Hexadecanamide

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  • Identifiers

    CAS number
    629-54-9

    Molecular formula
    C16H33NO

    SMILES
    CCCCCCCCCCCCCCCC(=O)N

    Safety labels

  • Odor profile

    Fragrance
    Waxy 58.66%
    Fatty 57.15%
    Meaty 36.0%
    Oily 31.69%
    Savory 30.51%
    Citrus 27.47%
    Fishy 27.36%
    Animal 26.78%
    Odorless 26.52%
    Fresh 24.86%

     

    Flavor
    Fatty 44.82%
    Waxy 37.32%
    Fat 31.58%
    Mild 31.53%
    Bland 28.96%
    Faint 27.13%
    Slightly waxy 25.21%
    Odorless 24.75%
    Oily 23.6%
    Bay oil 23.38%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    5.7

    pKa est.
    7.16 (neutral)

    Molecular weight
    255.44 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    356°C

    Melting point expt.

    • 107.00 °C. @ 760.00 mm Hg

    Flash point

    • 167.53 ˚C est.

  • Synonyms

    • Hexadecanamide
    • Palmitamide
    • 629-54-9
    • Palmitic amide
    • Cetyl amide
    • Palmitic acid amide
    • Amide 16
    • Amide HPL
    • Palmityl amide
    • QX1MQ82M73
    • CHEBI:74475
    • NSC-3327
    • DTXSID8044707
    • RefChem:145947
    • DTXCID6024707
    • 211-095-5
    • n-Hexadecanamide
    • C16H33NO
    • MFCD00025534
    • NSC 3327
    • UNII-QX1MQ82M73
    • EINECS 211-095-5
    • Hexadecanoic acid amide
    • Palmitamide/Hexadecanamide
    • SCHEMBL43384
    • CHEMBL32605
    • SCHEMBL501954
    • palmitamide (ACD/Name 4.0)
    • orb2664486
    • SCHEMBL16458602
    • MSK2982
    • NSC3327
    • BDBM50463964
    • LMFA08010009
    • SBB061049
    • AKOS015839800
    • MSK2982-1000M
    • EBC-618368
    • FH62594
    • NCGC00161182-02
    • PALMITAMIDE (PALMITIC ACID AMIDE)
    • AS-56522
    • SY038954
    • DB-054345
    • HY-121389
    • CS-0081845
    • H0067
    • NS00014846
    • ST50545478
    • A11794
    • Hexadecanamide Solution in Methanol, 1000ug/mL
    • F544712
    • Q18651888
    • 629-54-9

  • Applications

    Hexadecanamide is commonly used as a waxy fatty amide additive in plastics and polymer processing, functioning as a slip agent and anti-blocking lubricant to improve release properties and surface characteristics of films and molded parts. It may also serve as a lubricating additive in industrial lubricants and metalworking fluids, reducing friction and wear. In coatings and inks, hexadecanamide can act as a surface-modifying additive to adjust rheology, reduce blocking, and improve pigment dispersion. As an intermediate in organic synthesis, hexadecanamide can be used to prepare other fatty amide derivatives and specialty chemicals. Additionally, it may be used as a component in adhesives and sealants to influence viscosity and slip properties.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 78.11
    methanol 78.06
    isopropanol 98.94
    water 0.01
    ethyl acetate 162.55
    n-propanol 88.81
    acetone 130.96
    n-butanol 96.13
    acetonitrile 45.78
    DMF 240.53
    toluene 57.31
    isobutanol 81.29
    1,4-dioxane 158.29
    methyl acetate 94.13
    THF 621.91
    2-butanone 161.98
    n-pentanol 76.39
    sec-butanol 85.69
    n-hexane 33.26
    ethylene glycol 5.27
    NMP 399.09
    cyclohexane 75.57
    DMSO 354.06
    n-butyl acetate 248.71
    n-octanol 58.71
    chloroform 366.23
    n-propyl acetate 223.36
    acetic acid 70.75
    dichloromethane 315.65
    cyclohexanone 439.72
    propylene glycol 22.94
    isopropyl acetate 171.5
    DMAc 302.82
    2-ethoxyethanol 131.85
    isopentanol 113.48
    n-heptane 30.59
    ethyl formate 81.77
    1,2-dichloroethane 246.71
    n-hexanol 87.47
    2-methoxyethanol 166.88
    isobutyl acetate 171.21
    tetrachloromethane 90.58
    n-pentyl acetate 229.95
    transcutol 544.94
    n-heptanol 63.06
    ethylbenzene 49.57
    MIBK 184.47
    2-propoxyethanol 173.63
    tert-butanol 152.26
    MTBE 174.81
    2-butoxyethanol 154.7
    propionic acid 82.98
    o-xylene 56.84
    formic acid 14.02
    diethyl ether 125.62
    m-xylene 53.74
    p-xylene 73.58
    chlorobenzene 111.18
    dimethyl carbonate 37.64
    n-octane 11.32
    formamide 24.56
    cyclopentanone 515.46
    2-pentanone 194.84
    anisole 108.47
    cyclopentyl methyl ether 289.45
    gamma-butyrolactone 437.4
    1-methoxy-2-propanol 187.32
    pyridine 183.35
    3-pentanone 137.65
    furfural 291.32
    n-dodecane 6.57
    diethylene glycol 69.77
    diisopropyl ether 68.44
    tert-amyl alcohol 131.6
    acetylacetone 235.85
    n-hexadecane 8.04
    acetophenone 143.48
    methyl propionate 117.35
    isopentyl acetate 247.61
    trichloroethylene 398.98
    n-nonanol 61.06
    cyclohexanol 145.53
    benzyl alcohol 77.05
    2-ethylhexanol 88.08
    isooctanol 68.69
    dipropyl ether 195.8
    1,2-dichlorobenzene 137.85
    ethyl lactate 86.32
    propylene carbonate 256.29
    n-methylformamide 74.97
    2-pentanol 77.34
    n-pentane 18.52
    1-propoxy-2-propanol 192.93
    1-methoxy-2-propyl acetate 223.13
    2-(2-methoxypropoxy) propanol 138.55
    mesitylene 46.9
    ε-caprolactone 333.23
    p-cymene 52.46
    epichlorohydrin 396.26
    1,1,1-trichloroethane 276.25
    2-aminoethanol 27.85
    morpholine-4-carbaldehyde 268.29
    sulfolane 730.27
    2,2,4-trimethylpentane 15.97
    2-methyltetrahydrofuran 362.57
    n-hexyl acetate 218.08
    isooctane 11.61
    2-(2-butoxyethoxy)ethanol 192.86
    sec-butyl acetate 169.74
    tert-butyl acetate 242.77
    decalin 31.02
    glycerin 36.67
    diglyme 390.38
    acrylic acid 49.8
    isopropyl myristate 84.85
    n-butyric acid 205.25
    acetyl acetate 107.71
    di(2-ethylhexyl) phthalate 70.62
    ethyl propionate 168.25
    nitromethane 138.52
    1,2-diethoxyethane 242.07
    benzonitrile 101.89
    trioctyl phosphate 57.09
    1-bromopropane 173.7
    gamma-valerolactone 519.27
    n-decanol 41.35
    triethyl phosphate 112.28
    4-methyl-2-pentanol 63.53
    propionitrile 68.76
    vinylene carbonate 163.55
    1,1,2-trichlorotrifluoroethane 275.06
    DMS 108.69
    cumene 43.79
    2-octanol 52.92
    2-hexanone 204.55
    octyl acetate 96.49
    limonene 96.11
    1,2-dimethoxyethane 295.11
    ethyl orthosilicate 113.18
    tributyl phosphate 77.59
    diacetone alcohol 221.94
    N,N-dimethylaniline 85.84
    acrylonitrile 64.97
    aniline 71.24
    1,3-propanediol 65.35
    bromobenzene 126.99
    dibromomethane 232.62
    1,1,2,2-tetrachloroethane 434.97
    2-methyl-cyclohexyl acetate 192.39
    tetrabutyl urea 106.93
    diisobutyl methanol 67.39
    2-phenylethanol 87.76
    styrene 59.94
    dioctyl adipate 131.16
    dimethyl sulfate 107.44
    ethyl butyrate 221.98
    methyl lactate 65.75
    butyl lactate 157.8
    diethyl carbonate 117.76
    propanediol butyl ether 120.58
    triethyl orthoformate 178.92
    p-tert-butyltoluene 53.2
    methyl 4-tert-butylbenzoate 161.92
    morpholine 258.06
    tert-butylamine 100.33
    n-dodecanol 30.06
    dimethoxymethane 144.87
    ethylene carbonate 154.7
    cyrene 146.02
    2-ethoxyethyl acetate 213.94
    2-ethylhexyl acetate 202.55
    1,2,4-trichlorobenzene 163.49
    4-methylpyridine 177.13
    dibutyl ether 165.28
    2,6-dimethyl-4-heptanol 67.39
    DEF 223.25
    dimethyl isosorbide 304.03
    tetrachloroethylene 273.76
    eugenol 127.21
    triacetin 217.23
    span 80 139.34
    1,4-butanediol 25.16
    1,1-dichloroethane 215.49
    2-methyl-1-pentanol 82.04
    methyl formate 46.24
    2-methyl-1-butanol 90.72
    n-decane 14.9
    butyronitrile 105.16
    3,7-dimethyl-1-octanol 74.19
    1-chlorooctane 68.28
    1-chlorotetradecane 22.42
    n-nonane 14.52
    undecane 9.26
    tert-butylcyclohexane 25.89
    cyclooctane 18.66
    cyclopentanol 161.77
    tetrahydropyran 302.42
    tert-amyl methyl ether 146.33
    2,5,8-trioxanonane 243.7
    1-hexene 81.01
    2-isopropoxyethanol 124.83
    2,2,2-trifluoroethanol 30.91
    methyl butyrate 239.85

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction