Hydrocortisone Acetate

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  • Identifiers

    CAS number
    50-03-3

    Molecular formula
    C23H32O6

    SMILES
    CC(=O)OCC(=O)[C@]1(CC[C@@H]2[C@@]1(C[C@@H]([C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)O)C)O

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Woody 57.2%
    Odorless 32.07%
    Cedar 28.53%
    Mint 27.9%
    Fresh 27.17%
    Sweet 26.88%
    Floral 24.48%
    Dry 24.36%
    Fruity 24.11%
    Spicy 23.94%

     

    Flavor
    Bitter 79.43%
    Sweet-like 21.84%
    Cedarleaf 20.91%
    Odorless 20.42%
    Ripe apricot 20.37%
    Fenugreek 20.35%
    Fruity 20.12%
    Leaves 20.07%
    Seedy 20.06%
    Extremely sweet 20.03%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    2.2

    pKa est.
    5.48 (weak acid)

    Molecular weight
    404.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    296°C

    Flash point

    • 250.47 ˚C est.

  • Synonyms

    • hydrocortisone acetate
    • 50-03-3
    • Cortisol 21-acetate
    • Hydrocortisone 21-acetate
    • Cortell
    • Cortef acetate
    • Cortisol acetate
    • Cortifoam
    • Lanacort
    • Carmol HC
    • Dricort
    • Micort-hc
    • Hemsol-HC
    • Orabase HCA
    • U-CORT
    • NSC-741
    • 21-O-acetylcortisol
    • Cortucid
    • Hepacort Plus
    • Barquinol HC
    • Fucidin H
    • Genticin HC
    • Gppe Foam Aero
    • Gppe Ear Susp
    • Gppe Eye Crm
    • Hc45 Hydrocort
    • Hydrocortisoni acetas
    • CHEBI:17609
    • Chloromycetin Hydrocort
    • 3X7931PO74
    • 11beta,17,21-trihydroxypregn-4-ene-3,20-dione, 21-acetate
    • Pregn-4-ene-3,20-dione, 21-(acetyloxy)-11,17-dihydroxy-, (11beta)-
    • DTXCID0028612
    • 21-(Acetyloxy)-11,17-dihydroxypregn-4-ene-3,20-dione
    • Gerigentle
    • Astonea
    • Curaseb
    • Curetech
    • Lincoln
    • Nucort
    • Roosin
    • Glint
    • Cortisil Mdx
    • Medi-first
    • ZCort
    • Hair Sanity
    • Anti-itch Cream
    • Rectacort-HC
    • Hemmorex-HC
    • ZCort Ultra
    • 1% Hydrocortisone
    • Poli-A
    • HairSanity Step 1
    • Equate Hydrocortione
    • Neomed Pharmaceutical
    • Genuine Hydrocortisone
    • Gadaderm Hydrocortisone
    • Walgreens Eczema Relief
    • RefChem:55344
    • Vanicream HC Anti-Itch
    • Hydrocortisone Acetate 1%
    • Aftate Hydrocortisone Cream
    • Ancalima Hydrocortisone Cream
    • Immediate Comfort Bioelements
    • Medi-First 1% Hydrocortisone
    • Medi-First Hydrocortisone 1%
    • American Safety and First Aid
    • Green Guard Hydrocortisone 1%
    • Hair Sanity Hair Sanity Part I
    • MySimplePetLab Itchy Ear Relief
    • ADVANCED ANTI-ITCH THERAPY
    • Medi-First Plus Hydrocortisone 1%
    • Anti-Itch Vulva Cream 1 Hydrocortisone Acetate
    • Hydrocortisone Acetate Antipruritic (anti-itch)
    • Biocorneum HC Advanced Scar Supervision Anti-itch
    • Well and Good Relieve Itching and Soothe Skin Irritations
    • 11beta,17,21-Trihydroxypregn-4-ene-3,20-dione 21-acetate
    • Vagisil Anti-itch Creme Maximum Strength Sensitive Skin Formula
    • 200-004-4
    • Acetic acid / hydrocortisone
    • Anucort-Hc
    • DTXSID0048686
    • Hydrocortisat
    • Abbocort
    • Bambicort
    • Biocortar
    • Chemysone
    • Cortacream
    • Pabracort
    • Cortril acetate
    • Berlison F
    • Hycortole acetate
    • Hydrin-2
    • Cortaid
    • Hydrosone
    • Resicort
    • Cortes
    • Mysone
    • Wycort
    • Aceto-cort
    • Collusul-HC
    • Acetate-AS
    • Hysone-A
    • Hydroxycorticosterone acetate
    • Compound F acetate
    • Cortril acetate-AS
    • Hydrocortone acetate
    • Sintotrat
    • Velopural
    • Lenirit
    • Isopto-Hydrocortisone
    • Hydrocal
    • Cortisol, 21-acetate
    • Neo-Cortef
    • 17-Hydroxycorticosterone-21-acetate
    • MFCD00037714
    • Colifoam
    • NSC 741
    • 17-Hydroxycorticosterone acetate
    • Corticosterone, 17-hydroxy-, 21-acetate
    • MLS000069734
    • [2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
    • 17.alpha.-Hydroxycorticosterone acetate
    • Cortimycine
    • Glycocortison
    • Idrocortigamma
    • Iracetisone
    • 50-03-3

  • Applications

    Hydrocortisone Acetate (CAS 50-03-3) is primarily used as the active pharmaceutical ingredient in topical corticosteroid products, providing anti-inflammatory and antipruritic effects in dermatology. In pharmaceuticals, it is formulated into creams, ointments, gels, and solutions for the treatment of dermatitis, eczema, psoriasis, and other inflammatory skin conditions; in cosmetics and personal care, it may appear in medicated skincare formulations under regulatory controls; in veterinary medicine, it may be included in topical products for animals to address dermatologic conditions; in research and development, it is used as a model corticosteroid for formulation development and stability testing of topical dosage forms.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 16.57
    methanol 35.57
    isopropanol 11.17
    water 0.07
    ethyl acetate 8.82
    n-propanol 18.72
    acetone 24.2
    n-butanol 10.44
    acetonitrile 12.9
    DMF 88.96
    toluene 4.62
    isobutanol 6.79
    1,4-dioxane 44.55
    methyl acetate 10.51
    THF 108.28
    2-butanone 15.4
    n-pentanol 3.91
    sec-butanol 4.0
    n-hexane 0.08
    ethylene glycol 7.05
    NMP 51.86
    cyclohexane 0.32
    DMSO 113.97
    n-butyl acetate 5.05
    n-octanol 1.38
    chloroform 60.78
    n-propyl acetate 4.62
    acetic acid 34.47
    dichloromethane 30.92
    cyclohexanone 29.05
    propylene glycol 7.17
    isopropyl acetate 6.23
    DMAc 59.91
    2-ethoxyethanol 23.57
    isopentanol 5.44
    n-heptane 0.06
    ethyl formate 8.18
    1,2-dichloroethane 13.24
    n-hexanol 4.76
    2-methoxyethanol 69.23
    isobutyl acetate 2.94
    tetrachloromethane 3.45
    n-pentyl acetate 4.22
    transcutol 30.98
    n-heptanol 2.7
    ethylbenzene 1.53
    MIBK 6.78
    2-propoxyethanol 39.51
    tert-butanol 6.78
    MTBE 2.05
    2-butoxyethanol 16.13
    propionic acid 11.02
    o-xylene 2.18
    formic acid 24.73
    diethyl ether 5.46
    m-xylene 2.4
    p-xylene 1.89
    chlorobenzene 6.74
    dimethyl carbonate 14.83
    n-octane 0.04
    formamide 38.86
    cyclopentanone 51.97
    2-pentanone 11.4
    anisole 7.43
    cyclopentyl methyl ether 11.53
    gamma-butyrolactone 49.35
    1-methoxy-2-propanol 44.43
    pyridine 33.05
    3-pentanone 8.25
    furfural 41.24
    n-dodecane 0.03
    diethylene glycol 39.51
    diisopropyl ether 0.88
    tert-amyl alcohol 2.74
    acetylacetone 20.48
    n-hexadecane 0.04
    acetophenone 8.83
    methyl propionate 12.67
    isopentyl acetate 5.0
    trichloroethylene 41.43
    n-nonanol 1.66
    cyclohexanol 5.19
    benzyl alcohol 9.42
    2-ethylhexanol 1.62
    isooctanol 1.99
    dipropyl ether 2.15
    1,2-dichlorobenzene 6.02
    ethyl lactate 6.12
    propylene carbonate 16.12
    n-methylformamide 45.48
    2-pentanol 2.84
    n-pentane 0.12
    1-propoxy-2-propanol 15.81
    1-methoxy-2-propyl acetate 14.0
    2-(2-methoxypropoxy) propanol 12.29
    mesitylene 1.18
    ε-caprolactone 20.12
    p-cymene 0.85
    epichlorohydrin 60.99
    1,1,1-trichloroethane 8.65
    2-aminoethanol 16.04
    morpholine-4-carbaldehyde 65.77
    sulfolane 64.33
    2,2,4-trimethylpentane 0.06
    2-methyltetrahydrofuran 16.63
    n-hexyl acetate 4.53
    isooctane 0.05
    2-(2-butoxyethoxy)ethanol 15.49
    sec-butyl acetate 2.8
    tert-butyl acetate 6.35
    decalin 0.13
    glycerin 20.75
    diglyme 34.06
    acrylic acid 14.2
    isopropyl myristate 1.36
    n-butyric acid 16.04
    acetyl acetate 10.16
    di(2-ethylhexyl) phthalate 3.75
    ethyl propionate 5.16
    nitromethane 58.8
    1,2-diethoxyethane 5.3
    benzonitrile 8.19
    trioctyl phosphate 2.12
    1-bromopropane 3.99
    gamma-valerolactone 80.63
    n-decanol 0.92
    triethyl phosphate 3.47
    4-methyl-2-pentanol 1.96
    propionitrile 10.82
    vinylene carbonate 19.61
    1,1,2-trichlorotrifluoroethane 53.3
    DMS 8.52
    cumene 0.9
    2-octanol 1.04
    2-hexanone 5.36
    octyl acetate 2.04
    limonene 1.04
    1,2-dimethoxyethane 33.43
    ethyl orthosilicate 2.92
    tributyl phosphate 2.12
    diacetone alcohol 13.11
    N,N-dimethylaniline 4.19
    acrylonitrile 17.98
    aniline 11.01
    1,3-propanediol 26.93
    bromobenzene 5.63
    dibromomethane 13.89
    1,1,2,2-tetrachloroethane 31.08
    2-methyl-cyclohexyl acetate 4.76
    tetrabutyl urea 3.56
    diisobutyl methanol 1.0
    2-phenylethanol 10.51
    styrene 1.98
    dioctyl adipate 3.57
    dimethyl sulfate 27.62
    ethyl butyrate 4.07
    methyl lactate 16.49
    butyl lactate 6.18
    diethyl carbonate 3.39
    propanediol butyl ether 9.95
    triethyl orthoformate 4.0
    p-tert-butyltoluene 0.81
    methyl 4-tert-butylbenzoate 9.01
    morpholine 56.06
    tert-butylamine 1.8
    n-dodecanol 0.52
    dimethoxymethane 65.0
    ethylene carbonate 15.68
    cyrene 19.55
    2-ethoxyethyl acetate 9.95
    2-ethylhexyl acetate 3.36
    1,2,4-trichlorobenzene 9.07
    4-methylpyridine 19.46
    dibutyl ether 0.99
    2,6-dimethyl-4-heptanol 1.0
    DEF 13.75
    dimethyl isosorbide 22.26
    tetrachloroethylene 19.29
    eugenol 12.7
    triacetin 8.46
    span 80 9.0
    1,4-butanediol 6.34
    1,1-dichloroethane 10.27
    2-methyl-1-pentanol 2.47
    methyl formate 27.58
    2-methyl-1-butanol 4.2
    n-decane 0.06
    butyronitrile 7.49
    3,7-dimethyl-1-octanol 1.28
    1-chlorooctane 0.46
    1-chlorotetradecane 0.13
    n-nonane 0.05
    undecane 0.04
    tert-butylcyclohexane 0.09
    cyclooctane 0.09
    cyclopentanol 9.83
    tetrahydropyran 19.48
    tert-amyl methyl ether 1.76
    2,5,8-trioxanonane 21.52
    1-hexene 0.5
    2-isopropoxyethanol 10.44
    2,2,2-trifluoroethanol 13.98
    methyl butyrate 6.53

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction