Hydroxyproline palmitamide

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  • Identifiers

    CAS number
    41736-92-9

    Molecular formula
    C21H39NO4

    SMILES
    CCCCCCCCCCCCCCCC(=O)N1C[C@@H](C[C@H]1C(=O)O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 42.23%
    Waxy 35.9%
    Fatty 29.52%
    Oily 27.01%
    Citrus 26.75%
    Milky 26.3%
    Savory 26.01%
    Fresh 25.18%
    Lactonic 24.92%
    Herbal 24.06%

     

    Flavor
    Odorless 36.21%
    Bland 35.28%
    Mild 31.29%
    Fatty 28.52%
    Waxy 25.39%
    Faint 22.26%
    Slightly waxy 21.97%
    Bay oil 21.1%
    Cedarleaf 20.66%
    Oily 20.14%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    6.2

    pKa est.
    6.82 (neutral)

    Molecular weight
    369.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    555°C

    Flash point

    • 238.54 ˚C est.

  • Synonyms

    • Hydroxyproline palmitamide
    • 41736-92-9
    • N-Palmitoylhydroxyproline
    • 1FB378T0CE
    • UNII-1FB378T0CE
    • DTXSID40194573
    • L-Proline, 4-hydroxy-1-(1-oxohexadecyl)-, (4R)-
    • L-Proline, 4-hydroxy-1-(1-oxohexadecyl)-, trans-
    • RefChem:147255
    • DTXCID80117064
    • HYDROXYPROLINE PALMITAMIDE [INCI]
    • N-Hexadecanoyl-4-Hydroxyproline
    • (2S,4R)-1-hexadecanoyl-4-hydroxypyrrolidine-2-carboxylic acid
    • C21H39NO4
    • N-Hexadecanoyl-4-Hydroxyproline;
    • (2S,4R)-4-hydroxy-1-palmitoylpyrrolidine-2-carboxylic acid
    • SCHEMBL6516417
    • AKOS025311510
    • (4R)-1-Hexadecanoyl-4-hydroxy-L-proline
    • Q27252355
    • 41736-92-9

  • Applications

    Hydroxyproline palmitamide (CAS 41736-92-9) is a lipid-amino acid amide that can serve in various formulation roles across several industries. In cosmetics and personal care, it is used as a skin- and hair-conditioning agent and may function as a mild emulsifier or surfactant due to its amphiphilic structure. In household cleaning products, it may act as a co-surfactant or thickener modifier to improve texture and stability. In industrial manufacturing, it can be explored as a specialty intermediate for the synthesis of more complex hydroxyproline-based derivatives and as a lubricant or slip additive in polymer or coating formulations. In pharmaceutical and excipient contexts, it may be evaluated as an intermediate or formulation aid, subject to relevant regulatory controls. Its use will depend on local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 107.9
    methanol 184.85
    isopropanol 85.44
    water 0.88
    ethyl acetate 131.74
    n-propanol 96.32
    acetone 179.83
    n-butanol 80.73
    acetonitrile 73.22
    DMF 435.57
    toluene 32.93
    isobutanol 72.64
    1,4-dioxane 135.38
    methyl acetate 125.52
    THF 423.17
    2-butanone 173.93
    n-pentanol 73.19
    sec-butanol 88.77
    n-hexane 3.1
    ethylene glycol 13.5
    NMP 531.88
    cyclohexane 8.03
    DMSO 574.83
    n-butyl acetate 125.8
    n-octanol 37.59
    chloroform 239.04
    n-propyl acetate 151.47
    acetic acid 189.34
    dichloromethane 284.54
    cyclohexanone 364.3
    propylene glycol 31.16
    isopropyl acetate 132.94
    DMAc 750.92
    2-ethoxyethanol 200.51
    isopentanol 83.61
    n-heptane 2.0
    ethyl formate 113.45
    1,2-dichloroethane 201.57
    n-hexanol 42.53
    2-methoxyethanol 218.93
    isobutyl acetate 97.13
    tetrachloromethane 47.77
    n-pentyl acetate 144.4
    transcutol 417.72
    n-heptanol 42.73
    ethylbenzene 26.93
    MIBK 107.35
    2-propoxyethanol 142.41
    tert-butanol 107.31
    MTBE 96.29
    2-butoxyethanol 164.73
    propionic acid 125.7
    o-xylene 34.61
    formic acid 84.46
    diethyl ether 54.02
    m-xylene 26.27
    p-xylene 40.54
    chlorobenzene 71.06
    dimethyl carbonate 62.62
    n-octane 2.0
    formamide 165.8
    cyclopentanone 408.45
    2-pentanone 145.89
    anisole 69.32
    cyclopentyl methyl ether 128.98
    gamma-butyrolactone 448.51
    1-methoxy-2-propanol 178.51
    pyridine 174.89
    3-pentanone 99.85
    furfural 329.64
    n-dodecane 1.58
    diethylene glycol 82.03
    diisopropyl ether 20.86
    tert-amyl alcohol 111.56
    acetylacetone 208.92
    n-hexadecane 1.87
    acetophenone 120.46
    methyl propionate 117.11
    isopentyl acetate 129.72
    trichloroethylene 354.93
    n-nonanol 37.59
    cyclohexanol 94.83
    benzyl alcohol 83.44
    2-ethylhexanol 31.69
    isooctanol 39.13
    dipropyl ether 32.89
    1,2-dichlorobenzene 81.9
    ethyl lactate 85.02
    propylene carbonate 259.81
    n-methylformamide 181.3
    2-pentanol 52.43
    n-pentane 2.48
    1-propoxy-2-propanol 105.92
    1-methoxy-2-propyl acetate 148.32
    2-(2-methoxypropoxy) propanol 113.78
    mesitylene 18.09
    ε-caprolactone 343.31
    p-cymene 18.44
    epichlorohydrin 386.19
    1,1,1-trichloroethane 171.75
    2-aminoethanol 53.47
    morpholine-4-carbaldehyde 377.72
    sulfolane 616.42
    2,2,4-trimethylpentane 3.85
    2-methyltetrahydrofuran 239.12
    n-hexyl acetate 128.44
    isooctane 1.76
    2-(2-butoxyethoxy)ethanol 157.98
    sec-butyl acetate 105.81
    tert-butyl acetate 141.04
    decalin 6.17
    glycerin 58.18
    diglyme 347.27
    acrylic acid 97.89
    isopropyl myristate 35.11
    n-butyric acid 223.18
    acetyl acetate 106.09
    di(2-ethylhexyl) phthalate 48.5
    ethyl propionate 109.91
    nitromethane 326.96
    1,2-diethoxyethane 126.07
    benzonitrile 92.83
    trioctyl phosphate 34.67
    1-bromopropane 80.03
    gamma-valerolactone 575.72
    n-decanol 24.04
    triethyl phosphate 60.3
    4-methyl-2-pentanol 34.66
    propionitrile 68.32
    vinylene carbonate 196.87
    1,1,2-trichlorotrifluoroethane 316.35
    DMS 95.16
    cumene 21.5
    2-octanol 32.2
    2-hexanone 125.69
    octyl acetate 54.85
    limonene 27.33
    1,2-dimethoxyethane 287.56
    ethyl orthosilicate 57.22
    tributyl phosphate 46.88
    diacetone alcohol 173.86
    N,N-dimethylaniline 55.93
    acrylonitrile 84.62
    aniline 62.33
    1,3-propanediol 91.02
    bromobenzene 66.4
    dibromomethane 151.56
    1,1,2,2-tetrachloroethane 329.83
    2-methyl-cyclohexyl acetate 87.65
    tetrabutyl urea 67.31
    diisobutyl methanol 19.65
    2-phenylethanol 64.73
    styrene 32.04
    dioctyl adipate 69.31
    dimethyl sulfate 166.81
    ethyl butyrate 97.63
    methyl lactate 89.02
    butyl lactate 121.33
    diethyl carbonate 63.27
    propanediol butyl ether 112.37
    triethyl orthoformate 75.32
    p-tert-butyltoluene 16.98
    methyl 4-tert-butylbenzoate 118.8
    morpholine 243.49
    tert-butylamine 49.95
    n-dodecanol 15.84
    dimethoxymethane 166.79
    ethylene carbonate 178.23
    cyrene 142.92
    2-ethoxyethyl acetate 188.45
    2-ethylhexyl acetate 94.98
    1,2,4-trichlorobenzene 109.23
    4-methylpyridine 162.17
    dibutyl ether 45.68
    2,6-dimethyl-4-heptanol 19.65
    DEF 226.1
    dimethyl isosorbide 202.86
    tetrachloroethylene 213.53
    eugenol 117.98
    triacetin 152.78
    span 80 89.09
    1,4-butanediol 47.35
    1,1-dichloroethane 155.25
    2-methyl-1-pentanol 79.91
    methyl formate 113.16
    2-methyl-1-butanol 83.28
    n-decane 3.23
    butyronitrile 80.59
    3,7-dimethyl-1-octanol 36.57
    1-chlorooctane 23.62
    1-chlorotetradecane 7.02
    n-nonane 2.75
    undecane 2.14
    tert-butylcyclohexane 4.38
    cyclooctane 2.22
    cyclopentanol 122.97
    tetrahydropyran 172.55
    tert-amyl methyl ether 81.19
    2,5,8-trioxanonane 192.77
    1-hexene 18.63
    2-isopropoxyethanol 133.48
    2,2,2-trifluoroethanol 111.46
    methyl butyrate 192.86

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction