Histidine Monohydrochloride Monohydrate

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  • Identifiers

    CAS number
    5934-29-2

    Molecular formula
    C6H12ClN3O3

    SMILES
    C1=C(NC=N1)C[C@@H](C(=O)O)N.O.Cl

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 84.78%
    Savory 32.07%
    Meaty 24.38%
    Cooked 22.04%
    Roasted 19.0%
    Popcorn 18.62%
    Nutty 17.98%
    Cocoa 17.89%
    Milky 16.42%
    Bitter 15.98%

     

    Flavor
    Bitter 70.41%
    Odorless 64.62%
    Bland 33.32%
    Mild 30.58%
    Sweet-like 23.3%
    Very mild 22.97%
    Yeast 21.29%
    Nitrile 20.49%
    Bread crust 19.85%
    Roasted peanuts 19.85%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    5.76 (weak acid)

    Molecular weight
    209.63 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    425°C

    Flash point

    • 238.8 ˚C est.

  • Synonyms

    • 5934-29-2
    • L-Histidine Hydrochloride Monohydrate
    • L-Histidine hydrochloride hydrate
    • L-Histidine monohydrochloride monohydrate
    • L-Histidine, monohydrochloride, monohydrate
    • L-Histidine HCl hydrate
    • (S)-2-Amino-3-(1H-imidazol-4-yl)propanoic acid hydrochloride hydrate
    • H-His-OH.HCl.H2O
    • Histidine monohydrochloride monohydrate
    • Histidine hydrochloride hydrate
    • histidine hydrochloride monohydrate
    • Histidine, monohydrochloride, monohydrate, L-
    • MFCD00151027
    • X573657P6P
    • Histidine, hydrochloride, hydrate (1:1:1)
    • DTXSID00208089
    • (2S)-2-amino-3-(1H-imidazol-5-yl)propanoic acid;hydrate;hydrochloride
    • L-Histidine (hydrochloride hydrate)
    • 7048-02-4
    • L-Histidine monohydrate monohydrochloride
    • L-Histidine hydrochloride hydrate (JP17)
    • (2S)-2-amino-3-(1H-imidazol-4-yl)propanoic acid hydrate hydrochloride
    • (2S)-2-amino-3-(1H-imidazol-5-yl)propanoic acid hydrate hydrochloride
    • L-HISTIDINE HYDROCHLORIDE HYDRATE [JAN]
    • HISTIDINE, L-, HYDROCHLORIDE MONOHYDRATE
    • HISTIDINE, L-, MONOHYDROCHLORIDE MONOHYDRATE
    • HISTIDINE MONOHYDROCHLORIDE MONOHYDRATE, (-)-
    • L-HISTIDINE, HYDROCHLORIDE, HYDRATE (1:1:1)
    • HISTIDINE HYDROCHLORIDE MONOHYDRATE [EP MONOGRAPH]
    • L-HISTIDINE MONOHYDROCHLORIDE MONOHYDRATE [USP-RS]
    • Histidine Hydrochloride Monohydrate (L-Histidine Hydrochloride Monohydrate)
    • L-HISTIDINE MONOHYDROCHLORIDE [FCC]
    • HISTIDINE HYDROCHLORIDE MONOHYDRATE (EP MONOGRAPH)
    • L-Histidine, hydrochloride, monohydrate
    • L-HISTIDINE MONOHYDROCHLORIDE MONOHYDRATE (USP-RS)
    • L-histidin hydrate hydrochloride
    • UNII-X573657P6P
    • Histidine hydrochloride monohydrate; (S)-2-amino-3-(imidazol-4-yl)propanoic acid hydrochloride monohydrate
    • Histidine, monohydrochloride, monohydrate
    • C6H12ClN3O3
    • SCHEMBL50270
    • 645-35-2 (anhydrous)
    • DTXCID70130580
    • L-Histidine xhydrochloride hydrate
    • HY-W014423R
    • L-alpha-Amino-beta-(4-imidazolyl)propionic acid monohydrochloride
    • s3096
    • AKOS015855386
    • AKOS015919710
    • CS-W015139
    • FH30555
    • FH71192
    • HY-W014423
    • AS-64939
    • L-Histidine,hydrochloride,hydrate(1:?:1)
    • (Former JAN: L-Histidine Monohydrochloride)
    • NS00074196
    • D02072
    • D86696
    • D94452
    • L-Histidine (hydrochloride hydrate) (Standard)
    • L-Histidine hydrochloride hydrate, H-His-OH.HCl.H2O
    • Q27293570
    • L-Histidine monohydrochloride monohydrate, p.a., 98.5%
    • L-Histidine monohydrochloride monohydrate, >=98% (HPLC)
    • L-Histidine monohydrochloride monohydrate, >=99.0% (AT)
    • (S)-2-Amino-3-(1H-imidazol-4-yl)propanoicacidhydrochloride hydrate
    • L-HISTIDINE HYDROCHLORIDE HYDRATE L-HISTIDINE MONOHYDROCHLORIDE
    • L-HISTIDINE HYDROCHLORIDE HYDRATE L-HISTIDINE MONOHYDROCHLORIDE [JAN]
    • L-Histidine monohydrochloride monohydrate, SAJ special grade, >=99.0%
    • L-Histidine monohydrochloride monohydrate, Vetec(TM) reagent grade, 99%
    • (2S)-2-Amino-3-(1H-imidazol-4-yl)propanoic acid monohydrochloride monohydrate
    • Histidine hydrochloride monohydrate, European Pharmacopoeia (EP) Reference Standard
    • L-Histidine monohydrochloride monohydrate, Cell Culture Reagent (H-L-His-OH.HCl.H2O)
    • 611-821-4
    • L-Histidine monohydrochloride monohydrate, from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-101.0%
    • L-Histidine monohydrochloride monohydrate, United States Pharmacopeia (USP) Reference Standard

  • Applications

    Histidine Monohydrochloride Monohydrate (CAS 5934-29-2) is used as a histidine source in nutrition and pharmaceutical formulations, including parenteral and enteral nutrition products, as well as in cell culture and fermentation media to supply the essential amino acid histidine. It also serves as a nutritional feed additive in animal nutrition. In laboratory and biotechnological applications, it provides histidine for biochemical buffers and enzyme assays; the imidazole ring offers metal ion chelation, which can be leveraged in specialized formulations or process chemistries involving metals. Depending on formulation and regulatory constraints, it may also function as a pH-buffering component in relevant systems.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.15
    methanol 0.49
    isopropanol 0.39
    water 42.17
    ethyl acetate 0.5
    n-propanol 0.38
    acetone 0.76
    n-butanol 0.53
    acetonitrile 0.41
    DMF 248.73
    toluene 0.45
    isobutanol 0.52
    1,4-dioxane 6.91
    methyl acetate 0.32
    THF 2.82
    2-butanone 0.59
    n-pentanol 0.44
    sec-butanol 0.5
    n-hexane 0.19
    ethylene glycol 5.58
    NMP 100.36
    cyclohexane 0.51
    DMSO 35.23
    n-butyl acetate 0.38
    n-octanol 0.21
    chloroform 0.19
    n-propyl acetate 0.27
    acetic acid 4.71
    dichloromethane 0.34
    cyclohexanone 4.53
    propylene glycol 3.55
    isopropyl acetate 0.43
    DMAc 79.63
    2-ethoxyethanol 3.77
    isopentanol 0.74
    n-heptane 0.4
    ethyl formate 0.93
    1,2-dichloroethane 0.4
    n-hexanol 0.77
    2-methoxyethanol 11.04
    isobutyl acetate 0.16
    tetrachloromethane 0.21
    n-pentyl acetate 0.26
    transcutol 2.52
    n-heptanol 0.59
    ethylbenzene 0.33
    MIBK 0.56
    2-propoxyethanol 3.74
    tert-butanol 0.99
    MTBE 0.34
    2-butoxyethanol 2.38
    propionic acid 1.41
    o-xylene 0.97
    formic acid 38.42
    diethyl ether 0.31
    m-xylene 0.62
    p-xylene 0.61
    chlorobenzene 0.24
    dimethyl carbonate 1.48
    n-octane 0.12
    formamide 21.54
    cyclopentanone 4.31
    2-pentanone 0.77
    anisole 0.45
    cyclopentyl methyl ether 2.05
    gamma-butyrolactone 5.62
    1-methoxy-2-propanol 6.03
    pyridine 2.17
    3-pentanone 0.94
    furfural 11.08
    n-dodecane 0.05
    diethylene glycol 9.75
    diisopropyl ether 0.21
    tert-amyl alcohol 0.86
    acetylacetone 1.64
    n-hexadecane 0.06
    acetophenone 1.07
    methyl propionate 1.05
    isopentyl acetate 0.38
    trichloroethylene 0.53
    n-nonanol 0.26
    cyclohexanol 2.07
    benzyl alcohol 1.19
    2-ethylhexanol 0.59
    isooctanol 0.48
    dipropyl ether 0.82
    1,2-dichlorobenzene 0.33
    ethyl lactate 0.99
    propylene carbonate 2.44
    n-methylformamide 15.7
    2-pentanol 0.48
    n-pentane 0.14
    1-propoxy-2-propanol 2.1
    1-methoxy-2-propyl acetate 1.16
    2-(2-methoxypropoxy) propanol 2.18
    mesitylene 0.55
    ε-caprolactone 3.97
    p-cymene 0.47
    epichlorohydrin 2.09
    1,1,1-trichloroethane 0.2
    2-aminoethanol 4.62
    morpholine-4-carbaldehyde 57.22
    sulfolane 20.16
    2,2,4-trimethylpentane 0.09
    2-methyltetrahydrofuran 1.59
    n-hexyl acetate 0.24
    isooctane 0.05
    2-(2-butoxyethoxy)ethanol 2.51
    sec-butyl acetate 0.21
    tert-butyl acetate 0.48
    decalin 0.16
    glycerin 24.22
    diglyme 4.91
    acrylic acid 3.19
    isopropyl myristate 0.16
    n-butyric acid 1.64
    acetyl acetate 0.5
    di(2-ethylhexyl) phthalate 0.5
    ethyl propionate 0.41
    nitromethane 5.48
    1,2-diethoxyethane 0.51
    benzonitrile 0.74
    trioctyl phosphate 0.37
    1-bromopropane 0.19
    gamma-valerolactone 17.78
    n-decanol 0.24
    triethyl phosphate 0.67
    4-methyl-2-pentanol 0.38
    propionitrile 0.36
    vinylene carbonate 2.38
    1,1,2-trichlorotrifluoroethane 8.99
    DMS 0.53
    cumene 0.32
    2-octanol 0.27
    2-hexanone 0.39
    octyl acetate 0.22
    limonene 0.61
    1,2-dimethoxyethane 5.88
    ethyl orthosilicate 0.69
    tributyl phosphate 0.33
    diacetone alcohol 2.13
    N,N-dimethylaniline 1.2
    acrylonitrile 0.87
    aniline 1.08
    1,3-propanediol 4.21
    bromobenzene 0.19
    dibromomethane 0.2
    1,1,2,2-tetrachloroethane 0.78
    2-methyl-cyclohexyl acetate 0.55
    tetrabutyl urea 0.98
    diisobutyl methanol 0.47
    2-phenylethanol 1.01
    styrene 0.25
    dioctyl adipate 0.32
    dimethyl sulfate 6.17
    ethyl butyrate 0.53
    methyl lactate 3.72
    butyl lactate 0.85
    diethyl carbonate 0.34
    propanediol butyl ether 2.12
    triethyl orthoformate 0.74
    p-tert-butyltoluene 0.42
    methyl 4-tert-butylbenzoate 1.47
    morpholine 8.82
    tert-butylamine 0.45
    n-dodecanol 0.22
    dimethoxymethane 7.38
    ethylene carbonate 1.85
    cyrene 8.19
    2-ethoxyethyl acetate 0.46
    2-ethylhexyl acetate 0.35
    1,2,4-trichlorobenzene 0.49
    4-methylpyridine 2.04
    dibutyl ether 0.22
    2,6-dimethyl-4-heptanol 0.47
    DEF 9.11
    dimethyl isosorbide 3.93
    tetrachloroethylene 0.85
    eugenol 2.18
    triacetin 0.63
    span 80 2.13
    1,4-butanediol 2.37
    1,1-dichloroethane 0.17
    2-methyl-1-pentanol 0.52
    methyl formate 6.58
    2-methyl-1-butanol 0.75
    n-decane 0.08
    butyronitrile 0.45
    3,7-dimethyl-1-octanol 0.23
    1-chlorooctane 0.1
    1-chlorotetradecane 0.07
    n-nonane 0.08
    undecane 0.06
    tert-butylcyclohexane 0.08
    cyclooctane 0.25
    cyclopentanol 2.48
    tetrahydropyran 1.8
    tert-amyl methyl ether 0.54
    2,5,8-trioxanonane 4.48
    1-hexene 0.24
    2-isopropoxyethanol 1.69
    2,2,2-trifluoroethanol 5.79
    methyl butyrate 0.77

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction