Indigo carmine

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  • Identifiers

    CAS number
    860-22-0

    Molecular formula
    C16H8N2Na2O8S2

    SMILES
    C1=CC2=C(C=C1S(=O)(=O)[O-])C(=C(N2)C3=NC4=C(C3=O)C=C(C=C4)S(=O)(=O)[O-])O.[Na+].[Na+]

    Safety labels

  • Odor profile

    Fragrance
    Odorless 86.52%
    Cooked 19.23%
    Burnt 17.4%
    Bitter 16.91%
    Savory 16.8%
    Roasted 13.84%
    Clean 12.48%
    Milky 11.02%
    Pungent 10.32%
    Nutty 9.69%

     

    Flavor
    Bitter 94.25%
    Odorless 32.35%
    Bland 19.88%
    Nitrile 18.71%
    Very strong 17.12%
    Taco 17.06%
    Bread crust 17.0%
    Indole 16.91%
    Sweet-like 16.89%
    Cedarleaf 16.53%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    2.91 (strong acid)

    Molecular weight
    466.4 g/mol

    Flash point

    • 371.81 ˚C est.

  • Synonyms

    • Indigo carmine
    • 860-22-0
    • Acid Blue 74
    • Indigotindisulfonate sodium
    • Indigotine
    • indigocarmine
    • C.I. ACID BLUE 74
    • Sodium 3,3'-dioxo-[2,2'-biindolinylidene]-5,5'-disulfonate
    • Indigocarmin
    • C.I. Food Blue 1
    • FD&C Blue No. 2
    • Food Blue No. 2
    • FD & C blue no. 2
    • FD and C Blue No. 2
    • Sachsischblau
    • Murabba
    • Amacid Brilliant Blue
    • Indigotine Lake
    • Indocarmine F
    • Soluble Indigo
    • Disodium 5,5'-disulfoindigo
    • Indigotine B
    • Indigotine I
    • Indigotine N
    • Intense Blue
    • Indigotin I
    • Indigotine IA
    • C.I. 73015
    • C.I. 75781
    • Cilefa Blue R
    • Indigo Carmine A
    • Indigo Carmine X
    • C.I. Natural Blue 2
    • Grape Blue A
    • Airedale Blue IN
    • Acid Blue W
    • Sodium indigo-5,5'-bisulfonate
    • Sodium indigotindisulfonate
    • HD Indigo Carmine
    • Indigo Carmine AC
    • Indigo Carmine BP
    • Indigo carmine-
    • Indigotine Blue LZ
    • Atul Indigo Carmine
    • CI 73015
    • Bucacid indigotine B
    • C.I.FOOD BLUE 1
    • Grape Blue A Geigy
    • Maple Indigo Carmine
    • Edicol Supra Blue X
    • Indigo Carmine Powder
    • Mitsui Indigo Carmine
    • Holunder p-ac-5
    • Aniline Carmine powder
    • Acid Leather Blue IC
    • Dolkwal Indigo Carmine
    • Indigotine 85%
    • San-ei Indigo Carmine
    • Usacert Blue No. 2
    • Hexacert Blue No. 2
    • Canacert Indigo Carmine
    • Indigotine disodium salt
    • BLUDIGO
    • Indigotine Conc. Powder
    • Indigotine Extra Pure A
    • Disodium indigo-5,5-disulfonate
    • HD Indigo Carmine Supra
    • Sodium 5,5'-indigotindisulfonate
    • A.F. Blue No. 2
    • Indigo Carmine Conc. FQ
    • Gardenia grun p-ac-8
    • 1311 Blue
    • C.I. Food Blue 1, disodium salt
    • Disodium 5,5'-indigotin disulfonate
    • E 132
    • L Blue Z 5010
    • 12070 Blue
    • Bleu covalac w 6504
    • Indigotin-5,5'-disulfonic acid disodium salt
    • Hexacol Indigo Carmine Supra
    • Indigo Carmine Disodium Salt
    • 1H-Indole-5-sulfonic acid, 2-(1,3-dihydro-3-oxo-5-sulfo-2H-indol-2-ylidene)-2,3-dihydro-3-oxo-, disodium salt
    • Indigotindisulphonate sodium
    • Carmine Blue (biological stain)
    • C16H8N2Na2O8S2
    • Indigo Carmine (Biological Stain)
    • Indigo-5,5'-disulfonic acid disodium salt
    • INS NO.132
    • DTXSID1020190
    • Disodium 3,3'-dioxo-(delta2,2'-biindoline)-5,5'-disulfonate
    • Indigo disulfonate (Biological Stain)
    • Indigotindisulfonate sodium [USP]
    • INS-132
    • D3741U8K7L
    • MFCD00005723
    • CI-(1975)NO.73015
    • Disodium salt of 1-indigotin-S,S'-disulfonic acid
    • E-132
    • Soluble Indigo Blue
    • Indigocarmine [JAN]
    • Ci food blue 1:1
    • 2-(1,3-Dihydro-3-oxo-5-sulfo-2H-indol-2-ylidene)-2,3-dihydro-3-oxo-1H-indole-5-sulfonic acid, disodium salt
    • Indigotindisulfonate sodium (USP)
    • DTXCID801022742
    • L-Blau 2 [German]
    • Indigo-karmin [German]
    • Indigo-karmin
    • Modr Kysela 74 [Czech]
    • 1H-Indole-5-sulfonic acid, 2-(1,3-dihydro-3-oxo-5-sulfo-2H-indol-2-ylidene)-2,3-dihydro-3-oxo-, sodium salt (1:2)
    • CAS-860-22-0
    • Modr Kysela 74
    • Modr Potravinarska 1 [Czech]
    • CCRIS 1865
    • Modr Potravinarska 1
    • Schultz Nr. 1309 [German]
    • Food Blue 1:1
    • L-Blau 2
    • Schultz Nr. 1309
    • NCGC00187606-01
    • NSC 8646
    • Dinatrium indigolin-5,5'-disulfonat
    • EINECS 212-728-8
    • FD &C Blue No. 2
    • UNII-L06K8R7DQK
    • 5,5'-Indigodisulfonic Acid Disodium Salt (Technical Grade)
    • carmin indigo
    • indaco carminio
    • 860-22-0

  • Applications

    Indigo carmine, CAS 860-22-0, is a water-soluble blue dye used as a colorant across several industries. In food and beverage processing, it functions as a colorant for candies, beverages, and pharmaceutical tablets where permitted by local regulations. In textiles and coatings, it serves as a dye for cellulose fibers and as an additive in inks and printing coatings. In analytical chemistry, it is employed as a pH indicator for titrations and qualitative tests. In pharmaceuticals and personal care applications, it is used as a colorant for tablets, capsules, and cosmetic formulations where allowed, subject to regulatory limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1.17
    methanol 1.89
    isopropanol 0.97
    water 0.15
    ethyl acetate 1.03
    n-propanol 1.15
    acetone 2.94
    n-butanol 0.66
    acetonitrile 1.37
    DMF 123.89
    toluene 0.12
    isobutanol 0.5
    1,4-dioxane 5.69
    methyl acetate 2.35
    THF 10.04
    2-butanone 3.87
    n-pentanol 0.4
    sec-butanol 1.14
    n-hexane 0.01
    ethylene glycol 6.75
    NMP 40.59
    cyclohexane 0.02
    DMSO 19.89
    n-butyl acetate 1.24
    n-octanol 1.49
    chloroform 0.13
    n-propyl acetate 1.12
    acetic acid 2.73
    dichloromethane 0.17
    cyclohexanone 3.69
    propylene glycol 7.32
    isopropyl acetate 0.84
    DMAc 72.51
    2-ethoxyethanol 10.57
    isopentanol 0.38
    n-heptane 0.02
    ethyl formate 1.53
    1,2-dichloroethane 0.18
    n-hexanol 0.37
    2-methoxyethanol 37.78
    isobutyl acetate 0.35
    tetrachloromethane 0.01
    n-pentyl acetate 2.48
    transcutol 29.41
    n-heptanol 1.1
    ethylbenzene 0.06
    MIBK 0.73
    2-propoxyethanol 12.1
    tert-butanol 0.58
    MTBE 0.31
    2-butoxyethanol 10.89
    propionic acid 2.65
    o-xylene 0.1
    formic acid 7.92
    diethyl ether 0.58
    m-xylene 0.07
    p-xylene 0.09
    chlorobenzene 0.08
    dimethyl carbonate 3.94
    n-octane 0.02
    formamide 22.54
    cyclopentanone 9.44
    2-pentanone 1.79
    anisole 0.63
    cyclopentyl methyl ether 1.09
    gamma-butyrolactone 11.3
    1-methoxy-2-propanol 26.76
    pyridine 4.0
    3-pentanone 1.54
    furfural 12.16
    n-dodecane 0.03
    diethylene glycol 17.98
    diisopropyl ether 0.1
    tert-amyl alcohol 0.67
    acetylacetone 3.96
    n-hexadecane 0.03
    acetophenone 1.3
    methyl propionate 2.92
    isopentyl acetate 0.74
    trichloroethylene 0.5
    n-nonanol 1.54
    cyclohexanol 0.65
    benzyl alcohol 0.94
    2-ethylhexanol 0.23
    isooctanol 0.63
    dipropyl ether 0.71
    1,2-dichlorobenzene 0.09
    ethyl lactate 3.41
    propylene carbonate 2.52
    n-methylformamide 22.02
    2-pentanol 0.49
    n-pentane 0.01
    1-propoxy-2-propanol 9.57
    1-methoxy-2-propyl acetate 4.26
    2-(2-methoxypropoxy) propanol 9.56
    mesitylene 0.04
    ε-caprolactone 4.21
    p-cymene 0.08
    epichlorohydrin 4.73
    1,1,1-trichloroethane 0.04
    2-aminoethanol 6.19
    morpholine-4-carbaldehyde 58.31
    sulfolane 15.96
    2,2,4-trimethylpentane 0.0
    2-methyltetrahydrofuran 1.63
    n-hexyl acetate 2.67
    isooctane 0.0
    2-(2-butoxyethoxy)ethanol 16.53
    sec-butyl acetate 0.54
    tert-butyl acetate 0.78
    decalin 0.01
    glycerin 33.1
    diglyme 27.04
    acrylic acid 5.05
    isopropyl myristate 0.85
    n-butyric acid 1.55
    acetyl acetate 0.61
    di(2-ethylhexyl) phthalate 1.2
    ethyl propionate 1.07
    nitromethane 12.08
    1,2-diethoxyethane 3.65
    benzonitrile 0.96
    trioctyl phosphate 1.01
    1-bromopropane 0.07
    gamma-valerolactone 36.97
    n-decanol 1.0
    triethyl phosphate 0.59
    4-methyl-2-pentanol 0.19
    propionitrile 1.3
    vinylene carbonate 2.57
    1,1,2-trichlorotrifluoroethane 9.59
    DMS 2.68
    cumene 0.03
    2-octanol 0.93
    2-hexanone 1.18
    octyl acetate 1.53
    limonene 0.12
    1,2-dimethoxyethane 14.62
    ethyl orthosilicate 0.49
    tributyl phosphate 0.98
    diacetone alcohol 4.04
    N,N-dimethylaniline 0.55
    acrylonitrile 3.63
    aniline 0.62
    1,3-propanediol 6.58
    bromobenzene 0.05
    dibromomethane 0.06
    1,1,2,2-tetrachloroethane 0.45
    2-methyl-cyclohexyl acetate 0.71
    tetrabutyl urea 3.15
    diisobutyl methanol 0.15
    2-phenylethanol 1.01
    styrene 0.07
    dioctyl adipate 1.78
    dimethyl sulfate 6.69
    ethyl butyrate 1.03
    methyl lactate 12.19
    butyl lactate 6.37
    diethyl carbonate 0.69
    propanediol butyl ether 17.95
    triethyl orthoformate 1.31
    p-tert-butyltoluene 0.07
    methyl 4-tert-butylbenzoate 3.0
    morpholine 10.64
    tert-butylamine 0.13
    n-dodecanol 0.65
    dimethoxymethane 22.51
    ethylene carbonate 1.78
    cyrene 9.92
    2-ethoxyethyl acetate 6.18
    2-ethylhexyl acetate 0.57
    1,2,4-trichlorobenzene 0.19
    4-methylpyridine 1.73
    dibutyl ether 0.83
    2,6-dimethyl-4-heptanol 0.15
    DEF 7.06
    dimethyl isosorbide 10.94
    tetrachloroethylene 0.24
    eugenol 6.03
    triacetin 5.25
    span 80 8.13
    1,4-butanediol 2.18
    1,1-dichloroethane 0.09
    2-methyl-1-pentanol 0.23
    methyl formate 11.78
    2-methyl-1-butanol 0.47
    n-decane 0.05
    butyronitrile 0.7
    3,7-dimethyl-1-octanol 0.51
    1-chlorooctane 0.19
    1-chlorotetradecane 0.09
    n-nonane 0.04
    undecane 0.04
    tert-butylcyclohexane 0.0
    cyclooctane 0.01
    cyclopentanol 1.46
    tetrahydropyran 1.52
    tert-amyl methyl ether 0.41
    2,5,8-trioxanonane 18.77
    1-hexene 0.04
    2-isopropoxyethanol 4.37
    2,2,2-trifluoroethanol 2.12
    methyl butyrate 1.54

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction