Hexadecyl (2E)-3-(4-hydroxy-3-methoxyphenyl)-2-propenoate

Overview IFRA Request a quote

  • Identifiers

    CAS number
    158306-36-6

    Molecular formula
    C26H42O4

    SMILES
    CCCCCCCCCCCCCCCCOC(=O)/C=C/C1=CC(=C(C=C1)O)OC

    Safety labels

  • Odor profile

    Fragrance
    Waxy 42.94%
    Balsamic 41.21%
    Fatty 35.96%
    Odorless 35.65%
    Floral 33.32%
    Oily 32.37%
    Sweet 31.14%
    Spicy 28.73%
    Milky 24.82%
    Creamy 22.2%

     

    Flavor
    Waxy 34.93%
    Oily 31.49%
    Mild 30.22%
    Bland 29.02%
    Herbal 28.05%
    Balsam 26.52%
    Faint 25.34%
    Woody 25.07%
    Odorless 23.4%
    Fatty 22.63%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    9.6

    pKa est.
    9.02 (weak base)

    Molecular weight
    418.6 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    574°C

    Flash point

    • 210.55 ˚C est.

  • Synonyms

    • 158306-36-6
    • DTXSID901195388
    • Hexadecyl (2E)-3-(4-hydroxy-3-methoxyphenyl)-2-propenoate
    • RefChem:1086525
    • DTXCID201626621
    • Hexadecyl ferulate
    • 2-Propenoic acid, 3-(4-hydroxy-3-methoxyphenyl)-, hexadecyl ester, (2E)-
    • 64190-80-3
    • ferulic hexadecyl ester
    • CHEMBL4060370
    • SCHEMBL21001086
    • hexadecyl (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate
    • CHEBI:190388
    • 2-Propenoic acid, 3-(4-hydroxy-3-methoxyphenyl)-, hexadecyl ester
    • HEXADECYL (2E)-3-(4-HYDROXY-3-METHOXYPHENYL)PROP-2-ENOATE
    • hexadecyl (E)-3-(4-hydroxy-3-methoxy-phenyl)prop-2-enoate
    • hexacosanoic alcohol 3-(4-hydroxy-3-methoxybenzol)-trans-acryliceylenate
    • NCGC00386025-01!hexadecyl (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate
    • 64190-80-3

  • Applications

    Hexadecyl (2E)-3-(4-hydroxy-3-methoxyphenyl)-2-propenoate, CAS 158306-36-6, is an oil-soluble cinnamate ester primarily used as a UV absorber in cosmetics and personal care products, where it can be formulated into sunscreens and moisturizers. It is also employed as a UV stabilizer in coatings and plastics to improve resistance to light-induced degradation. As a cinnamate derivative, it may serve as an intermediate in the synthesis of related cinnamate compounds and can be considered a potential fragrance ingredient or fixative in perfumery formulations. Its use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 72.99
    methanol 93.14
    isopropanol 72.94
    water 0.75
    ethyl acetate 321.6
    n-propanol 80.3
    acetone 467.99
    n-butanol 68.91
    acetonitrile 164.34
    DMF 327.7
    toluene 85.89
    isobutanol 64.37
    1,4-dioxane 331.76
    methyl acetate 261.86
    THF 885.05
    2-butanone 325.37
    n-pentanol 60.26
    sec-butanol 86.65
    n-hexane 13.12
    ethylene glycol 7.9
    NMP 478.34
    cyclohexane 76.4
    DMSO 858.37
    n-butyl acetate 151.41
    n-octanol 46.32
    chloroform 752.89
    n-propyl acetate 228.09
    acetic acid 207.38
    dichloromethane 946.29
    cyclohexanone 652.21
    propylene glycol 18.57
    isopropyl acetate 213.05
    DMAc 636.87
    2-ethoxyethanol 137.47
    isopentanol 69.66
    n-heptane 10.44
    ethyl formate 153.76
    1,2-dichloroethane 679.31
    n-hexanol 36.46
    2-methoxyethanol 153.68
    isobutyl acetate 123.46
    tetrachloromethane 195.55
    n-pentyl acetate 243.33
    transcutol 386.61
    n-heptanol 49.94
    ethylbenzene 51.64
    MIBK 162.85
    2-propoxyethanol 96.78
    tert-butanol 117.94
    MTBE 167.57
    2-butoxyethanol 130.9
    propionic acid 147.65
    o-xylene 65.31
    formic acid 45.15
    diethyl ether 151.36
    m-xylene 50.6
    p-xylene 79.69
    chlorobenzene 169.3
    dimethyl carbonate 114.84
    n-octane 9.54
    formamide 127.19
    cyclopentanone 698.43
    2-pentanone 274.54
    anisole 110.98
    cyclopentyl methyl ether 260.13
    gamma-butyrolactone 679.42
    1-methoxy-2-propanol 127.02
    pyridine 308.2
    3-pentanone 243.0
    furfural 349.59
    n-dodecane 5.98
    diethylene glycol 47.7
    diisopropyl ether 50.9
    tert-amyl alcohol 117.54
    acetylacetone 416.09
    n-hexadecane 7.08
    acetophenone 162.37
    methyl propionate 229.74
    isopentyl acetate 140.43
    trichloroethylene 931.1
    n-nonanol 48.89
    cyclohexanol 142.86
    benzyl alcohol 79.84
    2-ethylhexanol 38.62
    isooctanol 51.52
    dipropyl ether 79.59
    1,2-dichlorobenzene 183.63
    ethyl lactate 82.78
    propylene carbonate 314.2
    n-methylformamide 149.09
    2-pentanol 53.62
    n-pentane 11.16
    1-propoxy-2-propanol 92.54
    1-methoxy-2-propyl acetate 161.19
    2-(2-methoxypropoxy) propanol 97.78
    mesitylene 35.54
    ε-caprolactone 478.78
    p-cymene 32.82
    epichlorohydrin 698.92
    1,1,1-trichloroethane 659.06
    2-aminoethanol 27.9
    morpholine-4-carbaldehyde 311.98
    sulfolane 893.22
    2,2,4-trimethylpentane 11.03
    2-methyltetrahydrofuran 446.77
    n-hexyl acetate 188.58
    isooctane 5.44
    2-(2-butoxyethoxy)ethanol 132.34
    sec-butyl acetate 149.0
    tert-butyl acetate 244.06
    decalin 19.29
    glycerin 30.15
    diglyme 351.22
    acrylic acid 112.95
    isopropyl myristate 59.17
    n-butyric acid 227.4
    acetyl acetate 221.14
    di(2-ethylhexyl) phthalate 54.61
    ethyl propionate 190.1
    nitromethane 502.72
    1,2-diethoxyethane 204.24
    benzonitrile 114.31
    trioctyl phosphate 43.66
    1-bromopropane 256.08
    gamma-valerolactone 717.03
    n-decanol 32.63
    triethyl phosphate 85.85
    4-methyl-2-pentanol 36.24
    propionitrile 123.91
    vinylene carbonate 257.03
    1,1,2-trichlorotrifluoroethane 360.42
    DMS 154.9
    cumene 36.1
    2-octanol 46.15
    2-hexanone 191.55
    octyl acetate 80.79
    limonene 52.18
    1,2-dimethoxyethane 315.62
    ethyl orthosilicate 84.85
    tributyl phosphate 56.94
    diacetone alcohol 197.85
    N,N-dimethylaniline 75.71
    acrylonitrile 136.04
    aniline 96.36
    1,3-propanediol 55.94
    bromobenzene 184.67
    dibromomethane 543.5
    1,1,2,2-tetrachloroethane 857.54
    2-methyl-cyclohexyl acetate 113.06
    tetrabutyl urea 81.98
    diisobutyl methanol 33.08
    2-phenylethanol 63.13
    styrene 64.59
    dioctyl adipate 104.73
    dimethyl sulfate 233.66
    ethyl butyrate 143.07
    methyl lactate 85.7
    butyl lactate 133.63
    diethyl carbonate 101.35
    propanediol butyl ether 86.01
    triethyl orthoformate 112.14
    p-tert-butyltoluene 31.39
    methyl 4-tert-butylbenzoate 146.05
    morpholine 362.45
    tert-butylamine 65.9
    n-dodecanol 23.78
    dimethoxymethane 241.96
    ethylene carbonate 262.21
    cyrene 122.48
    2-ethoxyethyl acetate 277.02
    2-ethylhexyl acetate 112.82
    1,2,4-trichlorobenzene 216.56
    4-methylpyridine 231.35
    dibutyl ether 97.91
    2,6-dimethyl-4-heptanol 33.08
    DEF 273.78
    dimethyl isosorbide 212.46
    tetrachloroethylene 502.3
    eugenol 120.39
    triacetin 216.9
    span 80 90.41
    1,4-butanediol 28.96
    1,1-dichloroethane 523.06
    2-methyl-1-pentanol 63.64
    methyl formate 128.88
    2-methyl-1-butanol 69.01
    n-decane 12.55
    butyronitrile 127.79
    3,7-dimethyl-1-octanol 45.11
    1-chlorooctane 53.29
    1-chlorotetradecane 17.77
    n-nonane 12.04
    undecane 8.02
    tert-butylcyclohexane 13.57
    cyclooctane 16.06
    cyclopentanol 163.21
    tetrahydropyran 439.25
    tert-amyl methyl ether 128.24
    2,5,8-trioxanonane 191.68
    1-hexene 39.85
    2-isopropoxyethanol 109.19
    2,2,2-trifluoroethanol 115.49
    methyl butyrate 258.41

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction