HC Orange No. 1

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  • Identifiers

    CAS number
    54381-08-7

    Molecular formula
    C12H10N2O3

    SMILES
    C1=CC=C(C(=C1)NC2=CC=C(C=C2)O)[N+](=O)[O-]

    Safety labels

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Fruity 45.95%
    Sweet 42.97%
    Grape 41.67%
    Odorless 36.92%
    Floral 32.36%
    Phenolic 29.65%
    Bitter 28.3%
    Animal 27.54%
    Powdery 25.63%
    Neroli 25.33%

     

    Flavor
    Bitter 69.09%
    Odorless 40.37%
    Mild 33.14%
    Fruity 23.47%
    Nitrile 21.19%
    Orange flower 21.1%
    Orange blossom 20.71%
    Very strong 20.66%
    Indole 20.42%
    Sweet-like 19.98%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.3

    pKa est.
    8.94 (weak base)

    Molecular weight
    230.22 g/mol

    Flash point

    • 198.62 ˚C est.

  • Synonyms

    • 54381-08-7
    • 4-((2-Nitrophenyl)amino)phenol
    • HC Orange 1
    • HC Orange no. 1
    • Phenol, 4-[(2-nitrophenyl)amino]-
    • 2-Nitro-4'-hydroxydiphenylamine
    • 4-[(2-nitrophenyl)amino]phenol
    • Phenol, 4-((2-nitrophenyl)amino)-
    • COLOREX HCO1
    • EINECS 259-132-4
    • Z92U49184U
    • 4'-HYDROXY-2-NITRODIPHENYLAMINE
    • DTXSID0068949
    • UNII-Z92U49184U
    • N-(4-HYDROXYPHENYL)-2-NITROANILINE
    • RefChem:145369
    • DTXCID5041695
    • HC ORANGE NO. 1 [INCI]
    • 259-132-4
    • 4-(2-nitroanilino)phenol
    • 4-(2-nitroanilino)benzenol
    • MFCD00239470
    • HC orange No 1
    • p-((o-Nitrophenyl)amino)phenol
    • 4-[(2-Nitrophenyl)amino]-phenol
    • MLS000736169
    • SCHEMBL109703
    • 4-hydroxy-2'-nitrodiphenylamine
    • CHEMBL1339868
    • HSDSBIUUVWRHTM-UHFFFAOYSA-N
    • REGID_for_CID_3846708
    • AKOS015915469
    • MS-3693
    • SB66559
    • NCGC00246574-01
    • SMR000338719
    • SY122322
    • DB-052551
    • CS-0156623
    • N1185
    • NS00013728
    • H11041
    • SR-01000310185
    • SR-01000310185-1
    • Q27295165
    • 54381-08-7

  • Applications

    HC Orange No. 1 (CAS 54381-08-7) is an azo-based synthetic dye used as a colorant in polymers and plastics, in coatings and printing inks, and for textile dyeing. It also functions as a dye intermediate in the synthesis of related colorants. Additionally, it may be employed as a staining or analytical indicator dye in laboratory and process-analytics applications, with performance and handling governed by formulation and regulatory constraints.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 18.79
    methanol 22.48
    isopropanol 11.0
    water 0.02
    ethyl acetate 95.66
    n-propanol 14.81
    acetone 173.02
    n-butanol 12.06
    acetonitrile 55.04
    DMF 238.85
    toluene 12.42
    isobutanol 8.17
    1,4-dioxane 77.0
    methyl acetate 140.56
    THF 249.31
    2-butanone 209.93
    n-pentanol 14.15
    sec-butanol 17.68
    n-hexane 0.04
    ethylene glycol 10.43
    NMP 118.2
    cyclohexane 0.05
    DMSO 311.2
    n-butyl acetate 50.34
    n-octanol 6.67
    chloroform 8.92
    n-propyl acetate 57.06
    acetic acid 39.9
    dichloromethane 11.79
    cyclohexanone 85.75
    propylene glycol 17.91
    isopropyl acetate 50.29
    DMAc 449.66
    2-ethoxyethanol 68.75
    isopentanol 16.59
    n-heptane 0.16
    ethyl formate 34.02
    1,2-dichloroethane 25.84
    n-hexanol 15.38
    2-methoxyethanol 124.77
    isobutyl acetate 25.02
    tetrachloromethane 0.59
    n-pentyl acetate 19.39
    transcutol 454.4
    n-heptanol 8.3
    ethylbenzene 7.91
    MIBK 47.1
    2-propoxyethanol 67.66
    tert-butanol 25.9
    MTBE 32.8
    2-butoxyethanol 36.53
    propionic acid 33.63
    o-xylene 9.14
    formic acid 21.71
    diethyl ether 18.23
    m-xylene 7.91
    p-xylene 9.5
    chlorobenzene 10.32
    dimethyl carbonate 56.16
    n-octane 0.08
    formamide 103.46
    cyclopentanone 182.33
    2-pentanone 87.17
    anisole 49.12
    cyclopentyl methyl ether 36.87
    gamma-butyrolactone 195.01
    1-methoxy-2-propanol 91.28
    pyridine 70.15
    3-pentanone 67.42
    furfural 115.82
    n-dodecane 0.23
    diethylene glycol 65.77
    diisopropyl ether 5.31
    tert-amyl alcohol 32.02
    acetylacetone 154.21
    n-hexadecane 0.28
    acetophenone 56.37
    methyl propionate 91.46
    isopentyl acetate 42.53
    trichloroethylene 67.97
    n-nonanol 7.66
    cyclohexanol 11.09
    benzyl alcohol 34.74
    2-ethylhexanol 12.11
    isooctanol 7.93
    dipropyl ether 15.19
    1,2-dichlorobenzene 11.34
    ethyl lactate 35.76
    propylene carbonate 68.15
    n-methylformamide 88.35
    2-pentanol 9.88
    n-pentane 0.03
    1-propoxy-2-propanol 50.99
    1-methoxy-2-propyl acetate 79.32
    2-(2-methoxypropoxy) propanol 67.79
    mesitylene 4.5
    ε-caprolactone 80.89
    p-cymene 7.24
    epichlorohydrin 208.06
    1,1,1-trichloroethane 12.57
    2-aminoethanol 20.35
    morpholine-4-carbaldehyde 146.38
    sulfolane 188.98
    2,2,4-trimethylpentane 0.32
    2-methyltetrahydrofuran 79.64
    n-hexyl acetate 28.24
    isooctane 0.23
    2-(2-butoxyethoxy)ethanol 88.34
    sec-butyl acetate 39.71
    tert-butyl acetate 59.99
    decalin 0.35
    glycerin 39.38
    diglyme 179.4
    acrylic acid 36.37
    isopropyl myristate 13.92
    n-butyric acid 34.7
    acetyl acetate 51.11
    di(2-ethylhexyl) phthalate 15.44
    ethyl propionate 56.39
    nitromethane 215.76
    1,2-diethoxyethane 72.39
    benzonitrile 31.99
    trioctyl phosphate 10.14
    1-bromopropane 4.5
    gamma-valerolactone 176.96
    n-decanol 6.38
    triethyl phosphate 22.57
    4-methyl-2-pentanol 9.57
    propionitrile 34.99
    vinylene carbonate 51.09
    1,1,2-trichlorotrifluoroethane 103.26
    DMS 54.94
    cumene 5.68
    2-octanol 5.1
    2-hexanone 60.57
    octyl acetate 17.24
    limonene 8.93
    1,2-dimethoxyethane 139.48
    ethyl orthosilicate 18.9
    tributyl phosphate 14.19
    diacetone alcohol 89.23
    N,N-dimethylaniline 26.66
    acrylonitrile 64.84
    aniline 26.06
    1,3-propanediol 31.76
    bromobenzene 7.39
    dibromomethane 3.98
    1,1,2,2-tetrachloroethane 50.21
    2-methyl-cyclohexyl acetate 29.53
    tetrabutyl urea 22.06
    diisobutyl methanol 9.38
    2-phenylethanol 31.37
    styrene 9.86
    dioctyl adipate 27.82
    dimethyl sulfate 109.45
    ethyl butyrate 40.64
    methyl lactate 61.74
    butyl lactate 26.33
    diethyl carbonate 29.28
    propanediol butyl ether 39.66
    triethyl orthoformate 27.25
    p-tert-butyltoluene 6.61
    methyl 4-tert-butylbenzoate 40.77
    morpholine 99.47
    tert-butylamine 7.83
    n-dodecanol 5.08
    dimethoxymethane 134.03
    ethylene carbonate 38.27
    cyrene 57.31
    2-ethoxyethyl acetate 51.9
    2-ethylhexyl acetate 31.05
    1,2,4-trichlorobenzene 20.14
    4-methylpyridine 60.67
    dibutyl ether 13.67
    2,6-dimethyl-4-heptanol 9.38
    DEF 92.23
    dimethyl isosorbide 103.79
    tetrachloroethylene 17.39
    eugenol 41.95
    triacetin 55.4
    span 80 36.83
    1,4-butanediol 11.55
    1,1-dichloroethane 12.35
    2-methyl-1-pentanol 19.4
    methyl formate 69.03
    2-methyl-1-butanol 14.97
    n-decane 0.29
    butyronitrile 23.61
    3,7-dimethyl-1-octanol 11.95
    1-chlorooctane 2.8
    1-chlorotetradecane 1.56
    n-nonane 0.18
    undecane 0.26
    tert-butylcyclohexane 0.44
    cyclooctane 0.03
    cyclopentanol 14.8
    tetrahydropyran 42.41
    tert-amyl methyl ether 32.4
    2,5,8-trioxanonane 128.51
    1-hexene 0.93
    2-isopropoxyethanol 47.49
    2,2,2-trifluoroethanol 18.89
    methyl butyrate 70.18

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction