Hydroxytyrosol

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  • Identifiers

    CAS number
    10597-60-1

    Molecular formula
    C8H10O3

    SMILES
    C1=CC(=C(C=C1CCO)O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Phenolic 60.81%
    Vanilla 48.6%
    Odorless 43.65%
    Balsamic 38.02%
    Sweet 36.89%
    Burnt 33.99%
    Smoky 33.52%
    Spicy 31.75%
    Creamy 29.14%
    Medicinal 28.44%

     

    Flavor
    Sweet 72.11%
    Bitter 50.4%
    Fruity 48.83%
    Mild 44.94%
    Phenolic 40.96%
    Vanilla 34.65%
    Creamy 32.0%
    Powdery 31.49%
    Spicy 29.72%
    Smoky 26.42%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -0.7

    pKa est.
    9.76 (weak base)

    Molecular weight
    154.16 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    345°C

    Flash point

    • 176.23 ˚C est.

  • Synonyms

    • Hydroxytyrosol
    • 10597-60-1
    • 3,4-Dihydroxyphenylethanol
    • 4-(2-hydroxyethyl)benzene-1,2-diol
    • 2-(3,4-Dihydroxyphenyl)ethanol
    • 4-(2-hydroxyethyl)-1,2-Benzenediol
    • Homoprotocatechuyl alcohol
    • QEU0NE4O90
    • CHEBI:68889
    • DTXSID70147451
    • RefChem:789576
    • 3,4-DHPEA
    • DTXCID7069942
    • 600-704-3
    • 4-(3-hydroxypropyl)benzene-1,2-diol
    • 3,4-Dihydroxyphenethyl Alcohol
    • dopet
    • 3-Hydroxytyrosol
    • 3,4-Dihydroxyphenethylalcohol
    • 1,2-Benzenediol, 4-(2-hydroxyethyl)-
    • 2-(3,4-Dihydroxyphenyl)ethyl Alcohol
    • MFCD01320529
    • beta-3,4-Dihydroxyphenylethyl alcohol
    • 3,4-Dihydroxyphenyl ethanol
    • hydroxy tyrosol
    • CHEMBL1950045
    • Hydroxy Tyrosol (>85%)
    • UNII-QEU0NE4O90
    • hydroxytyrol
    • 3,4-dihydroxy-1-benzeneethanol
    • Hydroxy Tyrosol-d3
    • Adrenaline Impurity 67
    • Hydroxytyrosol (Standard)
    • HYDROXYTYROSOL [MI]
    • 3,4-dihydroxy-phenylethanol
    • SCHEMBL44363
    • 3-Hydroxytyrosol - Technical
    • orb1304225
    • SCHEMBL9863267
    • HYDROXYTYROSOL [WHO-DD]
    • SCHEMBL21049763
    • SCHEMBL29414541
    • 3,4-dihydroxyphenylethyl alcohol
    • HY-N0570R
    • JUUBCHWRXWPFFH-UHFFFAOYSA-
    • 2-(3,4-dihydroxyphenyl) ethanol
    • GLXC-07713
    • Ba 2774
    • 2-(3,4-dihydroxy-phenyl)-ethanol
    • HY-N0570
    • ULA66090
    • BDBM50610571
    • MSK164449
    • s3826
    • 1,2-benzenediol-4-(2-hydroxyethyl)
    • 3-Hydroxytyrosol, >=98% (HPLC)
    • 3-Hydroxytyrosol, analytical standard
    • AKOS003368868
    • AC-5308
    • CCG-266246
    • DB12771
    • EBC-440084
    • FD15959
    • AS-10017
    • FD146402
    • ST088590
    • SY017402
    • DB-008830
    • CS-0009107
    • D2756
    • NS00023400
    • EN300-117537
    • 597D601
    • F209152
    • Q744577
    • BRD-K04809113-001-01-7
    • InChI=1/C8H10O3/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,9-11H,3-4H2
    • 10597-60-1

  • Applications

    Hydroxytyrosol (CAS 10597-60-1) is a natural phenolic compound with strong antioxidant activity. In cosmetics and personal care, it is used as an antioxidant and formulation stabilizer; in food processing, it is evaluated as a natural antioxidant to help extend shelf life and preserve quality. It is also considered as an ingredient for nutraceuticals/dietary supplements in active form. In materials science, hydroxytyrosol is investigated as an antioxidant stabilizer for polymers and in coatings and inks, supporting durability of films and finishes. Additional applications are being explored in areas such as agriculture and surface treatment, but these remain exploratory and subject to regulatory constraints.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 219.9
    methanol 503.98
    isopropanol 124.96
    water 20.86
    ethyl acetate 45.17
    n-propanol 115.11
    acetone 115.77
    n-butanol 77.71
    acetonitrile 22.88
    DMF 286.03
    toluene 2.6
    isobutanol 60.5
    1,4-dioxane 82.83
    methyl acetate 43.78
    THF 237.03
    2-butanone 50.72
    n-pentanol 37.32
    sec-butanol 76.33
    n-hexane 0.53
    ethylene glycol 276.87
    NMP 284.38
    cyclohexane 1.0
    DMSO 1098.82
    n-butyl acetate 27.55
    n-octanol 25.31
    chloroform 1.4
    n-propyl acetate 27.96
    acetic acid 202.19
    dichloromethane 3.01
    cyclohexanone 62.63
    propylene glycol 159.49
    isopropyl acetate 26.27
    DMAc 253.31
    2-ethoxyethanol 187.41
    isopentanol 67.21
    n-heptane 2.28
    ethyl formate 39.74
    1,2-dichloroethane 6.51
    n-hexanol 56.05
    2-methoxyethanol 430.13
    isobutyl acetate 10.16
    tetrachloromethane 2.81
    n-pentyl acetate 18.38
    transcutol 216.33
    n-heptanol 32.03
    ethylbenzene 2.84
    MIBK 36.81
    2-propoxyethanol 140.16
    tert-butanol 239.92
    MTBE 40.46
    2-butoxyethanol 72.37
    propionic acid 126.97
    o-xylene 5.38
    formic acid 354.72
    diethyl ether 18.03
    m-xylene 5.86
    p-xylene 3.37
    chlorobenzene 3.12
    dimethyl carbonate 32.87
    n-octane 0.95
    formamide 556.81
    cyclopentanone 140.38
    2-pentanone 56.55
    anisole 18.09
    cyclopentyl methyl ether 49.94
    gamma-butyrolactone 226.51
    1-methoxy-2-propanol 206.97
    pyridine 17.44
    3-pentanone 22.09
    furfural 113.35
    n-dodecane 0.83
    diethylene glycol 201.12
    diisopropyl ether 8.07
    tert-amyl alcohol 126.89
    acetylacetone 83.46
    n-hexadecane 0.9
    acetophenone 25.87
    methyl propionate 50.36
    isopentyl acetate 24.44
    trichloroethylene 10.07
    n-nonanol 22.06
    cyclohexanol 41.43
    benzyl alcohol 26.54
    2-ethylhexanol 25.21
    isooctanol 24.84
    dipropyl ether 18.97
    1,2-dichlorobenzene 5.72
    ethyl lactate 37.08
    propylene carbonate 70.19
    n-methylformamide 250.02
    2-pentanol 41.95
    n-pentane 0.75
    1-propoxy-2-propanol 86.89
    1-methoxy-2-propyl acetate 47.96
    2-(2-methoxypropoxy) propanol 66.16
    mesitylene 5.41
    ε-caprolactone 69.44
    p-cymene 6.67
    epichlorohydrin 114.04
    1,1,1-trichloroethane 5.22
    2-aminoethanol 292.09
    morpholine-4-carbaldehyde 190.24
    sulfolane 339.74
    2,2,4-trimethylpentane 1.38
    2-methyltetrahydrofuran 100.53
    n-hexyl acetate 26.88
    isooctane 1.27
    2-(2-butoxyethoxy)ethanol 90.62
    sec-butyl acetate 14.4
    tert-butyl acetate 41.35
    decalin 0.99
    glycerin 286.69
    diglyme 156.05
    acrylic acid 120.13
    isopropyl myristate 11.16
    n-butyric acid 97.68
    acetyl acetate 24.6
    di(2-ethylhexyl) phthalate 16.88
    ethyl propionate 23.67
    nitromethane 284.73
    1,2-diethoxyethane 32.64
    benzonitrile 13.66
    trioctyl phosphate 15.81
    1-bromopropane 2.4
    gamma-valerolactone 173.41
    n-decanol 16.44
    triethyl phosphate 16.83
    4-methyl-2-pentanol 28.14
    propionitrile 17.47
    vinylene carbonate 43.17
    1,1,2-trichlorotrifluoroethane 120.66
    DMS 23.47
    cumene 3.56
    2-octanol 16.82
    2-hexanone 24.6
    octyl acetate 16.85
    limonene 10.36
    1,2-dimethoxyethane 163.69
    ethyl orthosilicate 15.03
    tributyl phosphate 14.76
    diacetone alcohol 116.77
    N,N-dimethylaniline 17.3
    acrylonitrile 31.79
    aniline 13.22
    1,3-propanediol 293.18
    bromobenzene 1.92
    dibromomethane 1.81
    1,1,2,2-tetrachloroethane 9.89
    2-methyl-cyclohexyl acetate 21.73
    tetrabutyl urea 22.91
    diisobutyl methanol 18.46
    2-phenylethanol 31.7
    styrene 2.38
    dioctyl adipate 19.89
    dimethyl sulfate 88.85
    ethyl butyrate 22.38
    methyl lactate 76.05
    butyl lactate 28.98
    diethyl carbonate 15.84
    propanediol butyl ether 71.02
    triethyl orthoformate 17.36
    p-tert-butyltoluene 7.57
    methyl 4-tert-butylbenzoate 42.73
    morpholine 139.69
    tert-butylamine 59.45
    n-dodecanol 11.82
    dimethoxymethane 130.97
    ethylene carbonate 35.28
    cyrene 75.78
    2-ethoxyethyl acetate 32.94
    2-ethylhexyl acetate 15.56
    1,2,4-trichlorobenzene 8.53
    4-methylpyridine 14.94
    dibutyl ether 10.45
    2,6-dimethyl-4-heptanol 18.46
    DEF 78.33
    dimethyl isosorbide 90.5
    tetrachloroethylene 11.03
    eugenol 43.65
    triacetin 34.14
    span 80 49.76
    1,4-butanediol 102.95
    1,1-dichloroethane 2.9
    2-methyl-1-pentanol 31.67
    methyl formate 154.08
    2-methyl-1-butanol 56.15
    n-decane 1.23
    butyronitrile 17.33
    3,7-dimethyl-1-octanol 22.9
    1-chlorooctane 5.05
    1-chlorotetradecane 2.32
    n-nonane 1.14
    undecane 1.0
    tert-butylcyclohexane 1.19
    cyclooctane 0.8
    cyclopentanol 85.32
    tetrahydropyran 34.13
    tert-amyl methyl ether 32.01
    2,5,8-trioxanonane 111.06
    1-hexene 1.91
    2-isopropoxyethanol 97.08
    2,2,2-trifluoroethanol 90.25
    methyl butyrate 35.42

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction