Indole-3-acetamide

Overview IFRA Request a quote

  • Identifiers

    CAS number
    879-37-8

    Molecular formula
    C10H10N2O

    SMILES
    C1=CC=C2C(=C1)C(=CN2)CC(=O)N

    Safety labels

  • Odor profile

    Fragrance
    Fruity 39.38%
    Grape 35.29%
    Odorless 34.85%
    Cooked 30.61%
    Meaty 28.88%
    Savory 27.09%
    Animal 25.79%
    Cheesy 25.7%
    Burnt 24.57%
    Fatty 24.55%

     

    Flavor
    Odorless 46.07%
    Bitter 43.61%
    Mild 38.63%
    Nutty 24.32%
    Sour 23.7%
    Bread crust 21.94%
    Orange flower 21.5%
    Nitrile 21.42%
    Taco 21.13%
    Yeast 21.01%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    0.8

    pKa est.
    6.3 (neutral)

    Molecular weight
    174.2 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    436°C

    Melting point expt.

    • 150 - 151 °C

    Flash point

    • 213.97 ˚C est.

  • Synonyms

    • indole-3-acetamide
    • 879-37-8
    • 2-(1H-Indol-3-yl)acetamide
    • 3-Indoleacetamide
    • Indoleacetamide
    • (indol-3-yl)acetamide
    • O9SEW65XW3
    • DTXSID60236686
    • NSC-1969
    • CHEBI:16031
    • RefChem:148193
    • DTXCID90159177
    • 212-904-4
    • 1H-Indole-3-acetamide
    • 3-Indolylacetamide
    • MFCD00005641
    • 1H-Indol-3-ylacetamide
    • 2-(3-Indolyl)acetamide
    • 1-Indole-3-acetamide
    • NSC 1969
    • (1H-indol-3-yl)acetamide
    • Indole-3-acetamide (6CI,8CI)
    • 2-indol-3-ylacetamide
    • TSR
    • Auxin amide
    • 3-INDOLE ACETAMIDE
    • EINECS 212-904-4
    • 1H-indol-3-yl-acetamide
    • bmse000696
    • UNII-O9SEW65XW3
    • Indole-3-acetamide, 98%
    • Indole-3-acetamide (8CI)
    • Oprea1_704903
    • SCHEMBL40822
    • 879-06-1
    • 1H-Indole-3-ethanimidic acid
    • orb1302525
    • SCHEMBL2825118
    • SCHEMBL3447947
    • 3-Indolylacetamide;NSC 1969
    • 2-(1H-indol-3-yl)-acetamide
    • SCHEMBL29376364
    • ZOAMBXDOGPRZLP-UHFFFAOYSA-
    • NSC1969
    • 2-(1H-Indol-3-yl)acetamide #
    • HMS1740A02
    • HMS3604E11
    • HB0341
    • s5610
    • SBB055978
    • AKOS001129741
    • CCG-266389
    • CS-W017500
    • DB08652
    • EBC-152214
    • FI30384
    • FS-2701
    • HY-W016784
    • MSK157405-100A
    • SB15031
    • AC-23418
    • SY014237
    • DB-011565
    • I0668
    • NS00039231
    • ST51006791
    • EN300-74842
    • C02693
    • 879I378
    • F068789
    • Q27097844
    • Z33546521
    • Indole-3-acetamide Solution in Acetonitrile, 100ug/mL
    • 99FEA035-A073-4863-9F14-923310E3BC45
    • InChI=1/C10H10N2O/c11-10(13)5-7-6-12-9-4-2-1-3-8(7)9/h1-4,6,12H,5H2,(H2,11,13)
    • Indole-3-acetamide; 2-(1H-Indol-3-yl)acetamide; 2-(3-Indolyl)acetamide; 3-Indolylacetamide; NSC 1969
    • 879-37-8

  • Applications

    Indole-3-acetamide (CAS number: 879-37-8) is commonly used as a chemical intermediate in organic synthesis, serving as a precursor to indole-based compounds for research in pharmaceuticals and agrochemicals. In agriculture and plant science, it may function as a source of auxin-like activity or a building block for auxin derivatives used in plant growth regulation and tissue-culture applications. In fragrance and cosmetics, the indole scaffold can be leveraged for fragrance ingredient development, with Indole-3-acetamide acting as a precursor or intermediate for indole-containing notes. It also serves as a laboratory reagent for synthesis and as an analytical reference material in route development toward more complex molecules. Additionally, in materials chemistry, it can be explored as a building block for dyes and functional polymers containing indole motifs.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.74
    methanol 2.18
    isopropanol 0.36
    water 1.86
    ethyl acetate 0.48
    n-propanol 0.57
    acetone 0.57
    n-butanol 0.5
    acetonitrile 0.45
    DMF 5.17
    toluene 0.03
    isobutanol 0.55
    1,4-dioxane 0.65
    methyl acetate 1.06
    THF 3.64
    2-butanone 1.13
    n-pentanol 1.0
    sec-butanol 0.63
    n-hexane 0.01
    ethylene glycol 7.13
    NMP 29.98
    cyclohexane 0.0
    DMSO 3.46
    n-butyl acetate 1.85
    n-octanol 0.52
    chloroform 0.1
    n-propyl acetate 1.54
    acetic acid 6.95
    dichloromethane 0.11
    cyclohexanone 1.5
    propylene glycol 6.14
    isopropyl acetate 0.53
    DMAc 35.42
    2-ethoxyethanol 15.23
    isopentanol 0.95
    n-heptane 0.02
    ethyl formate 1.14
    1,2-dichloroethane 0.09
    n-hexanol 1.57
    2-methoxyethanol 13.69
    isobutyl acetate 1.68
    tetrachloromethane 0.08
    n-pentyl acetate 1.16
    transcutol 16.11
    n-heptanol 1.28
    ethylbenzene 0.08
    MIBK 0.94
    2-propoxyethanol 16.69
    tert-butanol 0.91
    MTBE 0.26
    2-butoxyethanol 9.07
    propionic acid 3.26
    o-xylene 0.07
    formic acid 23.87
    diethyl ether 0.09
    m-xylene 0.07
    p-xylene 0.18
    chlorobenzene 0.1
    dimethyl carbonate 1.8
    n-octane 0.01
    formamide 20.71
    cyclopentanone 4.83
    2-pentanone 0.54
    anisole 0.89
    cyclopentyl methyl ether 0.62
    gamma-butyrolactone 10.11
    1-methoxy-2-propanol 7.4
    pyridine 0.6
    3-pentanone 0.47
    furfural 13.2
    n-dodecane 0.01
    diethylene glycol 28.35
    diisopropyl ether 0.09
    tert-amyl alcohol 1.3
    acetylacetone 1.92
    n-hexadecane 0.02
    acetophenone 2.48
    methyl propionate 0.93
    isopentyl acetate 2.86
    trichloroethylene 0.29
    n-nonanol 0.65
    cyclohexanol 0.31
    benzyl alcohol 1.73
    2-ethylhexanol 1.19
    isooctanol 1.38
    dipropyl ether 0.52
    1,2-dichlorobenzene 0.24
    ethyl lactate 5.67
    propylene carbonate 5.71
    n-methylformamide 4.51
    2-pentanol 0.29
    n-pentane 0.0
    1-propoxy-2-propanol 7.67
    1-methoxy-2-propyl acetate 5.02
    2-(2-methoxypropoxy) propanol 12.08
    mesitylene 0.07
    ε-caprolactone 3.31
    p-cymene 0.27
    epichlorohydrin 3.61
    1,1,1-trichloroethane 0.12
    2-aminoethanol 7.59
    morpholine-4-carbaldehyde 19.32
    sulfolane 17.57
    2,2,4-trimethylpentane 0.01
    2-methyltetrahydrofuran 1.44
    n-hexyl acetate 1.3
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 11.41
    sec-butyl acetate 1.22
    tert-butyl acetate 1.2
    decalin 0.02
    glycerin 27.2
    diglyme 16.87
    acrylic acid 5.6
    isopropyl myristate 0.75
    n-butyric acid 2.3
    acetyl acetate 0.8
    di(2-ethylhexyl) phthalate 2.9
    ethyl propionate 1.44
    nitromethane 8.04
    1,2-diethoxyethane 1.41
    benzonitrile 0.95
    trioctyl phosphate 1.62
    1-bromopropane 0.04
    gamma-valerolactone 12.23
    n-decanol 0.55
    triethyl phosphate 2.98
    4-methyl-2-pentanol 0.52
    propionitrile 0.45
    vinylene carbonate 3.78
    1,1,2-trichlorotrifluoroethane 12.85
    DMS 2.84
    cumene 0.16
    2-octanol 0.56
    2-hexanone 1.79
    octyl acetate 1.14
    limonene 0.28
    1,2-dimethoxyethane 9.09
    ethyl orthosilicate 2.41
    tributyl phosphate 1.89
    diacetone alcohol 5.32
    N,N-dimethylaniline 1.08
    acrylonitrile 0.95
    aniline 0.22
    1,3-propanediol 5.46
    bromobenzene 0.07
    dibromomethane 0.05
    1,1,2,2-tetrachloroethane 0.29
    2-methyl-cyclohexyl acetate 3.38
    tetrabutyl urea 3.21
    diisobutyl methanol 0.64
    2-phenylethanol 2.57
    styrene 0.07
    dioctyl adipate 2.06
    dimethyl sulfate 6.61
    ethyl butyrate 2.11
    methyl lactate 7.02
    butyl lactate 4.28
    diethyl carbonate 2.17
    propanediol butyl ether 7.62
    triethyl orthoformate 2.53
    p-tert-butyltoluene 0.22
    methyl 4-tert-butylbenzoate 5.31
    morpholine 1.16
    tert-butylamine 0.23
    n-dodecanol 0.41
    dimethoxymethane 1.71
    ethylene carbonate 2.33
    cyrene 18.86
    2-ethoxyethyl acetate 3.08
    2-ethylhexyl acetate 2.03
    1,2,4-trichlorobenzene 0.41
    4-methylpyridine 0.49
    dibutyl ether 0.32
    2,6-dimethyl-4-heptanol 0.64
    DEF 1.52
    dimethyl isosorbide 17.5
    tetrachloroethylene 0.3
    eugenol 9.21
    triacetin 4.42
    span 80 6.59
    1,4-butanediol 5.71
    1,1-dichloroethane 0.05
    2-methyl-1-pentanol 1.78
    methyl formate 3.06
    2-methyl-1-butanol 0.96
    n-decane 0.02
    butyronitrile 0.38
    3,7-dimethyl-1-octanol 0.81
    1-chlorooctane 0.09
    1-chlorotetradecane 0.06
    n-nonane 0.01
    undecane 0.02
    tert-butylcyclohexane 0.02
    cyclooctane 0.0
    cyclopentanol 1.08
    tetrahydropyran 0.19
    tert-amyl methyl ether 0.44
    2,5,8-trioxanonane 15.9
    1-hexene 0.05
    2-isopropoxyethanol 8.88
    2,2,2-trifluoroethanol 7.1
    methyl butyrate 2.24

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction