Himachalol

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  • Identifiers

    CAS number
    1891-45-8

    Molecular formula
    C15H26O

    SMILES
    CC1=C[C@H]2[C@@H](CC1)[C@](CCCC2(C)C)(C)O

    Retention indicies (RI)

    • DB5: 1647.0

  • Odor profile

    Woody 71.54%
    Spicy 51.72%
    Herbal 50.94%
    Earthy 50.3%
    Sweet 42.79%
    Balsamic 39.45%
    Camphoreous 38.46%
    Amber 38.36%
    Dry 37.32%
    Pine 35.62%

    Scent© AI

  • Properties

    XLogP3-AA
    3.5

    Molecular weight
    222.37 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    298°C

    Flash point est.
    135.65 ˚C

  • Synonyms

    • Himachalol
    • 1891-45-8
    • (+)-2-Himachalen-7-ol
    • (4aR,5R,9aS)-2,5,9,9-tetramethyl-4,4a,6,7,8,9a-hexahydro-3H-benzo[7]annulen-5-ol
    • 2,4a,5,6,7,8,9,9a-Octahydro-3,5,5,9-tetramethyl-1H-benzocyclohepten-9-ol
    • 2,4a-beta,5,6,7,8,9,9a-beta-Octahydro-3,5,5,9-beta-tetramethyl-1H-benzocyclohepten-9-ol
    • CHEBI:5719
    • SCHEMBL2854768
    • 11alpha-himachal-4-en-11-ol
    • DTXSID70940424
    • LMPR0103480003
    • 1H-Benzocyclohepten-9-ol, 2,4a-beta,5,6,7,8,9,9a-beta-octahydro-3,5,5,9-beta-tetramethyl-
    • C09682
    • Q27106868
    • 3,5,5,9-Tetramethyl-2,4a,5,6,7,8,9,9a-octahydro-1H-benzo[7]annulen-9-ol

  • Applications

    Himachalol (CAS 1891-45-8) is a sesquiterpene alcohol occurring mainly in Himalayan cedarwood oil and is used in fragrance and personal-care applications as a warm, woody, slightly sweet–smoky note and as a fixative/modifier that extends and rounds woody–resinous accords in fine fragrances, soaps, detergents and candles; in agriculture and materials preservation, studies have reported termite/insect repellency and antifungal activity, suggesting utility as a bio-based protective additive for wood, cellulose materials and stored commodities; in biomedical research it is frequently evaluated in vitro and in preclinical models for anti-inflammatory, antimicrobial, antioxidant and antinociceptive properties, typically as an isolated constituent or as part of essential-oil fractions, supporting lead discovery and mechanism studies rather than any approved therapeutic use; in synthesis and analysis, himachalol serves as a reference standard and a starting scaffold for preparing oxygenated sesquiterpenes or bicyclic motifs, and is used in GC/MS authentication of natural vs adulterated cedarwood oils; practical deployment should consider oxidative/photo stability, matrix compatibility (pH, surfactants) and compliance with IFRA/REACH and occupational safety when handling concentrated oils.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 183.38
    methanol 131.2
    isopropanol 248.12
    water 0.31
    ethyl acetate 236.68
    n-propanol 217.55
    acetone 301.21
    n-butanol 232.93
    acetonitrile 175.49
    DMF 439.72
    toluene 361.2
    isobutanol 211.08
    1,4-dioxane 551.51
    methyl acetate 232.83
    THF 1011.03
    2-butanone 337.57
    n-pentanol 143.35
    sec-butanol 208.41
    n-hexane 51.29
    ethylene glycol 30.73
    NMP 363.49
    cyclohexane 118.58
    DMSO 238.45
    n-butyl acetate 278.95
    n-octanol 188.34
    chloroform 706.57
    n-propyl acetate 159.39
    acetic acid 85.82
    dichloromethane 476.5
    cyclohexanone 543.81
    propylene glycol 72.7
    isopropyl acetate 200.46
    DMAc 355.01
    2-ethoxyethanol 148.05
    isopentanol 215.88
    n-heptane 72.63
    ethyl formate 154.28
    1,2-dichloroethane 284.07
    n-hexanol 313.78
    2-methoxyethanol 237.16
    isobutyl acetate 159.44
    tetrachloromethane 130.81
    n-pentyl acetate 216.71
    transcutol 413.43
    n-heptanol 179.44
    ethylbenzene 186.42
    MIBK 220.98
    2-propoxyethanol 329.02
    tert-butanol 295.16
    MTBE 317.58
    2-butoxyethanol 214.75
    propionic acid 121.49
    o-xylene 223.6
    formic acid 19.55
    diethyl ether 277.07
    m-xylene 269.04
    p-xylene 221.26
    chlorobenzene 268.34
    dimethyl carbonate 111.04
    n-octane 35.25
    formamide 34.17
    cyclopentanone 608.14
    2-pentanone 290.56
    anisole 250.77
    cyclopentyl methyl ether 420.99
    gamma-butyrolactone 492.05
    1-methoxy-2-propanol 271.71
    pyridine 400.79
    3-pentanone 228.51
    furfural 345.21
    n-dodecane 30.44
    diethylene glycol 176.94
    diisopropyl ether 121.54
    tert-amyl alcohol 216.1
    acetylacetone 272.81
    n-hexadecane 35.67
    acetophenone 219.26
    methyl propionate 207.03
    isopentyl acetate 287.62
    trichloroethylene 491.49
    n-nonanol 162.04
    cyclohexanol 277.26
    benzyl alcohol 179.15
    2-ethylhexanol 194.19
    isooctanol 147.68
    dipropyl ether 228.03
    1,2-dichlorobenzene 239.65
    ethyl lactate 103.76
    propylene carbonate 287.68
    n-methylformamide 135.38
    2-pentanol 179.89
    n-pentane 63.4
    1-propoxy-2-propanol 277.49
    1-methoxy-2-propyl acetate 279.52
    2-(2-methoxypropoxy) propanol 213.14
    mesitylene 179.44
    ε-caprolactone 393.9
    p-cymene 156.2
    epichlorohydrin 470.74
    1,1,1-trichloroethane 342.6
    2-aminoethanol 75.5
    morpholine-4-carbaldehyde 414.56
    sulfolane 490.74
    2,2,4-trimethylpentane 37.33
    2-methyltetrahydrofuran 582.39
    n-hexyl acetate 311.13
    isooctane 36.71
    2-(2-butoxyethoxy)ethanol 255.1
    sec-butyl acetate 138.59
    tert-butyl acetate 236.1
    decalin 61.97
    glycerin 88.8
    diglyme 407.19
    acrylic acid 95.79
    isopropyl myristate 147.56
    n-butyric acid 203.25
    acetyl acetate 147.82
    di(2-ethylhexyl) phthalate 139.9
    ethyl propionate 156.11
    nitromethane 174.45
    1,2-diethoxyethane 227.46
    benzonitrile 252.14
    trioctyl phosphate 119.97
    1-bromopropane 294.06
    gamma-valerolactone 595.82
    n-decanol 125.96
    triethyl phosphate 106.35
    4-methyl-2-pentanol 135.02
    propionitrile 230.03
    vinylene carbonate 268.14
    1,1,2-trichlorotrifluoroethane 259.54
    DMS 203.45
    cumene 140.88
    2-octanol 140.39
    2-hexanone 190.58
    octyl acetate 182.71
    limonene 204.39
    1,2-dimethoxyethane 317.53
    ethyl orthosilicate 103.82
    tributyl phosphate 118.89
    diacetone alcohol 226.79
    N,N-dimethylaniline 182.63
    acrylonitrile 211.25
    aniline 236.46
    1,3-propanediol 124.18
    bromobenzene 316.33
    dibromomethane 371.25
    1,1,2,2-tetrachloroethane 446.79
    2-methyl-cyclohexyl acetate 200.22
    tetrabutyl urea 156.67
    diisobutyl methanol 129.38
    2-phenylethanol 239.57
    styrene 197.39
    dioctyl adipate 169.73
    dimethyl sulfate 154.61
    ethyl butyrate 187.69
    methyl lactate 120.13
    butyl lactate 168.79
    diethyl carbonate 123.12
    propanediol butyl ether 208.96
    triethyl orthoformate 146.07
    p-tert-butyltoluene 165.28
    methyl 4-tert-butylbenzoate 251.54
    morpholine 522.69
    tert-butylamine 220.3
    n-dodecanol 101.5
    dimethoxymethane 325.31
    ethylene carbonate 235.59
    cyrene 199.71
    2-ethoxyethyl acetate 235.55
    2-ethylhexyl acetate 242.11
    1,2,4-trichlorobenzene 274.78
    4-methylpyridine 414.79
    dibutyl ether 190.05
    2,6-dimethyl-4-heptanol 129.38
    DEF 245.03
    dimethyl isosorbide 367.59
    tetrachloroethylene 255.32
    eugenol 208.16
    triacetin 238.57
    span 80 223.57
    1,4-butanediol 56.48
    1,1-dichloroethane 345.11
    2-methyl-1-pentanol 137.62
    methyl formate 121.72
    2-methyl-1-butanol 194.83
    n-decane 50.91
    butyronitrile 256.86
    3,7-dimethyl-1-octanol 176.19
    1-chlorooctane 150.51
    1-chlorotetradecane 69.61
    n-nonane 49.47
    undecane 38.24
    tert-butylcyclohexane 56.8
    cyclooctane 52.44
    cyclopentanol 301.36
    tetrahydropyran 603.27
    tert-amyl methyl ether 224.0
    2,5,8-trioxanonane 291.94
    1-hexene 138.72
    2-isopropoxyethanol 137.44
    2,2,2-trifluoroethanol 43.15
    methyl butyrate 192.05

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Artemisia vestita (India) Artemisia vestita Wall. ex Dc., fam. Asteraceae (Compositae) 5.0%
Cedrus atlantica (Morocco) Cedrus atlantica Man., fam. Cupressaceae 0.25%
Magnolia coco Magnolia coco (Lour.) DC., fam. Magnoliaceae 0.6%
Hyptis crenata (Brazil) Hyptis crenata Pohl ex Benth, fam. Lamiaceae (Labiatae) 0.4%
Ferula stenocarpa Ferula stenocarpa Boiss. & Hausskn., fam. Apiaceae (Umbelliferae) 1.7%