Hydroxycetyl hydroxyethyl dimonium chloride

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  • Identifiers

    CAS number
    84643-53-8

    Molecular formula
    C20H44ClNO2

    SMILES
    CCCCCCCCCCCCCCC(C[N+](C)(C)CCO)O.[Cl-]

    Safety labels

    Corrosive
    Corrosive

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Waxy 54.28%
    Floral 51.01%
    Oily 47.13%
    Fatty 42.65%
    Fruity 40.81%
    Fresh 40.26%
    Woody 39.92%
    Citrus 33.96%
    Sweet 33.71%
    Clean 30.27%

     

    Flavor
    Mild 37.39%
    Waxy 33.11%
    Bland 29.99%
    Fatty 24.16%
    Floral 24.14%
    Oily 23.41%
    Delicate 22.92%
    Slightly waxy 22.32%
    Leathery 22.03%
    Flower 21.81%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    6.32 (neutral)

    Molecular weight
    366.0 g/mol

    Flash point

    • 13.64 ˚C est.

  • Synonyms

    • (2-Hydroxyethyl)(2-hydroxyhexadecyl)dimethylammonium chloride
    • 84643-53-8
    • HYDROXYCETYL HYDROXYETHYL DIMONIUM CHLORIDE
    • 640X9A7H9N
    • EINECS 283-450-2
    • HYDRO TRICHOSYL
    • DEHYQUART E
    • 1-Hexadecanaminium, 2-hydroxy-N-(2-hydroxyethyl)-N,N-dimethyl-, chloride
    • hydroxycetyl hydroxyethyl dimethyl ammonium chloride
    • 1-HEXADECANAMINIUM, 2-HYDROXY-N-(2-HYDROXYETHYL)-N,N-DIMETHYL-, CHLORIDE (1:1)
    • RefChem:789455
    • (+-)-HYDROXYCETYL HYDROXYETHYL DIMONIUM CHLORIDE
    • HYDROXYCETYL HYDROXYETHYL DIMONIUM CHLORIDE [INCI]
    • HYDROXYCETYL HYDROXYETHYL DIMONIUM CHLORIDE, (+-)-
    • UNII-640X9A7H9N
    • 2-hydroxyethyl-(2-hydroxyhexadecyl)-dimethylazanium;chloride
    • SCHEMBL2185310
    • RQWRCBGTSNWJKX-UHFFFAOYSA-M
    • DTXSID101004933
    • NS00013754
    • NS00089937
    • Q27263677
    • (+/-)-HYDROXYCETYL HYDROXYETHYL DIMONIUM CHLORIDE
    • HYDROXYCETYL HYDROXYETHYL DIMONIUM CHLORIDE, (+/-)-
    • 2-Hydroxy-N-(2-hydroxyethyl)-N,N-dimethylhexadecan-1-aminium chloride
    • 2-Hydroxyalkyl hydroxyethyl dimethyl ammonium compound C16 (2hAhEDMAC C16)
    • 84643-53-8

  • Applications

    Hydroxycetyl hydroxyethyl dimonium chloride (CAS 84643-53-8) is a cationic surfactant and conditioning agent commonly used in cosmetics and personal care to impart softness and conditioning to hair and skin. In cosmetics, particularly in hair care formulations, it functions as a conditioning quaternary ammonium compound, improving slip and manageability in shampoos and conditioners; in skin care it provides mild conditioning in emulsions and cleansers. In textile and fabric care, it serves as a fabric conditioning agent in fabric softeners and some laundry detergents, depositing on fibers to reduce static and improve hand feel. In cleaning applications, it can act as a surfactant and deposition aid in household cleaners and surface formulations. It can also function as an anti-static/conditioning additive in coatings, inks, and certain polymer formulations where a cationic surfactant is advantageous. Use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 156.58
    methanol 250.41
    isopropanol 95.05
    water 0.92
    ethyl acetate 119.8
    n-propanol 158.33
    acetone 108.2
    n-butanol 139.55
    acetonitrile 32.42
    DMF 176.39
    toluene 44.28
    isobutanol 126.84
    1,4-dioxane 228.4
    methyl acetate 88.55
    THF 448.49
    2-butanone 112.46
    n-pentanol 84.86
    sec-butanol 106.64
    n-hexane 12.3
    ethylene glycol 26.9
    NMP 450.72
    cyclohexane 67.05
    DMSO 380.06
    n-butyl acetate 170.68
    n-octanol 79.1
    chloroform 386.05
    n-propyl acetate 172.06
    acetic acid 302.7
    dichloromethane 329.46
    cyclohexanone 456.03
    propylene glycol 60.97
    isopropyl acetate 120.27
    DMAc 237.72
    2-ethoxyethanol 206.89
    isopentanol 129.16
    n-heptane 22.86
    ethyl formate 120.44
    1,2-dichloroethane 216.62
    n-hexanol 95.78
    2-methoxyethanol 271.99
    isobutyl acetate 126.89
    tetrachloromethane 109.62
    n-pentyl acetate 223.24
    transcutol 650.87
    n-heptanol 105.33
    ethylbenzene 31.94
    MIBK 108.84
    2-propoxyethanol 209.67
    tert-butanol 145.94
    MTBE 92.82
    2-butoxyethanol 251.52
    propionic acid 193.9
    o-xylene 50.89
    formic acid 120.98
    diethyl ether 70.69
    m-xylene 45.35
    p-xylene 45.69
    chlorobenzene 85.96
    dimethyl carbonate 46.38
    n-octane 8.77
    formamide 135.75
    cyclopentanone 404.75
    2-pentanone 120.31
    anisole 61.05
    cyclopentyl methyl ether 240.55
    gamma-butyrolactone 495.1
    1-methoxy-2-propanol 229.35
    pyridine 149.94
    3-pentanone 100.6
    furfural 350.6
    n-dodecane 4.3
    diethylene glycol 134.47
    diisopropyl ether 36.45
    tert-amyl alcohol 143.03
    acetylacetone 164.85
    n-hexadecane 5.04
    acetophenone 108.66
    methyl propionate 118.12
    isopentyl acetate 157.76
    trichloroethylene 408.05
    n-nonanol 76.2
    cyclohexanol 253.1
    benzyl alcohol 79.41
    2-ethylhexanol 88.97
    isooctanol 101.61
    dipropyl ether 115.97
    1,2-dichlorobenzene 106.95
    ethyl lactate 112.67
    propylene carbonate 287.41
    n-methylformamide 134.67
    2-pentanol 88.59
    n-pentane 11.74
    1-propoxy-2-propanol 212.28
    1-methoxy-2-propyl acetate 177.34
    2-(2-methoxypropoxy) propanol 138.39
    mesitylene 37.06
    ε-caprolactone 436.06
    p-cymene 43.57
    epichlorohydrin 381.82
    1,1,1-trichloroethane 211.6
    2-aminoethanol 92.32
    morpholine-4-carbaldehyde 341.04
    sulfolane 821.33
    2,2,4-trimethylpentane 13.99
    2-methyltetrahydrofuran 293.39
    n-hexyl acetate 187.74
    isooctane 7.77
    2-(2-butoxyethoxy)ethanol 230.19
    sec-butyl acetate 118.58
    tert-butyl acetate 170.09
    decalin 18.43
    glycerin 113.82
    diglyme 469.01
    acrylic acid 145.45
    isopropyl myristate 54.63
    n-butyric acid 333.95
    acetyl acetate 105.09
    di(2-ethylhexyl) phthalate 68.97
    ethyl propionate 120.35
    nitromethane 286.38
    1,2-diethoxyethane 159.41
    benzonitrile 80.17
    trioctyl phosphate 60.15
    1-bromopropane 98.61
    gamma-valerolactone 592.29
    n-decanol 46.47
    triethyl phosphate 97.48
    4-methyl-2-pentanol 63.14
    propionitrile 49.02
    vinylene carbonate 222.94
    1,1,2-trichlorotrifluoroethane 476.73
    DMS 107.78
    cumene 31.29
    2-octanol 67.7
    2-hexanone 117.24
    octyl acetate 78.67
    limonene 80.39
    1,2-dimethoxyethane 267.58
    ethyl orthosilicate 98.96
    tributyl phosphate 72.26
    diacetone alcohol 209.27
    N,N-dimethylaniline 57.97
    acrylonitrile 57.49
    aniline 81.16
    1,3-propanediol 164.69
    bromobenzene 82.18
    dibromomethane 203.98
    1,1,2,2-tetrachloroethane 419.33
    2-methyl-cyclohexyl acetate 156.62
    tetrabutyl urea 89.02
    diisobutyl methanol 57.58
    2-phenylethanol 85.86
    styrene 32.17
    dioctyl adipate 108.65
    dimethyl sulfate 126.04
    ethyl butyrate 156.38
    methyl lactate 97.4
    butyl lactate 199.71
    diethyl carbonate 93.05
    propanediol butyl ether 189.72
    triethyl orthoformate 153.21
    p-tert-butyltoluene 41.97
    methyl 4-tert-butylbenzoate 165.28
    morpholine 339.4
    tert-butylamine 87.54
    n-dodecanol 30.18
    dimethoxymethane 133.64
    ethylene carbonate 221.34
    cyrene 174.36
    2-ethoxyethyl acetate 234.05
    2-ethylhexyl acetate 140.76
    1,2,4-trichlorobenzene 139.08
    4-methylpyridine 111.51
    dibutyl ether 87.17
    2,6-dimethyl-4-heptanol 57.58
    DEF 182.4
    dimethyl isosorbide 262.69
    tetrachloroethylene 352.96
    eugenol 139.5
    triacetin 237.11
    span 80 158.26
    1,4-butanediol 59.83
    1,1-dichloroethane 148.15
    2-methyl-1-pentanol 85.29
    methyl formate 97.25
    2-methyl-1-butanol 131.24
    n-decane 10.51
    butyronitrile 63.32
    3,7-dimethyl-1-octanol 71.63
    1-chlorooctane 51.7
    1-chlorotetradecane 13.98
    n-nonane 10.31
    undecane 6.23
    tert-butylcyclohexane 14.71
    cyclooctane 17.65
    cyclopentanol 242.17
    tetrahydropyran 284.96
    tert-amyl methyl ether 93.72
    2,5,8-trioxanonane 255.21
    1-hexene 31.19
    2-isopropoxyethanol 158.17
    2,2,2-trifluoroethanol 171.35
    methyl butyrate 190.84

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction