Inosinic Acid

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  • Identifiers

    CAS number
    131-99-7

    Molecular formula
    C10H13N4O8P

    SMILES
    C1=NC2=C(C(=O)N1)N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(O)O)O)O

  • Odor profile

    Fragrance
    Odorless 90.34%
    Bitter 17.09%
    Savory 16.64%
    Cooked 14.62%
    Clean 14.16%
    Milky 14.04%
    Cooling 12.82%
    Alcoholic 10.71%
    Burnt 10.39%
    Meaty 10.22%

     

    Flavor
    Bitter 63.67%
    Odorless 57.26%
    Bland 32.63%
    Very mild 28.5%
    Mild 24.87%
    Sweet-like 24.51%
    Yeast 20.45%
    Nitrile 19.25%
    Formyl 18.97%
    Bread crust 18.9%

     

    Odor impact est.
    Odorless

  • Properties

    XLogP3-AA
    -3.0

    pKa est.
    6.5 (neutral)

    Molecular weight
    348.21 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    3044°C

    Flash point

    • 388.53 ˚C est.

    Solubility expt.

    • Freely soluble in water, slightly soluble in ethanol

  • Synonyms

    • Inosinic acid
    • 5'-inosinic acid
    • 131-99-7
    • inosine 5'-monophosphate
    • inosine monophosphate
    • 5'-IMP
    • 5'-inosinate
    • IMP
    • inosine 5'-phosphate
    • 5'-inosine monophosphate
    • INOSINE-5'-MONOPHOSPHATE
    • Inosine-5'-monophosphoric acid
    • Inosine 5'-Monophosphoric acid
    • BRN 0630517
    • UNII-TAO7US05G5
    • Cytosine inosinate
    • EINECS 205-045-1
    • TAO7US05G5
    • ribosylhypoxanthine monophosphate
    • CHEBI:17202
    • 30918-54-8
    • Inosine 5'-(dihydrogen phosphate)
    • 2'-inosine-5'-monophosphate
    • INOSINIC ACID, 5'-
    • hypoxanthosine 5'-monophosphate
    • INS NO.630
    • INS-630
    • inosinate
    • I-5'-P
    • CID 5280323
    • E-630
    • HYPOXANTHINE RIBOSIDE-5-PHOSPHORIC ACID
    • [(2R,3S,4R,5R)-3,4-Dihydroxy-5-(6-oxo-1H-purin-9-yl)oxolan-2-yl]methyl dihydrogen phosphate
    • Acid, Inosinic
    • [(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-hydroxypurin-9-yl)oxolan-2-yl]methyl dihydrogen phosphate
    • {[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-6,9-dihydro-3H-purin-9-yl)oxolan-2-yl]methoxy}phosphonic acid
    • inosinsaure
    • inosine phosphate
    • 1yfz
    • Inosinic acid;IMP
    • 5'-aInosinic acid
    • 1g9s
    • 1qk4
    • 1z6d
    • 5'-IMP; IMP; Inosine 5'-(dihydrogen phosphate)
    • Inosine 5' monophosphate
    • [3h]inosine monophosphate
    • Inosinic acid (Standard)
    • bmse000175
    • INOSINIC ACID [MI]
    • SCHEMBL19255
    • ((2R,3S,4R,5R)-3,4-Dihydroxy-5-(6-hydroxy-9H-purin-9-yl)tetrahydrofuran-2-yl)methyl dihydrogen phosphate
    • GTPL5124
    • CHEMBL1207374
    • BDBM19254
    • DTXSID80948097
    • 1p17
    • 1p19
    • Inosine-5'-(dihydrogen phosphate)
    • CYTOSINE INOSINATE [WHO-DD]
    • MFCD00066754
    • STL564942
    • AKOS015896456
    • AKOS015918470
    • AKOS030494380
    • DB04566
    • HY-108213R
    • NI10026
    • AS-56817
    • HY-108213
    • CS-0027540
    • NS00014854
    • C00130
    • F81515
    • A1-01972
    • Q27074273
    • BB128E2C-BC89-4360-B0A0-190DDF5C0B57
    • I-5 inverted exclamation marka-P IMP Inosinic Acid;IMP
    • Inosine 5'-monophosphate - from Saccharomyces Cerevisiae
    • [(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-3H-purin-9-yl)oxolan-2-yl]methyl dihydrogen
    • [(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-1H-purin-9-yl)tetrahydrofuran-2-yl]methyl dihydrogen phosphate
    • {[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-6,9-dihydro-1H-purin-9-yl)oxolan-2-yl]methoxy}phosphonic acid
    • 205-045-1
    • 25249-22-3

  • Applications

    Inosinic acid (IMP; CAS 131-99-7) is primarily used as a flavor-enhancing nucleotide in the food industry, contributing to umami when paired with other nucleotides and often used to boost savoriness in processed foods. It also serves as an intermediate in the industrial synthesis of nucleotides and nucleotide-containing ingredients for pharmaceutical and biotechnology applications. In bioprocessing, IMP can be included in fermentation or cell-culture media as a growth supplement to support microbial or mammalian production. It is also employed as a building block for nucleotide-based reagents used in research, development, and analytical standards. Its use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.25
    methanol 0.66
    isopropanol 0.32
    water 17.95
    ethyl acetate 0.05
    n-propanol 0.38
    acetone 0.13
    n-butanol 0.33
    acetonitrile 0.15
    DMF 10.6
    toluene 0.02
    isobutanol 0.23
    1,4-dioxane 0.34
    methyl acetate 0.12
    THF 0.62
    2-butanone 0.23
    n-pentanol 0.19
    sec-butanol 0.42
    n-hexane 0.02
    ethylene glycol 5.55
    NMP 28.62
    cyclohexane 0.05
    DMSO 13.56
    n-butyl acetate 0.13
    n-octanol 0.18
    chloroform 0.02
    n-propyl acetate 0.07
    acetic acid 1.68
    dichloromethane 0.02
    cyclohexanone 0.58
    propylene glycol 4.77
    isopropyl acetate 0.04
    DMAc 12.49
    2-ethoxyethanol 2.28
    isopentanol 0.22
    n-heptane 0.08
    ethyl formate 0.16
    1,2-dichloroethane 0.03
    n-hexanol 0.27
    2-methoxyethanol 5.83
    isobutyl acetate 0.02
    tetrachloromethane 0.02
    n-pentyl acetate 0.12
    transcutol 1.59
    n-heptanol 0.35
    ethylbenzene 0.02
    MIBK 0.08
    2-propoxyethanol 2.17
    tert-butanol 0.31
    MTBE 0.06
    2-butoxyethanol 1.64
    propionic acid 0.78
    o-xylene 0.04
    formic acid 19.68
    diethyl ether 0.09
    m-xylene 0.02
    p-xylene 0.03
    chlorobenzene 0.01
    dimethyl carbonate 0.32
    n-octane 0.03
    formamide 18.47
    cyclopentanone 0.98
    2-pentanone 0.14
    anisole 0.04
    cyclopentyl methyl ether 0.3
    gamma-butyrolactone 1.19
    1-methoxy-2-propanol 3.2
    pyridine 0.3
    3-pentanone 0.19
    furfural 1.6
    n-dodecane 0.02
    diethylene glycol 5.79
    diisopropyl ether 0.03
    tert-amyl alcohol 0.37
    acetylacetone 0.12
    n-hexadecane 0.02
    acetophenone 0.11
    methyl propionate 0.19
    isopentyl acetate 0.09
    trichloroethylene 0.03
    n-nonanol 0.2
    cyclohexanol 0.47
    benzyl alcohol 0.13
    2-ethylhexanol 0.16
    isooctanol 0.19
    dipropyl ether 0.29
    1,2-dichlorobenzene 0.01
    ethyl lactate 0.56
    propylene carbonate 0.35
    n-methylformamide 3.88
    2-pentanol 0.24
    n-pentane 0.03
    1-propoxy-2-propanol 1.48
    1-methoxy-2-propyl acetate 0.24
    2-(2-methoxypropoxy) propanol 1.07
    mesitylene 0.02
    ε-caprolactone 0.53
    p-cymene 0.04
    epichlorohydrin 0.27
    1,1,1-trichloroethane 0.01
    2-aminoethanol 4.15
    morpholine-4-carbaldehyde 8.45
    sulfolane 7.12
    2,2,4-trimethylpentane 0.01
    2-methyltetrahydrofuran 0.33
    n-hexyl acetate 0.1
    isooctane 0.0
    2-(2-butoxyethoxy)ethanol 1.54
    sec-butyl acetate 0.04
    tert-butyl acetate 0.05
    decalin 0.01
    glycerin 24.8
    diglyme 2.4
    acrylic acid 1.59
    isopropyl myristate 0.05
    n-butyric acid 0.36
    acetyl acetate 0.03
    di(2-ethylhexyl) phthalate 0.1
    ethyl propionate 0.08
    nitromethane 2.01
    1,2-diethoxyethane 0.19
    benzonitrile 0.08
    trioctyl phosphate 0.13
    1-bromopropane 0.02
    gamma-valerolactone 2.64
    n-decanol 0.15
    triethyl phosphate 0.2
    4-methyl-2-pentanol 0.09
    propionitrile 0.14
    vinylene carbonate 0.26
    1,1,2-trichlorotrifluoroethane 2.51
    DMS 0.1
    cumene 0.02
    2-octanol 0.2
    2-hexanone 0.11
    octyl acetate 0.09
    limonene 0.07
    1,2-dimethoxyethane 1.41
    ethyl orthosilicate 0.17
    tributyl phosphate 0.11
    diacetone alcohol 0.51
    N,N-dimethylaniline 0.08
    acrylonitrile 0.26
    aniline 0.11
    1,3-propanediol 2.78
    bromobenzene 0.0
    dibromomethane 0.02
    1,1,2,2-tetrachloroethane 0.06
    2-methyl-cyclohexyl acetate 0.12
    tetrabutyl urea 0.4
    diisobutyl methanol 0.09
    2-phenylethanol 0.15
    styrene 0.01
    dioctyl adipate 0.09
    dimethyl sulfate 1.25
    ethyl butyrate 0.15
    methyl lactate 1.72
    butyl lactate 0.56
    diethyl carbonate 0.11
    propanediol butyl ether 1.73
    triethyl orthoformate 0.26
    p-tert-butyltoluene 0.04
    methyl 4-tert-butylbenzoate 0.3
    morpholine 0.9
    tert-butylamine 0.12
    n-dodecanol 0.11
    dimethoxymethane 1.19
    ethylene carbonate 0.2
    cyrene 2.57
    2-ethoxyethyl acetate 0.15
    2-ethylhexyl acetate 0.08
    1,2,4-trichlorobenzene 0.02
    4-methylpyridine 0.13
    dibutyl ether 0.11
    2,6-dimethyl-4-heptanol 0.09
    DEF 0.94
    dimethyl isosorbide 1.31
    tetrachloroethylene 0.06
    eugenol 0.56
    triacetin 0.16
    span 80 0.77
    1,4-butanediol 1.42
    1,1-dichloroethane 0.01
    2-methyl-1-pentanol 0.13
    methyl formate 1.33
    2-methyl-1-butanol 0.3
    n-decane 0.03
    butyronitrile 0.1
    3,7-dimethyl-1-octanol 0.09
    1-chlorooctane 0.04
    1-chlorotetradecane 0.02
    n-nonane 0.03
    undecane 0.02
    tert-butylcyclohexane 0.01
    cyclooctane 0.03
    cyclopentanol 0.89
    tetrahydropyran 0.23
    tert-amyl methyl ether 0.11
    2,5,8-trioxanonane 1.9
    1-hexene 0.03
    2-isopropoxyethanol 0.73
    2,2,2-trifluoroethanol 2.25
    methyl butyrate 0.15

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction