Hederacoside C

Overview IFRA Request a quote

  • Identifiers

    CAS number
    14216-03-6

    Molecular formula
    C59H96O26

    SMILES
    C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)O[C@@H]2[C@H](O[C@H]([C@@H]([C@H]2O)O)OC[C@@H]3[C@H]([C@@H]([C@H]([C@@H](O3)OC(=O)[C@@]45CC[C@@]6(C(=CC[C@H]7[C@]6(CC[C@@H]8[C@@]7(CC[C@@H]([C@@]8(C)CO)O[C@H]9[C@@H]([C@H]([C@H](CO9)O)O)O[C@H]1[C@@H]([C@@H]([C@H]([C@@H](O1)C)O)O)O)C)C)[C@@H]4CC(CC5)(C)C)C)O)O)O)CO)O)O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 60.46%
    Woody 35.37%
    Sweet 31.03%
    Spicy 25.08%
    Cooling 23.11%
    Amber 20.42%
    Dry 20.01%
    Balsamic 19.89%
    Warm 19.34%
    Mint 19.11%

     

    Flavor
    Bitter 53.87%
    Sweet 38.84%
    Fatty 33.84%
    Odorless 33.67%
    Sweet-like 28.85%
    Bland 24.47%
    Cedarleaf 21.35%
    Metallic 20.95%
    Cauliflower 20.89%
    Patchouli 20.76%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    -2.0

    pKa est.
    3.79 (weak acid)

    Molecular weight
    1221.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    3506°C

    Flash point

    • 209.17 ˚C est.

  • Synonyms

    • Hederacoside C
    • Kalopanaxsaponin B
    • 14216-03-6
    • Tauroside H2
    • Akeboside Sth
    • Hederoside H1
    • Pericarsaponin Pk
    • Akebia saponin PK
    • Glycoside L-H2
    • Tauroside St-H2
    • Pulsatilla saponin F
    • 2608B2L1BQ
    • CHEBI:69371
    • DTXSID701317445
    • RefChem:40180
    • DTXCID401747257
    • 238-072-2
    • Olean-12-en-28-oic acid, 3-((2-O-(6-deoxy-alpha-L-mannopyranosyl)-alpha-L-arabinopyranosyl)oxy)-23-hydroxy-, O-6-deoxy-alpha-L-mannopyranosyl-(1-4)-O-beta-D-glucopyranosyl-(1-6)-beta-D-glucopyranosyl ester, (3beta,4alpha)-
    • ((2S,3R,4S,5S,6R)-6-(((2R,3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl)oxymethyl)-3,4,5-trihydroxyoxan-2-yl) (4aS,6aR,6aS,6bR,8aR,9R,10S,12aR,14bS)-10-((2S,3R,4S,5S)-4,5-dihydroxy-3-((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl)oxy-9-(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylate
    • Akebiasaponin PK
    • Astrantiasaponin H
    • MFCD00198062
    • C59H96O26
    • Olean-12-en-28-oic acid, 3- ((2-O-(6-deoxy-alpha-L-mannopyranosyl)-alpha-L-arabinopyranosyl)oxy)-23-hydroxy-, O-6-deoxy-alpha-L-mannopyranosyl-(1-4)-O-beta-D-glucopyranosyl-(1-6)-beta-D-glucopyranosyl ester, (3beta,4alpha)-
    • Kalopanax saponin B
    • UNII-2608B2L1BQ
    • Hederoside H
    • Hederacoside C?
    • EINECS 238-072-2
    • Kizuta saponin K(12)
    • Hederacoside C (Standard)
    • HEDERACOSIDE C with HPLC
    • SCHEMBL2997243
    • CHEMBL1910840
    • HY-N0253R
    • Hederasaponin C (Hederacoside C)
    • RYHDIBJJJRNDSX-MCGLQMIESA-N
    • HY-N0253
    • AKOS037514687
    • CCG-270660
    • CS-5691
    • EBC-618404
    • OH32563
    • AC-34096
    • DA-53923
    • NS00093705
    • S3919
    • Q27137710
    • 23-hydroxy-3beta-[(O-alpha-L-rhamnopyranosyl-(1->2)-alpha-L-arabinopyranosyl)oxy]olean-12-en-28-oic acid O-alpha-L-rhamnopyranosyl-(1->4)-O-beta-D-glucopyranosyl-(1->6)-beta-D-glucopyranosyl ester
    • 6-Deoxy-alpha-L-mannopyranosyl-(1->4)-beta-D-glucopyranosyl-(1->6)-1-O-(3beta-{[2-O-(6-deoxy-alpha-L-mannopyranosyl)-alpha-L-arabinopyranosyl]oxy}-23-hydroxy-28-oxoolean-12-en-28-yl)-beta-D-glucopyranose
    • 6-deoxy-alpha-L-mannopyranosyl-(1->4)-beta-D-glucopyranosyl-(1->6)-1-O-[(3beta)-3-{[2-O-(6-deoxy-alpha-L-mannopyranosyl)-alpha-L-arabinopyranosyl]oxy}-23-hydroxy-28-oxoolean-12-en-28-yl]-beta-D-glucopyranose
    • hederagenin 3-O-alpha-L-rhamnopyranosyl-(1->2)-O-alpha-L-arabinopyranoside 28-O-alpha-L-rhamnopyranosyl-(1->4)-O-beta-D-glucopyranosyl-(1->6)-O-beta-D-glucopyranosyl ester
    • OLEAN-12-EN-28-OIC ACID, 3- ((2-O-(6-DEOXY-.ALPHA.-L-MANNOPYRANOSYL)- .ALPHA.-L-ARABINOPYRANOSYL)OXY)-23-HYDROXY-, O-6-DEOXY-.ALPHA.-L- MANNOPYRANOSYL-(1-4)-O-.BETA.-D-GLUCOPYRANOSYL-(1-6)-.BETA.-D- GLUCOPYRANOSYL ESTER, (3.BETA.,4.ALPHA.)-
    • Olean-12-en-28-oic acid, 3-((2-O-(6-deoxy-alpha-l-mannopyranosyl)-alpha-l-arabinopyranosyl)oxy)-23-hydroxy-, O-6-deoxy-alpha-l-mannopyranosyl-(1.4)-O-beta-d-glucopyranosyl-(1.6)-beta-d-glucopyranosyl ester, (3beta,4alpha)-
    • 14216-03-6

  • Applications

    Hederacoside C (CAS 14216-03-6) is a triterpenoid saponin derived from Hedera helix (ivy leaf). In industry it is commonly used as a chemical marker for standardization of ivy leaf extracts in pharmaceutical and nutraceutical formulations; it may also be present as a constituent in ivy leaf-based herbal preparations. Because of its saponin nature, it can function as a surfactant or foaming agent, supporting formulation design in cosmetic and cleaning products; it is also used as an analytical reference compound for saponin chemistry and quality control of botanical extracts. Subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 3.19
    methanol 37.55
    isopropanol 1.09
    water 0.15
    ethyl acetate 2.56
    n-propanol 1.8
    acetone 4.68
    n-butanol 0.73
    acetonitrile 1.83
    DMF 66.58
    toluene 0.63
    isobutanol 0.68
    1,4-dioxane 11.69
    methyl acetate 3.6
    THF 20.19
    2-butanone 2.94
    n-pentanol 0.61
    sec-butanol 0.67
    n-hexane 0.02
    ethylene glycol 8.76
    NMP 60.31
    cyclohexane 0.06
    DMSO 57.38
    n-butyl acetate 1.09
    n-octanol 0.92
    chloroform 4.73
    n-propyl acetate 1.13
    acetic acid 38.49
    dichloromethane 4.52
    cyclohexanone 4.06
    propylene glycol 7.3
    isopropyl acetate 1.43
    DMAc 48.8
    2-ethoxyethanol 11.23
    isopentanol 0.44
    n-heptane 0.05
    ethyl formate 3.32
    1,2-dichloroethane 2.0
    n-hexanol 0.58
    2-methoxyethanol 29.7
    isobutyl acetate 0.59
    tetrachloromethane 0.55
    n-pentyl acetate 2.2
    transcutol 21.91
    n-heptanol 1.08
    ethylbenzene 0.23
    MIBK 0.99
    2-propoxyethanol 11.87
    tert-butanol 0.81
    MTBE 0.66
    2-butoxyethanol 8.31
    propionic acid 5.1
    o-xylene 0.47
    formic acid 58.09
    diethyl ether 1.06
    m-xylene 0.44
    p-xylene 0.28
    chlorobenzene 0.73
    dimethyl carbonate 9.41
    n-octane 0.03
    formamide 40.45
    cyclopentanone 10.85
    2-pentanone 1.88
    anisole 1.47
    cyclopentyl methyl ether 2.84
    gamma-butyrolactone 19.94
    1-methoxy-2-propanol 14.29
    pyridine 6.41
    3-pentanone 1.8
    furfural 23.91
    n-dodecane 0.02
    diethylene glycol 18.71
    diisopropyl ether 0.21
    tert-amyl alcohol 0.62
    acetylacetone 7.4
    n-hexadecane 0.02
    acetophenone 2.37
    methyl propionate 4.62
    isopentyl acetate 0.92
    trichloroethylene 7.22
    n-nonanol 0.96
    cyclohexanol 0.68
    benzyl alcohol 2.09
    2-ethylhexanol 0.3
    isooctanol 0.67
    dipropyl ether 0.79
    1,2-dichlorobenzene 0.91
    ethyl lactate 2.97
    propylene carbonate 7.22
    n-methylformamide 28.18
    2-pentanol 0.38
    n-pentane 0.04
    1-propoxy-2-propanol 5.73
    1-methoxy-2-propyl acetate 5.57
    2-(2-methoxypropoxy) propanol 6.61
    mesitylene 0.24
    ε-caprolactone 5.32
    p-cymene 0.22
    epichlorohydrin 15.26
    1,1,1-trichloroethane 1.04
    2-aminoethanol 9.08
    morpholine-4-carbaldehyde 61.9
    sulfolane 45.84
    2,2,4-trimethylpentane 0.02
    2-methyltetrahydrofuran 3.08
    n-hexyl acetate 2.24
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 9.26
    sec-butyl acetate 0.63
    tert-butyl acetate 1.63
    decalin 0.03
    glycerin 25.31
    diglyme 20.34
    acrylic acid 12.44
    isopropyl myristate 0.48
    n-butyric acid 3.65
    acetyl acetate 3.72
    di(2-ethylhexyl) phthalate 1.26
    ethyl propionate 1.23
    nitromethane 51.93
    1,2-diethoxyethane 2.82
    benzonitrile 1.32
    trioctyl phosphate 0.8
    1-bromopropane 0.43
    gamma-valerolactone 40.08
    n-decanol 0.53
    triethyl phosphate 0.97
    4-methyl-2-pentanol 0.25
    propionitrile 1.03
    vinylene carbonate 9.1
    1,1,2-trichlorotrifluoroethane 40.55
    DMS 3.76
    cumene 0.15
    2-octanol 0.52
    2-hexanone 0.99
    octyl acetate 1.03
    limonene 0.28
    1,2-dimethoxyethane 12.13
    ethyl orthosilicate 0.83
    tributyl phosphate 0.66
    diacetone alcohol 4.39
    N,N-dimethylaniline 1.34
    acrylonitrile 3.13
    aniline 1.5
    1,3-propanediol 6.15
    bromobenzene 0.6
    dibromomethane 1.58
    1,1,2,2-tetrachloroethane 4.97
    2-methyl-cyclohexyl acetate 1.03
    tetrabutyl urea 1.27
    diisobutyl methanol 0.21
    2-phenylethanol 1.89
    styrene 0.28
    dioctyl adipate 1.36
    dimethyl sulfate 23.83
    ethyl butyrate 1.03
    methyl lactate 13.28
    butyl lactate 3.54
    diethyl carbonate 0.83
    propanediol butyl ether 9.55
    triethyl orthoformate 1.4
    p-tert-butyltoluene 0.25
    methyl 4-tert-butylbenzoate 4.85
    morpholine 13.21
    tert-butylamine 0.23
    n-dodecanol 0.29
    dimethoxymethane 29.32
    ethylene carbonate 5.03
    cyrene 13.52
    2-ethoxyethyl acetate 6.73
    2-ethylhexyl acetate 0.67
    1,2,4-trichlorobenzene 1.62
    4-methylpyridine 2.97
    dibutyl ether 0.45
    2,6-dimethyl-4-heptanol 0.21
    DEF 5.82
    dimethyl isosorbide 12.04
    tetrachloroethylene 3.95
    eugenol 5.03
    triacetin 6.94
    span 80 6.37
    1,4-butanediol 2.43
    1,1-dichloroethane 1.01
    2-methyl-1-pentanol 0.37
    methyl formate 25.27
    2-methyl-1-butanol 0.47
    n-decane 0.05
    butyronitrile 0.62
    3,7-dimethyl-1-octanol 0.45
    1-chlorooctane 0.24
    1-chlorotetradecane 0.07
    n-nonane 0.04
    undecane 0.03
    tert-butylcyclohexane 0.02
    cyclooctane 0.03
    cyclopentanol 1.53
    tetrahydropyran 2.44
    tert-amyl methyl ether 0.68
    2,5,8-trioxanonane 12.31
    1-hexene 0.09
    2-isopropoxyethanol 4.14
    2,2,2-trifluoroethanol 16.04
    methyl butyrate 1.61

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction