Imipramine Hydrochloride

Overview IFRA Request a quote

  • Identifiers

    CAS number
    113-52-0

    Molecular formula
    C19H25ClN2

    SMILES
    CN(C)CCCN1C2=CC=CC=C2CCC3=CC=CC=C31.Cl

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Fishy 44.96%
    Animal 44.8%
    Cheesy 36.23%
    Ripe 31.79%
    Sweet 25.92%
    Burnt 23.66%
    Odorless 23.65%
    Meaty 22.79%
    Savory 21.91%
    Cooling 20.87%

     

    Flavor
    Bitter 35.6%
    Fruity 26.74%
    Mild 23.32%
    Herbal 21.53%
    Earthy 20.23%
    Green pepper 20.16%
    Cedarleaf 20.07%
    Nitrile 19.77%
    Syrup 19.76%
    Very strong 19.76%

     

    Odor impact est.
    Medium

  • Properties

    pKa est.
    6.94 (neutral)

    Molecular weight
    316.9 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    415°C

    Flash point

    • 194.25 ˚C est.

    Solubility expt.

    • >47.5 [ug/mL] (The mean of the results at pH 7.4)

  • Synonyms

    • Imipramine hydrochloride
    • 113-52-0
    • Imipramine Hcl
    • Tofranil
    • Chimoreptin
    • Chrytemin
    • Presamine
    • Pryleugan
    • Deprinol
    • Feinalmin
    • Imilanyle
    • Iprogen
    • Persamine
    • Pertofram
    • Pramine
    • Teperine
    • Tofranile
    • Imizine
    • IMP hydrochloride
    • IA-Pram
    • Psicopramine
    • Dynazina
    • Efuranol
    • Fujisawa
    • Imipramini
    • Thymopramin
    • Tipramine
    • Imidol
    • Janimine
    • Odeoxil
    • Venefon
    • Vionyl
    • Co cap imipramine 25
    • Antideprin hydrochloride
    • Imipramini hydrochloridum
    • Psychoforin
    • Imavate
    • Imizin
    • Imipram
    • Imipramine monohydrochloride
    • Melipramine HCl
    • SK-Pramine hydrochloride
    • Imizinum
    • MFCD00012669
    • UNII-BKE5Q1J60U
    • EINECS 204-030-7
    • BKE5Q1J60U
    • NSC 114900
    • NSC-114900
    • CHEBI:5882
    • G 22355
    • DTXSID7040738
    • N-(3-Dimethylaminopropyl)iminodibenzyl hydrochloride
    • Imipramine (hydrochloride)
    • 5-(3-(Dimethylamino)propyl)-10,11-dihydro-5H-dibenz(b,f)azepine monohydrochloride
    • N-(gamma-Dimethylaminopropyl)iminodibenzyl hydrochloride
    • 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine;hydrochloride
    • 5H-Dibenz(b,f)azepine-5-propanamine, 10,11-dihydro-N,N-dimethyl-, monohydrochloride
    • MLS000028430
    • Imipramine.HCl
    • DTXCID5020738
    • Imipramine hydrochloride [USP:JAN]
    • 5-(3-Dimethylaminopropyl)-10,11-dihydro-5H-dibenz(b,f)azepine hydrochloride
    • NSC114900
    • 5H-Dibenz(b,f)azepine, 10,11-dihydro-5-(3-(dimethylamino)propyl)-, hydrochloride
    • N-(gamma-Dimetilaminopropil)-iminodibenzile cloridrato
    • SK-Pramine
    • SMR000058388
    • Tofranil (TN)
    • 3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine hydrochloride
    • 5H-Dibenz(b,f)azepine, 5-(3-(dimethylamino)propyl)-10,11-dihydro-, monohydrochloride
    • 5H-Dibenz[b,f]azepine-5-propanamine, 10,11-dihydro-N,N-dimethyl-, monohydrochloride
    • G-22355
    • Imipramine hydrochloride (USP:JAN)
    • IMIPRAMINE HYDROCHLORIDE (MART.)
    • IMIPRAMINE HYDROCHLORIDE [MART.]
    • IMIPRAMINE HYDROCHLORIDE (USP-RS)
    • IMIPRAMINE HYDROCHLORIDE [USP-RS]
    • Imipramine hydrochloride [JAN]
    • IMIPRAMINE HYDROCHLORIDE (EP MONOGRAPH)
    • IMIPRAMINE HYDROCHLORIDE (USP IMPURITY)
    • IMIPRAMINE HYDROCHLORIDE (USP MONOGRAPH)
    • IMIPRAMINE HYDROCHLORIDE [EP MONOGRAPH]
    • IMIPRAMINE HYDROCHLORIDE [USP IMPURITY]
    • IMIPRAMINE HYDROCHLORIDE [USP MONOGRAPH]
    • Melipramine hydrochloride
    • SR-01000003064
    • CAS-113-52-0
    • 3-(10,11-dihydro-5H-dibenzo(b,f)azepin-5-yl)-N,N-dimethylpropan-1-amine hydrochloride
    • SK-Pramine HCl
    • 10,11-Dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine hydrochloride;Chrytemin;Imiprin
    • Prestwick_277
    • 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethyl-propan-1-amine
    • CPD000058388
    • 3-(10,11-dihydro-5H-dibenzo(b,f)azepin-5-yl)-N,N-dimethylpropan-1-aminium chloride
    • Opera_ID_319
    • N-(gamma-Dimetilaminopropil)-iminodibenzile cloridrato [Italian]
    • SureCN41766
    • Imipramine hydrochloride rs
    • CHEMBL1692
    • G 22150
    • REGID_for_CID_8228
    • SCHEMBL41765
    • MLS001146891
    • MLS002222195
    • SPECTRUM1500348
    • HY-B1490R
    • Imipramine for system suitability
    • HMS1568O05
    • HMS1920F17
    • Pharmakon1600-01500348
    • HY-B1490
    • Imipramine HCl - Bio-X trade mark
    • Tox21_301417
    • Tox21_500702
    • CCG-40208
    • IMIPRAMINE HYDROCHLORIDE [MI]
    • NSC757074
    • s4377
    • Imipramine hydrochloride (JP17/USP)
    • 10,11-Dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine hydrochloride
    • AKOS015895330
    • Imipramine (hydrochloride) (Standard)
    • AC-7587
    • CS-6180
    • FI24561
    • KS-1072
    • LP00702

  • Applications

    Imipramine Hydrochloride is primarily employed as a pharmaceutical active ingredient in the treatment of depressive disorders, acting as a tricyclic antidepressant, with historical use in enuresis management in children. In the pharmaceutical industry, it is formulated into dosage forms such as tablets and other marketed drug forms, serving as the API in these products. In analytical and research settings, it is used as a reference standard for method development and quality control (e.g., HPLC/LC-MS assays) and is studied in pharmacokinetic and pharmacology research to understand the disposition and interactions of the drug. Its use depends on local regulations and formulation limits, with practical applications focused mainly on pharmaceutical development, analytical testing, and research contexts.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 170.61
    methanol 193.65
    isopropanol 77.88
    water 1.26
    ethyl acetate 375.67
    n-propanol 182.8
    acetone 427.05
    n-butanol 174.78
    acetonitrile 180.02
    DMF 891.84
    toluene 237.22
    isobutanol 155.13
    1,4-dioxane 669.51
    methyl acetate 356.76
    THF 797.28
    2-butanone 389.1
    n-pentanol 180.1
    sec-butanol 105.31
    n-hexane 38.32
    ethylene glycol 78.91
    NMP 997.89
    cyclohexane 83.14
    DMSO 623.08
    n-butyl acetate 336.8
    n-octanol 60.92
    chloroform 2017.83
    n-propyl acetate 305.34
    acetic acid 451.97
    dichloromethane 1956.01
    cyclohexanone 679.46
    propylene glycol 72.07
    isopropyl acetate 222.81
    DMAc 878.12
    2-ethoxyethanol 365.87
    isopentanol 161.4
    n-heptane 29.7
    ethyl formate 417.66
    1,2-dichloroethane 1166.79
    n-hexanol 178.64
    2-methoxyethanol 420.15
    isobutyl acetate 252.34
    tetrachloromethane 310.23
    n-pentyl acetate 198.65
    transcutol 661.47
    n-heptanol 97.67
    ethylbenzene 107.32
    MIBK 190.35
    2-propoxyethanol 354.76
    tert-butanol 95.11
    MTBE 179.47
    2-butoxyethanol 239.41
    propionic acid 267.42
    o-xylene 142.6
    formic acid 193.91
    diethyl ether 290.27
    m-xylene 129.49
    p-xylene 153.38
    chlorobenzene 495.88
    dimethyl carbonate 273.73
    n-octane 13.45
    formamide 235.6
    cyclopentanone 883.0
    2-pentanone 300.32
    anisole 236.01
    cyclopentyl methyl ether 382.04
    gamma-butyrolactone 998.04
    1-methoxy-2-propanol 221.62
    pyridine 637.83
    3-pentanone 359.75
    furfural 925.86
    n-dodecane 9.94
    diethylene glycol 278.48
    diisopropyl ether 88.42
    tert-amyl alcohol 109.5
    acetylacetone 392.08
    n-hexadecane 11.52
    acetophenone 272.71
    methyl propionate 356.45
    isopentyl acetate 292.99
    trichloroethylene 2070.8
    n-nonanol 64.34
    cyclohexanol 208.73
    benzyl alcohol 232.35
    2-ethylhexanol 136.6
    isooctanol 86.7
    dipropyl ether 185.28
    1,2-dichlorobenzene 472.15
    ethyl lactate 169.61
    propylene carbonate 583.98
    n-methylformamide 383.36
    2-pentanol 93.77
    n-pentane 34.55
    1-propoxy-2-propanol 216.29
    1-methoxy-2-propyl acetate 310.64
    2-(2-methoxypropoxy) propanol 164.66
    mesitylene 82.76
    ε-caprolactone 581.87
    p-cymene 85.42
    epichlorohydrin 1151.75
    1,1,1-trichloroethane 878.04
    2-aminoethanol 119.61
    morpholine-4-carbaldehyde 823.89
    sulfolane 1060.68
    2,2,4-trimethylpentane 24.85
    2-methyltetrahydrofuran 495.26
    n-hexyl acetate 198.85
    isooctane 14.63
    2-(2-butoxyethoxy)ethanol 234.06
    sec-butyl acetate 201.93
    tert-butyl acetate 211.11
    decalin 41.03
    glycerin 140.74
    diglyme 516.5
    acrylic acid 306.89
    isopropyl myristate 82.25
    n-butyric acid 369.68
    acetyl acetate 322.44
    di(2-ethylhexyl) phthalate 112.8
    ethyl propionate 234.83
    nitromethane 649.69
    1,2-diethoxyethane 312.25
    benzonitrile 299.12
    trioctyl phosphate 75.97
    1-bromopropane 456.0
    gamma-valerolactone 965.72
    n-decanol 51.85
    triethyl phosphate 155.28
    4-methyl-2-pentanol 73.35
    propionitrile 198.47
    vinylene carbonate 614.29
    1,1,2-trichlorotrifluoroethane 919.15
    DMS 259.33
    cumene 81.84
    2-octanol 50.43
    2-hexanone 254.91
    octyl acetate 115.72
    limonene 126.24
    1,2-dimethoxyethane 536.75
    ethyl orthosilicate 152.64
    tributyl phosphate 104.88
    diacetone alcohol 186.54
    N,N-dimethylaniline 159.62
    acrylonitrile 248.22
    aniline 307.9
    1,3-propanediol 167.5
    bromobenzene 559.73
    dibromomethane 1145.17
    1,1,2,2-tetrachloroethane 1601.84
    2-methyl-cyclohexyl acetate 208.61
    tetrabutyl urea 122.12
    diisobutyl methanol 65.97
    2-phenylethanol 209.25
    styrene 164.85
    dioctyl adipate 145.12
    dimethyl sulfate 441.32
    ethyl butyrate 253.06
    methyl lactate 199.65
    butyl lactate 158.42
    diethyl carbonate 204.95
    propanediol butyl ether 131.61
    triethyl orthoformate 202.7
    p-tert-butyltoluene 76.04
    methyl 4-tert-butylbenzoate 186.64
    morpholine 630.41
    tert-butylamine 71.51
    n-dodecanol 43.39
    dimethoxymethane 471.05
    ethylene carbonate 532.56
    cyrene 257.58
    2-ethoxyethyl acetate 303.61
    2-ethylhexyl acetate 271.82
    1,2,4-trichlorobenzene 566.08
    4-methylpyridine 534.83
    dibutyl ether 115.64
    2,6-dimethyl-4-heptanol 65.97
    DEF 497.75
    dimethyl isosorbide 318.44
    tetrachloroethylene 1073.61
    eugenol 190.94
    triacetin 229.93
    span 80 136.88
    1,4-butanediol 123.36
    1,1-dichloroethane 761.73
    2-methyl-1-pentanol 180.08
    methyl formate 438.21
    2-methyl-1-butanol 176.32
    n-decane 15.77
    butyronitrile 221.46
    3,7-dimethyl-1-octanol 69.47
    1-chlorooctane 72.56
    1-chlorotetradecane 33.76
    n-nonane 14.8
    undecane 11.87
    tert-butylcyclohexane 31.04
    cyclooctane 29.55
    cyclopentanol 200.15
    tetrahydropyran 548.26
    tert-amyl methyl ether 161.35
    2,5,8-trioxanonane 318.12
    1-hexene 120.02
    2-isopropoxyethanol 245.18
    2,2,2-trifluoroethanol 279.17
    methyl butyrate 333.66

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction