Hydroxypropyl bis-hydroxyethyldimonium chloride

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  • Identifiers

    CAS number
    110528-94-4

    Molecular formula
    C11H28Cl2N2O3

    SMILES
    C[N+](C)(CCO)CC(C[N+](C)(C)CCO)O.[Cl-].[Cl-]

    Safety labels

  • Odor profile

    Fragrance
    Sweet 31.9%
    Odorless 30.76%
    Alcoholic 30.26%
    Mint 26.38%
    Fishy 25.92%
    Oily 24.64%
    Fruity 24.19%
    Green 23.65%
    Floral 23.64%
    Woody 23.27%

     

    Flavor
    Mild 31.35%
    Odorless 28.32%
    Sulfurous 25.83%
    Bland 24.97%
    Green 24.1%
    Bitter 23.8%
    Yeasty 21.29%
    Sweet-like 20.82%
    Rose acetate 20.46%
    Catty 20.0%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    5.23 (weak acid)

    Molecular weight
    307.25 g/mol

    Flash point

    • -68.68 ˚C est.

  • Synonyms

    • Hydroxypropyl bis-hydroxyethyldimonium chloride
    • UNII-1EO3O1X7HG
    • 1EO3O1X7HG
    • 110528-94-4
    • EC 807-137-2
    • 1,3-Propanediaminium, 2-hydroxy-N1,N3-bis(2-hydroxyethyl)-N1,N1,N3,N3-tetramethyl-, chloride (1:2)
    • COLAMOIST 200
    • DTXSID7074583
    • 1,3-PROPANEDIAMINIUM, 2-HYDROXY-N,N'-BIS(2-HYDROXYETHYL)-N,N,N',N'-TETRAMETHYL-, DICHLORIDE
    • RefChem:147263
    • DTXCID0033174
    • HYDROXYPROPYL BIS-HYDROXYETHYLDIMONIUM CHLORIDE [INCI]
    • 2-Hydroxy-N,N'-bis(2-hydroxyethyl)-N,N,N',N'-tetramethylpropane-1,3-diaminium dichloride
    • SCHEMBL29835099
    • BWDWHFVTDDCJOY-UHFFFAOYSA-L
    • Q27252331
    • 1,3-Propanediaminium, 2-hydroxy-N1,N3-bis(2-hydroxyethyl)-N1,N1N3,N3-tetramethyl-, chloride (1:2)
    • 2-Hydroxy-N~1~,N~3~-bis(2-hydroxyethyl)-N~1~,N~1~,N~3~,N~3~-tetramethylpropane-1,3-bis(aminium) dichloride
    • 110528-94-4

  • Applications

    Hydroxypropyl bis-hydroxyethyldimonium chloride (CAS 110528-94-4) is used primarily as a cationic conditioning agent and surfactant in cosmetics and personal care (hair conditioning, skin conditioning, emulsion stability). In household and cleaning products, it serves as a surfactant and wetting agent and may act as an antistatic additive in detergents and cleaners. In polymers, paints, and coatings, it is used as a surfactant, emulsion stabilizer, and rheology modifier for waterborne systems. In adhesives and coatings, it can improve wetting and adhesion. In electronics-related coatings, it can function as an antistatic additive for films and coatings. In agriculture, it may be used as an adjuvant to improve wetting and spread of agrochemicals in formulated products.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 99.0
    methanol 591.69
    isopropanol 9.41
    water 2609.79
    ethyl acetate 1.64
    n-propanol 42.23
    acetone 0.67
    n-butanol 12.86
    acetonitrile 2.2
    DMF 19.73
    toluene 0.39
    isobutanol 9.85
    1,4-dioxane 8.58
    methyl acetate 3.26
    THF 6.18
    2-butanone 1.2
    n-pentanol 3.48
    sec-butanol 7.79
    n-hexane 0.19
    ethylene glycol 685.72
    NMP 82.67
    cyclohexane 0.7
    DMSO 17.5
    n-butyl acetate 1.99
    n-octanol 2.61
    chloroform 8.52
    n-propyl acetate 1.38
    acetic acid 660.72
    dichloromethane 7.18
    cyclohexanone 5.0
    propylene glycol 277.87
    isopropyl acetate 0.54
    DMAc 19.9
    2-ethoxyethanol 33.66
    isopentanol 2.22
    n-heptane 0.49
    ethyl formate 9.29
    1,2-dichloroethane 2.46
    n-hexanol 7.1
    2-methoxyethanol 159.26
    isobutyl acetate 0.83
    tetrachloromethane 3.04
    n-pentyl acetate 1.6
    transcutol 35.56
    n-heptanol 6.03
    ethylbenzene 0.28
    MIBK 0.22
    2-propoxyethanol 38.98
    tert-butanol 2.88
    MTBE 0.4
    2-butoxyethanol 25.12
    propionic acid 112.43
    o-xylene 0.58
    formic acid 3902.58
    diethyl ether 0.8
    m-xylene 0.35
    p-xylene 0.41
    chlorobenzene 0.97
    dimethyl carbonate 2.68
    n-octane 0.18
    formamide 1038.15
    cyclopentanone 5.56
    2-pentanone 0.49
    anisole 0.73
    cyclopentyl methyl ether 2.3
    gamma-butyrolactone 27.97
    1-methoxy-2-propanol 28.97
    pyridine 6.78
    3-pentanone 0.84
    furfural 44.59
    n-dodecane 0.09
    diethylene glycol 119.6
    diisopropyl ether 0.13
    tert-amyl alcohol 3.75
    acetylacetone 0.74
    n-hexadecane 0.09
    acetophenone 1.58
    methyl propionate 3.76
    isopentyl acetate 1.28
    trichloroethylene 6.78
    n-nonanol 2.38
    cyclohexanol 10.41
    benzyl alcohol 4.57
    2-ethylhexanol 2.37
    isooctanol 2.94
    dipropyl ether 1.33
    1,2-dichlorobenzene 1.43
    ethyl lactate 8.77
    propylene carbonate 13.32
    n-methylformamide 94.74
    2-pentanol 2.16
    n-pentane 0.29
    1-propoxy-2-propanol 14.46
    1-methoxy-2-propyl acetate 3.68
    2-(2-methoxypropoxy) propanol 11.12
    mesitylene 0.26
    ε-caprolactone 13.24
    p-cymene 0.8
    epichlorohydrin 9.2
    1,1,1-trichloroethane 0.94
    2-aminoethanol 534.22
    morpholine-4-carbaldehyde 57.44
    sulfolane 45.08
    2,2,4-trimethylpentane 0.16
    2-methyltetrahydrofuran 3.17
    n-hexyl acetate 1.97
    isooctane 0.05
    2-(2-butoxyethoxy)ethanol 17.16
    sec-butyl acetate 0.54
    tert-butyl acetate 0.49
    decalin 0.2
    glycerin 703.1
    diglyme 18.86
    acrylic acid 207.59
    isopropyl myristate 0.49
    n-butyric acid 39.08
    acetyl acetate 1.69
    di(2-ethylhexyl) phthalate 2.79
    ethyl propionate 1.29
    nitromethane 79.05
    1,2-diethoxyethane 1.39
    benzonitrile 1.87
    trioctyl phosphate 1.89
    1-bromopropane 0.94
    gamma-valerolactone 30.22
    n-decanol 1.48
    triethyl phosphate 2.54
    4-methyl-2-pentanol 0.6
    propionitrile 2.54
    vinylene carbonate 19.98
    1,1,2-trichlorotrifluoroethane 121.06
    DMS 3.05
    cumene 0.33
    2-octanol 1.67
    2-hexanone 0.48
    octyl acetate 1.09
    limonene 0.99
    1,2-dimethoxyethane 6.61
    ethyl orthosilicate 2.45
    tributyl phosphate 1.93
    diacetone alcohol 2.32
    N,N-dimethylaniline 0.95
    acrylonitrile 5.94
    aniline 3.99
    1,3-propanediol 216.92
    bromobenzene 0.54
    dibromomethane 3.58
    1,1,2,2-tetrachloroethane 6.06
    2-methyl-cyclohexyl acetate 2.77
    tetrabutyl urea 2.27
    diisobutyl methanol 0.76
    2-phenylethanol 5.37
    styrene 0.28
    dioctyl adipate 1.42
    dimethyl sulfate 7.33
    ethyl butyrate 1.66
    methyl lactate 19.75
    butyl lactate 7.69
    diethyl carbonate 1.64
    propanediol butyl ether 27.01
    triethyl orthoformate 2.56
    p-tert-butyltoluene 0.78
    methyl 4-tert-butylbenzoate 4.38
    morpholine 23.67
    tert-butylamine 1.24
    n-dodecanol 0.94
    dimethoxymethane 5.26
    ethylene carbonate 11.98
    cyrene 24.95
    2-ethoxyethyl acetate 3.35
    2-ethylhexyl acetate 1.35
    1,2,4-trichlorobenzene 2.31
    4-methylpyridine 2.09
    dibutyl ether 0.48
    2,6-dimethyl-4-heptanol 0.76
    DEF 3.67
    dimethyl isosorbide 15.35
    tetrachloroethylene 11.96
    eugenol 9.31
    triacetin 4.87
    span 80 17.95
    1,4-butanediol 45.95
    1,1-dichloroethane 0.87
    2-methyl-1-pentanol 1.34
    methyl formate 41.2
    2-methyl-1-butanol 5.12
    n-decane 0.16
    butyronitrile 1.37
    3,7-dimethyl-1-octanol 1.1
    1-chlorooctane 0.48
    1-chlorotetradecane 0.18
    n-nonane 0.16
    undecane 0.12
    tert-butylcyclohexane 0.15
    cyclooctane 0.24
    cyclopentanol 16.34
    tetrahydropyran 3.43
    tert-amyl methyl ether 0.66
    2,5,8-trioxanonane 13.1
    1-hexene 0.31
    2-isopropoxyethanol 8.14
    2,2,2-trifluoroethanol 318.49
    methyl butyrate 1.88

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction