Hexadecyl propionate

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  • Identifiers

    CAS number
    6221-96-1

    Molecular formula
    C19H38O2

    SMILES
    CCCCCCCCCCCCCCCCOC(=O)CC

    Safety labels

  • Odor profile

    Fragrance
    Waxy 72.56%
    Fatty 69.29%
    Oily 63.23%
    Fruity 41.68%
    Sweet 38.39%
    Creamy 31.89%
    Odorless 26.71%
    Dairy 26.14%
    Clean 26.1%
    Soapy 24.36%

     

    Flavor
    Waxy 75.05%
    Oily 50.04%
    Fatty 48.37%
    Soapy 45.62%
    Mild 42.16%
    Coconut 38.63%
    Sweet 36.58%
    Fat 36.12%
    Fruity 34.24%
    Creamy 34.11%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    8.2

    pKa est.
    7.46 (neutral)

    Molecular weight
    298.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    357°C

    Flash point

    • 155.97 ˚C est.

  • Synonyms

    • Hexadecyl propionate
    • hexadecyl propanoate
    • 6221-96-1
    • 1-Hexadecanol, propanoate
    • HEXADECYLPROPIONATE
    • CHEMBL138543
    • Propanoic acid, hexadecyl ester
    • NSC-53827
    • NSC-67972
    • Propionic acid hexadecyl ester
    • EINECS 228-301-4
    • Propionsaurecetylester
    • AI3-06111
    • 1-Hexadecanol, propionate
    • HAT8G77L9G
    • 1-Hexadecanol, 1-propanoate
    • SCHEMBL160710
    • orb2664698
    • SCHEMBL5238456
    • SCHEMBL5238461
    • DTXSID80211273
    • NSC53827
    • NSC67972
    • BDBM50171294
    • MFCD28972109
    • NSC 53827
    • NSC 67972
    • AKOS037645120
    • AS-57261
    • NS00034964
    • D93028
    • 6221-96-1

  • Applications

    Hexadecyl propionate (CAS 6221-96-1) is a waxy ester commonly used as an emollient and slip agent in cosmetics and personal care formulations, providing conditioning feel in lotions, creams and makeup. It can also function as a fragrance solvent or carrier in perfumery, aiding dissolution and delivery of fragrance components. In coatings, inks and related industrial formulations it serves as a processing aid and plasticizer-like additive to improve spreading, glide and flexibility. In polymer and plastics formulations it may act as a processing aid or lubricant to enhance processing characteristics and tactile properties. It also finds use as a conditioning lipid additive in certain household cleaners and polishes. Its use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 131.66
    methanol 126.58
    isopropanol 234.86
    water 0.03
    ethyl acetate 1359.43
    n-propanol 231.5
    acetone 710.81
    n-butanol 308.56
    acetonitrile 329.38
    DMF 970.83
    toluene 473.46
    isobutanol 273.95
    1,4-dioxane 1038.94
    methyl acetate 716.44
    THF 2131.1
    2-butanone 1039.25
    n-pentanol 231.06
    sec-butanol 331.85
    n-hexane 189.21
    ethylene glycol 7.87
    NMP 1822.8
    cyclohexane 840.72
    DMSO 918.25
    n-butyl acetate 1479.56
    n-octanol 298.46
    chloroform 2735.48
    n-propyl acetate 1638.56
    acetic acid 245.73
    dichloromethane 2942.34
    cyclohexanone 2977.49
    propylene glycol 29.54
    isopropyl acetate 1262.16
    DMAc 1491.75
    2-ethoxyethanol 423.53
    isopentanol 429.32
    n-heptane 196.9
    ethyl formate 494.94
    1,2-dichloroethane 2083.33
    n-hexanol 239.34
    2-methoxyethanol 423.02
    isobutyl acetate 995.84
    tetrachloromethane 726.75
    n-pentyl acetate 1765.26
    transcutol 2131.31
    n-heptanol 247.49
    ethylbenzene 378.2
    MIBK 1108.6
    2-propoxyethanol 454.19
    tert-butanol 472.84
    MTBE 1046.92
    2-butoxyethanol 584.44
    propionic acid 308.77
    o-xylene 438.67
    formic acid 32.87
    diethyl ether 924.33
    m-xylene 380.66
    p-xylene 603.68
    chlorobenzene 875.64
    dimethyl carbonate 209.5
    n-octane 84.47
    formamide 87.9
    cyclopentanone 2426.47
    2-pentanone 1246.96
    anisole 714.91
    cyclopentyl methyl ether 1569.36
    gamma-butyrolactone 2134.69
    1-methoxy-2-propanol 526.41
    pyridine 1281.18
    3-pentanone 1012.72
    furfural 1325.6
    n-dodecane 41.09
    diethylene glycol 132.79
    diisopropyl ether 490.14
    tert-amyl alcohol 553.68
    acetylacetone 1373.9
    n-hexadecane 53.52
    acetophenone 870.14
    methyl propionate 817.96
    isopentyl acetate 1381.24
    trichloroethylene 3161.35
    n-nonanol 300.58
    cyclohexanol 800.75
    benzyl alcohol 352.73
    2-ethylhexanol 359.51
    isooctanol 299.09
    dipropyl ether 1020.21
    1,2-dichlorobenzene 1087.78
    ethyl lactate 359.03
    propylene carbonate 1241.36
    n-methylformamide 313.15
    2-pentanol 329.77
    n-pentane 112.33
    1-propoxy-2-propanol 620.62
    1-methoxy-2-propyl acetate 1051.21
    2-(2-methoxypropoxy) propanol 486.44
    mesitylene 327.84
    ε-caprolactone 2395.36
    p-cymene 319.25
    epichlorohydrin 2106.28
    1,1,1-trichloroethane 2424.09
    2-aminoethanol 41.95
    morpholine-4-carbaldehyde 1400.26
    sulfolane 2789.85
    2,2,4-trimethylpentane 105.65
    2-methyltetrahydrofuran 2013.98
    n-hexyl acetate 1537.58
    isooctane 67.03
    2-(2-butoxyethoxy)ethanol 688.62
    sec-butyl acetate 1226.82
    tert-butyl acetate 1571.3
    decalin 247.22
    glycerin 50.29
    diglyme 1758.77
    acrylic acid 182.65
    isopropyl myristate 488.08
    n-butyric acid 906.45
    acetyl acetate 791.8
    di(2-ethylhexyl) phthalate 291.37
    ethyl propionate 1338.42
    nitromethane 752.08
    1,2-diethoxyethane 1423.84
    benzonitrile 654.96
    trioctyl phosphate 243.51
    1-bromopropane 1373.58
    gamma-valerolactone 2785.79
    n-decanol 184.26
    triethyl phosphate 565.24
    4-methyl-2-pentanol 263.76
    propionitrile 463.82
    vinylene carbonate 899.85
    1,1,2-trichlorotrifluoroethane 1131.55
    DMS 670.21
    cumene 275.05
    2-octanol 287.05
    2-hexanone 1197.68
    octyl acetate 554.47
    limonene 669.87
    1,2-dimethoxyethane 1600.56
    ethyl orthosilicate 573.67
    tributyl phosphate 358.45
    diacetone alcohol 939.33
    N,N-dimethylaniline 509.06
    acrylonitrile 430.79
    aniline 416.91
    1,3-propanediol 121.76
    bromobenzene 1139.75
    dibromomethane 2006.32
    1,1,2,2-tetrachloroethane 3069.95
    2-methyl-cyclohexyl acetate 977.9
    tetrabutyl urea 535.75
    diisobutyl methanol 309.92
    2-phenylethanol 328.7
    styrene 473.94
    dioctyl adipate 699.22
    dimethyl sulfate 458.15
    ethyl butyrate 1536.82
    methyl lactate 222.12
    butyl lactate 769.06
    diethyl carbonate 717.84
    propanediol butyl ether 394.04
    triethyl orthoformate 1024.45
    p-tert-butyltoluene 286.13
    methyl 4-tert-butylbenzoate 816.55
    morpholine 1458.25
    tert-butylamine 366.99
    n-dodecanol 132.51
    dimethoxymethane 625.48
    ethylene carbonate 938.99
    cyrene 503.22
    2-ethoxyethyl acetate 1406.16
    2-ethylhexyl acetate 1236.67
    1,2,4-trichlorobenzene 1198.9
    4-methylpyridine 1336.88
    dibutyl ether 1190.59
    2,6-dimethyl-4-heptanol 309.92
    DEF 1625.67
    dimethyl isosorbide 1171.71
    tetrachloroethylene 2038.5
    eugenol 560.27
    triacetin 1183.48
    span 80 520.02
    1,4-butanediol 55.03
    1,1-dichloroethane 1819.98
    2-methyl-1-pentanol 332.52
    methyl formate 208.08
    2-methyl-1-butanol 372.74
    n-decane 105.28
    butyronitrile 657.9
    3,7-dimethyl-1-octanol 357.93
    1-chlorooctane 501.34
    1-chlorotetradecane 144.35
    n-nonane 108.65
    undecane 60.02
    tert-butylcyclohexane 181.89
    cyclooctane 197.23
    cyclopentanol 681.98
    tetrahydropyran 1998.86
    tert-amyl methyl ether 951.74
    2,5,8-trioxanonane 913.48
    1-hexene 424.53
    2-isopropoxyethanol 431.75
    2,2,2-trifluoroethanol 121.32
    methyl butyrate 1899.36

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction