Hydroxy-Alpha-Sanshool

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  • Identifiers

    CAS number
    83883-10-7

    Molecular formula
    C16H25NO2

    SMILES
    C/C=C/C=C/C=C\CC/C=C/C(=O)NCC(C)(C)O

    Safety labels

  • Odor profile

    Fragrance
    Fruity 44.28%
    Spicy 40.89%
    Meaty 35.86%
    Herbal 35.67%
    Citrus 32.92%
    Sweet 28.5%
    Fresh 25.73%
    Tropical 25.44%
    Woody 24.98%
    Floral 24.91%

     

    Flavor
    Spicy 32.05%
    Herbal 30.84%
    Sweet 26.67%
    Citrus 24.29%
    Oriental 22.76%
    Mouldy 21.73%
    Ocimene 21.71%
    Diterpene 20.64%
    Woody 20.58%
    Floral 20.53%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    2.8

    pKa est.
    9.65 (weak base)

    Molecular weight
    263.37 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    367°C

    Flash point

    • 206.21 ˚C est.

  • Synonyms

    • Hydroxy-alpha-sanshool
    • 83883-10-7
    • (2E,6Z,8E,10E)-N-(2-HYDROXY-2-METHYLPROPYL)DODECA-2,6,8,10-TETRAENAMIDE
    • RefChem:147120
    • C16H25NO2
    • CHEMBL1084610
    • HalphaS
    • (2E,6Z,8E,10E)-N-(2-hydroxy-2-methyl-propyl)dodeca-2,6,8,10-tetraenamide
    • orb1685390
    • SCHEMBL1031361
    • DTXSID20700212
    • CHEBI:172306
    • GLXC-19305
    • HY-N6825
    • BDBM50318477
    • EX-A12299
    • MFCD17779317
    • MSK159085
    • NSC795966
    • AKOS016001468
    • EBC-615939
    • FH36486
    • NSC-795966
    • AC-34644
    • MS-23715
    • CS-0100239
    • E80694
    • (2e,6z,8e,10e)-N-(2-hydroxy-2methylpropyl)dodeca-2,6,8,10-tetraenamide
    • 2E,6Z,8E,10E-Dodecatetraenoic acid N-(2-hydroxy-2-methylpropyl)amide
    • 83883-10-7

  • Applications

    Hydroxy-Alpha-Sanshool (CAS 83883-10-7) is recognized as a sensory-active and flavor-related component with primary applications in the food and beverage sector to replicate or enhance Sichuan pepper notes and tingling sensation; it is also studied as a sensory-active ingredient in food processing and product development. In cosmetics and personal care, it may be considered as a sensory modifier to impart tingling or peppery cues in skin and hair care formulations as an active ingredient. It can serve as a chemical intermediate to access other sanshool derivatives for synthesis and product development. In fragrance and aroma research, it may be explored as a potential odorant note to convey peppery character in fragrance formulations. Additionally, it is used in sensory science and formulation development to understand activation of TRP channels and related perception, guiding formulation design.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 215.25
    methanol 332.99
    isopropanol 123.27
    water 0.52
    ethyl acetate 49.77
    n-propanol 131.81
    acetone 94.56
    n-butanol 115.41
    acetonitrile 31.23
    DMF 207.8
    toluene 15.11
    isobutanol 76.55
    1,4-dioxane 102.14
    methyl acetate 53.75
    THF 219.02
    2-butanone 81.12
    n-pentanol 112.53
    sec-butanol 100.91
    n-hexane 5.83
    ethylene glycol 31.9
    NMP 106.41
    cyclohexane 4.92
    DMSO 238.18
    n-butyl acetate 61.19
    n-octanol 46.75
    chloroform 125.96
    n-propyl acetate 58.79
    acetic acid 114.83
    dichloromethane 78.37
    cyclohexanone 96.68
    propylene glycol 95.32
    isopropyl acetate 44.99
    DMAc 316.38
    2-ethoxyethanol 185.76
    isopentanol 95.5
    n-heptane 3.71
    ethyl formate 46.67
    1,2-dichloroethane 57.12
    n-hexanol 95.9
    2-methoxyethanol 232.09
    isobutyl acetate 57.57
    tetrachloromethane 10.97
    n-pentyl acetate 38.85
    transcutol 390.56
    n-heptanol 44.35
    ethylbenzene 18.62
    MIBK 61.0
    2-propoxyethanol 177.2
    tert-butanol 133.24
    MTBE 76.96
    2-butoxyethanol 105.94
    propionic acid 69.5
    o-xylene 15.64
    formic acid 58.22
    diethyl ether 47.22
    m-xylene 16.07
    p-xylene 23.76
    chlorobenzene 23.57
    dimethyl carbonate 24.07
    n-octane 2.26
    formamide 51.41
    cyclopentanone 101.18
    2-pentanone 63.1
    anisole 51.1
    cyclopentyl methyl ether 57.25
    gamma-butyrolactone 92.06
    1-methoxy-2-propanol 169.65
    pyridine 56.84
    3-pentanone 42.35
    furfural 96.15
    n-dodecane 2.46
    diethylene glycol 131.53
    diisopropyl ether 15.05
    tert-amyl alcohol 105.87
    acetylacetone 74.09
    n-hexadecane 2.64
    acetophenone 55.64
    methyl propionate 44.12
    isopentyl acetate 69.85
    trichloroethylene 103.58
    n-nonanol 42.4
    cyclohexanol 62.54
    benzyl alcohol 55.68
    2-ethylhexanol 51.29
    isooctanol 37.5
    dipropyl ether 37.58
    1,2-dichlorobenzene 25.11
    ethyl lactate 52.85
    propylene carbonate 65.43
    n-methylformamide 71.24
    2-pentanol 62.02
    n-pentane 3.38
    1-propoxy-2-propanol 117.05
    1-methoxy-2-propyl acetate 78.75
    2-(2-methoxypropoxy) propanol 109.37
    mesitylene 11.56
    ε-caprolactone 81.95
    p-cymene 15.68
    epichlorohydrin 112.9
    1,1,1-trichloroethane 40.16
    2-aminoethanol 97.04
    morpholine-4-carbaldehyde 143.77
    sulfolane 125.89
    2,2,4-trimethylpentane 4.65
    2-methyltetrahydrofuran 101.63
    n-hexyl acetate 64.57
    isooctane 3.16
    2-(2-butoxyethoxy)ethanol 146.27
    sec-butyl acetate 49.06
    tert-butyl acetate 59.92
    decalin 5.57
    glycerin 102.49
    diglyme 227.76
    acrylic acid 53.59
    isopropyl myristate 27.5
    n-butyric acid 96.65
    acetyl acetate 32.66
    di(2-ethylhexyl) phthalate 36.39
    ethyl propionate 41.77
    nitromethane 93.92
    1,2-diethoxyethane 90.56
    benzonitrile 40.64
    trioctyl phosphate 24.75
    1-bromopropane 33.45
    gamma-valerolactone 151.89
    n-decanol 30.52
    triethyl phosphate 32.26
    4-methyl-2-pentanol 47.09
    propionitrile 39.32
    vinylene carbonate 54.25
    1,1,2-trichlorotrifluoroethane 134.96
    DMS 41.24
    cumene 17.74
    2-octanol 27.13
    2-hexanone 71.74
    octyl acetate 35.1
    limonene 22.11
    1,2-dimethoxyethane 228.39
    ethyl orthosilicate 34.51
    tributyl phosphate 31.56
    diacetone alcohol 98.85
    N,N-dimethylaniline 46.51
    acrylonitrile 41.17
    aniline 33.55
    1,3-propanediol 122.25
    bromobenzene 19.14
    dibromomethane 52.72
    1,1,2,2-tetrachloroethane 113.99
    2-methyl-cyclohexyl acetate 56.45
    tetrabutyl urea 44.61
    diisobutyl methanol 27.67
    2-phenylethanol 55.57
    styrene 19.38
    dioctyl adipate 46.91
    dimethyl sulfate 44.89
    ethyl butyrate 47.79
    methyl lactate 55.55
    butyl lactate 56.9
    diethyl carbonate 34.41
    propanediol butyl ether 116.97
    triethyl orthoformate 45.05
    p-tert-butyltoluene 15.03
    methyl 4-tert-butylbenzoate 61.4
    morpholine 153.02
    tert-butylamine 63.87
    n-dodecanol 22.42
    dimethoxymethane 100.63
    ethylene carbonate 44.07
    cyrene 84.59
    2-ethoxyethyl acetate 61.15
    2-ethylhexyl acetate 53.43
    1,2,4-trichlorobenzene 35.19
    4-methylpyridine 57.22
    dibutyl ether 39.56
    2,6-dimethyl-4-heptanol 27.67
    DEF 76.94
    dimethyl isosorbide 137.88
    tetrachloroethylene 61.85
    eugenol 71.73
    triacetin 71.59
    span 80 88.39
    1,4-butanediol 67.91
    1,1-dichloroethane 48.3
    2-methyl-1-pentanol 98.12
    methyl formate 49.2
    2-methyl-1-butanol 80.47
    n-decane 4.25
    butyronitrile 54.3
    3,7-dimethyl-1-octanol 44.46
    1-chlorooctane 19.87
    1-chlorotetradecane 7.94
    n-nonane 3.77
    undecane 3.11
    tert-butylcyclohexane 6.19
    cyclooctane 1.81
    cyclopentanol 59.91
    tetrahydropyran 95.92
    tert-amyl methyl ether 62.09
    2,5,8-trioxanonane 160.43
    1-hexene 26.94
    2-isopropoxyethanol 124.56
    2,2,2-trifluoroethanol 30.28
    methyl butyrate 67.63

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction