HC Yellow 4

Overview IFRA Request a quote

  • Identifiers

    CAS number
    59820-43-8

    Molecular formula
    C10H14N2O5

    SMILES
    C1=CC(=C(C=C1[N+](=O)[O-])OCCO)NCCO

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 57.38%
    Sweet 37.31%
    Savory 23.62%
    Milky 23.38%
    Vanilla 21.31%
    Alcoholic 19.79%
    Creamy 18.66%
    Fishy 17.81%
    Musk 16.94%
    Bitter 16.52%

     

    Flavor
    Odorless 57.57%
    Bitter 44.97%
    Mild 33.31%
    Bland 28.6%
    Very mild 27.9%
    Sweet-like 25.68%
    Faint 20.94%
    Fruity 20.9%
    Yeast 20.2%
    Orange flower 20.12%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    0.3

    pKa est.
    8.88 (weak base)

    Molecular weight
    242.23 g/mol

    Melting point expt.

    • 284 to 291 °F (NTP, 1992)

    Flash point

    • 230.68 ˚C est.

    Solubility expt.

    • less than 0.1 mg/mL at 68.9 °F (NTP, 1992)

  • Synonyms

    • 59820-43-8
    • 2-((2-(2-Hydroxyethoxy)-4-nitrophenyl)amino)ethanol
    • N,O-Di(2-hydroxyethyl)-2-amino-5-nitrophenol
    • HC Yellow 4
    • HC YELLOW NO. 4
    • Ethanol, 2-[[2-(2-hydroxyethoxy)-4-nitrophenyl]amino]-
    • Colorex HCY4
    • 2-(3-Nitro-6-(beta-hydroxyethylamino)phenoxy)ethanol
    • DTXSID6021458
    • 0N97D5G157
    • DTXCID601458
    • Ethanol, 2-((2-(2-hydroxyethoxy)-4-nitrophenyl)amino)-
    • RefChem:783438
    • 428-840-7
    • NCI-C56019
    • MFCD03265655
    • 2-[2-(2-hydroxyethoxy)-4-nitroanilino]ethanol
    • CCRIS 4258
    • UNII-0N97D5G157
    • HC amarillo 4
    • HC Giallo 4
    • HC Jaune 4
    • Rodol 2G Y4
    • COLIPA B038
    • 2-[2-(2-hydroxyethoxy)-4-nitro-anilino]ethanol
    • SCHEMBL109798
    • CHEMBL1573069
    • SCHEMBL29392721
    • CHEBI:82474
    • 2-({2-[(2-hydroxyethyl)amino]-5-nitrophenyl}oxy)ethanol
    • PNENOUKIPPERMY-UHFFFAOYSA-N
    • HC YELLOW NO. 4 [HSDB]
    • HC YELLOW NO. 4 [IARC]
    • Tox21_201014
    • MSK161170
    • AKOS015890453
    • NCGC00091524-01
    • NCGC00091524-02
    • NCGC00258567-01
    • AS-15897
    • CAS-59820-43-8
    • DB-337605
    • CS-0135935
    • NS00021238
    • C19431
    • O10439
    • 820H438
    • F079465
    • 2-(2-(2-Hydroxyethoxy)-4-nitrophenylamino)ethanol
    • 2-[2-(2-Hydroxyethoxy)-4-nitroanilino]ethan-1-ol
    • Q27155973
    • 2-[[2-(2-Hydroxyethoxy)-4-nitrophenyl]amino]-ethanol
    • 2-((2-(2-Hydroxyethoxy)-4-nitrophenyl)amino)ethan-1-ol
    • 2-(3-NITRO-6-(.BETA.-HYDROXYETHYLAMINO)PHENOXY)ETHANOL
    • 59820-43-8

  • Applications

    HC Yellow 4 (CAS 59820-43-8) is a colorant/pigment used in practical applications such as coatings and paints, inks, and plastics to impart color; it is also evaluated for cosmetic and personal care color formulations under regulatory limits, and may serve as an intermediate or pigment in pigment synthesis, with applications in adhesives and textile dyeing/printing on fabrics.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 14.89
    methanol 39.04
    isopropanol 7.17
    water 6.19
    ethyl acetate 15.52
    n-propanol 8.36
    acetone 46.75
    n-butanol 5.72
    acetonitrile 14.53
    DMF 412.02
    toluene 1.74
    isobutanol 5.31
    1,4-dioxane 15.43
    methyl acetate 20.52
    THF 33.94
    2-butanone 19.13
    n-pentanol 6.12
    sec-butanol 6.22
    n-hexane 0.11
    ethylene glycol 39.07
    NMP 357.95
    cyclohexane 0.27
    DMSO 997.71
    n-butyl acetate 11.25
    n-octanol 4.01
    chloroform 2.6
    n-propyl acetate 12.12
    acetic acid 100.7
    dichloromethane 7.9
    cyclohexanone 38.17
    propylene glycol 26.59
    isopropyl acetate 9.5
    DMAc 466.62
    2-ethoxyethanol 53.05
    isopentanol 6.8
    n-heptane 0.33
    ethyl formate 17.57
    1,2-dichloroethane 10.0
    n-hexanol 5.76
    2-methoxyethanol 84.72
    isobutyl acetate 5.05
    tetrachloromethane 0.52
    n-pentyl acetate 6.2
    transcutol 123.12
    n-heptanol 4.44
    ethylbenzene 1.88
    MIBK 9.52
    2-propoxyethanol 32.24
    tert-butanol 12.28
    MTBE 5.42
    2-butoxyethanol 18.38
    propionic acid 29.95
    o-xylene 3.56
    formic acid 169.24
    diethyl ether 3.01
    m-xylene 2.61
    p-xylene 2.61
    chlorobenzene 2.87
    dimethyl carbonate 27.62
    n-octane 0.18
    formamide 264.16
    cyclopentanone 65.84
    2-pentanone 13.67
    anisole 9.63
    cyclopentyl methyl ether 10.09
    gamma-butyrolactone 104.8
    1-methoxy-2-propanol 48.35
    pyridine 17.53
    3-pentanone 11.86
    furfural 93.4
    n-dodecane 0.19
    diethylene glycol 59.51
    diisopropyl ether 1.48
    tert-amyl alcohol 12.32
    acetylacetone 44.99
    n-hexadecane 0.21
    acetophenone 24.28
    methyl propionate 25.81
    isopentyl acetate 10.11
    trichloroethylene 16.6
    n-nonanol 4.18
    cyclohexanol 7.92
    benzyl alcohol 15.92
    2-ethylhexanol 4.67
    isooctanol 4.07
    dipropyl ether 4.38
    1,2-dichlorobenzene 4.86
    ethyl lactate 23.81
    propylene carbonate 40.36
    n-methylformamide 118.63
    2-pentanol 3.58
    n-pentane 0.1
    1-propoxy-2-propanol 22.59
    1-methoxy-2-propyl acetate 24.45
    2-(2-methoxypropoxy) propanol 34.9
    mesitylene 2.24
    ε-caprolactone 39.06
    p-cymene 2.96
    epichlorohydrin 54.8
    1,1,1-trichloroethane 2.57
    2-aminoethanol 35.29
    morpholine-4-carbaldehyde 165.66
    sulfolane 272.33
    2,2,4-trimethylpentane 0.22
    2-methyltetrahydrofuran 15.84
    n-hexyl acetate 9.3
    isooctane 0.13
    2-(2-butoxyethoxy)ethanol 35.66
    sec-butyl acetate 6.95
    tert-butyl acetate 12.66
    decalin 0.32
    glycerin 79.75
    diglyme 71.56
    acrylic acid 51.38
    isopropyl myristate 4.09
    n-butyric acid 21.17
    acetyl acetate 16.47
    di(2-ethylhexyl) phthalate 9.5
    ethyl propionate 11.76
    nitromethane 214.12
    1,2-diethoxyethane 14.05
    benzonitrile 11.54
    trioctyl phosphate 6.32
    1-bromopropane 1.73
    gamma-valerolactone 106.56
    n-decanol 3.33
    triethyl phosphate 12.15
    4-methyl-2-pentanol 3.11
    propionitrile 7.48
    vinylene carbonate 36.8
    1,1,2-trichlorotrifluoroethane 84.69
    DMS 22.89
    cumene 1.88
    2-octanol 2.56
    2-hexanone 9.89
    octyl acetate 6.27
    limonene 4.17
    1,2-dimethoxyethane 54.2
    ethyl orthosilicate 9.52
    tributyl phosphate 8.06
    diacetone alcohol 32.82
    N,N-dimethylaniline 11.88
    acrylonitrile 22.76
    aniline 7.32
    1,3-propanediol 31.06
    bromobenzene 2.13
    dibromomethane 2.98
    1,1,2,2-tetrachloroethane 12.35
    2-methyl-cyclohexyl acetate 12.37
    tetrabutyl urea 14.29
    diisobutyl methanol 3.27
    2-phenylethanol 12.4
    styrene 2.11
    dioctyl adipate 12.02
    dimethyl sulfate 114.82
    ethyl butyrate 12.19
    methyl lactate 46.97
    butyl lactate 13.94
    diethyl carbonate 11.46
    propanediol butyl ether 25.55
    triethyl orthoformate 10.79
    p-tert-butyltoluene 2.81
    methyl 4-tert-butylbenzoate 22.47
    morpholine 30.86
    tert-butylamine 3.46
    n-dodecanol 2.62
    dimethoxymethane 58.84
    ethylene carbonate 26.03
    cyrene 55.46
    2-ethoxyethyl acetate 16.02
    2-ethylhexyl acetate 7.43
    1,2,4-trichlorobenzene 8.23
    4-methylpyridine 16.69
    dibutyl ether 3.35
    2,6-dimethyl-4-heptanol 3.27
    DEF 58.02
    dimethyl isosorbide 51.35
    tetrachloroethylene 8.02
    eugenol 24.02
    triacetin 27.07
    span 80 22.42
    1,4-butanediol 19.38
    1,1-dichloroethane 2.56
    2-methyl-1-pentanol 6.85
    methyl formate 82.54
    2-methyl-1-butanol 6.42
    n-decane 0.28
    butyronitrile 5.86
    3,7-dimethyl-1-octanol 4.81
    1-chlorooctane 1.29
    1-chlorotetradecane 0.68
    n-nonane 0.23
    undecane 0.22
    tert-butylcyclohexane 0.25
    cyclooctane 0.16
    cyclopentanol 11.52
    tetrahydropyran 6.52
    tert-amyl methyl ether 6.57
    2,5,8-trioxanonane 57.09
    1-hexene 0.53
    2-isopropoxyethanol 26.82
    2,2,2-trifluoroethanol 55.65
    methyl butyrate 18.52

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction