)
    • Osten;
    • Ipriflavone, INN
    • TC-80
    • 7-Isopropoxy-3-phenyl-chromen-4-one
    • 7-isopropoxy-isoflavone
    • Ipriflavone (Standard)
    • Ipriflavone (JAN/INN)
    • IPRIFLAVONE [MI]
    • Opera_ID_1176
    • IPRIFLAVONE [INN]
    • IPRIFLAVONE [JAN]
    • Ipriflavone (JP18/INN)
    • IPRIFLAVONE [VANDF]
    • Cambridge id 6663564
    • cid_3747
    • IPRIFLAVONE [MART.]
    • Oprea1_106310
    • Oprea1_275552
    • IPRIFLAVONE [WHO-DD]
    • MLS000759494
    • MLS001146879
    • MLS001424060
    • MLS006011644
    • SCHEMBL111472
    • 7-isopropoxy-3-phenyl-chromone
    • CHEMBL165790
    • orb1310736
    • Ipriflavone, analytical standard
    • SCHEMBL29485035
    • BDBM43662
    • HY-N0094R
    • SFBODOKJTYAUCM-UHFFFAOYSA-
    • FL113
    • HMS2051J15
    • HMS2234M05
    • HMS3371E17
    • HMS3393J15
    • HMS3656K19
    • HMS3715D04
    • HMS5081E03
    • TN-39
    • HY-N0094
    • Tox21_111532
    • Tox21_113172
    • MSK169313
    • s2422
    • STL512460
    • AKOS003627375
    • Tox21_111532_1
    • Tox21_113172_1
    • AC-8130
    • CCG-100963
    • CS-6395
    • DB13618
    • FI07802
    • NC00213
    • NSC 755888
    • 7-(methylethoxy)-3-phenylchromen-4-one
    • NCGC00018139-01
    • NCGC00018139-02
    • NCGC00018139-03
    • NCGC00018139-04
    • NCGC00018139-05
    • NCGC00018139-07
    • NCGC00018139-08
    • AS-12306
    • ST083683
    • SY057448
    • 3-phenyl-7-propan-2-yloxy-chromen-4-one
    • DB-048754
    • I0669
    • NS00010326
    • SW197593-2
    • 3-phenyl-7-propan-2-yloxy-1-benzopyran-4-one
    • D01338
    • D70301
    • AB00384280-21
    • 212I227
    • F806943
    • 35212-22-7

  • Applications

    Ipriflavone, CAS number: 35212-22-7, is primarily used as a pharmaceutical intermediate and research chemical, providing a core isoflavone scaffold for the synthesis of related derivatives in drug development; in some markets it is also marketed or evaluated as a nutraceutical/dietary supplement ingredient; in cosmetic research it has been explored as a bioactive scaffold for isoflavone-derived formulations; and in chemical synthesis it serves as a reference reagent in isoflavone chemistry and related R&D workflows.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 16.0
    methanol 15.89
    isopropanol 9.58
    water 0.02
    ethyl acetate 46.58
    n-propanol 15.21
    acetone 80.49
    n-butanol 15.56
    acetonitrile 42.83
    DMF 229.86
    toluene 57.06
    isobutanol 13.57
    1,4-dioxane 121.68
    methyl acetate 77.09
    THF 322.46
    2-butanone 66.2
    n-pentanol 14.34
    sec-butanol 9.74
    n-hexane 0.57
    ethylene glycol 8.45
    NMP 269.68
    cyclohexane 1.57
    DMSO 210.37
    n-butyl acetate 31.5
    n-octanol 4.78
    chloroform 299.55
    n-propyl acetate 36.51
    acetic acid 63.14
    dichloromethane 486.22
    cyclohexanone 138.14
    propylene glycol 8.76
    isopropyl acetate 30.39
    DMAc 250.52
    2-ethoxyethanol 40.18
    isopentanol 17.08
    n-heptane 0.66
    ethyl formate 32.89
    1,2-dichloroethane 298.98
    n-hexanol 11.25
    2-methoxyethanol 74.24
    isobutyl acetate 27.87
    tetrachloromethane 8.55
    n-pentyl acetate 19.67
    transcutol 235.49
    n-heptanol 6.24
    ethylbenzene 14.33
    MIBK 33.97
    2-propoxyethanol 46.73
    tert-butanol 14.52
    MTBE 19.17
    2-butoxyethanol 23.19
    propionic acid 35.78
    o-xylene 17.88
    formic acid 18.2
    diethyl ether 23.05
    m-xylene 21.22
    p-xylene 20.37
    chlorobenzene 87.96
    dimethyl carbonate 50.29
    n-octane 0.41
    formamide 40.32
    cyclopentanone 231.69
    2-pentanone 47.6
    anisole 43.33
    cyclopentyl methyl ether 82.19
    gamma-butyrolactone 251.85
    1-methoxy-2-propanol 43.84
    pyridine 171.34
    3-pentanone 42.91
    furfural 202.39
    n-dodecane 0.59
    diethylene glycol 48.01
    diisopropyl ether 5.99
    tert-amyl alcohol 12.02
    acetylacetone 96.02
    n-hexadecane 0.72
    acetophenone 48.42
    methyl propionate 61.64
    isopentyl acetate 33.89
    trichloroethylene 537.99
    n-nonanol 5.79
    cyclohexanol 23.8
    benzyl alcohol 39.23
    2-ethylhexanol 10.04
    isooctanol 6.85
    dipropyl ether 15.28
    1,2-dichlorobenzene 70.17
    ethyl lactate 21.02
    propylene carbonate 95.5
    n-methylformamide 63.64
    2-pentanol 8.11
    n-pentane 0.41
    1-propoxy-2-propanol 28.94
    1-methoxy-2-propyl acetate 53.3
    2-(2-methoxypropoxy) propanol 40.58
    mesitylene 8.87
    ε-caprolactone 109.62
    p-cymene 9.41
    epichlorohydrin 426.34
    1,1,1-trichloroethane 92.99
    2-aminoethanol 14.13
    morpholine-4-carbaldehyde 200.26
    sulfolane 271.56
    2,2,4-trimethylpentane 0.87
    2-methyltetrahydrofuran 129.36
    n-hexyl acetate 23.11
    isooctane 0.58
    2-(2-butoxyethoxy)ethanol 46.93
    sec-butyl acetate 24.65
    tert-butyl acetate 35.07
    decalin 1.77
    glycerin 22.05
    diglyme 116.96
    acrylic acid 47.17
    isopropyl myristate 11.45
    n-butyric acid 39.77
    acetyl acetate 43.02
    di(2-ethylhexyl) phthalate 17.22
    ethyl propionate 32.27
    nitromethane 159.82
    1,2-diethoxyethane 50.74
    benzonitrile 56.36
    trioctyl phosphate 9.28
    1-bromopropane 58.89
    gamma-valerolactone 259.34
    n-decanol 4.8
    triethyl phosphate 21.59
    4-methyl-2-pentanol 7.64
    propionitrile 31.68
    vinylene carbonate 95.83
    1,1,2-trichlorotrifluoroethane 155.32
    DMS 56.61
    cumene 9.36
    2-octanol 4.06
    2-hexanone 36.96
    octyl acetate 14.04
    limonene 11.87
    1,2-dimethoxyethane 91.28
    ethyl orthosilicate 19.34
    tributyl phosphate 14.68
    diacetone alcohol 43.52
    N,N-dimethylaniline 25.72
    acrylonitrile 62.12
    aniline 62.78
    1,3-propanediol 23.04
    bromobenzene 92.23
    dibromomethane 209.06
    1,1,2,2-tetrachloroethane 303.35
    2-methyl-cyclohexyl acetate 30.13
    tetrabutyl urea 20.37
    diisobutyl methanol 8.07
    2-phenylethanol 32.57
    styrene 22.65
    dioctyl adipate 23.84
    dimethyl sulfate 96.1
    ethyl butyrate 28.3
    methyl lactate 32.8
    butyl lactate 19.33
    diethyl carbonate 24.09
    propanediol butyl ether 18.27
    triethyl orthoformate 24.22
    p-tert-butyltoluene 7.95
    methyl 4-tert-butylbenzoate 35.89
    morpholine 146.8
    tert-butylamine 7.59
    n-dodecanol 4.12
    dimethoxymethane 113.64
    ethylene carbonate 73.67
    cyrene 50.78
    2-ethoxyethyl acetate 46.76
    2-ethylhexyl acetate 26.33
    1,2,4-trichlorobenzene 92.5
    4-methylpyridine 138.5
    dibutyl ether 13.02
    2,6-dimethyl-4-heptanol 8.07
    DEF 74.71
    dimethyl isosorbide 91.52
    tetrachloroethylene 151.72
    eugenol 35.58
    triacetin 43.38
    span 80 25.09
    1,4-butanediol 10.17
    1,1-dichloroethane 130.76
    2-methyl-1-pentanol 17.65
    methyl formate 61.82
    2-methyl-1-butanol 15.39
    n-decane 0.82
    butyronitrile 28.03
    3,7-dimethyl-1-octanol 8.18
    1-chlorooctane 5.31
    1-chlorotetradecane 2.82
    n-nonane 0.64
    undecane 0.68
    tert-butylcyclohexane 1.42
    cyclooctane 0.39
    cyclopentanol 35.76
    tetrahydropyran 90.27
    tert-amyl methyl ether 17.2
    2,5,8-trioxanonane 83.41
    1-hexene 5.5
    2-isopropoxyethanol 29.26
    2,2,2-trifluoroethanol 28.88
    methyl butyrate 44.11

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction