Hydroxyethyl Starch

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  • Identifiers

    CAS number
    9005-27-0

    Molecular formula
    C22H44O17

    SMILES
    C(COC[C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)OCCO)OCCO)OCCO)OCCO)O.C([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O)O)O)O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 67.07%
    Alcoholic 40.56%
    Sweet 22.6%
    Fishy 21.34%
    Ethereal 16.51%
    Oily 14.76%
    Solvent 14.24%
    Clean 14.24%
    Cooling 13.33%
    Buttery 12.05%

     

    Flavor
    Odorless 56.78%
    Sweet 54.27%
    Bitter 37.78%
    Sweet-like 32.2%
    Fatty 29.64%
    Very slight 23.74%
    Alcoholic 23.42%
    Cauliflower 22.97%
    Creamy 22.06%
    Soup 20.95%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    3.81 (weak acid)

    Molecular weight
    580.6 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    2183°C

    Flash point

    • 261.69 ˚C est.

  • Synonyms

    • 9005-27-0
    • Venofundin
    • Volulyte
    • VetStarch
    • Hydroxyethylstarch
    • HYDROSTARCH
    • RefChem:789475
    • DTXSID3046829
    • 1GVO236S58
    • HES 130/0.4
    • HES-130/0.4
    • HYDROXYETHYL STARCH 130/0.4 Substitution
    • (2S,3R,4S,5S,6R)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol;2-[[(2R,3R,4S,5R,6S)-3,4,5,6-tetrakis(2-hydroxyethoxy)oxan-2-yl]methoxy]ethanol
    • MFCD00131356
    • Hetastarch, Technical Grade
    • orb2938945
    • CHEMBL1730764
    • SCHEMBL28286620
    • DNZMDASEFMLYBU-RNBXVSKKSA-N
    • Hydroxyethyl starch (high Mw) CRS
    • C22H44O17
    • Hydroxyethyl starch (medium MW) CRS
    • AKOS030254900
    • G72626
    • (2S,3R,4S,5S,6R)-6-(hydroxymethyl)tetrahydropyran-2,3,4,5-tetrol;2-[[(2R,3R,4S,5R,6S)-3,4,5,6-tetrakis(2-hydroxyethoxy)tetrahydropyran-2-yl]methoxy]ethanol
    • 9005-27-0

  • Applications

    Hydroxyethyl Starch (CAS 9005-27-0) is a hydroxyethylated polysaccharide commonly used as a thickener and stabilizer in cosmetics and personal care; it also serves as a viscosity modifier in household cleaners and as a thickener for water-based coatings and printing inks; it functions as a thickener in water-based adhesives; in pharmaceutical contexts it is used as an excipient and viscosity-modifying agent in topical and parenteral formulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 17.29
    methanol 71.66
    isopropanol 4.58
    water 400.27
    ethyl acetate 4.11
    n-propanol 10.95
    acetone 5.1
    n-butanol 6.14
    acetonitrile 4.07
    DMF 153.01
    toluene 1.03
    isobutanol 4.67
    1,4-dioxane 9.02
    methyl acetate 5.86
    THF 8.82
    2-butanone 3.9
    n-pentanol 3.56
    sec-butanol 4.14
    n-hexane 0.22
    ethylene glycol 97.22
    NMP 266.83
    cyclohexane 1.05
    DMSO 311.14
    n-butyl acetate 2.7
    n-octanol 2.59
    chloroform 6.37
    n-propyl acetate 2.62
    acetic acid 152.78
    dichloromethane 9.44
    cyclohexanone 14.13
    propylene glycol 53.24
    isopropyl acetate 2.25
    DMAc 135.43
    2-ethoxyethanol 29.62
    isopentanol 3.16
    n-heptane 0.61
    ethyl formate 10.95
    1,2-dichloroethane 7.0
    n-hexanol 3.09
    2-methoxyethanol 75.36
    isobutyl acetate 1.34
    tetrachloromethane 1.76
    n-pentyl acetate 3.0
    transcutol 43.29
    n-heptanol 3.44
    ethylbenzene 0.69
    MIBK 1.66
    2-propoxyethanol 19.06
    tert-butanol 3.29
    MTBE 0.95
    2-butoxyethanol 15.66
    propionic acid 46.65
    o-xylene 1.82
    formic acid 534.36
    diethyl ether 1.32
    m-xylene 1.06
    p-xylene 0.8
    chlorobenzene 1.55
    dimethyl carbonate 15.61
    n-octane 0.3
    formamide 384.54
    cyclopentanone 18.0
    2-pentanone 2.73
    anisole 1.64
    cyclopentyl methyl ether 5.14
    gamma-butyrolactone 51.73
    1-methoxy-2-propanol 31.67
    pyridine 9.85
    3-pentanone 3.8
    furfural 61.72
    n-dodecane 0.2
    diethylene glycol 51.73
    diisopropyl ether 0.52
    tert-amyl alcohol 3.75
    acetylacetone 7.84
    n-hexadecane 0.22
    acetophenone 5.25
    methyl propionate 10.17
    isopentyl acetate 2.17
    trichloroethylene 13.29
    n-nonanol 2.54
    cyclohexanol 9.18
    benzyl alcohol 6.69
    2-ethylhexanol 1.95
    isooctanol 2.29
    dipropyl ether 2.14
    1,2-dichlorobenzene 2.68
    ethyl lactate 13.09
    propylene carbonate 24.71
    n-methylformamide 105.02
    2-pentanol 2.29
    n-pentane 0.36
    1-propoxy-2-propanol 11.21
    1-methoxy-2-propyl acetate 8.24
    2-(2-methoxypropoxy) propanol 15.18
    mesitylene 0.9
    ε-caprolactone 22.82
    p-cymene 1.32
    epichlorohydrin 18.36
    1,1,1-trichloroethane 2.23
    2-aminoethanol 79.45
    morpholine-4-carbaldehyde 126.49
    sulfolane 178.68
    2,2,4-trimethylpentane 0.26
    2-methyltetrahydrofuran 4.5
    n-hexyl acetate 3.07
    isooctane 0.1
    2-(2-butoxyethoxy)ethanol 18.62
    sec-butyl acetate 1.42
    tert-butyl acetate 2.4
    decalin 0.41
    glycerin 175.5
    diglyme 31.25
    acrylic acid 91.8
    isopropyl myristate 1.26
    n-butyric acid 26.12
    acetyl acetate 6.24
    di(2-ethylhexyl) phthalate 4.1
    ethyl propionate 3.39
    nitromethane 109.66
    1,2-diethoxyethane 3.66
    benzonitrile 3.93
    trioctyl phosphate 3.24
    1-bromopropane 1.55
    gamma-valerolactone 58.67
    n-decanol 1.84
    triethyl phosphate 6.2
    4-methyl-2-pentanol 1.2
    propionitrile 3.48
    vinylene carbonate 31.83
    1,1,2-trichlorotrifluoroethane 116.73
    DMS 7.75
    cumene 0.7
    2-octanol 1.61
    2-hexanone 1.71
    octyl acetate 2.19
    limonene 1.99
    1,2-dimethoxyethane 15.05
    ethyl orthosilicate 4.56
    tributyl phosphate 3.54
    diacetone alcohol 8.66
    N,N-dimethylaniline 3.18
    acrylonitrile 10.1
    aniline 5.03
    1,3-propanediol 49.77
    bromobenzene 1.13
    dibromomethane 4.54
    1,1,2,2-tetrachloroethane 13.32
    2-methyl-cyclohexyl acetate 3.74
    tetrabutyl urea 6.54
    diisobutyl methanol 1.27
    2-phenylethanol 4.64
    styrene 0.72
    dioctyl adipate 4.1
    dimethyl sulfate 66.69
    ethyl butyrate 3.42
    methyl lactate 41.64
    butyl lactate 9.92
    diethyl carbonate 3.63
    propanediol butyl ether 21.09
    triethyl orthoformate 4.42
    p-tert-butyltoluene 1.28
    methyl 4-tert-butylbenzoate 9.85
    morpholine 19.12
    tert-butylamine 1.54
    n-dodecanol 1.39
    dimethoxymethane 22.9
    ethylene carbonate 20.49
    cyrene 39.92
    2-ethoxyethyl acetate 5.95
    2-ethylhexyl acetate 1.83
    1,2,4-trichlorobenzene 4.62
    4-methylpyridine 4.95
    dibutyl ether 1.15
    2,6-dimethyl-4-heptanol 1.27
    DEF 20.29
    dimethyl isosorbide 24.4
    tetrachloroethylene 12.55
    eugenol 11.53
    triacetin 11.42
    span 80 16.1
    1,4-butanediol 23.73
    1,1-dichloroethane 2.08
    2-methyl-1-pentanol 2.35
    methyl formate 59.72
    2-methyl-1-butanol 4.35
    n-decane 0.31
    butyronitrile 2.18
    3,7-dimethyl-1-octanol 1.69
    1-chlorooctane 0.89
    1-chlorotetradecane 0.44
    n-nonane 0.3
    undecane 0.24
    tert-butylcyclohexane 0.21
    cyclooctane 0.54
    cyclopentanol 11.87
    tetrahydropyran 4.09
    tert-amyl methyl ether 1.76
    2,5,8-trioxanonane 25.18
    1-hexene 0.4
    2-isopropoxyethanol 10.28
    2,2,2-trifluoroethanol 142.16
    methyl butyrate 4.78

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction