Hispidulin

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  • Identifiers

    CAS number
    1447-88-7

    Molecular formula
    C16H12O6

    SMILES
    COC1=C(C2=C(C=C1O)OC(=CC2=O)C3=CC=C(C=C3)O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Phenolic 66.0%
    Odorless 43.59%
    Burnt 38.4%
    Smoky 33.65%
    Spicy 31.7%
    Medicinal 31.01%
    Vanilla 28.72%
    Balsamic 24.9%
    Savory 22.14%
    Woody 21.62%

     

    Flavor
    Bitter 90.08%
    Odorless 22.8%
    Sweet-like 21.31%
    Eugenol 21.14%
    Parsley 21.09%
    Cedarleaf 20.81%
    Lovage 20.55%
    Very strong 20.4%
    Indole 20.33%
    Flat 20.3%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    1.7

    pKa est.
    9.5 (weak base)

    Molecular weight
    300.26 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    732°C

    Flash point

    • 226.11 ˚C est.

  • Synonyms

    • Hispidulin
    • 1447-88-7
    • Dinatin
    • Scutellarein 6-methyl ether
    • 4',5,7-Trihydroxy-6-methoxyflavone
    • 4H-1-BENZOPYRAN-4-ONE, 5,7-DIHYDROXY-2-(4-HYDROXYPHENYL)-6-METHOXY-
    • Salvitin
    • 5,7-dihydroxy-2-(4-hydroxyphenyl)-6-methoxychromen-4-one
    • NSC 122415
    • NSC-122415
    • N7F61604C2
    • CHEBI:75902
    • DTXSID30162786
    • 4',5,7-trihydroxy-6-methoxy-flavone
    • RefChem:38925
    • DTXCID7085277
    • 5,7-Dihydroxy-2-(4-hydroxyphenyl)-6-methoxy-4H-chromen-4-one
    • 6-O-Methylapigenin
    • MFCD00143504
    • TCMDC-123942
    • NSC122415
    • 5,7-Dihydroxy-2-(4-hydroxyphenyl)-6-methoxy-4H-1-benzopyran-4-one
    • Flavone, 4',5,7-trihydroxy-6-methoxy-
    • CHEMBL293776
    • 5,7-dihydroxy-2-(4-hydroxyphenyl)-6-methoxy-chromen-4-one
    • 6-methoxyapigenin
    • Hispidulin?
    • CCRIS 8484
    • 6-methoxy apigenin
    • HISPEDULIN
    • Hispidulin (Standard)
    • 6-O-methylscutellarein
    • Oprea1_873387
    • MLS000728540
    • SCHEMBL514926
    • Hispidulin - Bio-X trade mark
    • MEGxp0_000683
    • orb1296134
    • Hispidulin, >=98% (HPLC)
    • SCHEMBL29458970
    • UNII-N7F61604C2
    • ACon1_000933
    • cid_5281628
    • HY-N1950R
    • PubChem SID: 26725244
    • IHFBPDAQLQOCBX-UHFFFAOYSA-N
    • 4',7-Trihydroxy-6-methoxyflavone
    • HMS2223A03
    • HMS3344G13
    • HMS3868N13
    • HY-N1950
    • Flavone,5,7-trihydroxy-6-methoxy-
    • BDBM50049395
    • LMPK12111159
    • s3296
    • ZB1763
    • 4?,5,7-Trihydroxy-6-methoxyflavone
    • AKOS004110694
    • 5,7,4''-Trihydroxy-6-methoxyflavone
    • CS-6502
    • DB14008
    • EBC-457091
    • FH73251
    • NCGC00167728-01
    • NCGC00167728-02
    • NCGC00169216-01
    • AC-34245
    • AS-78830
    • BH300089
    • DA-74175
    • NCI60_000530
    • SMR000445653
    • ST024778
    • SY121814
    • NS00069992
    • 447H887
    • BRD-K72066874-001-01-0
    • Q15410994
    • 5,7-Dihydroxy-2-(4-hydroxy-phenyl)-6-methoxy-chromen-4-one
    • 4H-1-Benzopyran-4-one,7-dihydroxy-2-(4-hydroxyphenyl)-6-methoxy-
    • 5,7-Dihydroxy-2-(4-hydroxyphenyl)-6-methoxy-4H-chromen-4-one #
    • 4H-1-Benzopyran-4-one, 5, 7-dihydroxy-2-(4-hydroxyphenyl)-6-methoxy-
    • HUL
    • 1447-88-7

  • Applications

    Hispidulin (CAS 1447-88-7) is primarily studied for pharmaceutical and biomedical research as a natural flavone, often serving as an intermediate or building block for flavonoid derivatives and used as a reference standard in analytical chemistry (e.g., HPLC/LC methods). In cosmetics and personal care, it is evaluated for antioxidant activity and other bioactive potential suitable for inclusion in formulations. In chemical synthesis, it can act as an intermediate for the preparation of related flavonoids. In polymers and coatings, it may be explored as an antioxidant or stabilizer additive for polymer systems and coatings. Its use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.26
    methanol 0.27
    isopropanol 0.46
    water 0.0
    ethyl acetate 0.72
    n-propanol 0.68
    acetone 0.28
    n-butanol 0.69
    acetonitrile 0.29
    DMF 14.65
    toluene 0.05
    isobutanol 0.52
    1,4-dioxane 2.33
    methyl acetate 1.04
    THF 14.98
    2-butanone 1.23
    n-pentanol 0.57
    sec-butanol 0.88
    n-hexane 0.0
    ethylene glycol 2.19
    NMP 23.98
    cyclohexane 0.0
    DMSO 118.95
    n-butyl acetate 1.11
    n-octanol 0.45
    chloroform 0.02
    n-propyl acetate 1.03
    acetic acid 1.71
    dichloromethane 0.04
    cyclohexanone 2.58
    propylene glycol 3.45
    isopropyl acetate 0.7
    DMAc 23.82
    2-ethoxyethanol 8.43
    isopentanol 0.83
    n-heptane 0.02
    ethyl formate 0.49
    1,2-dichloroethane 0.1
    n-hexanol 0.39
    2-methoxyethanol 21.87
    isobutyl acetate 0.62
    tetrachloromethane 0.0
    n-pentyl acetate 1.0
    transcutol 65.21
    n-heptanol 0.58
    ethylbenzene 0.05
    MIBK 0.83
    2-propoxyethanol 11.03
    tert-butanol 1.11
    MTBE 0.47
    2-butoxyethanol 4.95
    propionic acid 1.68
    o-xylene 0.07
    formic acid 1.87
    diethyl ether 0.22
    m-xylene 0.06
    p-xylene 0.07
    chlorobenzene 0.05
    dimethyl carbonate 1.86
    n-octane 0.01
    formamide 4.77
    cyclopentanone 6.45
    2-pentanone 0.78
    anisole 0.62
    cyclopentyl methyl ether 1.63
    gamma-butyrolactone 11.86
    1-methoxy-2-propanol 17.33
    pyridine 1.3
    3-pentanone 0.59
    furfural 9.05
    n-dodecane 0.01
    diethylene glycol 16.57
    diisopropyl ether 0.1
    tert-amyl alcohol 1.27
    acetylacetone 2.51
    n-hexadecane 0.02
    acetophenone 1.16
    methyl propionate 1.69
    isopentyl acetate 1.42
    trichloroethylene 0.24
    n-nonanol 0.57
    cyclohexanol 0.8
    benzyl alcohol 0.96
    2-ethylhexanol 0.5
    isooctanol 0.65
    dipropyl ether 0.82
    1,2-dichlorobenzene 0.1
    ethyl lactate 2.73
    propylene carbonate 2.59
    n-methylformamide 3.49
    2-pentanol 0.54
    n-pentane 0.0
    1-propoxy-2-propanol 8.43
    1-methoxy-2-propyl acetate 5.74
    2-(2-methoxypropoxy) propanol 10.05
    mesitylene 0.05
    ε-caprolactone 4.08
    p-cymene 0.16
    epichlorohydrin 10.95
    1,1,1-trichloroethane 0.03
    2-aminoethanol 2.75
    morpholine-4-carbaldehyde 27.27
    sulfolane 46.19
    2,2,4-trimethylpentane 0.01
    2-methyltetrahydrofuran 3.19
    n-hexyl acetate 1.4
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 13.17
    sec-butyl acetate 0.76
    tert-butyl acetate 1.52
    decalin 0.01
    glycerin 20.2
    diglyme 27.08
    acrylic acid 2.6
    isopropyl myristate 0.75
    n-butyric acid 1.36
    acetyl acetate 0.64
    di(2-ethylhexyl) phthalate 1.23
    ethyl propionate 1.14
    nitromethane 5.98
    1,2-diethoxyethane 4.5
    benzonitrile 0.5
    trioctyl phosphate 0.84
    1-bromopropane 0.05
    gamma-valerolactone 20.94
    n-decanol 0.44
    triethyl phosphate 1.61
    4-methyl-2-pentanol 0.43
    propionitrile 0.46
    vinylene carbonate 1.85
    1,1,2-trichlorotrifluoroethane 14.43
    DMS 2.7
    cumene 0.06
    2-octanol 0.36
    2-hexanone 1.04
    octyl acetate 0.92
    limonene 0.21
    1,2-dimethoxyethane 11.72
    ethyl orthosilicate 1.44
    tributyl phosphate 1.1
    diacetone alcohol 6.74
    N,N-dimethylaniline 0.62
    acrylonitrile 1.15
    aniline 0.42
    1,3-propanediol 4.92
    bromobenzene 0.03
    dibromomethane 0.02
    1,1,2,2-tetrachloroethane 0.33
    2-methyl-cyclohexyl acetate 1.55
    tetrabutyl urea 1.97
    diisobutyl methanol 0.53
    2-phenylethanol 1.1
    styrene 0.05
    dioctyl adipate 1.96
    dimethyl sulfate 8.12
    ethyl butyrate 1.38
    methyl lactate 6.6
    butyl lactate 2.65
    diethyl carbonate 1.08
    propanediol butyl ether 6.19
    triethyl orthoformate 2.19
    p-tert-butyltoluene 0.17
    methyl 4-tert-butylbenzoate 3.5
    morpholine 7.03
    tert-butylamine 0.25
    n-dodecanol 0.34
    dimethoxymethane 7.54
    ethylene carbonate 1.25
    cyrene 11.49
    2-ethoxyethyl acetate 3.48
    2-ethylhexyl acetate 0.97
    1,2,4-trichlorobenzene 0.23
    4-methylpyridine 0.77
    dibutyl ether 0.78
    2,6-dimethyl-4-heptanol 0.53
    DEF 3.07
    dimethyl isosorbide 20.0
    tetrachloroethylene 0.11
    eugenol 4.37
    triacetin 4.51
    span 80 5.33
    1,4-butanediol 1.35
    1,1-dichloroethane 0.02
    2-methyl-1-pentanol 0.74
    methyl formate 1.95
    2-methyl-1-butanol 0.85
    n-decane 0.02
    butyronitrile 0.32
    3,7-dimethyl-1-octanol 0.65
    1-chlorooctane 0.11
    1-chlorotetradecane 0.07
    n-nonane 0.01
    undecane 0.02
    tert-butylcyclohexane 0.01
    cyclooctane 0.0
    cyclopentanol 1.54
    tetrahydropyran 0.8
    tert-amyl methyl ether 0.76
    2,5,8-trioxanonane 20.65
    1-hexene 0.02
    2-isopropoxyethanol 5.22
    2,2,2-trifluoroethanol 0.97
    methyl butyrate 1.47

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction