HC Blue 2

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  • Identifiers

    CAS number
    33229-34-4

    Molecular formula
    C12H19N3O5

    SMILES
    C1=CC(=C(C=C1N(CCO)CCO)[N+](=O)[O-])NCCO

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 51.45%
    Sweet 44.72%
    Fishy 29.81%
    Savory 24.6%
    Alcoholic 20.58%
    Animal 18.47%
    Cooling 18.46%
    Milky 18.44%
    Bitter 17.55%
    Musk 16.99%

     

    Flavor
    Odorless 64.23%
    Bitter 49.74%
    Mild 34.45%
    Bland 28.76%
    Sweet-like 26.87%
    Very mild 23.69%
    Yeast 20.83%
    Very slight 19.94%
    Orange flower 19.83%
    Faint 19.55%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    0.4

    pKa est.
    8.18 (weak base)

    Molecular weight
    285.3 g/mol

    Melting point expt.

    • 182 to 194 °F (NTP, 1992)
    • 93-98 °C (98% pure)

    Flash point

    • 277.22 ˚C est.

    Solubility expt.

    • less than 1 mg/mL at 75 °F (NTP, 1992)
    • Soluble in water, ethanol, methanol and acetone

  • Synonyms

    • 33229-34-4
    • HC Blue no. 2
    • HC Blue 2
    • NCI-C54897
    • DTXSID6020193
    • 6C0EL1931V
    • Ethanol, 2,2'-((4-((2-hydroxyethyl)amino)-3-nitrophenyl)imino)di-
    • DTXCID80193
    • N1,N4,N4-Tris(2-hydroxyethyl)-2-nitro-p-phenylenediamine
    • COVARINE BLUE W 6122
    • p-Phenylenediamine, 3-nitro-N(sup 1),N(sup 1),N(sup 4)-tris(2-hydroxyethyl)-
    • RefChem:145365
    • 251-410-3
    • 2,2'-[4-(2-Hydroxyethylamino)-3-nitrophenylimino]diethanol
    • 2,2'-((4-((2-Hydroxyethyl)amino)-3-nitrophenyl)azanediyl)diethanol
    • 2-[4-[bis(2-hydroxyethyl)amino]-2-nitroanilino]ethanol
    • 2,2'-((4-((2-Hydroxyethyl)amino)-3-nitrophenyl)imino)bisethanol
    • MFCD00071762
    • Ethanol, 2,2'-((4-((2-hydroxyethyl)amino)-3-nitrophenyl)imino)bis-
    • 2,2'-((4-((2-Hydroxyethyl)amino)-3-nitrophenyl)imino)bis(ethanol)
    • N,N',N'-Tris(2-hydroxyethyl)-2-nitro-p-phenylenediamine
    • N1,N4,N4-Tris(2'-hydroxyethyl)-2-nitro-p-phenylenediamine
    • HC BLUE #2
    • CAS-33229-34-4
    • CCRIS 1358
    • HSDB 4213
    • EINECS 251-410-3
    • HC BLUE NO.2
    • BRN 2148848
    • UNII-6C0EL1931V
    • 2,2'-(4-(2-HYDROXYETHYLAMINO)-3-NITROPHENYLIMINO)DIETHANOL
    • 2,2'-[[4-[(2-Hydroxyethyl)amino]-3-nitrophenyl]imino]bis[ethanol]
    • HC Azul 2
    • HC Bleu 2
    • COLOREX HCB2
    • 3-Nitro-N(sup 1),N(sup 1),N(sup 4)-tris(2-hydroxyethyl)-
    • HC Blu 2
    • JAROCOL BLUE 2
    • EC 251-410-3
    • N(sup 1),N(sup 4),N(sup 4)-Tris(2-hydroxyethyl)-2-nitro-para-phenylenediamine
    • SCHEMBL109266
    • HC BLUE NO.2 [HSDB]
    • CHEMBL1561876
    • SCHEMBL29829407
    • CHEBI:82472
    • 2-[4-[bis(2-hydroxyethyl)amino]-2-nitro-anilino]ethanol
    • HC BLUE NO. 2 [IARC]
    • MIWUTEVJIISHCP-UHFFFAOYSA-N
    • 2,2'-({4-[(2-hydroxyethyl)amino]-3-nitrophenyl}imino)diethanol
    • COVARIANE BLEU W 6122 LP
    • Tox21_202257
    • Tox21_302947
    • AKOS015895598
    • AC-8293
    • CS-W012231
    • NCGC00091249-01
    • NCGC00091249-02
    • NCGC00091249-03
    • NCGC00091249-04
    • NCGC00256575-01
    • NCGC00259806-01
    • AS-11935
    • DB-048365
    • NS00004134
    • T2787
    • C19429
    • 229H344
    • Q27155970
    • N1,N4,N4-Tris(2-hydroxyethyl)-2-nitro-1,4-phenylenediamine
    • 2,2'-[[4-[(2-Hydroxyethyl)amino]-3-nitrophenyl]imino]bis-ethanol
    • 2,2'-[4-(2-Hydroxyethylamino)-3-nitrophenylimino]diethanol, 98%
    • 2,2'-({4-[(2-Hydroxyethyl)amino]-3-nitrophenyl}azanediyl)di(ethan-1-ol)
    • 2,2 inverted exclamation mark -(4-(2-hydroxyethylamino)-3-nitro-phenylimino
    • 33229-34-4

  • Applications

    HC Blue 2 (CAS 33229-34-4) is a blue colorant used across multiple industries: dyeing and printing on textiles and leather, colorant for plastics and polymers, inks and coatings for printing and packaging, colorant for paper and packaging applications; it also may be viewed as a color intermediate in dye synthesis and production, subject to applicable regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 3.37
    methanol 11.88
    isopropanol 1.51
    water 9.62
    ethyl acetate 3.58
    n-propanol 2.54
    acetone 4.45
    n-butanol 1.9
    acetonitrile 3.0
    DMF 71.44
    toluene 0.79
    isobutanol 1.69
    1,4-dioxane 3.12
    methyl acetate 4.27
    THF 6.59
    2-butanone 3.56
    n-pentanol 2.1
    sec-butanol 1.64
    n-hexane 0.08
    ethylene glycol 19.1
    NMP 149.28
    cyclohexane 0.15
    DMSO 226.67
    n-butyl acetate 2.76
    n-octanol 0.93
    chloroform 1.86
    n-propyl acetate 2.4
    acetic acid 34.86
    dichloromethane 3.69
    cyclohexanone 12.19
    propylene glycol 12.94
    isopropyl acetate 2.28
    DMAc 146.53
    2-ethoxyethanol 16.82
    isopentanol 2.06
    n-heptane 0.15
    ethyl formate 5.18
    1,2-dichloroethane 4.07
    n-hexanol 2.06
    2-methoxyethanol 30.85
    isobutyl acetate 1.29
    tetrachloromethane 0.71
    n-pentyl acetate 1.59
    transcutol 23.03
    n-heptanol 1.38
    ethylbenzene 0.75
    MIBK 2.24
    2-propoxyethanol 12.59
    tert-butanol 2.72
    MTBE 0.82
    2-butoxyethanol 6.44
    propionic acid 12.44
    o-xylene 1.5
    formic acid 100.47
    diethyl ether 0.68
    m-xylene 1.13
    p-xylene 1.09
    chlorobenzene 1.15
    dimethyl carbonate 7.12
    n-octane 0.08
    formamide 97.82
    cyclopentanone 16.34
    2-pentanone 2.75
    anisole 1.74
    cyclopentyl methyl ether 2.92
    gamma-butyrolactone 33.8
    1-methoxy-2-propanol 14.11
    pyridine 4.91
    3-pentanone 3.21
    furfural 30.13
    n-dodecane 0.06
    diethylene glycol 28.13
    diisopropyl ether 0.42
    tert-amyl alcohol 2.88
    acetylacetone 8.6
    n-hexadecane 0.07
    acetophenone 5.77
    methyl propionate 6.55
    isopentyl acetate 2.79
    trichloroethylene 7.11
    n-nonanol 1.04
    cyclohexanol 3.07
    benzyl alcohol 5.16
    2-ethylhexanol 1.56
    isooctanol 1.26
    dipropyl ether 1.2
    1,2-dichlorobenzene 1.92
    ethyl lactate 7.65
    propylene carbonate 14.59
    n-methylformamide 32.16
    2-pentanol 0.98
    n-pentane 0.07
    1-propoxy-2-propanol 7.16
    1-methoxy-2-propyl acetate 7.23
    2-(2-methoxypropoxy) propanol 10.59
    mesitylene 0.88
    ε-caprolactone 14.54
    p-cymene 1.22
    epichlorohydrin 13.83
    1,1,1-trichloroethane 1.8
    2-aminoethanol 16.84
    morpholine-4-carbaldehyde 56.09
    sulfolane 93.75
    2,2,4-trimethylpentane 0.09
    2-methyltetrahydrofuran 3.42
    n-hexyl acetate 1.85
    isooctane 0.05
    2-(2-butoxyethoxy)ethanol 10.77
    sec-butyl acetate 1.63
    tert-butyl acetate 2.99
    decalin 0.16
    glycerin 44.44
    diglyme 17.63
    acrylic acid 21.01
    isopropyl myristate 1.03
    n-butyric acid 8.36
    acetyl acetate 4.58
    di(2-ethylhexyl) phthalate 2.95
    ethyl propionate 2.91
    nitromethane 44.18
    1,2-diethoxyethane 2.85
    benzonitrile 3.63
    trioctyl phosphate 1.94
    1-bromopropane 0.87
    gamma-valerolactone 33.31
    n-decanol 0.84
    triethyl phosphate 4.53
    4-methyl-2-pentanol 0.92
    propionitrile 2.55
    vinylene carbonate 14.07
    1,1,2-trichlorotrifluoroethane 40.2
    DMS 6.1
    cumene 0.78
    2-octanol 0.7
    2-hexanone 2.2
    octyl acetate 1.48
    limonene 1.45
    1,2-dimethoxyethane 11.08
    ethyl orthosilicate 3.55
    tributyl phosphate 2.46
    diacetone alcohol 9.34
    N,N-dimethylaniline 2.74
    acrylonitrile 6.23
    aniline 2.68
    1,3-propanediol 14.82
    bromobenzene 0.88
    dibromomethane 1.89
    1,1,2,2-tetrachloroethane 5.97
    2-methyl-cyclohexyl acetate 4.14
    tetrabutyl urea 4.75
    diisobutyl methanol 1.04
    2-phenylethanol 4.55
    styrene 0.71
    dioctyl adipate 2.92
    dimethyl sulfate 32.08
    ethyl butyrate 3.26
    methyl lactate 17.28
    butyl lactate 4.35
    diethyl carbonate 3.47
    propanediol butyl ether 7.23
    triethyl orthoformate 3.33
    p-tert-butyltoluene 1.08
    methyl 4-tert-butylbenzoate 7.23
    morpholine 6.42
    tert-butylamine 0.9
    n-dodecanol 0.68
    dimethoxymethane 9.59
    ethylene carbonate 10.04
    cyrene 23.95
    2-ethoxyethyl acetate 3.49
    2-ethylhexyl acetate 2.15
    1,2,4-trichlorobenzene 3.15
    4-methylpyridine 4.32
    dibutyl ether 0.67
    2,6-dimethyl-4-heptanol 1.04
    DEF 13.07
    dimethyl isosorbide 19.48
    tetrachloroethylene 4.54
    eugenol 8.53
    triacetin 6.64
    span 80 7.22
    1,4-butanediol 8.81
    1,1-dichloroethane 1.33
    2-methyl-1-pentanol 2.32
    methyl formate 18.97
    2-methyl-1-butanol 2.07
    n-decane 0.09
    butyronitrile 1.8
    3,7-dimethyl-1-octanol 1.18
    1-chlorooctane 0.37
    1-chlorotetradecane 0.21
    n-nonane 0.08
    undecane 0.08
    tert-butylcyclohexane 0.12
    cyclooctane 0.09
    cyclopentanol 4.33
    tetrahydropyran 1.54
    tert-amyl methyl ether 1.34
    2,5,8-trioxanonane 17.1
    1-hexene 0.28
    2-isopropoxyethanol 7.59
    2,2,2-trifluoroethanol 30.98
    methyl butyrate 4.17

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction