Hexaethylene glycol monohexadecyl ether

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  • Identifiers

    CAS number
    5168-91-2

    Molecular formula
    C28H58O7

    SMILES
    CCCCCCCCCCCCCCCCOCCOCCOCCOCCOCCOCCO

    Safety labels

  • Odor profile

    Fragrance
    Waxy 37.95%
    Odorless 33.07%
    Alcoholic 31.65%
    Oily 29.24%
    Fresh 26.05%
    Sweet 22.78%
    Fatty 21.9%
    Clean 21.67%
    Fruity 20.65%
    Ethereal 18.56%

     

    Flavor
    Waxy 50.61%
    Fatty 38.4%
    Green 36.74%
    Mushroom 35.7%
    Oily 34.12%
    Sweet 33.83%
    Floral 32.73%
    Fruity 30.88%
    Earthy 30.84%
    Mild 28.24%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    6.5

    pKa est.
    5.63 (weak acid)

    Molecular weight
    506.8 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    726°C

    Flash point

    • 234.15 ˚C est.

  • Synonyms

    • Hexaethylene glycol monohexadecyl ether
    • 5168-91-2
    • 3,6,9,12,15,18-Hexaoxatetratriacontan-1-ol
    • DTXSID10965959
    • RefChem:1086532
    • DTXCID301393613
    • 2-[2-[2-[2-[2-(2-hexadecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethanol
    • HEXAETHYLENEGLYCOLMONOHEXADECYLETHER
    • Ceteth-6 [INCI]
    • C16E6
    • SCHEMBL60936
    • orb2939420
    • UOFCAQWHTQFNHS-UHFFFAOYSA-N
    • HY-W250179
    • DB-213705
    • CS-0256355
    • NS00076707
    • Hexaethylene glycol monohexadecyl ether, BioXtra, >=99.0% (TLC)
    • 5168-91-2

  • Applications

    Hexaethylene glycol monohexadecyl ether, CAS 5168-91-2, is a nonionic polyether alkyl ether that functions as a surfactant in various formulations. It is commonly used as a nonionic surfactant and emulsifier in household and industrial cleaners; as a solubilizer and wetting agent in cosmetics and personal care products; as a dispersant and emulsifier in coatings, inks, and polymer formulations; as a processing aid and rheology modifier in polymer and plastics manufacturing; and may be used as a solvent or co-solvent in pharmaceutical and agrochemical formulations, subject to regulatory limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1.1
    methanol 1.97
    isopropanol 0.86
    water 0.14
    ethyl acetate 15.73
    n-propanol 1.84
    acetone 8.58
    n-butanol 1.82
    acetonitrile 4.01
    DMF 22.3
    toluene 8.39
    isobutanol 1.81
    1,4-dioxane 19.81
    methyl acetate 11.95
    THF 41.66
    2-butanone 13.58
    n-pentanol 2.32
    sec-butanol 2.27
    n-hexane 1.44
    ethylene glycol 0.58
    NMP 113.08
    cyclohexane 7.78
    DMSO 48.02
    n-butyl acetate 17.11
    n-octanol 5.35
    chloroform 80.8
    n-propyl acetate 18.46
    acetic acid 13.16
    dichloromethane 86.48
    cyclohexanone 51.01
    propylene glycol 0.91
    isopropyl acetate 12.85
    DMAc 63.94
    2-ethoxyethanol 9.65
    isopentanol 2.36
    n-heptane 3.13
    ethyl formate 9.55
    1,2-dichloroethane 43.14
    n-hexanol 2.23
    2-methoxyethanol 7.66
    isobutyl acetate 11.63
    tetrachloromethane 20.41
    n-pentyl acetate 30.19
    transcutol 65.95
    n-heptanol 4.48
    ethylbenzene 6.56
    MIBK 9.2
    2-propoxyethanol 9.24
    tert-butanol 2.06
    MTBE 6.19
    2-butoxyethanol 15.77
    propionic acid 9.29
    o-xylene 10.75
    formic acid 5.38
    diethyl ether 5.33
    m-xylene 6.91
    p-xylene 8.78
    chlorobenzene 16.45
    dimethyl carbonate 10.38
    n-octane 1.65
    formamide 9.05
    cyclopentanone 53.95
    2-pentanone 11.24
    anisole 12.93
    cyclopentyl methyl ether 29.02
    gamma-butyrolactone 67.03
    1-methoxy-2-propanol 7.36
    pyridine 25.1
    3-pentanone 16.24
    furfural 58.59
    n-dodecane 0.95
    diethylene glycol 4.69
    diisopropyl ether 3.69
    tert-amyl alcohol 4.72
    acetylacetone 24.16
    n-hexadecane 1.14
    acetophenone 23.97
    methyl propionate 15.69
    isopentyl acetate 16.84
    trichloroethylene 98.45
    n-nonanol 6.11
    cyclohexanol 8.11
    benzyl alcohol 8.01
    2-ethylhexanol 4.73
    isooctanol 5.09
    dipropyl ether 12.38
    1,2-dichlorobenzene 27.67
    ethyl lactate 12.3
    propylene carbonate 39.01
    n-methylformamide 9.34
    2-pentanol 1.91
    n-pentane 0.9
    1-propoxy-2-propanol 11.67
    1-methoxy-2-propyl acetate 22.85
    2-(2-methoxypropoxy) propanol 22.64
    mesitylene 6.0
    ε-caprolactone 55.36
    p-cymene 7.77
    epichlorohydrin 59.77
    1,1,1-trichloroethane 45.95
    2-aminoethanol 1.41
    morpholine-4-carbaldehyde 54.24
    sulfolane 165.61
    2,2,4-trimethylpentane 1.83
    2-methyltetrahydrofuran 29.52
    n-hexyl acetate 24.02
    isooctane 0.67
    2-(2-butoxyethoxy)ethanol 23.21
    sec-butyl acetate 15.09
    tert-butyl acetate 20.14
    decalin 4.43
    glycerin 3.01
    diglyme 66.44
    acrylic acid 9.96
    isopropyl myristate 9.54
    n-butyric acid 13.95
    acetyl acetate 20.13
    di(2-ethylhexyl) phthalate 10.08
    ethyl propionate 19.58
    nitromethane 32.64
    1,2-diethoxyethane 26.27
    benzonitrile 11.49
    trioctyl phosphate 7.23
    1-bromopropane 16.36
    gamma-valerolactone 75.52
    n-decanol 3.89
    triethyl phosphate 26.51
    4-methyl-2-pentanol 1.87
    propionitrile 4.59
    vinylene carbonate 35.82
    1,1,2-trichlorotrifluoroethane 68.16
    DMS 21.71
    cumene 5.75
    2-octanol 4.24
    2-hexanone 13.22
    octyl acetate 11.74
    limonene 13.02
    1,2-dimethoxyethane 25.68
    ethyl orthosilicate 24.4
    tributyl phosphate 10.57
    diacetone alcohol 16.12
    N,N-dimethylaniline 14.15
    acrylonitrile 6.58
    aniline 8.17
    1,3-propanediol 1.96
    bromobenzene 21.98
    dibromomethane 45.13
    1,1,2,2-tetrachloroethane 97.23
    2-methyl-cyclohexyl acetate 25.84
    tetrabutyl urea 17.49
    diisobutyl methanol 4.08
    2-phenylethanol 6.86
    styrene 6.81
    dioctyl adipate 21.76
    dimethyl sulfate 41.5
    ethyl butyrate 25.58
    methyl lactate 9.87
    butyl lactate 20.65
    diethyl carbonate 18.21
    propanediol butyl ether 10.49
    triethyl orthoformate 31.38
    p-tert-butyltoluene 7.19
    methyl 4-tert-butylbenzoate 34.08
    morpholine 22.54
    tert-butylamine 1.71
    n-dodecanol 2.8
    dimethoxymethane 12.65
    ethylene carbonate 29.57
    cyrene 34.04
    2-ethoxyethyl acetate 38.66
    2-ethylhexyl acetate 18.67
    1,2,4-trichlorobenzene 39.23
    4-methylpyridine 18.69
    dibutyl ether 14.35
    2,6-dimethyl-4-heptanol 4.08
    DEF 26.47
    dimethyl isosorbide 60.27
    tetrachloroethylene 63.72
    eugenol 24.8
    triacetin 52.87
    span 80 17.99
    1,4-butanediol 1.38
    1,1-dichloroethane 23.31
    2-methyl-1-pentanol 3.6
    methyl formate 8.81
    2-methyl-1-butanol 3.05
    n-decane 2.27
    butyronitrile 4.17
    3,7-dimethyl-1-octanol 5.78
    1-chlorooctane 9.15
    1-chlorotetradecane 2.9
    n-nonane 2.13
    undecane 1.36
    tert-butylcyclohexane 2.58
    cyclooctane 3.44
    cyclopentanol 8.48
    tetrahydropyran 21.03
    tert-amyl methyl ether 10.71
    2,5,8-trioxanonane 41.69
    1-hexene 2.85
    2-isopropoxyethanol 8.23
    2,2,2-trifluoroethanol 13.01
    methyl butyrate 24.98

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction