Hexamethyldisiloxane

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  • Identifiers

    CAS number
    107-46-0

    Molecular formula
    C6H18OSi2

    SMILES
    C[Si](C)(C)O[Si](C)(C)C

    Safety labels

    Flammable
    Flammable

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Mint 34.46%
    Camphoreous 32.58%
    Fishy 29.13%
    Fermented 26.12%
    Fresh 24.88%
    Woody 24.2%
    Ethereal 23.86%
    Earthy 22.36%
    Sulfurous 22.3%
    Green 22.02%

     

    Flavor
    Pungent 33.35%
    Green 28.59%
    Earthy 22.55%
    Oily 20.98%
    Mild 20.42%
    Camphor 20.13%
    Blackberry 19.79%
    Catty 19.56%
    Black currant 19.37%
    Cat-urine 19.27%

     

    Odor impact est.
    Medium

  • Properties

    pKa est.
    9.17 (weak base)

    Molecular weight
    162.38 g/mol

    Melting point expt.

    • -66 °C

    Boiling point

    • 99 °C

    Flash point

    • -1.01 ˚C est.
    • -30 °C

    Solubility expt.

    • In water, 0.93 mg/L at 25 °C
    • 0.93 mg/L @ 25 °C (exp)

  • Synonyms

    • HEXAMETHYLDISILOXANE
    • 107-46-0
    • Disiloxane, hexamethyl-
    • Oxybis(trimethylsilane)
    • Fluka AG
    • Hexamethyl disiloxane
    • Bis(trimethylsilyl)ether
    • Belsil DM 0.65
    • Bis(trimethylsilyl)oxide
    • Bistrimethylsilyl ether
    • KF 96L
    • Silane, oxybis(trimethyl-
    • Dow corning 200
    • OS 10
    • D7M4659BPU
    • AEC DISILOXANE
    • DTXSID4026769
    • MIRASIL HMS
    • NSC-43346
    • VOLASIL DM-0.65
    • DTXCID406769
    • SI-TEC DM 0.65
    • CHEBI:78002
    • SF1000N-0.65CST
    • NSC43346
    • RefChem:7516
    • SF1000N-0.65 cSt
    • Xiameter PMX-200 Silicone Fluid 0.65 cSt
    • 203-492-7
    • HMDSO
    • Bis(trimethylsilyl) ether
    • trimethyl(trimethylsilyloxy)silane
    • 1,1,1,3,3,3-Hexamethyldisiloxane
    • SWS-F 221
    • Bis(trimethylsilyl) oxide
    • MFCD00008265
    • NSC 43346
    • trimethylsilyl ether
    • trimethyl[(trimethylsilyl)oxy]silane
    • Silane, oxybis(trimethyl)-
    • ((CH3)3Si)2O
    • 26298-61-3
    • NCGC00164086-01
    • Disiloxane, 1,1,1,3,3,3-hexamethyl-
    • Bis-trimethylsilyl oxide
    • C6H18OSi2
    • CAS-107-46-0
    • Dimethicone ~4000 (Polydimethylsiloxane)
    • CCRIS 1325
    • HSDB 5378
    • SILCOREL(R) ADP1000 ANTIFOAM COMPOUND
    • EINECS 203-492-7
    • UNII-D7M4659BPU
    • AI3-51466
    • bis-tms ether
    • di-tms ether
    • TMS ether
    • trimethylsilylether
    • Dimethicone, BAN
    • Dimethicone (NF)
    • hexamethyl-disiloxane
    • HMDO
    • Dimeticone (JAN/INN)
    • Polydimethylsiloxane,PDMS
    • Sentry dimethicone (TN)
    • Medetomidine Impurity 43
    • Dimethicone, viscosity 10
    • Dimethicone, viscosity 50
    • EC 203-492-7
    • DISILOXANE,HEXAMETHYL
    • SCHEMBL6413
    • Dimethicone, viscosity 100
    • Dow corning 200/0.65
    • Dimethicone, viscosity 1000
    • Dimethicone, viscosity 2000
    • Hexamethyldisiloxane NMR grade
    • Hexamethyldisiloxane, >=98%
    • SCHEMBL373489
    • Dimethicone, viscosity 10000
    • Hexamethyldisiloxane, NMR grade
    • SCHEMBL8728760
    • CHEMBL3184090
    • SCHEMBL17911300
    • SCHEMBL18227330
    • HEXAMETHYLDISILOXANE [MI]
    • HEXAMETHYLDISILOXANE [HSDB]
    • HEXAMETHYLDISILOXANE [VANDF]
    • Tox21_112082
    • Tox21_201713
    • Tox21_303119
    • Dimethyl Silicone Fluid Silicone Oil
    • EBC-50135
    • MSK001099
    • AKOS000119927
    • Hexamethyldisiloxane (analytical grade)
    • MSK001099-100M
    • 1,1,1,3,3,3-Hexamethyldisiloxane #
    • NCGC00164086-02
    • NCGC00257007-01
    • NCGC00259262-01
    • FD165432
    • DB-040758
    • H0091
    • H7310
    • Hexamethyldisiloxane, NMR grade, >=99.5%
    • NS00041276
    • WLN: 1-SI-1&1&O-SI-1&1&1
    • S09650
    • S09675
    • Hexamethyldisiloxane, puriss., >=98.5% (GC)
    • A801702
    • Hexamethyldisiloxane, viscosity 0.65 cSt (25 C)
    • Q419440
    • Hexamethyldisiloxane Solution in Methanol, 100ug/mL
    • BRD-K26674746-001-01-4
    • F0001-0143
    • Z104473212
    • Hexamethyldisiloxane, for GC derivatization, >=98% (GC)
    • InChI=1/C6H18OSi2/c1-8(2,3)7-9(4,5)6/h1-6H
    • 107-46-0

  • Applications

    Hexamethyldisiloxane (CAS 107-46-0) is commonly used as a volatile solvent and carrier for fragrance and cosmetic formulations; it also serves as an organosilicon intermediate in the synthesis of siloxane resins and specialty coatings. It acts as a precursor for silicon-oxide (SiOx) thin films and protective coatings in electronics and photonics via plasma-enhanced or chemical vapor deposition. In coatings and inks, it functions as a processing aid to improve flow, uniformity and drying, while contributing hydrophobic properties. It is also employed as a cleaning solvent for electronics manufacturing to remove organic residues from surfaces prior to subsequent processing.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1271.05
    methanol 1610.52
    isopropanol 772.95
    water 20.12
    ethyl acetate 656.65
    n-propanol 989.89
    acetone 779.42
    n-butanol 754.37
    acetonitrile 472.85
    DMF 753.18
    toluene 491.9
    isobutanol 534.84
    1,4-dioxane 1311.79
    methyl acetate 559.88
    THF 2481.68
    2-butanone 681.03
    n-pentanol 468.46
    sec-butanol 635.64
    n-hexane 492.07
    ethylene glycol 336.04
    NMP 924.05
    cyclohexane 791.59
    DMSO 756.84
    n-butyl acetate 582.93
    n-octanol 438.42
    chloroform 917.95
    n-propyl acetate 385.72
    acetic acid 616.27
    dichloromethane 820.39
    cyclohexanone 1011.46
    propylene glycol 412.2
    isopropyl acetate 413.45
    DMAc 515.45
    2-ethoxyethanol 579.24
    isopentanol 418.25
    n-heptane 519.15
    ethyl formate 427.76
    1,2-dichloroethane 582.33
    n-hexanol 926.47
    2-methoxyethanol 1141.37
    isobutyl acetate 238.15
    tetrachloromethane 341.97
    n-pentyl acetate 468.67
    transcutol 1030.68
    n-heptanol 465.01
    ethylbenzene 195.68
    MIBK 358.34
    2-propoxyethanol 1165.16
    tert-butanol 616.53
    MTBE 548.92
    2-butoxyethanol 548.32
    propionic acid 571.41
    o-xylene 266.52
    formic acid 325.39
    diethyl ether 1142.77
    m-xylene 337.14
    p-xylene 208.66
    chlorobenzene 365.45
    dimethyl carbonate 222.6
    n-octane 183.56
    formamide 356.92
    cyclopentanone 1159.56
    2-pentanone 663.52
    anisole 317.92
    cyclopentyl methyl ether 1151.62
    gamma-butyrolactone 1105.27
    1-methoxy-2-propanol 835.01
    pyridine 697.74
    3-pentanone 550.97
    furfural 670.43
    n-dodecane 102.99
    diethylene glycol 693.91
    diisopropyl ether 352.92
    tert-amyl alcohol 471.17
    acetylacetone 494.86
    n-hexadecane 112.52
    acetophenone 243.24
    methyl propionate 548.74
    isopentyl acetate 437.72
    trichloroethylene 642.65
    n-nonanol 375.07
    cyclohexanol 767.73
    benzyl alcohol 239.03
    2-ethylhexanol 486.73
    isooctanol 303.0
    dipropyl ether 843.07
    1,2-dichlorobenzene 277.94
    ethyl lactate 194.89
    propylene carbonate 509.7
    n-methylformamide 594.33
    2-pentanol 525.27
    n-pentane 507.6
    1-propoxy-2-propanol 817.49
    1-methoxy-2-propyl acetate 538.84
    2-(2-methoxypropoxy) propanol 293.42
    mesitylene 234.79
    ε-caprolactone 797.66
    p-cymene 200.13
    epichlorohydrin 836.17
    1,1,1-trichloroethane 471.17
    2-aminoethanol 594.26
    morpholine-4-carbaldehyde 775.12
    sulfolane 878.51
    2,2,4-trimethylpentane 128.76
    2-methyltetrahydrofuran 1374.14
    n-hexyl acetate 581.43
    isooctane 116.65
    2-(2-butoxyethoxy)ethanol 490.85
    sec-butyl acetate 247.62
    tert-butyl acetate 410.68
    decalin 180.66
    glycerin 474.01
    diglyme 775.5
    acrylic acid 421.6
    isopropyl myristate 231.13
    n-butyric acid 639.02
    acetyl acetate 351.81
    di(2-ethylhexyl) phthalate 161.58
    ethyl propionate 351.54
    nitromethane 602.84
    1,2-diethoxyethane 604.27
    benzonitrile 277.01
    trioctyl phosphate 163.79
    1-bromopropane 652.1
    gamma-valerolactone 1065.53
    n-decanol 270.98
    triethyl phosphate 176.18
    4-methyl-2-pentanol 264.25
    propionitrile 491.75
    vinylene carbonate 410.13
    1,1,2-trichlorotrifluoroethane 482.22
    DMS 287.87
    cumene 145.43
    2-octanol 336.0
    2-hexanone 408.64
    octyl acetate 294.78
    limonene 372.85
    1,2-dimethoxyethane 772.69
    ethyl orthosilicate 195.72
    tributyl phosphate 174.87
    diacetone alcohol 390.9
    N,N-dimethylaniline 235.25
    acrylonitrile 425.94
    aniline 452.16
    1,3-propanediol 639.68
    bromobenzene 349.45
    dibromomethane 773.79
    1,1,2,2-tetrachloroethane 568.94
    2-methyl-cyclohexyl acetate 314.43
    tetrabutyl urea 237.11
    diisobutyl methanol 250.16
    2-phenylethanol 389.83
    styrene 238.87
    dioctyl adipate 225.65
    dimethyl sulfate 242.39
    ethyl butyrate 388.87
    methyl lactate 289.15
    butyl lactate 326.99
    diethyl carbonate 216.43
    propanediol butyl ether 453.99
    triethyl orthoformate 315.75
    p-tert-butyltoluene 221.09
    methyl 4-tert-butylbenzoate 290.81
    morpholine 1389.81
    tert-butylamine 508.47
    n-dodecanol 210.85
    dimethoxymethane 918.4
    ethylene carbonate 400.32
    cyrene 250.86
    2-ethoxyethyl acetate 472.46
    2-ethylhexyl acetate 406.21
    1,2,4-trichlorobenzene 309.6
    4-methylpyridine 592.95
    dibutyl ether 508.31
    2,6-dimethyl-4-heptanol 250.16
    DEF 577.72
    dimethyl isosorbide 532.77
    tetrachloroethylene 485.07
    eugenol 264.75
    triacetin 319.74
    span 80 381.9
    1,4-butanediol 265.01
    1,1-dichloroethane 541.01
    2-methyl-1-pentanol 276.35
    methyl formate 428.57
    2-methyl-1-butanol 437.29
    n-decane 185.93
    butyronitrile 493.28
    3,7-dimethyl-1-octanol 319.86
    1-chlorooctane 345.38
    1-chlorotetradecane 147.74
    n-nonane 205.26
    undecane 131.5
    tert-butylcyclohexane 157.99
    cyclooctane 335.55
    cyclopentanol 916.22
    tetrahydropyran 1601.39
    tert-amyl methyl ether 476.68
    2,5,8-trioxanonane 480.73
    1-hexene 596.6
    2-isopropoxyethanol 375.86
    2,2,2-trifluoroethanol 221.76
    methyl butyrate 382.79

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction