Hexyldodecyl Salicylate

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  • Identifiers

    CAS number
    220778-06-3

    Molecular formula
    C25H42O3

    SMILES
    CCCCCCCCCCC(CCCCCC)COC(=O)C1=CC=CC=C1O

    Safety labels

  • Odor profile

    Fragrance
    Waxy 58.43%
    Floral 48.97%
    Balsamic 48.09%
    Oily 46.07%
    Fatty 39.93%
    Sweet 34.17%
    Fresh 30.02%
    Fruity 30.0%
    Herbal 27.11%
    Odorless 26.33%

     

    Flavor
    Mild 34.01%
    Bland 32.55%
    Waxy 28.54%
    Faint 26.78%
    Oily 25.73%
    Odorless 24.74%
    Fatty 23.38%
    Herbal 23.02%
    Slightly waxy 22.23%
    Balsam 21.38%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    11.1

    pKa est.
    7.81 (neutral)

    Molecular weight
    390.6 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    467°C

    Flash point

    • 194.88 ˚C est.

  • Synonyms

    • Hexyldodecyl salicylate
    • 0VQ276Y3EF
    • Salicylic acid, 2-hexyldodecyl ester
    • UNII-0VQ276Y3EF
    • 220778-06-3
    • RefChem:146370
    • (+-)-HEXYLDODECYL SALICYLATE
    • HEXYLDODECYL SALICYLATE [INCI]
    • HEXYLDODECYL SALICYLATE, (+-)-
    • (+/-)-Hexyldodecyl salicylate
    • Hexyldodecyl salicylate, (+/-)-
    • 2-hexyldodecyl 2-hydroxybenzoate
    • SCHEMBL30190011
    • DTXSID10944704
    • Q27237297
    • 220778-06-3

  • Applications

    Hexyldodecyl Salicylate (CAS 220778-06-3) is primarily used as an emollient and solvent in cosmetics and personal-care formulations, providing skin conditioning and a smooth, spreadable texture while serving as a carrier for active ingredients and fragrance oils. In perfumery, it functions as a fragrance solvent and carrier, helping dissolve and deliver fragrance components and potentially contributing to fragrance release profiles. It also finds use in household products as a solvent/emollient component in cleaners, detergents, and laundry aids to improve slip and skin feel. In industrial manufacturing and coatings, it can act as a plasticizer or processing aid to improve flexibility and handling of resin systems and formulated coatings. It may also be used as a solvent/vehicle in certain topical pharmaceutical formulations, subject to regulatory limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 835.44
    methanol 574.43
    isopropanol 969.64
    water 0.29
    ethyl acetate 2612.99
    n-propanol 1025.31
    acetone 3385.72
    n-butanol 989.47
    acetonitrile 929.97
    DMF 2837.13
    toluene 981.12
    isobutanol 861.38
    1,4-dioxane 1949.01
    methyl acetate 1806.44
    THF 5099.49
    2-butanone 2904.2
    n-pentanol 509.48
    sec-butanol 996.39
    n-hexane 114.94
    ethylene glycol 36.22
    NMP 3815.53
    cyclohexane 660.37
    DMSO 2884.19
    n-butyl acetate 1353.74
    n-octanol 254.18
    chloroform 4232.03
    n-propyl acetate 1612.62
    acetic acid 819.77
    dichloromethane 5081.3
    cyclohexanone 5052.9
    propylene glycol 138.35
    isopropyl acetate 1846.21
    DMAc 3421.73
    2-ethoxyethanol 799.73
    isopentanol 907.48
    n-heptane 65.7
    ethyl formate 996.41
    1,2-dichloroethane 4871.16
    n-hexanol 369.42
    2-methoxyethanol 1187.98
    isobutyl acetate 952.56
    tetrachloromethane 997.44
    n-pentyl acetate 1495.73
    transcutol 2654.61
    n-heptanol 297.81
    ethylbenzene 373.62
    MIBK 1561.04
    2-propoxyethanol 798.46
    tert-butanol 1206.75
    MTBE 1984.94
    2-butoxyethanol 756.33
    propionic acid 954.78
    o-xylene 615.68
    formic acid 141.18
    diethyl ether 1832.74
    m-xylene 538.47
    p-xylene 563.64
    chlorobenzene 1760.51
    dimethyl carbonate 643.22
    n-octane 36.36
    formamide 436.37
    cyclopentanone 5145.83
    2-pentanone 2660.5
    anisole 851.93
    cyclopentyl methyl ether 2530.87
    gamma-butyrolactone 4336.23
    1-methoxy-2-propanol 1255.76
    pyridine 2589.77
    3-pentanone 1956.88
    furfural 2150.56
    n-dodecane 22.49
    diethylene glycol 279.86
    diisopropyl ether 556.14
    tert-amyl alcohol 1117.45
    acetylacetone 2663.13
    n-hexadecane 28.18
    acetophenone 982.43
    methyl propionate 1830.71
    isopentyl acetate 1335.51
    trichloroethylene 6208.22
    n-nonanol 254.89
    cyclohexanol 1444.08
    benzyl alcohol 549.09
    2-ethylhexanol 318.26
    isooctanol 328.76
    dipropyl ether 717.73
    1,2-dichlorobenzene 1532.7
    ethyl lactate 477.45
    propylene carbonate 2172.51
    n-methylformamide 1051.22
    2-pentanol 781.42
    n-pentane 130.03
    1-propoxy-2-propanol 758.45
    1-methoxy-2-propyl acetate 1329.82
    2-(2-methoxypropoxy) propanol 497.86
    mesitylene 345.08
    ε-caprolactone 3578.67
    p-cymene 205.52
    epichlorohydrin 5134.64
    1,1,1-trichloroethane 4460.55
    2-aminoethanol 189.21
    morpholine-4-carbaldehyde 2282.24
    sulfolane 5390.97
    2,2,4-trimethylpentane 97.79
    2-methyltetrahydrofuran 3897.41
    n-hexyl acetate 1308.93
    isooctane 56.51
    2-(2-butoxyethoxy)ethanol 798.22
    sec-butyl acetate 1176.88
    tert-butyl acetate 2080.45
    decalin 139.88
    glycerin 162.5
    diglyme 1908.98
    acrylic acid 577.84
    isopropyl myristate 367.03
    n-butyric acid 1927.14
    acetyl acetate 1313.03
    di(2-ethylhexyl) phthalate 271.36
    ethyl propionate 1389.29
    nitromethane 2292.82
    1,2-diethoxyethane 1426.54
    benzonitrile 878.23
    trioctyl phosphate 209.92
    1-bromopropane 2599.29
    gamma-valerolactone 4969.25
    n-decanol 162.76
    triethyl phosphate 405.93
    4-methyl-2-pentanol 425.04
    propionitrile 1017.79
    vinylene carbonate 1515.03
    1,1,2-trichlorotrifluoroethane 2147.46
    DMS 936.14
    cumene 224.46
    2-octanol 263.12
    2-hexanone 1413.91
    octyl acetate 479.3
    limonene 427.74
    1,2-dimethoxyethane 1732.6
    ethyl orthosilicate 406.58
    tributyl phosphate 293.37
    diacetone alcohol 1608.09
    N,N-dimethylaniline 484.3
    acrylonitrile 972.23
    aniline 996.13
    1,3-propanediol 469.97
    bromobenzene 1930.4
    dibromomethane 3272.83
    1,1,2,2-tetrachloroethane 5488.33
    2-methyl-cyclohexyl acetate 740.12
    tetrabutyl urea 422.65
    diisobutyl methanol 221.95
    2-phenylethanol 455.16
    styrene 527.71
    dioctyl adipate 562.29
    dimethyl sulfate 1269.5
    ethyl butyrate 1068.18
    methyl lactate 591.94
    butyl lactate 773.57
    diethyl carbonate 593.89
    propanediol butyl ether 493.24
    triethyl orthoformate 669.52
    p-tert-butyltoluene 197.4
    methyl 4-tert-butylbenzoate 829.62
    morpholine 3038.88
    tert-butylamine 734.4
    n-dodecanol 114.99
    dimethoxymethane 1662.99
    ethylene carbonate 1601.3
    cyrene 596.4
    2-ethoxyethyl acetate 1700.82
    2-ethylhexyl acetate 1013.45
    1,2,4-trichlorobenzene 1850.88
    4-methylpyridine 2391.5
    dibutyl ether 669.51
    2,6-dimethyl-4-heptanol 221.95
    DEF 2610.18
    dimethyl isosorbide 1181.1
    tetrachloroethylene 3169.63
    eugenol 588.25
    triacetin 1116.46
    span 80 493.7
    1,4-butanediol 148.33
    1,1-dichloroethane 4179.51
    2-methyl-1-pentanol 531.86
    methyl formate 729.79
    2-methyl-1-butanol 880.76
    n-decane 47.75
    butyronitrile 1151.23
    3,7-dimethyl-1-octanol 309.83
    1-chlorooctane 322.73
    1-chlorotetradecane 93.01
    n-nonane 44.78
    undecane 30.51
    tert-butylcyclohexane 100.33
    cyclooctane 118.36
    cyclopentanol 1543.03
    tetrahydropyran 3932.36
    tert-amyl methyl ether 1343.88
    2,5,8-trioxanonane 937.1
    1-hexene 423.29
    2-isopropoxyethanol 673.33
    2,2,2-trifluoroethanol 408.29
    methyl butyrate 1928.8

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction