Hexacosanoic Acid

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  • Identifiers

    CAS number
    506-46-7

    Molecular formula
    C26H52O2

    SMILES
    CCCCCCCCCCCCCCCCCCCCCCCCCC(=O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Waxy 83.34%
    Fatty 66.36%
    Oily 39.84%
    Odorless 32.32%
    Creamy 19.68%
    Savory 18.02%
    Fishy 17.92%
    Meaty 17.38%
    Dairy 15.81%
    Sweet 15.35%

     

    Flavor
    Waxy 54.21%
    Fatty 48.58%
    Mild 39.04%
    Bland 34.12%
    Faint 31.72%
    Fat 30.79%
    Odorless 28.24%
    Alkane 27.58%
    Oily 25.96%
    Slightly waxy 25.74%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    11.8

    pKa est.
    8.28 (weak base)

    Molecular weight
    396.7 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    495°C

    Melting point expt.

    • 88.5 °C

    Flash point

    • 238.85 ˚C est.

  • Synonyms

    • HEXACOSANOIC ACID
    • 506-46-7
    • Cerotic acid
    • Ceratinic acid
    • Ceric acid
    • Cerinic acid
    • Cerylic acid
    • n-Hexacosanoic acid
    • Cerotinic acid
    • D42CQN6P36
    • C26:0
    • NSC-4205
    • DTXSID7075050
    • CHEBI:31009
    • RefChem:785921
    • Very Long Chain Fatty Acid
    • C26:0 (VLCFA)
    • DTXCID2040862
    • CHEBI:27283
    • 208-040-2
    • Hexacosanic acid
    • MFCD00002811
    • NSC4205
    • cerinate
    • FA 26:0
    • FA(26:0)
    • HEXACOSANOICACID
    • UNII-D42CQN6P36
    • Hexacosansaeure
    • hexacosoic acid
    • hexaeicosanoic acid
    • NSC 4205
    • EINECS 208-040-2
    • Ceratinic acid; Ceric acid
    • Cerotic acid (6CI,7CI)
    • hexacosanoate (n-C26:0)
    • SCHEMBL134632
    • CHEMBL464787
    • Hexacosanoic acid (8CI,9CI)
    • orb1300078
    • orb3025476
    • CH3-[CH2]24-COOH
    • Hexacosanoic acid (Cerotic acid)
    • n-C26:0
    • LMFA01010026
    • MSK159770
    • Hexacosanoic acid, analytical standard
    • AKOS015892942
    • FH23777
    • AS-47827
    • SY013864
    • DB-008615
    • Hexacosanoic acid, >=95% (capillary GC)
    • HY-113301
    • CS-0059548
    • Hexacosanoic acid, technical, >=90% (GC)
    • NS00013439
    • C21931
    • F16302
    • F239843
    • Q903348
    • Hexacosanoic acid 100 microg/mL in Dichloromethane
    • D1350C66-1C64-4B94-A33A-412D70EF327D
    • 506-46-7

  • Applications

    Hexacosanoic acid (CAS 506-46-7) is a very long-chain saturated fatty acid commonly used in cosmetics and personal care as an emollient and thickening agent, and as a waxy component in creams, lip balms, and hair care formulations. It is also employed as a wax constituent in coatings and inks to impart hardness, gloss, and slip, and as a processing aid or lubricant in polymer and plastics formulations. In household products, it can appear in candles, wax-based polishes, and automotive care products; in pharmaceuticals, it may serve as a lipid-based excipient or thickener in topical formulations, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1.27
    methanol 1.83
    isopropanol 1.3
    water 0.01
    ethyl acetate 9.55
    n-propanol 1.91
    acetone 5.82
    n-butanol 2.44
    acetonitrile 1.6
    DMF 17.08
    toluene 4.84
    isobutanol 2.09
    1,4-dioxane 14.29
    methyl acetate 6.75
    THF 65.29
    2-butanone 10.37
    n-pentanol 3.31
    sec-butanol 2.65
    n-hexane 2.54
    ethylene glycol 0.22
    NMP 92.22
    cyclohexane 9.29
    DMSO 29.64
    n-butyl acetate 22.97
    n-octanol 9.51
    chloroform 49.14
    n-propyl acetate 22.09
    acetic acid 4.59
    dichloromethane 43.87
    cyclohexanone 50.46
    propylene glycol 0.77
    isopropyl acetate 14.62
    DMAc 54.44
    2-ethoxyethanol 9.18
    isopentanol 4.15
    n-heptane 3.75
    ethyl formate 5.41
    1,2-dichloroethane 26.64
    n-hexanol 4.08
    2-methoxyethanol 7.01
    isobutyl acetate 18.17
    tetrachloromethane 14.49
    n-pentyl acetate 48.18
    transcutol 97.95
    n-heptanol 7.85
    ethylbenzene 7.06
    MIBK 16.65
    2-propoxyethanol 12.75
    tert-butanol 4.77
    MTBE 11.12
    2-butoxyethanol 23.4
    propionic acid 4.81
    o-xylene 7.35
    formic acid 1.25
    diethyl ether 5.16
    m-xylene 5.67
    p-xylene 10.04
    chlorobenzene 11.17
    dimethyl carbonate 4.85
    n-octane 2.46
    formamide 2.43
    cyclopentanone 57.7
    2-pentanone 11.42
    anisole 13.87
    cyclopentyl methyl ether 32.2
    gamma-butyrolactone 52.8
    1-methoxy-2-propanol 10.1
    pyridine 15.88
    3-pentanone 12.1
    furfural 37.63
    n-dodecane 1.35
    diethylene glycol 4.36
    diisopropyl ether 6.06
    tert-amyl alcohol 7.85
    acetylacetone 21.19
    n-hexadecane 1.64
    acetophenone 23.92
    methyl propionate 9.38
    isopentyl acetate 29.63
    trichloroethylene 53.81
    n-nonanol 11.07
    cyclohexanol 8.7
    benzyl alcohol 6.93
    2-ethylhexanol 7.92
    isooctanol 10.33
    dipropyl ether 19.21
    1,2-dichlorobenzene 21.2
    ethyl lactate 12.02
    propylene carbonate 36.0
    n-methylformamide 4.46
    2-pentanol 2.89
    n-pentane 1.16
    1-propoxy-2-propanol 19.28
    1-methoxy-2-propyl acetate 31.99
    2-(2-methoxypropoxy) propanol 35.74
    mesitylene 6.58
    ε-caprolactone 52.11
    p-cymene 9.73
    epichlorohydrin 45.62
    1,1,1-trichloroethane 37.6
    2-aminoethanol 0.95
    morpholine-4-carbaldehyde 43.44
    sulfolane 149.13
    2,2,4-trimethylpentane 2.82
    2-methyltetrahydrofuran 38.45
    n-hexyl acetate 44.57
    isooctane 1.74
    2-(2-butoxyethoxy)ethanol 39.29
    sec-butyl acetate 21.11
    tert-butyl acetate 34.5
    decalin 6.07
    glycerin 2.16
    diglyme 90.0
    acrylic acid 3.63
    isopropyl myristate 17.7
    n-butyric acid 11.25
    acetyl acetate 10.3
    di(2-ethylhexyl) phthalate 14.47
    ethyl propionate 19.93
    nitromethane 10.97
    1,2-diethoxyethane 36.41
    benzonitrile 8.86
    trioctyl phosphate 11.08
    1-bromopropane 14.31
    gamma-valerolactone 75.19
    n-decanol 6.83
    triethyl phosphate 27.63
    4-methyl-2-pentanol 4.15
    propionitrile 2.75
    vinylene carbonate 23.21
    1,1,2-trichlorotrifluoroethane 41.93
    DMS 20.23
    cumene 7.52
    2-octanol 8.77
    2-hexanone 19.59
    octyl acetate 19.09
    limonene 16.21
    1,2-dimethoxyethane 32.53
    ethyl orthosilicate 28.62
    tributyl phosphate 15.61
    diacetone alcohol 30.39
    N,N-dimethylaniline 15.85
    acrylonitrile 2.92
    aniline 4.99
    1,3-propanediol 2.02
    bromobenzene 15.0
    dibromomethane 28.41
    1,1,2,2-tetrachloroethane 65.94
    2-methyl-cyclohexyl acetate 41.08
    tetrabutyl urea 27.64
    diisobutyl methanol 9.25
    2-phenylethanol 8.56
    styrene 6.68
    dioctyl adipate 33.44
    dimethyl sulfate 19.44
    ethyl butyrate 32.13
    methyl lactate 7.08
    butyl lactate 33.9
    diethyl carbonate 18.16
    propanediol butyl ether 19.23
    triethyl orthoformate 37.84
    p-tert-butyltoluene 9.9
    methyl 4-tert-butylbenzoate 50.36
    morpholine 20.33
    tert-butylamine 4.0
    n-dodecanol 4.66
    dimethoxymethane 10.75
    ethylene carbonate 20.47
    cyrene 36.39
    2-ethoxyethyl acetate 45.57
    2-ethylhexyl acetate 27.73
    1,2,4-trichlorobenzene 27.16
    4-methylpyridine 14.8
    dibutyl ether 27.32
    2,6-dimethyl-4-heptanol 9.25
    DEF 20.79
    dimethyl isosorbide 95.05
    tetrachloroethylene 37.61
    eugenol 34.37
    triacetin 58.09
    span 80 31.77
    1,4-butanediol 1.21
    1,1-dichloroethane 18.07
    2-methyl-1-pentanol 5.7
    methyl formate 3.58
    2-methyl-1-butanol 3.84
    n-decane 3.27
    butyronitrile 3.71
    3,7-dimethyl-1-octanol 12.64
    1-chlorooctane 13.86
    1-chlorotetradecane 4.13
    n-nonane 3.07
    undecane 1.96
    tert-butylcyclohexane 4.97
    cyclooctane 3.3
    cyclopentanol 9.41
    tetrahydropyran 22.9
    tert-amyl methyl ether 15.84
    2,5,8-trioxanonane 58.3
    1-hexene 4.78
    2-isopropoxyethanol 9.7
    2,2,2-trifluoroethanol 3.77
    methyl butyrate 28.88

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction