Histidine Monohydrochloride

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  • Identifiers

    CAS number
    645-35-2

    Molecular formula
    C6H10ClN3O2

    SMILES
    C1=C(NC=N1)C[C@@H](C(=O)O)N.Cl

    Safety labels

  • Odor profile

    Fragrance
    Odorless 84.78%
    Savory 32.07%
    Meaty 24.38%
    Cooked 22.04%
    Roasted 19.0%
    Popcorn 18.62%
    Nutty 17.98%
    Cocoa 17.89%
    Milky 16.42%
    Bitter 15.98%

     

    Flavor
    Bitter 70.41%
    Odorless 64.62%
    Bland 33.32%
    Mild 30.58%
    Sweet-like 23.3%
    Very mild 22.97%
    Yeast 21.29%
    Nitrile 20.49%
    Bread crust 19.85%
    Roasted peanuts 19.85%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    5.76 (weak acid)

    Molecular weight
    191.61 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    425°C

    Flash point

    • 238.8 ˚C est.

  • Synonyms

    • L-Histidine hydrochloride
    • 645-35-2
    • 1007-42-7
    • Histidine hydrochloride
    • Histidine HCl
    • Histidine monohydrochloride
    • L-Histidine, monohydrochloride
    • L-Histidine monohydrochloride
    • L-Histidine hydrochloride (VAN)
    • Histidine hydrochloride, L-
    • L-Histidine, hydrochloride (1:1)
    • Histidine hydrochloride (VAN)
    • (-)-Histidine monohydrochloride
    • EINECS 211-438-9
    • Histidine monohydrochloride, L-(+)-
    • NSC 257867
    • PHOTONYL
    • DTXSID3020700
    • Histidine monohydrochloride [NF]
    • AI3-18473
    • 1D5Q932XM6
    • EINECS 213-754-2
    • NSC-257867
    • DL-Histidine, hydrochloride
    • L-Histidine, monohydrochloride, hydrate
    • SUNACTYL LS 9610
    • OSMHYDRAN LS 8453
    • DTXCID70700
    • P.P.A.A.
    • Histidine, hydrochloride (1:1)
    • Histidine, monohydrochloride
    • EINECS 229-266-8
    • NSC 206275
    • HISTIDINE HYDROCHLORIDE [WHO-DD]
    • HISTIDINE, L-, MONOHYDROCHLORIDE
    • HISTIDINE MONOHYDROCHLORIDE ANHYDROUS
    • CCRIS 7814
    • L-HISTIDINE MONOHYDROCHLORIDE [FCC]
    • RefChem:788395
    • Histidine hydrochloride, L
    • LHistidine, monohydrochloride
    • HISTIDINE HCL [INCI]
    • LHistidine, hydrochloride (1:1)
    • Histidine monohydrochloride, L(+)
    • 645352: ()Histidine monohydrochloride
    • 7048024: LHistidine monohydrochloride, monohydrate
    • 211-438-9
    • 213-754-2
    • 7048-02-4
    • (S)-2-Amino-3-(1H-imidazol-4-yl)propanoic acid hydrochloride
    • H-His-OH.xHCl
    • l-Histidine.HCl
    • MFCD00064556
    • L-Hisidine monohydrocholoride
    • (2S)-2-amino-3-(1H-imidazol-5-yl)propanoic acid hydrochloride
    • NCGC00093950-01
    • (2S)-2-amino-3-(1H-imidazol-5-yl)propanoic acid;hydrochloride
    • (2S)-2-Amino-3-(1H-imidazol-4-yl)-propanoic acid hydrochloride
    • H-His-OH.HCl.H2O
    • Histidine, hydrochloride
    • H-His-OH.HCl
    • UNII-1D5Q932XM6
    • histidine, chloride
    • (2S)-2-amino-3-(1H-imidazol-4-yl)propanoic acid hydrochloride
    • L-Histidine xhydrochloride
    • SCHEMBL209483
    • SCHEMBL209484
    • (S)-2-Amino-3-(1H-imidazol-4-yl)propanoic acid HCl
    • orb2695117
    • L-Hisidine (monohydrocholoride)
    • CHEMBL1256578
    • Histidine, monohydrochloride, DL-
    • (-)-Histidine monohydrochloride; Histidine hydrochloride; Histidine monohydrochloride; L-Histidine hydrochloride
    • AAA64535
    • Tox21_111234
    • Tox21_500566
    • AKOS015898038
    • L-Histidine HCl (H-L-His-OH.HCl)
    • CCG-221870
    • DS-6380
    • FD20036
    • Histidine Hydrochloride (for injection)
    • L-Histidine--hydrogen chloride (1/1)
    • LP00566
    • NCGC00261251-01
    • CAS-645-35-2
    • FH182686
    • SY259043
    • DB-029959
    • DB-308116
    • CS-0009863
    • EU-0100566
    • H0150
    • NS00079890
    • NS00079950
    • ST51037609
    • EN300-74584
    • H 8125
    • F240823
    • F794142
    • SR-01000075269
    • SR-01000075269-1
    • Q27252266
    • (S)-2-Amino-3-(1h-imidazol-5-yl)propanoic acid hydrochloride
    • S(+)-alpha-Amino-1H-imidazole-4-propanoic acid hydrochloride
    • 56272-24-3
    • 70605-39-9
    • 645-35-2

  • Applications

    Histidine monohydrochloride is commonly used as a source of histidine in animal feed and as a dietary supplement for humans; in pharmaceutical and clinical nutrition contexts, it provides an essential amino acid source and can act as a pH buffer in parenteral nutrition solutions and related formulations. In biotechnological and laboratory settings, it serves as a nutrient and buffering component in culture media and protein formulations, helping maintain pH and supply histidine. It can also function as an intermediate or starting material in pharmaceutical and chemical syntheses, and may be employed as a nutritional ingredient in certain fortified foods. All uses are subject to local regulations and formulation constraints.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.15
    methanol 0.49
    isopropanol 0.39
    water 42.17
    ethyl acetate 0.5
    n-propanol 0.38
    acetone 0.76
    n-butanol 0.53
    acetonitrile 0.41
    DMF 248.73
    toluene 0.45
    isobutanol 0.52
    1,4-dioxane 6.91
    methyl acetate 0.32
    THF 2.82
    2-butanone 0.59
    n-pentanol 0.44
    sec-butanol 0.5
    n-hexane 0.19
    ethylene glycol 5.58
    NMP 100.36
    cyclohexane 0.51
    DMSO 35.23
    n-butyl acetate 0.38
    n-octanol 0.21
    chloroform 0.19
    n-propyl acetate 0.27
    acetic acid 4.71
    dichloromethane 0.34
    cyclohexanone 4.53
    propylene glycol 3.55
    isopropyl acetate 0.43
    DMAc 79.63
    2-ethoxyethanol 3.77
    isopentanol 0.74
    n-heptane 0.4
    ethyl formate 0.93
    1,2-dichloroethane 0.4
    n-hexanol 0.77
    2-methoxyethanol 11.04
    isobutyl acetate 0.16
    tetrachloromethane 0.21
    n-pentyl acetate 0.26
    transcutol 2.52
    n-heptanol 0.59
    ethylbenzene 0.33
    MIBK 0.56
    2-propoxyethanol 3.74
    tert-butanol 0.99
    MTBE 0.34
    2-butoxyethanol 2.38
    propionic acid 1.41
    o-xylene 0.97
    formic acid 38.42
    diethyl ether 0.31
    m-xylene 0.62
    p-xylene 0.61
    chlorobenzene 0.24
    dimethyl carbonate 1.48
    n-octane 0.12
    formamide 21.54
    cyclopentanone 4.31
    2-pentanone 0.77
    anisole 0.45
    cyclopentyl methyl ether 2.05
    gamma-butyrolactone 5.62
    1-methoxy-2-propanol 6.03
    pyridine 2.17
    3-pentanone 0.94
    furfural 11.08
    n-dodecane 0.05
    diethylene glycol 9.75
    diisopropyl ether 0.21
    tert-amyl alcohol 0.86
    acetylacetone 1.64
    n-hexadecane 0.06
    acetophenone 1.07
    methyl propionate 1.05
    isopentyl acetate 0.38
    trichloroethylene 0.53
    n-nonanol 0.26
    cyclohexanol 2.07
    benzyl alcohol 1.19
    2-ethylhexanol 0.59
    isooctanol 0.48
    dipropyl ether 0.82
    1,2-dichlorobenzene 0.33
    ethyl lactate 0.99
    propylene carbonate 2.44
    n-methylformamide 15.7
    2-pentanol 0.48
    n-pentane 0.14
    1-propoxy-2-propanol 2.1
    1-methoxy-2-propyl acetate 1.16
    2-(2-methoxypropoxy) propanol 2.18
    mesitylene 0.55
    ε-caprolactone 3.97
    p-cymene 0.47
    epichlorohydrin 2.09
    1,1,1-trichloroethane 0.2
    2-aminoethanol 4.62
    morpholine-4-carbaldehyde 57.22
    sulfolane 20.16
    2,2,4-trimethylpentane 0.09
    2-methyltetrahydrofuran 1.59
    n-hexyl acetate 0.24
    isooctane 0.05
    2-(2-butoxyethoxy)ethanol 2.51
    sec-butyl acetate 0.21
    tert-butyl acetate 0.48
    decalin 0.16
    glycerin 24.22
    diglyme 4.91
    acrylic acid 3.19
    isopropyl myristate 0.16
    n-butyric acid 1.64
    acetyl acetate 0.5
    di(2-ethylhexyl) phthalate 0.5
    ethyl propionate 0.41
    nitromethane 5.48
    1,2-diethoxyethane 0.51
    benzonitrile 0.74
    trioctyl phosphate 0.37
    1-bromopropane 0.19
    gamma-valerolactone 17.78
    n-decanol 0.24
    triethyl phosphate 0.67
    4-methyl-2-pentanol 0.38
    propionitrile 0.36
    vinylene carbonate 2.38
    1,1,2-trichlorotrifluoroethane 8.99
    DMS 0.53
    cumene 0.32
    2-octanol 0.27
    2-hexanone 0.39
    octyl acetate 0.22
    limonene 0.61
    1,2-dimethoxyethane 5.88
    ethyl orthosilicate 0.69
    tributyl phosphate 0.33
    diacetone alcohol 2.13
    N,N-dimethylaniline 1.2
    acrylonitrile 0.87
    aniline 1.08
    1,3-propanediol 4.21
    bromobenzene 0.19
    dibromomethane 0.2
    1,1,2,2-tetrachloroethane 0.78
    2-methyl-cyclohexyl acetate 0.55
    tetrabutyl urea 0.98
    diisobutyl methanol 0.47
    2-phenylethanol 1.01
    styrene 0.25
    dioctyl adipate 0.32
    dimethyl sulfate 6.17
    ethyl butyrate 0.53
    methyl lactate 3.72
    butyl lactate 0.85
    diethyl carbonate 0.34
    propanediol butyl ether 2.12
    triethyl orthoformate 0.74
    p-tert-butyltoluene 0.42
    methyl 4-tert-butylbenzoate 1.47
    morpholine 8.82
    tert-butylamine 0.45
    n-dodecanol 0.22
    dimethoxymethane 7.38
    ethylene carbonate 1.85
    cyrene 8.19
    2-ethoxyethyl acetate 0.46
    2-ethylhexyl acetate 0.35
    1,2,4-trichlorobenzene 0.49
    4-methylpyridine 2.04
    dibutyl ether 0.22
    2,6-dimethyl-4-heptanol 0.47
    DEF 9.11
    dimethyl isosorbide 3.93
    tetrachloroethylene 0.85
    eugenol 2.18
    triacetin 0.63
    span 80 2.13
    1,4-butanediol 2.37
    1,1-dichloroethane 0.17
    2-methyl-1-pentanol 0.52
    methyl formate 6.58
    2-methyl-1-butanol 0.75
    n-decane 0.08
    butyronitrile 0.45
    3,7-dimethyl-1-octanol 0.23
    1-chlorooctane 0.1
    1-chlorotetradecane 0.07
    n-nonane 0.08
    undecane 0.06
    tert-butylcyclohexane 0.08
    cyclooctane 0.25
    cyclopentanol 2.48
    tetrahydropyran 1.8
    tert-amyl methyl ether 0.54
    2,5,8-trioxanonane 4.48
    1-hexene 0.24
    2-isopropoxyethanol 1.69
    2,2,2-trifluoroethanol 5.79
    methyl butyrate 0.77

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction