Hinokiol

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  • Identifiers

    CAS number
    564-73-8

    Molecular formula
    C20H30O2

    SMILES
    CC(C)C1=C(C=C2C(=C1)CC[C@@H]3[C@@]2(CC[C@@H](C3(C)C)O)C)O

    Safety labels

  • Odor profile

    Fragrance
    Woody 57.1%
    Phenolic 50.01%
    Spicy 47.69%
    Sweet 43.67%
    Leathery 39.1%
    Dry 36.7%
    Balsamic 35.59%
    Musk 35.31%
    Amber 34.75%
    Camphoreous 34.55%

     

    Flavor
    Woody 58.08%
    Camphor 47.95%
    Bitter 40.57%
    Spicy 32.12%
    Pine 31.77%
    Herbal 31.54%
    Spice 29.1%
    Medicinal 28.09%
    Balsam 26.58%
    Phenolic 26.39%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    5.2

    pKa est.
    9.02 (weak base)

    Molecular weight
    302.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    584°C

    Flash point

    • 212.92 ˚C est.

  • Synonyms

    • HINOKIOL
    • 564-73-8
    • (2S,4aS,10aR)-1,1,4a-trimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthrene-2,6-diol
    • RefChem:922966
    • SCHEMBL854936
    • orb2299447
    • CHEMBL1277661
    • BDBM50483052
    • FS-10022
    • 564-73-8

  • Applications

    Hinokiol (CAS 564-73-8) is a fragrance-active constituent derived from hinoki oil. In perfumery, it serves as a fragrance ingredient and fixative. In cosmetics and personal care, it may be used as a fragrance additive in products such as lotions, shampoos, and soaps. In household products, it can be included to impart woody notes and overall scent. It is often evaluated as an intermediate or building block for fragrance compound synthesis, and may be explored for use in coatings and inks as a scent additive; in the realm of polymers and plastics, it may be investigated as a natural aroma additive.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 233.87
    methanol 179.21
    isopropanol 173.88
    water 0.27
    ethyl acetate 200.64
    n-propanol 223.43
    acetone 224.2
    n-butanol 199.06
    acetonitrile 70.38
    DMF 399.03
    toluene 125.43
    isobutanol 118.6
    1,4-dioxane 455.52
    methyl acetate 120.54
    THF 949.1
    2-butanone 162.43
    n-pentanol 59.9
    sec-butanol 60.96
    n-hexane 6.98
    ethylene glycol 16.04
    NMP 107.33
    cyclohexane 14.44
    DMSO 142.19
    n-butyl acetate 179.7
    n-octanol 36.44
    chloroform 243.77
    n-propyl acetate 87.5
    acetic acid 65.56
    dichloromethane 178.48
    cyclohexanone 230.23
    propylene glycol 19.64
    isopropyl acetate 187.11
    DMAc 198.41
    2-ethoxyethanol 127.96
    isopentanol 141.32
    n-heptane 6.81
    ethyl formate 68.98
    1,2-dichloroethane 169.66
    n-hexanol 147.5
    2-methoxyethanol 327.08
    isobutyl acetate 87.02
    tetrachloromethane 43.1
    n-pentyl acetate 116.94
    transcutol 367.71
    n-heptanol 69.4
    ethylbenzene 44.37
    MIBK 153.36
    2-propoxyethanol 350.56
    tert-butanol 193.25
    MTBE 253.28
    2-butoxyethanol 159.66
    propionic acid 50.39
    o-xylene 58.87
    formic acid 24.63
    diethyl ether 344.8
    m-xylene 95.5
    p-xylene 53.12
    chlorobenzene 102.69
    dimethyl carbonate 87.42
    n-octane 3.79
    formamide 54.3
    cyclopentanone 294.66
    2-pentanone 215.37
    anisole 97.01
    cyclopentyl methyl ether 252.96
    gamma-butyrolactone 231.56
    1-methoxy-2-propanol 278.46
    pyridine 198.84
    3-pentanone 131.33
    furfural 164.0
    n-dodecane 2.22
    diethylene glycol 166.03
    diisopropyl ether 83.3
    tert-amyl alcohol 73.23
    acetylacetone 204.57
    n-hexadecane 2.71
    acetophenone 75.67
    methyl propionate 148.14
    isopentyl acetate 187.17
    trichloroethylene 255.74
    n-nonanol 38.68
    cyclohexanol 81.9
    benzyl alcohol 61.7
    2-ethylhexanol 58.56
    isooctanol 54.54
    dipropyl ether 118.4
    1,2-dichlorobenzene 81.74
    ethyl lactate 39.52
    propylene carbonate 109.49
    n-methylformamide 146.14
    2-pentanol 83.32
    n-pentane 10.41
    1-propoxy-2-propanol 189.99
    1-methoxy-2-propyl acetate 236.53
    2-(2-methoxypropoxy) propanol 94.29
    mesitylene 53.49
    ε-caprolactone 166.22
    p-cymene 34.85
    epichlorohydrin 312.71
    1,1,1-trichloroethane 136.7
    2-aminoethanol 55.39
    morpholine-4-carbaldehyde 251.28
    sulfolane 180.6
    2,2,4-trimethylpentane 5.4
    2-methyltetrahydrofuran 271.27
    n-hexyl acetate 110.99
    isooctane 7.14
    2-(2-butoxyethoxy)ethanol 154.86
    sec-butyl acetate 75.47
    tert-butyl acetate 210.13
    decalin 7.48
    glycerin 37.06
    diglyme 314.39
    acrylic acid 39.21
    isopropyl myristate 40.88
    n-butyric acid 127.18
    acetyl acetate 106.34
    di(2-ethylhexyl) phthalate 41.13
    ethyl propionate 84.37
    nitromethane 128.86
    1,2-diethoxyethane 203.6
    benzonitrile 69.98
    trioctyl phosphate 32.95
    1-bromopropane 106.73
    gamma-valerolactone 391.33
    n-decanol 27.17
    triethyl phosphate 44.11
    4-methyl-2-pentanol 67.55
    propionitrile 109.92
    vinylene carbonate 114.15
    1,1,2-trichlorotrifluoroethane 127.91
    DMS 100.82
    cumene 32.29
    2-octanol 36.05
    2-hexanone 76.41
    octyl acetate 49.92
    limonene 39.98
    1,2-dimethoxyethane 291.69
    ethyl orthosilicate 49.85
    tributyl phosphate 35.43
    diacetone alcohol 161.07
    N,N-dimethylaniline 66.19
    acrylonitrile 106.19
    aniline 115.63
    1,3-propanediol 139.84
    bromobenzene 99.1
    dibromomethane 125.25
    1,1,2,2-tetrachloroethane 201.5
    2-methyl-cyclohexyl acetate 73.4
    tetrabutyl urea 46.42
    diisobutyl methanol 42.47
    2-phenylethanol 111.47
    styrene 47.02
    dioctyl adipate 49.68
    dimethyl sulfate 103.0
    ethyl butyrate 92.16
    methyl lactate 59.5
    butyl lactate 76.42
    diethyl carbonate 55.8
    propanediol butyl ether 80.59
    triethyl orthoformate 78.76
    p-tert-butyltoluene 40.71
    methyl 4-tert-butylbenzoate 96.09
    morpholine 480.88
    tert-butylamine 108.91
    n-dodecanol 19.4
    dimethoxymethane 540.01
    ethylene carbonate 114.37
    cyrene 81.18
    2-ethoxyethyl acetate 190.45
    2-ethylhexyl acetate 128.01
    1,2,4-trichlorobenzene 86.97
    4-methylpyridine 181.24
    dibutyl ether 55.75
    2,6-dimethyl-4-heptanol 42.47
    DEF 156.27
    dimethyl isosorbide 178.56
    tetrachloroethylene 137.24
    eugenol 89.44
    triacetin 86.05
    span 80 76.22
    1,4-butanediol 25.01
    1,1-dichloroethane 145.3
    2-methyl-1-pentanol 50.79
    methyl formate 92.55
    2-methyl-1-butanol 91.73
    n-decane 4.66
    butyronitrile 118.78
    3,7-dimethyl-1-octanol 40.32
    1-chlorooctane 23.58
    1-chlorotetradecane 8.23
    n-nonane 4.07
    undecane 3.09
    tert-butylcyclohexane 7.74
    cyclooctane 5.8
    cyclopentanol 75.75
    tetrahydropyran 438.71
    tert-amyl methyl ether 99.33
    2,5,8-trioxanonane 156.28
    1-hexene 28.15
    2-isopropoxyethanol 92.83
    2,2,2-trifluoroethanol 30.48
    methyl butyrate 88.06

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction