Hexaethylene Glycol

Overview IFRA Request a quote

  • Identifiers

    CAS number
    2615-15-8

    Molecular formula
    C12H26O7

    SMILES
    C(COCCOCCOCCOCCOCCO)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 52.71%
    Alcoholic 39.06%
    Ethereal 22.43%
    Fishy 19.65%
    Solvent 14.42%
    Sweet 14.09%
    Oily 12.96%
    Fresh 12.49%
    Clean 11.9%
    Musty 9.18%

     

    Flavor
    Sweet 38.9%
    Odorless 38.62%
    Bitter 33.51%
    Alcoholic 30.21%
    Musty 29.83%
    Fatty 25.66%
    Sweet-like 25.12%
    Vegetable 24.14%
    Very slight 23.1%
    Creamy 22.25%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -1.9

    pKa est.
    4.05 (weak acid)

    Molecular weight
    282.33 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    508°C

    Flash point

    • 200.43 ˚C est.

  • Synonyms

    • HEXAETHYLENE GLYCOL
    • 2615-15-8
    • 3,6,9,12,15-Pentaoxaheptadecane-1,17-diol
    • Hexagol
    • Hexaoxyethylene glycol
    • 2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethanol
    • DTXSID2058629
    • CHEBI:49793
    • 2-(2-(2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethanol
    • RefChem:922913
    • DTXCID0032316
    • 220-045-1
    • HO-PEG6-OH
    • Hexaethyleneglycol
    • MFCD00002877
    • NSC 201209
    • C12H26O7
    • Ethanol, 2,2'-(oxybis(ethyleneoxyethyleneoxy))di-
    • EINECS 220-045-1
    • P6G
    • OH-PEG6-OH
    • BRN 1638281
    • AI3-01457
    • 2-[2-(2-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethan-1-ol
    • 2-[2-[2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethanol; 2,2'-[oxybis(oxy-2,1-ethanediyloxy-2,1-ethanediyloxy)]bis Ethanol; Hexagol; Hexaoxyethylene Glycol; NSC 201209
    • Hexa[ethylene glycol]
    • Hexaethylene glycol, 97%
    • NONOXYNOL-9_met079
    • 2,2'-[Oxybis(ethyleneoxyethyleneoxy)]bisethanol
    • SCHEMBL38159
    • 4-01-00-02406 (Beilstein Handbook Reference)
    • orb1909400
    • CHEMBL1235082
    • WLN: Q2/O2/ 5Q
    • NSC201209
    • SBB060195
    • AKOS015839803
    • MSK161930-1000M
    • NCGC00159371-02
    • NCGC00159371-03
    • AS-19157
    • BP-21034
    • BP-21475
    • DA-74106
    • SY024148
    • HY-141230
    • 3,9,12,15-Pentaoxaheptadecane-1,17-diol
    • CS-0115001
    • H1432
    • NS00001003
    • ST51046426
    • Hexaethylene glycol, purum, >=95.0% (GC)
    • EN300-226100
    • Ethanol,2'-[oxybis(ethyleneoxyethyleneoxy)]di-
    • F242074
    • Hexaethylene glycol Solution in Methanol, 1000ug/mL
    • Q27104720
    • Ethanol,2'-[oxybis(oxy-2,1-ethanediyloxy-2,1-ethanediyloxy)]bis-
    • Ethanol, 2,2'-(oxybis(oxy-2,1-ethanediyloxy-2,1-ethanediyloxy))bis-
    • 6529-43-7
    • 2615-15-8

  • Applications

    Hexaethylene glycol (CAS 2615-15-8) is a diol used as a reactive intermediate and high-boiling solvent in polymer and resin manufacture. It serves as a chain extender and crosslinker for polyurethane and polyester polyols, enabling coatings, adhesives, and elastomer formulations. It also functions as a processing solvent and aid in coatings, inks, and cleaning formulations, where its polarity and viscosity help dissolve additives. In polymer technology, it can act as a plasticizer and coupling agent to tune viscosity and flexibility of formulations. It may also be used as a co-solvent and humectant in specialty cosmetic or personal-care products and as a building block for further chemical synthesis. Regulation and formulation limits apply.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 7.86
    methanol 20.57
    isopropanol 3.96
    water 10.41
    ethyl acetate 8.53
    n-propanol 6.95
    acetone 9.44
    n-butanol 4.47
    acetonitrile 8.88
    DMF 88.42
    toluene 2.82
    isobutanol 4.27
    1,4-dioxane 22.93
    methyl acetate 12.39
    THF 31.64
    2-butanone 8.91
    n-pentanol 3.52
    sec-butanol 4.84
    n-hexane 0.94
    ethylene glycol 11.08
    NMP 172.61
    cyclohexane 4.74
    DMSO 239.92
    n-butyl acetate 6.5
    n-octanol 3.57
    chloroform 36.5
    n-propyl acetate 6.99
    acetic acid 53.62
    dichloromethane 46.13
    cyclohexanone 28.42
    propylene glycol 7.8
    isopropyl acetate 4.39
    DMAc 112.57
    2-ethoxyethanol 20.82
    isopentanol 3.08
    n-heptane 2.13
    ethyl formate 12.62
    1,2-dichloroethane 27.58
    n-hexanol 3.01
    2-methoxyethanol 30.96
    isobutyl acetate 3.52
    tetrachloromethane 8.32
    n-pentyl acetate 5.48
    transcutol 51.4
    n-heptanol 2.91
    ethylbenzene 1.93
    MIBK 2.65
    2-propoxyethanol 13.9
    tert-butanol 4.65
    MTBE 3.5
    2-butoxyethanol 10.86
    propionic acid 25.79
    o-xylene 4.4
    formic acid 70.23
    diethyl ether 4.32
    m-xylene 2.09
    p-xylene 2.87
    chlorobenzene 6.04
    dimethyl carbonate 9.08
    n-octane 0.89
    formamide 89.7
    cyclopentanone 35.68
    2-pentanone 4.98
    anisole 5.46
    cyclopentyl methyl ether 11.95
    gamma-butyrolactone 64.69
    1-methoxy-2-propanol 16.42
    pyridine 23.69
    3-pentanone 7.93
    furfural 70.43
    n-dodecane 0.57
    diethylene glycol 18.0
    diisopropyl ether 1.31
    tert-amyl alcohol 5.89
    acetylacetone 10.42
    n-hexadecane 0.64
    acetophenone 11.29
    methyl propionate 11.56
    isopentyl acetate 5.16
    trichloroethylene 45.17
    n-nonanol 3.7
    cyclohexanol 9.82
    benzyl alcohol 7.8
    2-ethylhexanol 3.15
    isooctanol 2.52
    dipropyl ether 6.14
    1,2-dichlorobenzene 10.18
    ethyl lactate 10.8
    propylene carbonate 27.12
    n-methylformamide 42.59
    2-pentanol 2.57
    n-pentane 1.0
    1-propoxy-2-propanol 10.79
    1-methoxy-2-propyl acetate 9.8
    2-(2-methoxypropoxy) propanol 17.05
    mesitylene 1.84
    ε-caprolactone 32.24
    p-cymene 3.04
    epichlorohydrin 40.26
    1,1,1-trichloroethane 13.0
    2-aminoethanol 14.21
    morpholine-4-carbaldehyde 85.09
    sulfolane 171.17
    2,2,4-trimethylpentane 0.82
    2-methyltetrahydrofuran 17.15
    n-hexyl acetate 6.55
    isooctane 0.26
    2-(2-butoxyethoxy)ethanol 17.96
    sec-butyl acetate 3.8
    tert-butyl acetate 4.65
    decalin 1.61
    glycerin 25.06
    diglyme 44.45
    acrylic acid 37.33
    isopropyl myristate 3.03
    n-butyric acid 16.89
    acetyl acetate 10.57
    di(2-ethylhexyl) phthalate 5.2
    ethyl propionate 8.2
    nitromethane 75.88
    1,2-diethoxyethane 10.29
    benzonitrile 8.88
    trioctyl phosphate 3.74
    1-bromopropane 7.9
    gamma-valerolactone 58.76
    n-decanol 2.65
    triethyl phosphate 12.99
    4-methyl-2-pentanol 1.4
    propionitrile 6.73
    vinylene carbonate 30.27
    1,1,2-trichlorotrifluoroethane 83.26
    DMS 12.24
    cumene 1.85
    2-octanol 1.99
    2-hexanone 4.76
    octyl acetate 4.33
    limonene 4.96
    1,2-dimethoxyethane 31.75
    ethyl orthosilicate 10.78
    tributyl phosphate 5.87
    diacetone alcohol 8.15
    N,N-dimethylaniline 7.42
    acrylonitrile 12.99
    aniline 8.28
    1,3-propanediol 11.76
    bromobenzene 5.51
    dibromomethane 24.84
    1,1,2,2-tetrachloroethane 49.01
    2-methyl-cyclohexyl acetate 9.04
    tetrabutyl urea 9.76
    diisobutyl methanol 2.25
    2-phenylethanol 5.33
    styrene 2.5
    dioctyl adipate 8.92
    dimethyl sulfate 38.73
    ethyl butyrate 9.75
    methyl lactate 16.23
    butyl lactate 8.9
    diethyl carbonate 8.92
    propanediol butyl ether 10.61
    triethyl orthoformate 11.75
    p-tert-butyltoluene 2.83
    methyl 4-tert-butylbenzoate 13.69
    morpholine 32.76
    tert-butylamine 3.18
    n-dodecanol 2.09
    dimethoxymethane 18.42
    ethylene carbonate 22.45
    cyrene 27.79
    2-ethoxyethyl acetate 9.05
    2-ethylhexyl acetate 4.96
    1,2,4-trichlorobenzene 15.01
    4-methylpyridine 12.87
    dibutyl ether 4.92
    2,6-dimethyl-4-heptanol 2.25
    DEF 23.36
    dimethyl isosorbide 34.47
    tetrachloroethylene 38.24
    eugenol 13.55
    triacetin 19.33
    span 80 13.02
    1,4-butanediol 6.32
    1,1-dichloroethane 10.21
    2-methyl-1-pentanol 2.89
    methyl formate 28.43
    2-methyl-1-butanol 4.08
    n-decane 1.07
    butyronitrile 4.49
    3,7-dimethyl-1-octanol 3.06
    1-chlorooctane 3.05
    1-chlorotetradecane 1.32
    n-nonane 1.04
    undecane 0.75
    tert-butylcyclohexane 0.86
    cyclooctane 1.84
    cyclopentanol 13.52
    tetrahydropyran 14.41
    tert-amyl methyl ether 4.72
    2,5,8-trioxanonane 35.91
    1-hexene 1.66
    2-isopropoxyethanol 9.81
    2,2,2-trifluoroethanol 45.95
    methyl butyrate 11.6

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction