Guanidinoacetic Acid

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  • Identifiers

    CAS number
    352-97-6

    Molecular formula
    C3H7N3O2

    SMILES
    C(C(=O)O)N=C(N)N

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 70.03%
    Meaty 28.86%
    Savory 28.2%
    Fishy 24.37%
    Cooked 20.63%
    Cheesy 20.18%
    Pungent 19.41%
    Sulfurous 17.21%
    Roasted 16.66%
    Ripe 14.1%

     

    Flavor
    Odorless 57.28%
    Mild 30.88%
    Bland 24.82%
    Bitter 22.87%
    Yeast 22.07%
    Sour 21.78%
    Cooked 21.43%
    Mousy 21.0%
    Nutty 20.87%
    Very mild 20.59%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -1.6

    pKa est.
    8.7 (weak base)

    Molecular weight
    117.11 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    308°C

    Flash point

    • 144.98 ˚C est.

    Solubility expt.

    • 3.6 mg/mL at 15 °C

  • Synonyms

    • glycocyamine
    • 352-97-6
    • guanidinoacetic acid
    • Guanidineacetic acid
    • Guanidoacetic acid
    • N-amidinoglycine
    • Betacyamine
    • Guanyl glycine
    • Betasyamine
    • guanidinoacetate
    • Guanidylacetic acid
    • GLYCINE, N-AMIDINO-
    • Guanidine, (carboxymethyl)-
    • glycine, N-(aminoiminomethyl)-
    • amidinoglycine
    • Acetic acid, ((aminoiminomethyl)amino)-
    • 2-(diaminomethylideneamino)acetic acid
    • 2-carbamimidamidoacetic acid
    • N-(aminoiminomethyl)-glycine
    • GO52O1A04E
    • NSC1901
    • NSC-1901
    • NSC-26360
    • NSC-227847
    • CHEBI:16344
    • 2-[[Amino(imino)methyl]amino]acetic acid
    • 2-((AMINO(IMINO)METHYL)AMINO)ACETIC ACID
    • Acetic acid, [(aminoiminomethyl)amino]-
    • 2-{[amino(imino)methyl]amino}acetic acid
    • CHEBI:131444
    • 2-([AMINO(IMINO)METHYL]AMINO)ACETIC ACID
    • RefChem:663881
    • 206-529-5
    • 2-(diaminomethylideneazaniumyl)acetate
    • 2-Guanidinoacetic acid
    • Glykocyamin
    • N-Guanylglycine
    • N-[AMINO(IMINO)METHYL]GLYCINE
    • N-carbamimidoylglycine
    • N-(Aminoiminomethyl)glycine
    • GUANIDINO ACETATE
    • MFCD00004278
    • N-(carbamimidoyl)glycine
    • NSC 1901
    • (carbamimidamido)acetic acid
    • .alpha.-Guanidinoacetic acid
    • CHEMBL281593
    • n-amidino-glycine
    • NMG
    • EINECS 206-529-5
    • UNII-GO52O1A04E
    • Glucocyamine
    • Guanidoacetate
    • Guanidylacetate
    • Guanidineacetate
    • AI3-17119
    • a-Guanidinoacetate
    • b-Guanidinoacetate
    • beta-Guanidinoacetate
    • guanidine acetic acid
    • alpha-Guanidinoacetate
    • a-Guanidinoacetic acid
    • b-Guanidinoacetic acid
    • beta-Guanidinoacetic acid
    • GUANIDOACETIC_ACID
    • (carboxymethyl)-Guanidine
    • alpha-Guanidinoacetic acid
    • GLYCOCYAMINE [MI]
    • bmse000384
    • Guanidineacetic acid, 99%
    • 2-(amidinoamino)acetic acid
    • SCHEMBL33970
    • SCHEMBL33971
    • 2-carbamimidamido-acetic acid
    • GLYCOCYAMINE [WHO-DD]
    • Glycine, N-amidino- (8CI)
    • GTPL5325
    • orb1303032
    • SCHEMBL11866140
    • SCHEMBL30542331
    • (Diaminomethylenamino)-essigsaure
    • DTXSID50861885
    • MSK8334
    • [(aminoiminomethyl)amino]-Acetate
    • HMS3604I10
    • GAA; Glycocyamine; Guanidinoacetate
    • NSC26360
    • AC2229
    • BDBM50021601
    • EBC-47551
    • NSC 26360
    • NSC227847
    • s6340
    • SBB028198
    • STL164350
    • [(aminoiminomethyl)amino]-Acetic acid
    • 2-[[Amino(imino)methyl]amino]acetate
    • AKOS005363765
    • DB02751
    • FG23711
    • HY-W021448
    • 2-[(diaminomethylidene)amino]acetic acid
    • ([Amino(imino)methyl]amino)acetic acid #
    • AS-10760
    • SY015122
    • DB-069193
    • CS-0040590
    • G0167
    • NS00009387
    • EN300-49151
    • C00581
    • F450285
    • Q2740979
    • Z586248684
    • 352-97-6

  • Applications

    Guanidinoacetic acid (CAS 352-97-6) has practical applications as a chemical intermediate and reagent across several sectors. In animal nutrition, it is evaluated as a feed additive to support growth performance in poultry and other livestock. In pharmaceutical development and biochemical research, it serves as a substrate and reagent for studies of creatine biosynthesis and guanidino-group chemistry. In industrial manufacturing, it functions as a building block for creatine-related derivatives and other specialty guanidino compounds, enabling scalable synthesis routes. In laboratory settings, it is used as a biochemical reagent for enzymology and related guanidino-chemistry investigations. Subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.11
    methanol 0.35
    isopropanol 0.04
    water 2.29
    ethyl acetate 0.03
    n-propanol 0.06
    acetone 0.04
    n-butanol 0.04
    acetonitrile 0.04
    DMF 3.13
    toluene 0.01
    isobutanol 0.04
    1,4-dioxane 0.07
    methyl acetate 0.05
    THF 0.26
    2-butanone 0.03
    n-pentanol 0.03
    sec-butanol 0.03
    n-hexane 0.01
    ethylene glycol 0.83
    NMP 2.86
    cyclohexane 0.0
    DMSO 3.14
    n-butyl acetate 0.07
    n-octanol 0.03
    chloroform 0.07
    n-propyl acetate 0.04
    acetic acid 0.32
    dichloromethane 0.08
    cyclohexanone 0.09
    propylene glycol 0.44
    isopropyl acetate 0.02
    DMAc 2.24
    2-ethoxyethanol 0.33
    isopentanol 0.04
    n-heptane 0.01
    ethyl formate 0.45
    1,2-dichloroethane 0.04
    n-hexanol 0.06
    2-methoxyethanol 1.1
    isobutyl acetate 0.02
    tetrachloromethane 0.06
    n-pentyl acetate 0.04
    transcutol 0.23
    n-heptanol 0.06
    ethylbenzene 0.01
    MIBK 0.03
    2-propoxyethanol 0.48
    tert-butanol 0.06
    MTBE 0.02
    2-butoxyethanol 0.38
    propionic acid 0.14
    o-xylene 0.02
    formic acid 4.3
    diethyl ether 0.01
    m-xylene 0.01
    p-xylene 0.02
    chlorobenzene 0.01
    dimethyl carbonate 0.18
    n-octane 0.0
    formamide 2.37
    cyclopentanone 0.22
    2-pentanone 0.03
    anisole 0.04
    cyclopentyl methyl ether 0.06
    gamma-butyrolactone 0.53
    1-methoxy-2-propanol 0.42
    pyridine 0.08
    3-pentanone 0.03
    furfural 2.22
    n-dodecane 0.0
    diethylene glycol 1.22
    diisopropyl ether 0.01
    tert-amyl alcohol 0.06
    acetylacetone 0.07
    n-hexadecane 0.0
    acetophenone 0.09
    methyl propionate 0.06
    isopentyl acetate 0.06
    trichloroethylene 0.07
    n-nonanol 0.03
    cyclohexanol 0.03
    benzyl alcohol 0.08
    2-ethylhexanol 0.04
    isooctanol 0.04
    dipropyl ether 0.04
    1,2-dichlorobenzene 0.03
    ethyl lactate 0.22
    propylene carbonate 0.46
    n-methylformamide 1.45
    2-pentanol 0.02
    n-pentane 0.0
    1-propoxy-2-propanol 0.28
    1-methoxy-2-propyl acetate 0.14
    2-(2-methoxypropoxy) propanol 0.41
    mesitylene 0.01
    ε-caprolactone 0.16
    p-cymene 0.03
    epichlorohydrin 0.24
    1,1,1-trichloroethane 0.03
    2-aminoethanol 0.67
    morpholine-4-carbaldehyde 2.06
    sulfolane 1.82
    2,2,4-trimethylpentane 0.0
    2-methyltetrahydrofuran 0.07
    n-hexyl acetate 0.04
    isooctane 0.0
    2-(2-butoxyethoxy)ethanol 0.34
    sec-butyl acetate 0.02
    tert-butyl acetate 0.03
    decalin 0.0
    glycerin 2.46
    diglyme 0.84
    acrylic acid 0.27
    isopropyl myristate 0.02
    n-butyric acid 0.14
    acetyl acetate 0.04
    di(2-ethylhexyl) phthalate 0.09
    ethyl propionate 0.05
    nitromethane 0.56
    1,2-diethoxyethane 0.03
    benzonitrile 0.07
    trioctyl phosphate 0.07
    1-bromopropane 0.02
    gamma-valerolactone 0.81
    n-decanol 0.03
    triethyl phosphate 0.17
    4-methyl-2-pentanol 0.02
    propionitrile 0.04
    vinylene carbonate 0.51
    1,1,2-trichlorotrifluoroethane 1.6
    DMS 0.07
    cumene 0.02
    2-octanol 0.03
    2-hexanone 0.03
    octyl acetate 0.03
    limonene 0.02
    1,2-dimethoxyethane 0.72
    ethyl orthosilicate 0.13
    tributyl phosphate 0.08
    diacetone alcohol 0.15
    N,N-dimethylaniline 0.1
    acrylonitrile 0.1
    aniline 0.04
    1,3-propanediol 0.44
    bromobenzene 0.01
    dibromomethane 0.04
    1,1,2,2-tetrachloroethane 0.09
    2-methyl-cyclohexyl acetate 0.08
    tetrabutyl urea 0.18
    diisobutyl methanol 0.03
    2-phenylethanol 0.09
    styrene 0.01
    dioctyl adipate 0.05
    dimethyl sulfate 0.94
    ethyl butyrate 0.07
    methyl lactate 0.47
    butyl lactate 0.2
    diethyl carbonate 0.09
    propanediol butyl ether 0.35
    triethyl orthoformate 0.12
    p-tert-butyltoluene 0.03
    methyl 4-tert-butylbenzoate 0.24
    morpholine 0.13
    tert-butylamine 0.03
    n-dodecanol 0.02
    dimethoxymethane 0.43
    ethylene carbonate 0.28
    cyrene 0.76
    2-ethoxyethyl acetate 0.05
    2-ethylhexyl acetate 0.05
    1,2,4-trichlorobenzene 0.04
    4-methylpyridine 0.1
    dibutyl ether 0.02
    2,6-dimethyl-4-heptanol 0.03
    DEF 0.23
    dimethyl isosorbide 0.86
    tetrachloroethylene 0.1
    eugenol 0.42
    triacetin 0.09
    span 80 0.22
    1,4-butanediol 0.19
    1,1-dichloroethane 0.02
    2-methyl-1-pentanol 0.03
    methyl formate 1.41
    2-methyl-1-butanol 0.04
    n-decane 0.0
    butyronitrile 0.05
    3,7-dimethyl-1-octanol 0.03
    1-chlorooctane 0.01
    1-chlorotetradecane 0.01
    n-nonane 0.0
    undecane 0.0
    tert-butylcyclohexane 0.0
    cyclooctane 0.0
    cyclopentanol 0.08
    tetrahydropyran 0.02
    tert-amyl methyl ether 0.02
    2,5,8-trioxanonane 0.7
    1-hexene 0.01
    2-isopropoxyethanol 0.11
    2,2,2-trifluoroethanol 0.61
    methyl butyrate 0.1

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction