Hexadecanolactone

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  • Identifiers

    CAS number
    109-29-5

    Molecular formula
    C16H30O2

    SMILES
    C1CCCCCCCC(=O)OCCCCCCC1

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Musk 91.41%
    Sweet 77.79%
    Animal 65.89%
    Powdery 58.4%
    Waxy 54.67%
    Amber 54.06%
    Fruity 51.4%
    Fatty 38.74%
    Dry 37.62%
    Woody 36.21%

    Scent© AI

  • Properties

    XLogP3-AA
    6.3

    pKa est.
    12.08 (strong base)

    Molecular weight
    254.41 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    350°C

    Flash point est.
    159.82 ˚C

  • Synonyms

    • 16-Hexadecanolide
    • 109-29-5
    • OXACYCLOHEPTADECAN-2-ONE
    • Hexadecanolide
    • hexadecanolactone
    • Cyclohexadecanolide
    • 16-Hexadecanolactone
    • 1,16-Hexadecanolide
    • Juniperic acid lactone
    • Dihydroambrettolide
    • 1,16-Hexadecalactone
    • 1,16-Hexadecanolactone
    • 1-oxacycloheptadecan-2-one
    • 16-Hydroxyhexadecanoic acid lactone
    • NSC 33546
    • EINECS 203-662-0
    • BRN 0148631
    • DTXSID4047622
    • AI3-37208
    • 64E2HO00C7
    • MFCD00039668
    • NSC-33546
    • Hexadecanoic acid, 16-hydroxy-, omicron-lactone
    • DTXCID2027622
    • 5-17-09-00108 (Beilstein Handbook Reference)
    • NSC33546
    • HEXADECANOIC ACID, 16-HYDROXY-, O-LACTONE
    • juniper muscone
    • UNII-64E2HO00C7
    • JUNIPERIC ACID, LACTONE
    • hexadecano-16-lactone
    • 2-Oxacyclo-heptadecanone
    • 16-Hexadecanolide, 97%
    • SCHEMBL111372
    • HEXADECANOLACTONE [INCI]
    • CHEMBL3189021
    • CHEBI:179821
    • Hexadecanolide, >=98%, stabilized
    • Tox21_302621
    • CCG-36363
    • Hexadecanoic acid, .omicron.-lactone
    • LMFA07040054
    • 16-Hexadecanolide, reference material
    • AKOS040744516
    • 16-Hexadecanolide, analytical standard
    • NCGC00256920-01
    • AS-81214
    • CAS-109-29-5
    • FH153651
    • SY038613
    • DB-040861
    • HY-119392
    • CS-0068061
    • H1219
    • NS00012529
    • F10387
    • Hexadecanoic acid, 16-hydroxy-, .omicron.-lactone
    • Q21099108
    • 203-662-0
    • Silvanone Supra

  • Applications

    Hexadecanolide (also known as 15-hexadecanolide or musk T), CAS 109-29-5, is a macrocyclic lactone with a soft, long-lasting musky odor that is widely employed as a premium fragrance ingredient and fixative in fine perfumes, creams, personal-care products, deodorants, scented soaps, detergents, candles, and food flavors; owing to its good oil miscibility and high oxidative stability it is further investigated for encapsulating aroma microcapsules, extending topical drug release profiles, acting as a carrier for beverage flavors, supporting sensory studies of natural musk notes in the food industry, and being incorporated into “green” cosmetic formulations because it can be synthesized from renewable fatty acids, complies with IFRA and EU safety guidelines, enables reduction of traditional nitro musks, and enhances overall product sustainability.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 334.49
    methanol 246.86
    isopropanol 427.69
    water 0.03
    ethyl acetate 1411.07
    n-propanol 424.82
    acetone 1251.82
    n-butanol 442.07
    acetonitrile 642.43
    DMF 1573.03
    toluene 920.78
    isobutanol 389.76
    1,4-dioxane 1320.41
    methyl acetate 848.35
    THF 2828.09
    2-butanone 1202.36
    n-pentanol 317.61
    sec-butanol 425.69
    n-hexane 269.13
    ethylene glycol 29.22
    NMP 1953.97
    cyclohexane 696.65
    DMSO 1382.14
    n-butyl acetate 1264.66
    n-octanol 285.68
    chloroform 4250.49
    n-propyl acetate 1185.11
    acetic acid 526.71
    dichloromethane 4028.54
    cyclohexanone 2798.38
    propylene glycol 90.16
    isopropyl acetate 1136.29
    DMAc 1319.2
    2-ethoxyethanol 449.02
    isopentanol 494.64
    n-heptane 225.36
    ethyl formate 644.44
    1,2-dichloroethane 2544.1
    n-hexanol 367.65
    2-methoxyethanol 635.31
    isobutyl acetate 769.06
    tetrachloromethane 679.03
    n-pentyl acetate 1204.86
    transcutol 2286.76
    n-heptanol 251.16
    ethylbenzene 489.06
    MIBK 909.84
    2-propoxyethanol 603.16
    tert-butanol 591.65
    MTBE 883.16
    2-butoxyethanol 558.03
    propionic acid 573.96
    o-xylene 551.67
    formic acid 79.75
    diethyl ether 1010.09
    m-xylene 566.14
    p-xylene 661.31
    chlorobenzene 1441.65
    dimethyl carbonate 358.39
    n-octane 82.58
    formamide 187.53
    cyclopentanone 2914.2
    2-pentanone 1346.43
    anisole 794.81
    cyclopentyl methyl ether 1632.11
    gamma-butyrolactone 2778.29
    1-methoxy-2-propanol 673.82
    pyridine 2245.23
    3-pentanone 1038.43
    furfural 2013.7
    n-dodecane 48.26
    diethylene glycol 250.63
    diisopropyl ether 453.58
    tert-amyl alcohol 536.97
    acetylacetone 1495.93
    n-hexadecane 59.91
    acetophenone 884.29
    methyl propionate 952.81
    isopentyl acetate 1082.47
    trichloroethylene 4354.56
    n-nonanol 272.5
    cyclohexanol 892.84
    benzyl alcohol 505.33
    2-ethylhexanol 379.71
    isooctanol 268.39
    dipropyl ether 932.61
    1,2-dichlorobenzene 1377.97
    ethyl lactate 352.89
    propylene carbonate 1575.54
    n-methylformamide 572.37
    2-pentanol 433.82
    n-pentane 184.58
    1-propoxy-2-propanol 656.81
    1-methoxy-2-propyl acetate 930.22
    2-(2-methoxypropoxy) propanol 495.82
    mesitylene 401.73
    ε-caprolactone 2120.4
    p-cymene 327.68
    epichlorohydrin 2535.18
    1,1,1-trichloroethane 2470.29
    2-aminoethanol 118.63
    morpholine-4-carbaldehyde 1546.74
    sulfolane 3225.51
    2,2,4-trimethylpentane 92.22
    2-methyltetrahydrofuran 2009.17
    n-hexyl acetate 1173.2
    isooctane 77.51
    2-(2-butoxyethoxy)ethanol 744.66
    sec-butyl acetate 851.91
    tert-butyl acetate 1100.98
    decalin 236.85
    glycerin 136.46
    diglyme 1574.76
    acrylic acid 436.9
    isopropyl myristate 423.38
    n-butyric acid 1183.62
    acetyl acetate 905.81
    di(2-ethylhexyl) phthalate 296.98
    ethyl propionate 1009.79
    nitromethane 1167.91
    1,2-diethoxyethane 1185.36
    benzonitrile 980.88
    trioctyl phosphate 224.26
    1-bromopropane 1523.3
    gamma-valerolactone 2782.6
    n-decanol 185.4
    triethyl phosphate 437.5
    4-methyl-2-pentanol 297.81
    propionitrile 781.55
    vinylene carbonate 1277.48
    1,1,2-trichlorotrifluoroethane 1471.11
    DMS 752.03
    cumene 315.89
    2-octanol 249.48
    2-hexanone 974.92
    octyl acetate 496.54
    limonene 549.24
    1,2-dimethoxyethane 1220.55
    ethyl orthosilicate 405.67
    tributyl phosphate 329.67
    diacetone alcohol 787.14
    N,N-dimethylaniline 522.27
    acrylonitrile 938.43
    aniline 824.39
    1,3-propanediol 260.99
    bromobenzene 1849.71
    dibromomethane 2678.11
    1,1,2,2-tetrachloroethane 3701.72
    2-methyl-cyclohexyl acetate 719.47
    tetrabutyl urea 436.03
    diisobutyl methanol 298.21
    2-phenylethanol 435.5
    styrene 684.8
    dioctyl adipate 614.97
    dimethyl sulfate 640.56
    ethyl butyrate 1050.39
    methyl lactate 347.51
    butyl lactate 621.3
    diethyl carbonate 616.19
    propanediol butyl ether 439.07
    triethyl orthoformate 700.88
    p-tert-butyltoluene 302.48
    methyl 4-tert-butylbenzoate 730.53
    morpholine 1645.19
    tert-butylamine 446.91
    n-dodecanol 142.09
    dimethoxymethane 854.25
    ethylene carbonate 1194.28
    cyrene 477.71
    2-ethoxyethyl acetate 1090.46
    2-ethylhexyl acetate 917.85
    1,2,4-trichlorobenzene 1512.59
    4-methylpyridine 1891.08
    dibutyl ether 878.14
    2,6-dimethyl-4-heptanol 298.21
    DEF 1523.69
    dimethyl isosorbide 1019.38
    tetrachloroethylene 2346.27
    eugenol 530.08
    triacetin 994.12
    span 80 564.03
    1,4-butanediol 100.59
    1,1-dichloroethane 2375.0
    2-methyl-1-pentanol 343.21
    methyl formate 395.8
    2-methyl-1-butanol 433.2
    n-decane 99.1
    butyronitrile 931.37
    3,7-dimethyl-1-octanol 337.65
    1-chlorooctane 424.81
    1-chlorotetradecane 146.65
    n-nonane 104.86
    undecane 65.17
    tert-butylcyclohexane 172.52
    cyclooctane 212.26
    cyclopentanol 895.92
    tetrahydropyran 2045.98
    tert-amyl methyl ether 732.78
    2,5,8-trioxanonane 908.47
    1-hexene 602.16
    2-isopropoxyethanol 417.76
    2,2,2-trifluoroethanol 216.11
    methyl butyrate 1390.75

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Achillea wilhelmsii (Egypt) Achillea wilhelmsii C. Koch (A. santolina Auct. Mult.), fam. Asteraceae 0.15%
Achillea wilhelmsii (Turkey) Achillea wilhelmsii C. Koch (A. santolina Auct. Mult.), fam. Asteraceae 0.01%