Hydroxystearamidopropyl trimonium methosulfate

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  • Identifiers

    CAS number
    127312-00-9

    Molecular formula
    C25H54N2O6S

    SMILES
    CCCCCCC(CCCCCCCCCCC(=O)NCCC[N+](C)(C)C)O.COS(=O)(=O)[O-]

    Safety labels

  • Odor profile

    Fragrance
    Woody 35.21%
    Mint 34.51%
    Cooling 34.27%
    Oily 32.1%
    Waxy 31.34%
    Savory 30.06%
    Fresh 29.86%
    Herbal 29.49%
    Fishy 29.36%
    Animal 28.14%

     

    Flavor
    Bland 33.76%
    Mild 31.58%
    Odorless 25.64%
    Herbal 25.23%
    Faint 21.98%
    Delicate 21.57%
    Slightly waxy 21.52%
    Bay oil 20.44%
    Leathery 20.43%
    Yeasty 20.35%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    8.12 (weak base)

    Molecular weight
    510.8 g/mol

    Flash point

    • 120.58 ˚C est.

  • Synonyms

    • Hydroxystearamidopropyl trimonium methosulfate
    • 127312-00-9
    • UNII-72HY9H9U1I
    • 72HY9H9U1I
    • (+/-)-Hydroxystearamidopropyl trimonium methosulfate
    • Hydroxystearamidopropyl trimonium methosulfate, (+/-)-
    • 1-Propanaminium, 3-((12-hydroxy-1-oxooctadecyl)amino)-N,N,N-trimethyl-, methyl sulfate (Salt)
    • 3-((12-Hydroxy-1-oxooctadecyl)amino)-N,N,N-trimethyl-1-propanaminium methyl sulfate (Salt)
    • 3-(12-hydroxyoctadecanoylamino)propyl-trimethylazanium;methyl sulfate
    • Q27266078
    • 127312-00-9

  • Applications

    Hydroxystearamidopropyl trimonium methosulfate, CAS 127312-00-9, is commonly used as a cationic surfactant and conditioning agent in cosmetic formulations, particularly in hair care products such as shampoos, conditioners, and body cleansers, to improve slip, manageability, and mildness. In other industries, it may serve as a surfactant and emulsifier in household cleaning products; as a fabric softener and anti-static additive in textile processing; as a wetting and leveling agent in coatings and inks; and as a processing aid or compatibilizer in polymer or latex formulations, with potential use as a surfactant additive in adhesives to improve wetting and film formation.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 54.23
    methanol 95.04
    isopropanol 36.97
    water 0.71
    ethyl acetate 96.85
    n-propanol 61.73
    acetone 87.03
    n-butanol 63.16
    acetonitrile 18.75
    DMF 200.55
    toluene 43.99
    isobutanol 57.8
    1,4-dioxane 115.94
    methyl acetate 74.81
    THF 290.96
    2-butanone 117.89
    n-pentanol 51.2
    sec-butanol 59.42
    n-hexane 6.76
    ethylene glycol 9.58
    NMP 471.07
    cyclohexane 24.79
    DMSO 208.87
    n-butyl acetate 100.54
    n-octanol 50.47
    chloroform 353.04
    n-propyl acetate 115.73
    acetic acid 185.41
    dichloromethane 272.97
    cyclohexanone 330.07
    propylene glycol 24.35
    isopropyl acetate 99.34
    DMAc 436.09
    2-ethoxyethanol 129.63
    isopentanol 68.98
    n-heptane 7.27
    ethyl formate 71.11
    1,2-dichloroethane 162.15
    n-hexanol 44.82
    2-methoxyethanol 141.03
    isobutyl acetate 92.14
    tetrachloromethane 85.1
    n-pentyl acetate 157.39
    transcutol 524.95
    n-heptanol 57.38
    ethylbenzene 26.01
    MIBK 102.03
    2-propoxyethanol 118.92
    tert-butanol 62.3
    MTBE 77.88
    2-butoxyethanol 173.15
    propionic acid 105.8
    o-xylene 43.74
    formic acid 82.62
    diethyl ether 53.88
    m-xylene 33.99
    p-xylene 38.19
    chlorobenzene 67.61
    dimethyl carbonate 45.49
    n-octane 3.43
    formamide 89.53
    cyclopentanone 314.8
    2-pentanone 118.82
    anisole 54.12
    cyclopentyl methyl ether 177.3
    gamma-butyrolactone 307.69
    1-methoxy-2-propanol 129.54
    pyridine 119.0
    3-pentanone 109.48
    furfural 257.29
    n-dodecane 1.83
    diethylene glycol 59.89
    diisopropyl ether 25.17
    tert-amyl alcohol 92.37
    acetylacetone 141.13
    n-hexadecane 2.2
    acetophenone 96.25
    methyl propionate 101.06
    isopentyl acetate 111.43
    trichloroethylene 362.82
    n-nonanol 50.2
    cyclohexanol 127.66
    benzyl alcohol 57.76
    2-ethylhexanol 43.44
    isooctanol 55.59
    dipropyl ether 53.74
    1,2-dichlorobenzene 81.65
    ethyl lactate 72.72
    propylene carbonate 202.26
    n-methylformamide 93.87
    2-pentanol 47.49
    n-pentane 5.78
    1-propoxy-2-propanol 114.79
    1-methoxy-2-propyl acetate 132.96
    2-(2-methoxypropoxy) propanol 132.0
    mesitylene 23.86
    ε-caprolactone 316.26
    p-cymene 25.09
    epichlorohydrin 295.67
    1,1,1-trichloroethane 179.67
    2-aminoethanol 35.73
    morpholine-4-carbaldehyde 292.13
    sulfolane 549.31
    2,2,4-trimethylpentane 9.6
    2-methyltetrahydrofuran 212.25
    n-hexyl acetate 145.1
    isooctane 3.86
    2-(2-butoxyethoxy)ethanol 177.62
    sec-butyl acetate 98.63
    tert-butyl acetate 141.47
    decalin 9.75
    glycerin 49.73
    diglyme 410.53
    acrylic acid 87.46
    isopropyl myristate 37.59
    n-butyric acid 194.04
    acetyl acetate 78.18
    di(2-ethylhexyl) phthalate 51.39
    ethyl propionate 93.19
    nitromethane 197.03
    1,2-diethoxyethane 114.4
    benzonitrile 50.23
    trioctyl phosphate 37.02
    1-bromopropane 80.37
    gamma-valerolactone 438.16
    n-decanol 28.62
    triethyl phosphate 71.16
    4-methyl-2-pentanol 37.21
    propionitrile 28.74
    vinylene carbonate 156.5
    1,1,2-trichlorotrifluoroethane 409.84
    DMS 79.16
    cumene 21.76
    2-octanol 38.89
    2-hexanone 101.36
    octyl acetate 53.73
    limonene 45.94
    1,2-dimethoxyethane 190.06
    ethyl orthosilicate 75.25
    tributyl phosphate 48.89
    diacetone alcohol 161.62
    N,N-dimethylaniline 49.52
    acrylonitrile 34.76
    aniline 59.43
    1,3-propanediol 60.27
    bromobenzene 65.71
    dibromomethane 169.57
    1,1,2,2-tetrachloroethane 361.26
    2-methyl-cyclohexyl acetate 106.58
    tetrabutyl urea 65.67
    diisobutyl methanol 26.97
    2-phenylethanol 54.5
    styrene 27.9
    dioctyl adipate 77.39
    dimethyl sulfate 143.43
    ethyl butyrate 98.94
    methyl lactate 76.16
    butyl lactate 139.34
    diethyl carbonate 57.36
    propanediol butyl ether 142.58
    triethyl orthoformate 101.19
    p-tert-butyltoluene 24.05
    methyl 4-tert-butylbenzoate 138.54
    morpholine 203.13
    tert-butylamine 37.47
    n-dodecanol 17.12
    dimethoxymethane 107.85
    ethylene carbonate 136.98
    cyrene 145.4
    2-ethoxyethyl acetate 201.0
    2-ethylhexyl acetate 98.52
    1,2,4-trichlorobenzene 113.41
    4-methylpyridine 110.4
    dibutyl ether 55.38
    2,6-dimethyl-4-heptanol 26.97
    DEF 197.09
    dimethyl isosorbide 210.32
    tetrachloroethylene 270.82
    eugenol 111.69
    triacetin 194.83
    span 80 113.41
    1,4-butanediol 26.23
    1,1-dichloroethane 123.14
    2-methyl-1-pentanol 63.21
    methyl formate 69.05
    2-methyl-1-butanol 77.26
    n-decane 4.93
    butyronitrile 38.45
    3,7-dimethyl-1-octanol 48.59
    1-chlorooctane 31.38
    1-chlorotetradecane 7.15
    n-nonane 4.61
    undecane 2.77
    tert-butylcyclohexane 8.32
    cyclooctane 7.28
    cyclopentanol 112.31
    tetrahydropyran 177.5
    tert-amyl methyl ether 102.2
    2,5,8-trioxanonane 204.11
    1-hexene 22.12
    2-isopropoxyethanol 100.48
    2,2,2-trifluoroethanol 104.48
    methyl butyrate 141.07

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction