Hydroxyethylcellulose

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  • Identifiers

    CAS number
    1041187-47-6

    Molecular formula
    C36H70O19

    SMILES
    CC(COCC1C(C(C(C(O1)OC2C(OC(C(C2OCC(C)O)OCC(C)O)OCC(C)O)COCC(C)O)OCC(C)O)OCC(C)O)OCC(C)O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 60.84%
    Alcoholic 35.27%
    Sweet 23.27%
    Buttery 22.21%
    Fruity 18.2%
    Milky 16.7%
    Fishy 16.35%
    Oily 16.1%
    Ethereal 15.54%
    Savory 14.81%

     

    Flavor
    Odorless 49.33%
    Sweet 35.11%
    Bitter 33.58%
    Sweet-like 28.83%
    Fatty 27.28%
    Fruity 25.75%
    Mild 23.7%
    Creamy 23.57%
    Very slight 22.8%
    Cauliflower 21.71%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -3.0

    pKa est.
    4.13 (weak acid)

    Molecular weight
    806.9 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    4213°C

    Melting point expt.

    • Decomposes at 205ºC as Cellosize
    • Browning temp: 205-210 °C

    Flash point

    • 198.21 ˚C est.

    Solubility expt.

    • Soluble
    • Very soluble in water
    • Soluble in hot or cold water
    • Partially soluble in acetic acid
    • Insoluble in alcohol
    • For more Solubility (Complete) data for HYDROXYETHYLCELLULOSE (6 total), please visit the HSDB record page.
    • Solubility in water: good

  • Synonyms

    • Cellulose hydroxyethylate
    • HYDROXYETHYLCELLULOSE
    • Cellulose hydroxyethyl ether
    • 2-Hydroxyethyl cellulose ether
    • HYDROXYETHYL CELLULOSE (II)
    • HYDROXYETHYL CELLULOSE [II]
    • HYDROXYETHYL CELLULOSE (USP-RS)
    • HYDROXYETHYL CELLULOSE [USP-RS]
    • 1-{[3,4,5-tris(2-hydroxypropoxy)-6-{[4,5,6-tris(2-hydroxypropoxy)-2-[(2-hydroxypropoxy)methyl]oxan-3-yl]oxy}oxan-2-yl]methoxy}propan-2-ol
    • HYDROXYETHYLCELLULOSE (EP MONOGRAPH)
    • HYDROXYETHYLCELLULOSE [EP MONOGRAPH]
    • Cellulosize
    • Cellosize
    • Natrosol
    • Cellosize QP
    • Cellosize WP
    • Tylose H series
    • Natrosol LR
    • Tylose P
    • Tylose PX
    • Cellosize QP3
    • Tylose PZ series
    • Tylose PSX
    • Cellosize (TN)
    • Tylose P-X
    • Tylose PS-X
    • 1-((3,4,5-tris(2-hydroxypropoxy)-6-((4,5,6-tris(2-hydroxypropoxy)-2-((2-hydroxypropoxy)methyl)oxan-3-yl)oxy)oxan-2-yl)methoxy)propan-2-ol
    • Cellosize UT 40
    • Cellosize WP 09
    • H. E. Cellulose
    • Tylose P-Z series
    • Glutofix 600
    • Natrosol 150L
    • Natrosol 180HH
    • Natrosol 180L
    • Natrosol 240JR
    • Natrosol 250
    • Natrosol 250G
    • Natrosol 250H
    • Natrosol 250HHP
    • Natrosol 250HHR
    • Natrosol 250HR
    • Natrosol 250HX
    • Natrosol 250L
    • Natrosol 250M
    • Natrosol 250MH
    • Natrosol 300H
    • Hercules N 100
    • Natrosol 250 M
    • Natrosol 250H4R
    • Natrosol L 250
    • Cellosize WP 300
    • Tylose H 20
    • Fuji hec-BL 20
    • Caswell No. 487
    • Natrosol 250 HHR
    • Cellosize WP 300H
    • Cellosize WP 400H
    • Unicel QP 100MH
    • 2Hydroxyethyl cellulose
    • Fuji HECBL 20
    • Tylose H 300
    • Cellosize QP 1500
    • Cellosize QP 4400
    • Cellosize WP 4400
    • Cellosize WPO 9H17
    • hydroxyl ethyl cellulose
    • Unicel QP 300 H
    • Cellosize 4400H16
    • Cellosize QP 30000
    • Hydroxyethyl cellulose ether
    • Hydroxyethyl ether cellulose
    • Hec-Al 5000
    • Unicel QP 52000 H
    • Hydroxyethyl cellulose [NF]
    • T4V6TWG28D
    • 2Hydroxyethyl cellulose ether
    • Cellulose 2hydroxyethyl ether
    • HECAl 5000
    • Walocel HT 6.000 PFV
    • Cellulose, 2hydroxyethyl ether
    • HSDB 578
    • Cellulose, ethylene oxidegrafted
    • DTXSID1049643
    • CHEBI:85249
    • Cellulose, ethylene oxide-grafted
    • AH 15
    • BL 15
    • HYDROXYETHYLCELLULOSE [JAN]
    • HYDROXYETHYLCELLULOSE [INCI]
    • DB11602
    • EPA Pesticide Chemical Code 046201
    • 1-[[3,4,5-tris(2-hydroxypropoxy)-6-[4,5,6-tris(2-hydroxypropoxy)-2-(2-hydroxypropoxymethyl)oxan-3-yl]oxyoxan-2-yl]methoxy]propan-2-ol
    • HYDROXYETHYL CELLULOSE, UNSPECIFIED
    • J 164
    • EN300-28265989
    • 1041187-47-6
    • 618-387-5

  • Applications

    Hydroxyethylcellulose (CAS 1041187-47-6) is a nonionic cellulose ether used as a thickener and rheology modifier across multiple industries. In cosmetics and personal care, it provides viscosity stability in shampoos, creams, and gels and helps stabilize emulsions. In household cleaning products, it thickens liquids such as detergents and cleaners and can improve foam structure. In paints and coatings, it acts as a thickener and rheology modifier to control sag, leveling, and flow in aqueous systems and inks. In adhesives and sealants, it serves as a thickener and flow modifier to tailor viscosity and sag resistance. In pharmaceuticals, it is used in topical gels and suspensions as a viscosity modifier and thickening agent, improving texture and stability. It may be used in other industrial formulations as a stabilizer or thickener, subject to formulation constraints.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 17.38
    methanol 83.6
    isopropanol 6.49
    water 22.31
    ethyl acetate 14.62
    n-propanol 16.63
    acetone 12.43
    n-butanol 9.73
    acetonitrile 6.8
    DMF 157.55
    toluene 4.16
    isobutanol 7.95
    1,4-dioxane 16.16
    methyl acetate 18.48
    THF 29.28
    2-butanone 15.46
    n-pentanol 6.02
    sec-butanol 7.98
    n-hexane 0.28
    ethylene glycol 38.65
    NMP 412.3
    cyclohexane 0.6
    DMSO 131.07
    n-butyl acetate 7.79
    n-octanol 4.46
    chloroform 27.21
    n-propyl acetate 7.78
    acetic acid 211.91
    dichloromethane 30.95
    cyclohexanone 31.4
    propylene glycol 49.23
    isopropyl acetate 7.52
    DMAc 190.49
    2-ethoxyethanol 39.77
    isopentanol 4.92
    n-heptane 0.5
    ethyl formate 19.35
    1,2-dichloroethane 15.18
    n-hexanol 4.26
    2-methoxyethanol 89.45
    isobutyl acetate 3.96
    tetrachloromethane 4.23
    n-pentyl acetate 10.97
    transcutol 86.81
    n-heptanol 5.74
    ethylbenzene 1.44
    MIBK 4.89
    2-propoxyethanol 36.31
    tert-butanol 4.01
    MTBE 2.89
    2-butoxyethanol 33.9
    propionic acid 69.83
    o-xylene 3.73
    formic acid 333.46
    diethyl ether 4.32
    m-xylene 2.67
    p-xylene 1.54
    chlorobenzene 4.45
    dimethyl carbonate 35.59
    n-octane 0.26
    formamide 222.84
    cyclopentanone 52.08
    2-pentanone 11.45
    anisole 3.84
    cyclopentyl methyl ether 17.32
    gamma-butyrolactone 113.47
    1-methoxy-2-propanol 59.02
    pyridine 21.64
    3-pentanone 13.02
    furfural 104.93
    n-dodecane 0.15
    diethylene glycol 49.71
    diisopropyl ether 1.07
    tert-amyl alcohol 6.53
    acetylacetone 20.04
    n-hexadecane 0.16
    acetophenone 10.7
    methyl propionate 30.26
    isopentyl acetate 5.83
    trichloroethylene 44.41
    n-nonanol 4.33
    cyclohexanol 11.1
    benzyl alcohol 9.7
    2-ethylhexanol 2.72
    isooctanol 3.71
    dipropyl ether 4.44
    1,2-dichlorobenzene 5.91
    ethyl lactate 21.77
    propylene carbonate 50.57
    n-methylformamide 117.07
    2-pentanol 4.89
    n-pentane 0.42
    1-propoxy-2-propanol 24.45
    1-methoxy-2-propyl acetate 24.8
    2-(2-methoxypropoxy) propanol 27.53
    mesitylene 1.3
    ε-caprolactone 56.51
    p-cymene 1.7
    epichlorohydrin 55.5
    1,1,1-trichloroethane 7.63
    2-aminoethanol 52.0
    morpholine-4-carbaldehyde 209.55
    sulfolane 279.9
    2,2,4-trimethylpentane 0.35
    2-methyltetrahydrofuran 16.62
    n-hexyl acetate 9.82
    isooctane 0.11
    2-(2-butoxyethoxy)ethanol 32.96
    sec-butyl acetate 4.68
    tert-butyl acetate 6.53
    decalin 0.35
    glycerin 141.89
    diglyme 61.06
    acrylic acid 119.39
    isopropyl myristate 2.28
    n-butyric acid 49.88
    acetyl acetate 14.74
    di(2-ethylhexyl) phthalate 6.37
    ethyl propionate 9.21
    nitromethane 180.67
    1,2-diethoxyethane 8.76
    benzonitrile 5.82
    trioctyl phosphate 4.48
    1-bromopropane 4.8
    gamma-valerolactone 152.89
    n-decanol 2.52
    triethyl phosphate 9.86
    4-methyl-2-pentanol 2.11
    propionitrile 5.87
    vinylene carbonate 57.96
    1,1,2-trichlorotrifluoroethane 181.52
    DMS 17.74
    cumene 1.03
    2-octanol 2.82
    2-hexanone 5.53
    octyl acetate 4.82
    limonene 2.83
    1,2-dimethoxyethane 21.92
    ethyl orthosilicate 7.81
    tributyl phosphate 5.05
    diacetone alcohol 19.82
    N,N-dimethylaniline 5.04
    acrylonitrile 13.77
    aniline 9.78
    1,3-propanediol 38.36
    bromobenzene 3.88
    dibromomethane 13.42
    1,1,2,2-tetrachloroethane 34.99
    2-methyl-cyclohexyl acetate 7.19
    tetrabutyl urea 8.2
    diisobutyl methanol 1.4
    2-phenylethanol 6.5
    styrene 1.51
    dioctyl adipate 7.23
    dimethyl sulfate 121.11
    ethyl butyrate 8.8
    methyl lactate 71.9
    butyl lactate 23.98
    diethyl carbonate 6.37
    propanediol butyl ether 40.98
    triethyl orthoformate 9.79
    p-tert-butyltoluene 1.76
    methyl 4-tert-butylbenzoate 22.68
    morpholine 35.11
    tert-butylamine 1.53
    n-dodecanol 1.47
    dimethoxymethane 47.77
    ethylene carbonate 35.9
    cyrene 62.9
    2-ethoxyethyl acetate 23.97
    2-ethylhexyl acetate 4.98
    1,2,4-trichlorobenzene 10.94
    4-methylpyridine 14.86
    dibutyl ether 2.46
    2,6-dimethyl-4-heptanol 1.4
    DEF 40.44
    dimethyl isosorbide 44.94
    tetrachloroethylene 24.73
    eugenol 20.45
    triacetin 37.56
    span 80 27.67
    1,4-butanediol 16.36
    1,1-dichloroethane 7.74
    2-methyl-1-pentanol 4.13
    methyl formate 84.27
    2-methyl-1-butanol 8.15
    n-decane 0.32
    butyronitrile 4.1
    3,7-dimethyl-1-octanol 2.73
    1-chlorooctane 1.56
    1-chlorotetradecane 0.44
    n-nonane 0.31
    undecane 0.21
    tert-butylcyclohexane 0.24
    cyclooctane 0.37
    cyclopentanol 17.43
    tetrahydropyran 10.03
    tert-amyl methyl ether 5.3
    2,5,8-trioxanonane 37.42
    1-hexene 0.88
    2-isopropoxyethanol 17.87
    2,2,2-trifluoroethanol 138.01
    methyl butyrate 13.35

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction