Hexaglycerol

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  • Identifiers

    CAS number
    36675-34-0

    Molecular formula
    C18H38O13

    SMILES
    C([C@@H](COC[C@@H](COC[C@H](COC[C@H](COC[C@H](COC[C@H](CO)O)O)O)O)O)O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 59.38%
    Alcoholic 34.31%
    Sweet 26.77%
    Fishy 24.2%
    Oily 19.36%
    Ethereal 16.48%
    Buttery 14.48%
    Solvent 14.3%
    Clean 14.05%
    Fresh 12.84%

     

    Flavor
    Odorless 64.03%
    Sweet 48.96%
    Sweet-like 31.6%
    Bitter 23.45%
    Very mild 23.08%
    Bland 22.3%
    Very slight 21.36%
    Mild 19.93%
    Cauliflower 19.54%
    Soup 18.55%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -5.6

    pKa est.
    5.09 (weak acid)

    Molecular weight
    462.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    2691°C

    Flash point

    • 321.27 ˚C est.

  • Synonyms

    • Hexaglycerol
    • 36675-34-0
    • (2S)-3-[(2S)-3-[(2S)-3-[(2R)-3-[(2S)-3-[(2S)-2,3-dihydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropoxy]propane-1,2-diol
    • HEXAGLYCERIN
    • FWTZRWTUPSQZOG-UGDFAFBOSA-N
    • SCHEMBL29379854
    • (2S,6S,10R,14S,18S,22S)-4,8,12,16,20-Pentaoxatricosan-1,2,6,10,14,18,22,23-Octaol
    • 36675-34-0

  • Applications

    Hexaglycerol (CAS 36675-34-0) is a multi-functional polyol widely used as a crosslinking agent and precursor for polymer systems in coatings, adhesives, and plastics, and it can also serve as a reactive solvent in UV-curable formulations. In coatings and inks, it is commonly employed as a crosslinker or reactive diluent to enhance mechanical properties and chemical resistance after curing. In cosmetics and personal care, hexaglycerol functions as a humectant and solvent, helping to stabilize formulations and improve texture and moisture retention. In industrial manufacturing, it may be used as an intermediate for the synthesis of specialty polyols and resins, as well as an additive to improve processing and compatibility of polymer blends. In cleaning products, it can act as a humectant/solvent to support formulation stability and performance. The exact use depends on local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1.36
    methanol 6.09
    isopropanol 0.39
    water 62.55
    ethyl acetate 0.18
    n-propanol 1.01
    acetone 0.44
    n-butanol 0.57
    acetonitrile 0.26
    DMF 19.5
    toluene 0.13
    isobutanol 0.41
    1,4-dioxane 0.98
    methyl acetate 0.31
    THF 1.49
    2-butanone 0.43
    n-pentanol 0.33
    sec-butanol 0.44
    n-hexane 0.03
    ethylene glycol 6.11
    NMP 30.46
    cyclohexane 0.13
    DMSO 41.53
    n-butyl acetate 0.13
    n-octanol 0.34
    chloroform 0.29
    n-propyl acetate 0.16
    acetic acid 5.4
    dichloromethane 0.42
    cyclohexanone 1.34
    propylene glycol 4.43
    isopropyl acetate 0.11
    DMAc 15.62
    2-ethoxyethanol 2.88
    isopentanol 0.26
    n-heptane 0.1
    ethyl formate 0.49
    1,2-dichloroethane 0.34
    n-hexanol 0.25
    2-methoxyethanol 7.6
    isobutyl acetate 0.08
    tetrachloromethane 0.11
    n-pentyl acetate 0.24
    transcutol 5.11
    n-heptanol 0.39
    ethylbenzene 0.07
    MIBK 0.14
    2-propoxyethanol 1.79
    tert-butanol 0.29
    MTBE 0.12
    2-butoxyethanol 1.9
    propionic acid 1.94
    o-xylene 0.17
    formic acid 31.38
    diethyl ether 0.16
    m-xylene 0.09
    p-xylene 0.08
    chlorobenzene 0.07
    dimethyl carbonate 0.81
    n-octane 0.05
    formamide 24.49
    cyclopentanone 1.92
    2-pentanone 0.29
    anisole 0.16
    cyclopentyl methyl ether 0.72
    gamma-butyrolactone 2.99
    1-methoxy-2-propanol 3.53
    pyridine 0.84
    3-pentanone 0.39
    furfural 3.75
    n-dodecane 0.02
    diethylene glycol 3.58
    diisopropyl ether 0.05
    tert-amyl alcohol 0.41
    acetylacetone 0.4
    n-hexadecane 0.02
    acetophenone 0.39
    methyl propionate 0.61
    isopentyl acetate 0.1
    trichloroethylene 0.51
    n-nonanol 0.33
    cyclohexanol 0.9
    benzyl alcohol 0.46
    2-ethylhexanol 0.18
    isooctanol 0.24
    dipropyl ether 0.3
    1,2-dichlorobenzene 0.09
    ethyl lactate 0.81
    propylene carbonate 0.91
    n-methylformamide 8.28
    2-pentanol 0.25
    n-pentane 0.05
    1-propoxy-2-propanol 1.2
    1-methoxy-2-propyl acetate 0.44
    2-(2-methoxypropoxy) propanol 1.63
    mesitylene 0.06
    ε-caprolactone 1.54
    p-cymene 0.09
    epichlorohydrin 1.27
    1,1,1-trichloroethane 0.08
    2-aminoethanol 6.19
    morpholine-4-carbaldehyde 13.92
    sulfolane 16.51
    2,2,4-trimethylpentane 0.03
    2-methyltetrahydrofuran 0.65
    n-hexyl acetate 0.27
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 2.27
    sec-butyl acetate 0.09
    tert-butyl acetate 0.13
    decalin 0.04
    glycerin 17.46
    diglyme 4.16
    acrylic acid 3.66
    isopropyl myristate 0.08
    n-butyric acid 1.15
    acetyl acetate 0.16
    di(2-ethylhexyl) phthalate 0.2
    ethyl propionate 0.22
    nitromethane 4.45
    1,2-diethoxyethane 0.41
    benzonitrile 0.18
    trioctyl phosphate 0.19
    1-bromopropane 0.14
    gamma-valerolactone 5.7
    n-decanol 0.21
    triethyl phosphate 0.34
    4-methyl-2-pentanol 0.1
    propionitrile 0.23
    vinylene carbonate 1.1
    1,1,2-trichlorotrifluoroethane 7.08
    DMS 0.34
    cumene 0.06
    2-octanol 0.2
    2-hexanone 0.19
    octyl acetate 0.16
    limonene 0.17
    1,2-dimethoxyethane 1.77
    ethyl orthosilicate 0.31
    tributyl phosphate 0.18
    diacetone alcohol 0.71
    N,N-dimethylaniline 0.31
    acrylonitrile 0.5
    aniline 0.43
    1,3-propanediol 3.55
    bromobenzene 0.05
    dibromomethane 0.24
    1,1,2,2-tetrachloroethane 0.6
    2-methyl-cyclohexyl acetate 0.22
    tetrabutyl urea 0.44
    diisobutyl methanol 0.1
    2-phenylethanol 0.26
    styrene 0.07
    dioctyl adipate 0.25
    dimethyl sulfate 3.93
    ethyl butyrate 0.22
    methyl lactate 2.63
    butyl lactate 0.74
    diethyl carbonate 0.15
    propanediol butyl ether 2.65
    triethyl orthoformate 0.34
    p-tert-butyltoluene 0.09
    methyl 4-tert-butylbenzoate 0.83
    morpholine 2.39
    tert-butylamine 0.15
    n-dodecanol 0.14
    dimethoxymethane 2.57
    ethylene carbonate 0.71
    cyrene 4.26
    2-ethoxyethyl acetate 0.43
    2-ethylhexyl acetate 0.1
    1,2,4-trichlorobenzene 0.15
    4-methylpyridine 0.43
    dibutyl ether 0.18
    2,6-dimethyl-4-heptanol 0.1
    DEF 1.79
    dimethyl isosorbide 2.14
    tetrachloroethylene 0.56
    eugenol 0.97
    triacetin 0.76
    span 80 1.64
    1,4-butanediol 1.5
    1,1-dichloroethane 0.09
    2-methyl-1-pentanol 0.21
    methyl formate 3.64
    2-methyl-1-butanol 0.44
    n-decane 0.05
    butyronitrile 0.16
    3,7-dimethyl-1-octanol 0.15
    1-chlorooctane 0.11
    1-chlorotetradecane 0.04
    n-nonane 0.05
    undecane 0.03
    tert-butylcyclohexane 0.02
    cyclooctane 0.08
    cyclopentanol 1.16
    tetrahydropyran 0.57
    tert-amyl methyl ether 0.25
    2,5,8-trioxanonane 2.97
    1-hexene 0.06
    2-isopropoxyethanol 0.96
    2,2,2-trifluoroethanol 4.91
    methyl butyrate 0.35

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction