Homosalate

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  • Identifiers

    CAS number
    118-56-9

    Molecular formula
    C16H22O3

    SMILES
    CC1CC(CC(C1)(C)C)OC(=O)C2=CC=CC=C2O

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Herbal 51.41%
    Sweet 41.04%
    Balsamic 40.88%
    Mint 36.83%
    Green 33.7%
    Woody 32.66%
    Floral 31.64%
    Spicy 29.37%
    Fresh 27.96%
    Phenolic 27.65%

     

    Flavor
    Bitter 47.84%
    Woody 46.87%
    Herbal 46.6%
    Sweet 41.95%
    Balsam 30.31%
    Spicy 30.18%
    Camphor 28.46%
    Minty 27.12%
    Floral 27.01%
    Powdery 26.63%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    5.0

    pKa est.
    7.98 (neutral)

    Molecular weight
    262.34 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point

    • 322 to 329 °F at 760 mmHg (NTP, 1992)

    Flash point

    • 147.89 ˚C est.
    • greater than 200 °F (NTP, 1992)

    Solubility expt.

    • Insoluble (<1 mg/ml at 79 °F) (NTP, 1992)

  • Synonyms

    • Homosalate
    • 118-56-9
    • Homomenthyl salicylate
    • Coppertone
    • 3,3,5-TRIMETHYLCYCLOHEXYL SALICYLATE
    • Heliopan
    • Heliophan
    • Filtersol ''A''
    • m-Homomenthyl salicylate
    • Homosalato
    • Homosalatum
    • 3,3,5-Trimethylcyclohexyl 2-hydroxybenzoate
    • (3,3,5-trimethylcyclohexyl) 2-hydroxybenzoate
    • Caswell No. 482B
    • 52253-93-7
    • Benzoic acid, 2-hydroxy-, 3,3,5-trimethylcyclohexyl ester
    • CCRIS 4885
    • NSC 164918
    • Metahomomenthyl salicylate
    • Homosalatum [INN-Latin]
    • Homosalato [INN-Spanish]
    • Salicylic acid, m-homomenthyl ester
    • EINECS 204-260-8
    • 2-Hydroxybenzoic acid 3,3,5-trimethylcyclohexyl ester
    • UNII-V06SV4M95S
    • MFCD00019377
    • Salicylic Acid 3,3,5-Trimethylcyclohexyl Ester
    • EPA Pesticide Chemical Code 076603
    • NSC-164918
    • V06SV4M95S
    • Homosalate [USAN:USP:INN]
    • DTXSID1026241
    • EC 204-260-8
    • Salicylic acid, 3,3,5-trimethylcyclohexyl ester
    • NCGC00091888-01
    • Homosalatum (INN-Latin)
    • Homosalato (INN-Spanish)
    • HOMOSALATE (MART.)
    • HOMOSALATE [MART.]
    • HOMOSALATE (USP-RS)
    • HOMOSALATE [USP-RS]
    • Homosalate (USAN:USP:INN)
    • DTXCID606241
    • Salicylic acid, 3,3,5-trimethylcyclohexyl ester (8CI)
    • HOMOSALATE (USP IMPURITY)
    • HOMOSALATE [USP IMPURITY]
    • HOMOSALATE (USP MONOGRAPH)
    • HOMOSALATE [USP MONOGRAPH]
    • Filtrosol A
    • component of Coppertone
    • SR-05000001884
    • Homosalat
    • Kemester HMS
    • CAS-118-56-9
    • Homosalate; Salicylic acid 3,3,5-trimethylcyclohexyl ester; 3,3,5-Trimethylcyclohexyl salicylate
    • Filtersol''A''
    • Homosalate (Standard)
    • HOMOSALATE [MI]
    • Homosalate (USP/INN)
    • HOMOSALATE [INN]
    • Prestwick1_001090
    • Prestwick2_001090
    • Prestwick3_001090
    • HOMOSALATE [USAN]
    • HOMOSALATE [WHO-DD]
    • SCHEMBL16207
    • BSPBio_001140
    • SPECTRUM1505020
    • SPBio_003030
    • BPBio1_001254
    • Sun Protection Facial SPF 50
    • CHEMBL1377575
    • CHEBI:91642
    • HY-B0928R
    • MSK3404
    • 3,5-Trimethylcyclohexyl salicylate
    • HMS1571I22
    • HMS2093G22
    • HMS2098I22
    • HMS3715I22
    • Pharmakon1600-01505020
    • component of Coppertone (Salt/Mix)
    • HY-B0928
    • 3,3,5-Trimethylcyclohexylsalicylate
    • Tox21_111174
    • Tox21_202109
    • Tox21_303082
    • Homosalate(mixture of cis and trans)
    • NSC164918
    • NSC758908
    • s4572
    • AKOS015904082
    • Tox21_111174_1
    • CCG-213330
    • DB11064
    • NSC-758908
    • NCGC00091888-02
    • NCGC00091888-03
    • NCGC00091888-04
    • NCGC00091888-05
    • NCGC00091888-06
    • NCGC00091888-09
    • NCGC00257063-01
    • NCGC00259658-01
    • AS-10409
    • DA-54062
    • SY051923
    • SBI-0206787.P001
    • AB00514041
    • NS00009551
    • Salicylic acid,3,5-trimethylcyclohexyl ester
    • T2278
    • Benzoic acid, 3,3,5-trimethylcyclohexyl ester
    • D04450
    • E78223
    • AB00514041_02
    • EN300-7381967
    • Q2260189
    • SR-05000001884-1
    • SR-05000001884-2
    • BRD-A34751532-001-03-6
    • BRD-A34751532-001-04-4
    • BRD-A34751532-001-06-9
    • 2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester
    • Homosalate, United States Pharmacopeia (USP) Reference Standard
    • Homosalate, Pharmaceutical Secondary Standard; Certified Reference Material
    • 204-260-8

  • Applications

    Homosalate (CAS 118-56-9) is an organic UV absorber primarily used in cosmetics and personal care to absorb UVB and protect the skin in products such as sunscreens, moisturizers, and makeup. It is used as a UV-absorbing additive in coatings and inks to improve outdoor light stability of surfaces. It is also employed in polymer formulations as a UV absorber stabilizer for plastics and related materials. In industrial manufacturing and formulation development, homosalate may be considered an intermediate and/or solvent component for certain cosmetic systems and related formulations, depending on local regulations and formulation limits. Its use is subject to regulatory and formulation constraints, and no safety claims are made herein.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 2051.94
    methanol 1851.38
    isopropanol 1534.59
    water 0.28
    ethyl acetate 1485.35
    n-propanol 1446.77
    acetone 1834.12
    n-butanol 1302.0
    acetonitrile 943.36
    DMF 2221.12
    toluene 327.2
    isobutanol 935.16
    1,4-dioxane 1569.99
    methyl acetate 1087.88
    THF 3831.79
    2-butanone 1279.12
    n-pentanol 514.58
    sec-butanol 890.69
    n-hexane 28.91
    ethylene glycol 213.84
    NMP 1262.3
    cyclohexane 48.27
    DMSO 1962.52
    n-butyl acetate 837.52
    n-octanol 233.88
    chloroform 1297.85
    n-propyl acetate 551.79
    acetic acid 1075.6
    dichloromethane 1129.85
    cyclohexanone 1367.7
    propylene glycol 552.38
    isopropyl acetate 956.2
    DMAc 1177.12
    2-ethoxyethanol 756.69
    isopentanol 974.75
    n-heptane 19.36
    ethyl formate 616.92
    1,2-dichloroethane 1098.7
    n-hexanol 756.5
    2-methoxyethanol 2303.34
    isobutyl acetate 390.54
    tetrachloromethane 99.55
    n-pentyl acetate 368.9
    transcutol 3786.2
    n-heptanol 244.98
    ethylbenzene 114.18
    MIBK 804.45
    2-propoxyethanol 1467.02
    tert-butanol 1445.24
    MTBE 1099.72
    2-butoxyethanol 548.58
    propionic acid 768.87
    o-xylene 159.75
    formic acid 365.29
    diethyl ether 1085.67
    m-xylene 270.69
    p-xylene 147.45
    chlorobenzene 464.05
    dimethyl carbonate 454.24
    n-octane 9.36
    formamide 621.91
    cyclopentanone 1891.35
    2-pentanone 1320.49
    anisole 386.77
    cyclopentyl methyl ether 1262.92
    gamma-butyrolactone 1960.42
    1-methoxy-2-propanol 1961.68
    pyridine 883.74
    3-pentanone 643.4
    furfural 1044.67
    n-dodecane 9.84
    diethylene glycol 1011.92
    diisopropyl ether 308.36
    tert-amyl alcohol 862.62
    acetylacetone 1267.95
    n-hexadecane 11.65
    acetophenone 328.75
    methyl propionate 1035.13
    isopentyl acetate 770.59
    trichloroethylene 1684.67
    n-nonanol 207.28
    cyclohexanol 748.47
    benzyl alcohol 326.84
    2-ethylhexanol 319.2
    isooctanol 202.99
    dipropyl ether 353.69
    1,2-dichlorobenzene 361.89
    ethyl lactate 269.19
    propylene carbonate 975.26
    n-methylformamide 1116.03
    2-pentanol 774.85
    n-pentane 36.44
    1-propoxy-2-propanol 986.92
    1-methoxy-2-propyl acetate 1034.79
    2-(2-methoxypropoxy) propanol 601.6
    mesitylene 152.19
    ε-caprolactone 1137.13
    p-cymene 98.13
    epichlorohydrin 2548.61
    1,1,1-trichloroethane 780.21
    2-aminoethanol 671.93
    morpholine-4-carbaldehyde 1450.26
    sulfolane 1775.67
    2,2,4-trimethylpentane 28.18
    2-methyltetrahydrofuran 1999.9
    n-hexyl acetate 575.81
    isooctane 34.23
    2-(2-butoxyethoxy)ethanol 995.36
    sec-butyl acetate 416.85
    tert-butyl acetate 1063.51
    decalin 26.61
    glycerin 588.72
    diglyme 1441.53
    acrylic acid 551.31
    isopropyl myristate 209.52
    n-butyric acid 1270.83
    acetyl acetate 662.27
    di(2-ethylhexyl) phthalate 188.44
    ethyl propionate 495.83
    nitromethane 1747.97
    1,2-diethoxyethane 901.0
    benzonitrile 427.84
    trioctyl phosphate 141.94
    1-bromopropane 599.05
    gamma-valerolactone 2186.36
    n-decanol 155.48
    triethyl phosphate 165.37
    4-methyl-2-pentanol 451.22
    propionitrile 695.81
    vinylene carbonate 702.35
    1,1,2-trichlorotrifluoroethane 1062.8
    DMS 517.41
    cumene 84.2
    2-octanol 160.03
    2-hexanone 504.03
    octyl acetate 276.91
    limonene 163.77
    1,2-dimethoxyethane 1118.36
    ethyl orthosilicate 165.67
    tributyl phosphate 197.97
    diacetone alcohol 1209.13
    N,N-dimethylaniline 218.87
    acrylonitrile 723.72
    aniline 530.87
    1,3-propanediol 1168.63
    bromobenzene 425.02
    dibromomethane 727.02
    1,1,2,2-tetrachloroethane 1336.1
    2-methyl-cyclohexyl acetate 320.49
    tetrabutyl urea 219.41
    diisobutyl methanol 181.9
    2-phenylethanol 448.42
    styrene 136.39
    dioctyl adipate 289.33
    dimethyl sulfate 555.07
    ethyl butyrate 415.58
    methyl lactate 548.72
    butyl lactate 339.64
    diethyl carbonate 250.14
    propanediol butyl ether 614.7
    triethyl orthoformate 283.69
    p-tert-butyltoluene 113.73
    methyl 4-tert-butylbenzoate 372.84
    morpholine 2450.52
    tert-butylamine 690.59
    n-dodecanol 114.94
    dimethoxymethane 1842.07
    ethylene carbonate 667.36
    cyrene 387.84
    2-ethoxyethyl acetate 654.83
    2-ethylhexyl acetate 529.85
    1,2,4-trichlorobenzene 454.68
    4-methylpyridine 988.41
    dibutyl ether 270.96
    2,6-dimethyl-4-heptanol 181.9
    DEF 1022.81
    dimethyl isosorbide 952.82
    tetrachloroethylene 592.72
    eugenol 349.26
    triacetin 477.0
    span 80 502.0
    1,4-butanediol 254.82
    1,1-dichloroethane 1123.18
    2-methyl-1-pentanol 436.52
    methyl formate 763.51
    2-methyl-1-butanol 745.99
    n-decane 16.31
    butyronitrile 833.97
    3,7-dimethyl-1-octanol 287.07
    1-chlorooctane 127.82
    1-chlorotetradecane 48.53
    n-nonane 14.9
    undecane 12.4
    tert-butylcyclohexane 31.07
    cyclooctane 16.05
    cyclopentanol 909.02
    tetrahydropyran 1744.75
    tert-amyl methyl ether 629.1
    2,5,8-trioxanonane 922.53
    1-hexene 151.55
    2-isopropoxyethanol 555.36
    2,2,2-trifluoroethanol 282.17
    methyl butyrate 621.1

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction