Icaridin

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  • Identifiers

    CAS number
    119515-38-7

    Molecular formula
    C12H23NO3

    SMILES
    CCC(C)OC(=O)N1CCCCC1CCO

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 43.08%
    Cooling 38.02%
    Mint 38.0%
    Herbal 27.27%
    Sweet 25.94%
    Oily 22.92%
    Fruity 22.76%
    Fresh 22.67%
    Lactonic 20.09%
    Floral 19.17%

     

    Flavor
    Fruity 53.8%
    Bitter 30.96%
    Tropical 28.19%
    Floral 23.4%
    Fruit 23.17%
    Odorless 22.05%
    Berry 22.03%
    Mild 21.72%
    Sweet-like 20.82%
    Grape 20.5%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    2.0

    pKa est.
    7.74 (neutral)

    Molecular weight
    229.32 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very slow

    Melting point expt.

    • < -170
    • < -170 °C

    Boiling point

    • 208 at 1013 hPa
    • 296 °C
    • BP: 208 °C at 1013 hPa

    Flash point

    • 153.0 ˚C est.

    Solubility expt.

    • Insoluble
    • In water, 8.2 g/L (pH 4-9); 8.6 g/L (unbuffered), at 20 °C
    • In water, 8.2X10+3 mg/L at 20 °C, pH 4-9
    • In acetone, 7520 g/L at 20 °C

  • Synonyms

    • Icaridin
    • Picaridin
    • 119515-38-7
    • Bayrepel
    • Icaridine
    • Icaridina
    • Pikaridin
    • Propidine
    • sec-butyl 2-(2-hydroxyethyl)piperidine-1-carboxylate
    • Cutter Advanced
    • Icaridin [INN]
    • Icaridinum
    • Saltidin
    • 1-Piperidinecarboxylic acid, 2-(2-hydroxyethyl)-, 1-methylpropyl ester
    • Lcaridin
    • 1-(1-Methylpropoxycarbonyl)-2-(2-hydroxyethyl)piperidine
    • HSDB 7374
    • Icaridine [INN-French]
    • Icaridinum [INN-Latin]
    • Icaridina [INN-Spanish]
    • UNII-N51GQX0837
    • CCRIS 8576
    • DTXSID0034227
    • 2-(2-Hydroxyethyl)-1-piperidinecarboxylic acid 1-methylpropyl ester
    • N51GQX0837
    • 1-Methylpropyl 2-(2-hydroxyethyl)-1-piperidinecarboxylate
    • 1-Methylpropyl 2-(2-hydroxyethyl)piperidine-1-carboxylate
    • MFCD01756488
    • butan-2-yl 2-(2-hydroxyethyl)piperidine-1-carboxylate
    • hydroxyethyl isobutyl piperidine carboxylate
    • DTXCID8014227
    • EC 423-210-8
    • Kbr 3023
    • Icaridine (INN-French)
    • Icaridinum (INN-Latin)
    • Icaridina (INN-Spanish)
    • ICARIDIN (MART.)
    • ICARIDIN [MART.]
    • (RS)-SEC-BUTYL (RS)-2-(2-HYDROXYETHYL)PIPERIDINE-1-CARBOXYLATE
    • Icaridin-d3
    • Icaridin (Picaridin)
    • ICARIDIN [HSDB]
    • PICARIDIN [MI]
    • ICARIDIN [WHO-DD]
    • SCHEMBL135432
    • SG Plus Repellent Aroma Mist
    • 119515-38-7 unlabeled
    • CHEMBL2104314
    • CHEBI:143733
    • BCP21313
    • Tox21_301141
    • 2-(2-Hydroxyethyl)-1-piperidinecarboxylic Acid 1-Methyl-d3-propyl Ester
    • AKOS005145519
    • AC-6795
    • DB14074
    • DS-3268
    • FP27035
    • NCGC00163920-01
    • NCGC00163920-02
    • NCGC00163920-03
    • NCGC00255039-01
    • Picaridin 100 microg/mL in Acetonitrile
    • SY111276
    • DB-188907
    • HY-116144
    • CAS-119515-38-7
    • CS-0064147
    • NS00008107
    • D70300
    • Picaridin; KBR 3023; KBR-3023; KBR3023
    • Q418792
    • 1-(1-Methylpropoxycarbonyl)2-(2-hydroxyethyl)piperidine
    • 1-Piperidinecarboxylic acid, 2-(2-hydroxyethyl)-2-methylpropyl ester
    • sec-Butyl 2-(2-hydroxyethyl)piperidine-1- carboxylate/icaridine (icaridine)
    • sec-Butyl 2-(2-hydroxyethyl)piperidine-1-carboxylate/icaridine (icaridine)
    • 2-(2-Hydroxyethyl)-1-piperidinecarboxylic acid 1-methyl-propyl ester;Icaridin;KBR 3023
    • 658051-75-3

  • Applications

    Icaridin (CAS 119515-38-7) is primarily used as an active ingredient in human insect repellents, typically formulated in topical products such as sprays, lotions, and wipes to protect people from mosquitoes and other biting insects when outdoors. It is commonly incorporated in cosmetics/personal care products with a repellent function. It is also included in household products such as insect-repellent aerosols and wipes for indoor use. In the textile field, Icaridin may be applied to clothing, bags, and other fabrics to impart repellency, and related sprays are used on outdoor gear and camping equipment to maintain protection on fabric and gear surfaces. Its use is subject to local regulations and formulation limits, so practitioners should verify compliance for their specific market.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1703.99
    methanol 2914.04
    isopropanol 1245.5
    water 8.71
    ethyl acetate 279.39
    n-propanol 1092.78
    acetone 529.43
    n-butanol 862.76
    acetonitrile 274.89
    DMF 878.49
    toluene 96.83
    isobutanol 718.55
    1,4-dioxane 700.35
    methyl acetate 220.95
    THF 789.29
    2-butanone 301.59
    n-pentanol 512.79
    sec-butanol 693.06
    n-hexane 5.26
    ethylene glycol 346.79
    NMP 584.06
    cyclohexane 20.46
    DMSO 1023.41
    n-butyl acetate 226.56
    n-octanol 105.34
    chloroform 1197.11
    n-propyl acetate 170.48
    acetic acid 1650.83
    dichloromethane 881.04
    cyclohexanone 653.38
    propylene glycol 514.16
    isopropyl acetate 216.9
    DMAc 538.29
    2-ethoxyethanol 526.78
    isopentanol 536.73
    n-heptane 2.49
    ethyl formate 392.31
    1,2-dichloroethane 493.7
    n-hexanol 300.51
    2-methoxyethanol 1100.47
    isobutyl acetate 122.36
    tetrachloromethane 82.58
    n-pentyl acetate 146.08
    transcutol 856.23
    n-heptanol 121.83
    ethylbenzene 47.0
    MIBK 166.46
    2-propoxyethanol 452.43
    tert-butanol 780.21
    MTBE 204.53
    2-butoxyethanol 257.93
    propionic acid 642.7
    o-xylene 68.85
    formic acid 876.44
    diethyl ether 156.29
    m-xylene 68.91
    p-xylene 75.63
    chlorobenzene 261.76
    dimethyl carbonate 81.99
    n-octane 2.0
    formamide 728.14
    cyclopentanone 601.33
    2-pentanone 257.84
    anisole 111.98
    cyclopentyl methyl ether 204.94
    gamma-butyrolactone 728.69
    1-methoxy-2-propanol 613.86
    pyridine 567.4
    3-pentanone 132.25
    furfural 732.87
    n-dodecane 3.14
    diethylene glycol 457.17
    diisopropyl ether 36.85
    tert-amyl alcohol 491.53
    acetylacetone 274.46
    n-hexadecane 3.62
    acetophenone 146.54
    methyl propionate 172.79
    isopentyl acetate 194.31
    trichloroethylene 983.99
    n-nonanol 86.89
    cyclohexanol 519.73
    benzyl alcohol 249.8
    2-ethylhexanol 111.22
    isooctanol 94.64
    dipropyl ether 46.28
    1,2-dichlorobenzene 216.78
    ethyl lactate 120.54
    propylene carbonate 427.27
    n-methylformamide 647.72
    2-pentanol 380.22
    n-pentane 6.81
    1-propoxy-2-propanol 263.67
    1-methoxy-2-propyl acetate 176.39
    2-(2-methoxypropoxy) propanol 184.17
    mesitylene 43.3
    ε-caprolactone 566.89
    p-cymene 33.62
    epichlorohydrin 696.72
    1,1,1-trichloroethane 309.17
    2-aminoethanol 732.47
    morpholine-4-carbaldehyde 565.3
    sulfolane 763.14
    2,2,4-trimethylpentane 7.34
    2-methyltetrahydrofuran 450.45
    n-hexyl acetate 173.45
    isooctane 5.17
    2-(2-butoxyethoxy)ethanol 295.98
    sec-butyl acetate 107.79
    tert-butyl acetate 163.33
    decalin 9.4
    glycerin 605.24
    diglyme 438.91
    acrylic acid 574.2
    isopropyl myristate 55.8
    n-butyric acid 1069.37
    acetyl acetate 228.41
    di(2-ethylhexyl) phthalate 94.6
    ethyl propionate 109.2
    nitromethane 943.52
    1,2-diethoxyethane 165.73
    benzonitrile 286.71
    trioctyl phosphate 67.35
    1-bromopropane 197.46
    gamma-valerolactone 871.24
    n-decanol 60.65
    triethyl phosphate 62.51
    4-methyl-2-pentanol 159.3
    propionitrile 276.81
    vinylene carbonate 445.28
    1,1,2-trichlorotrifluoroethane 651.81
    DMS 125.85
    cumene 36.66
    2-octanol 78.38
    2-hexanone 170.11
    octyl acetate 81.22
    limonene 46.75
    1,2-dimethoxyethane 530.29
    ethyl orthosilicate 58.5
    tributyl phosphate 79.34
    diacetone alcohol 271.11
    N,N-dimethylaniline 78.03
    acrylonitrile 364.25
    aniline 287.52
    1,3-propanediol 1034.08
    bromobenzene 215.94
    dibromomethane 512.27
    1,1,2,2-tetrachloroethane 823.18
    2-methyl-cyclohexyl acetate 102.41
    tetrabutyl urea 94.54
    diisobutyl methanol 55.14
    2-phenylethanol 199.87
    styrene 70.08
    dioctyl adipate 97.72
    dimethyl sulfate 145.75
    ethyl butyrate 106.43
    methyl lactate 185.7
    butyl lactate 161.4
    diethyl carbonate 78.88
    propanediol butyl ether 291.4
    triethyl orthoformate 82.26
    p-tert-butyltoluene 31.11
    methyl 4-tert-butylbenzoate 139.66
    morpholine 909.04
    tert-butylamine 284.86
    n-dodecanol 44.38
    dimethoxymethane 299.11
    ethylene carbonate 382.86
    cyrene 200.18
    2-ethoxyethyl acetate 179.96
    2-ethylhexyl acetate 128.27
    1,2,4-trichlorobenzene 252.87
    4-methylpyridine 461.71
    dibutyl ether 59.2
    2,6-dimethyl-4-heptanol 55.14
    DEF 291.46
    dimethyl isosorbide 241.15
    tetrachloroethylene 537.5
    eugenol 172.31
    triacetin 160.07
    span 80 200.88
    1,4-butanediol 400.86
    1,1-dichloroethane 483.54
    2-methyl-1-pentanol 337.92
    methyl formate 393.66
    2-methyl-1-butanol 490.03
    n-decane 4.47
    butyronitrile 403.75
    3,7-dimethyl-1-octanol 95.34
    1-chlorooctane 33.97
    1-chlorotetradecane 13.51
    n-nonane 3.5
    undecane 3.61
    tert-butylcyclohexane 7.88
    cyclooctane 4.21
    cyclopentanol 600.13
    tetrahydropyran 559.66
    tert-amyl methyl ether 111.78
    2,5,8-trioxanonane 279.7
    1-hexene 39.8
    2-isopropoxyethanol 278.09
    2,2,2-trifluoroethanol 380.55
    methyl butyrate 194.49

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction