Glyzaglabrin

Overview IFRA Request a quote

  • Identifiers

    CAS number
    65242-64-0

    Molecular formula
    C16H10O6

    SMILES
    C1OC2=C(O1)C(=C(C=C2)C3=COC4=C(C3=O)C=CC(=C4)O)O

    Safety labels

  • Odor profile

    Fragrance
    Phenolic 54.39%
    Odorless 42.71%
    Burnt 34.19%
    Spicy 30.33%
    Vanilla 25.2%
    Smoky 24.51%
    Medicinal 22.97%
    Balsamic 21.59%
    Fruity 21.56%
    Bitter 20.17%

     

    Flavor
    Bitter 97.22%
    Sweet-like 18.98%
    Cedarleaf 18.69%
    Parsley 18.33%
    Lovage 18.3%
    Very strong 18.18%
    Indole 17.88%
    Nitrile 17.52%
    Eugenol 17.49%
    Bland 17.37%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    2.3

    pKa est.
    8.29 (weak base)

    Molecular weight
    298.25 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    663°C

    Flash point

    • 238.9 ˚C est.

  • Synonyms

    • Glyzaglabrin
    • 7,2'-Dihydroxy-3',4'-methylenedioxyisoflavone
    • 7-hydroxy-3-(4-hydroxy-1,3-benzodioxol-5-yl)chromen-4-one
    • RefChem:1086133
    • 65242-64-0
    • SCHEMBL30266739
    • CHEBI:174835
    • DTXSID501164335
    • LMPK12050085
    • C03662
    • 7-Hydroxy-3-(4-hydroxy-1,3-benzodioxol-5-yl)-4H-1-benzopyran-4-one
    • 7-Hydroxy-3-(4-hydroxy-2H-1,3-benzodioxol-5-yl)-4H-1-benzopyran-4-one
    • 65242-64-0

  • Applications

    Glyzaglabrin (CAS 65242-64-0) may serve as an intermediate in organic synthesis and as a solvent/co-solvent in various industrial formulations; it is also evaluated as a fragrance fixative in perfumery and can be used in cosmetics/personal care as a solvent or carrier for aroma compounds and active ingredients; in polymer and plastic formulations it can act as a stabilizer or plasticizer; in coatings and inks it may function as a solvent or processing aid; it could also be considered for household cleaning products where solvency is beneficial. Actual use depends on regulatory requirements and formulation constraints.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.21
    methanol 0.18
    isopropanol 0.49
    water 0.0
    ethyl acetate 0.82
    n-propanol 0.51
    acetone 0.98
    n-butanol 0.63
    acetonitrile 0.57
    DMF 7.28
    toluene 0.08
    isobutanol 0.42
    1,4-dioxane 3.77
    methyl acetate 1.1
    THF 12.3
    2-butanone 2.45
    n-pentanol 0.43
    sec-butanol 0.81
    n-hexane 0.0
    ethylene glycol 0.81
    NMP 4.24
    cyclohexane 0.01
    DMSO 18.76
    n-butyl acetate 0.87
    n-octanol 0.56
    chloroform 0.03
    n-propyl acetate 0.9
    acetic acid 1.25
    dichloromethane 0.05
    cyclohexanone 2.93
    propylene glycol 0.79
    isopropyl acetate 0.99
    DMAc 15.2
    2-ethoxyethanol 5.71
    isopentanol 0.84
    n-heptane 0.01
    ethyl formate 0.48
    1,2-dichloroethane 0.12
    n-hexanol 0.34
    2-methoxyethanol 10.98
    isobutyl acetate 0.5
    tetrachloromethane 0.01
    n-pentyl acetate 1.21
    transcutol 26.77
    n-heptanol 0.6
    ethylbenzene 0.07
    MIBK 1.18
    2-propoxyethanol 6.5
    tert-butanol 0.92
    MTBE 0.61
    2-butoxyethanol 4.16
    propionic acid 0.85
    o-xylene 0.11
    formic acid 1.02
    diethyl ether 0.4
    m-xylene 0.09
    p-xylene 0.11
    chlorobenzene 0.05
    dimethyl carbonate 1.17
    n-octane 0.01
    formamide 3.18
    cyclopentanone 4.65
    2-pentanone 1.44
    anisole 0.64
    cyclopentyl methyl ether 1.37
    gamma-butyrolactone 4.32
    1-methoxy-2-propanol 8.03
    pyridine 1.82
    3-pentanone 1.03
    furfural 3.88
    n-dodecane 0.02
    diethylene glycol 7.67
    diisopropyl ether 0.15
    tert-amyl alcohol 1.12
    acetylacetone 3.0
    n-hexadecane 0.03
    acetophenone 1.11
    methyl propionate 1.3
    isopentyl acetate 1.19
    trichloroethylene 0.27
    n-nonanol 0.78
    cyclohexanol 0.83
    benzyl alcohol 0.88
    2-ethylhexanol 0.44
    isooctanol 0.64
    dipropyl ether 0.78
    1,2-dichlorobenzene 0.09
    ethyl lactate 1.42
    propylene carbonate 1.08
    n-methylformamide 2.03
    2-pentanol 0.59
    n-pentane 0.0
    1-propoxy-2-propanol 5.16
    1-methoxy-2-propyl acetate 3.59
    2-(2-methoxypropoxy) propanol 7.04
    mesitylene 0.06
    ε-caprolactone 2.87
    p-cymene 0.16
    epichlorohydrin 5.69
    1,1,1-trichloroethane 0.05
    2-aminoethanol 1.16
    morpholine-4-carbaldehyde 11.19
    sulfolane 8.86
    2,2,4-trimethylpentane 0.01
    2-methyltetrahydrofuran 2.73
    n-hexyl acetate 1.58
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 8.85
    sec-butyl acetate 0.77
    tert-butyl acetate 1.47
    decalin 0.01
    glycerin 4.96
    diglyme 18.04
    acrylic acid 1.06
    isopropyl myristate 0.94
    n-butyric acid 1.11
    acetyl acetate 0.57
    di(2-ethylhexyl) phthalate 0.98
    ethyl propionate 1.02
    nitromethane 4.34
    1,2-diethoxyethane 4.35
    benzonitrile 0.56
    trioctyl phosphate 0.7
    1-bromopropane 0.06
    gamma-valerolactone 12.73
    n-decanol 0.62
    triethyl phosphate 0.98
    4-methyl-2-pentanol 0.47
    propionitrile 0.71
    vinylene carbonate 0.88
    1,1,2-trichlorotrifluoroethane 5.02
    DMS 1.72
    cumene 0.07
    2-octanol 0.47
    2-hexanone 1.34
    octyl acetate 1.11
    limonene 0.21
    1,2-dimethoxyethane 10.59
    ethyl orthosilicate 0.95
    tributyl phosphate 0.92
    diacetone alcohol 5.01
    N,N-dimethylaniline 0.55
    acrylonitrile 1.35
    aniline 0.51
    1,3-propanediol 2.99
    bromobenzene 0.03
    dibromomethane 0.02
    1,1,2,2-tetrachloroethane 0.31
    2-methyl-cyclohexyl acetate 1.15
    tetrabutyl urea 1.89
    diisobutyl methanol 0.5
    2-phenylethanol 1.0
    styrene 0.06
    dioctyl adipate 1.66
    dimethyl sulfate 2.89
    ethyl butyrate 1.15
    methyl lactate 2.76
    butyl lactate 1.86
    diethyl carbonate 0.76
    propanediol butyl ether 3.65
    triethyl orthoformate 1.69
    p-tert-butyltoluene 0.15
    methyl 4-tert-butylbenzoate 2.22
    morpholine 6.96
    tert-butylamine 0.23
    n-dodecanol 0.49
    dimethoxymethane 5.42
    ethylene carbonate 0.76
    cyrene 4.88
    2-ethoxyethyl acetate 3.15
    2-ethylhexyl acetate 0.81
    1,2,4-trichlorobenzene 0.22
    4-methylpyridine 0.96
    dibutyl ether 1.2
    2,6-dimethyl-4-heptanol 0.5
    DEF 2.88
    dimethyl isosorbide 8.93
    tetrachloroethylene 0.16
    eugenol 2.91
    triacetin 3.05
    span 80 3.69
    1,4-butanediol 0.88
    1,1-dichloroethane 0.05
    2-methyl-1-pentanol 0.62
    methyl formate 1.16
    2-methyl-1-butanol 0.74
    n-decane 0.04
    butyronitrile 0.54
    3,7-dimethyl-1-octanol 0.71
    1-chlorooctane 0.17
    1-chlorotetradecane 0.1
    n-nonane 0.02
    undecane 0.03
    tert-butylcyclohexane 0.01
    cyclooctane 0.0
    cyclopentanol 0.93
    tetrahydropyran 1.55
    tert-amyl methyl ether 0.83
    2,5,8-trioxanonane 13.39
    1-hexene 0.03
    2-isopropoxyethanol 3.62
    2,2,2-trifluoroethanol 0.74
    methyl butyrate 1.24

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction