Glycol Salicylate

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  • Identifiers

    CAS number
    87-28-5

    Molecular formula
    C9H10O4

    SMILES
    C1=CC=C(C(=C1)C(=O)OCCO)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Sweet 56.73%
    Balsamic 51.91%
    Floral 46.08%
    Phenolic 36.56%
    Odorless 35.07%
    Aromatic 30.8%
    Herbal 30.46%
    Vanilla 28.72%
    Powdery 26.64%
    Green 26.13%

     

    Flavor
    Sweet 48.37%
    Odorless 35.17%
    Bitter 34.34%
    Balsam 34.0%
    Mild 33.85%
    Fruity 32.07%
    Floral 31.66%
    Wintergreen 30.92%
    Powdery 30.42%
    Faint 29.02%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    1.9

    pKa est.
    8.17 (weak base)

    Molecular weight
    182.17 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • 25

    Boiling point

    • 166

    Flash point

    • 169.02 ˚C est.

    Solubility expt.

    • 13.1 g/L

  • Synonyms

    • 2-Hydroxyethyl salicylate
    • 87-28-5
    • 2-Hydroxyethyl 2-hydroxybenzoate
    • GLYCOL SALICYLATE
    • Ethylene glycol monosalicylate
    • Glycol monosalicylate
    • Ethylene glycol salicylate
    • hydroxyethyl salicylate
    • Benzoic acid, 2-hydroxy-, 2-hydroxyethyl ester
    • 2-Hydroxybenzoic acid 2-hydroxyethyl ester
    • Salicylic acid, 2-hydroxyethyl ester
    • 3I1VBB7AXH
    • DTXSID4048987
    • 2-hydroxyethyl 2-oxidanylbenzoate
    • NSC-72097
    • 2-Hydroxybenzoic acid, 2-hydroxyethyl ester
    • DTXCID4028913
    • CHEBI:86541
    • RefChem:663897
    • ethyleneglycolmonosalicylic acid ester
    • 201-737-2
    • Espirosal
    • Spirosal
    • Glysal
    • Rheumacyl
    • Sarocol
    • Monoglycol salicylate
    • GL 7
    • Glykolsalicylat
    • Traumasenex
    • Ethylene glycol, salicylate
    • Kytta-gel
    • Ethylene glycol, monosalicylate
    • 1,2-Ethylene glycol monosalicylate
    • Aethylenglykolsalicylat
    • MFCD00002862
    • Ethylene glycol monosali
    • Ethylenglycol-monosalicylsaeureester
    • .beta.-Hydroxyethyl salicylate
    • NCGC00159379-03
    • Glycol salicylate (JAN)
    • GLYCOL SALICYLATE [JAN]
    • UNII-3I1VBB7AXH
    • Hydroxyethylsalylate
    • Norgesic (TN)
    • Phlogont (TN)
    • EINECS 201-737-2
    • Salicylic Acid 2-Hydroxyethyl Ester
    • NSC 72097
    • hydroxy ethyl salicylate
    • AI3-05033
    • 2-hydroxyethyl-salicylate
    • bmse000750
    • Hydroxyethyl salicylate CRS
    • Glycol salicylate (Standard)
    • SCHEMBL15402
    • GLYCOL SALICYLATE [MI]
    • CHEMBL173562
    • orb1707947
    • SCHEMBL1416199
    • SCHEMBL29392370
    • HY-B2208R
    • LVYLCBNXHHHPSB-UHFFFAOYSA-
    • GLYCOL SALICYLATE [MART.]
    • GLYCOL SALICYLATE [WHO-DD]
    • CS-B1707
    • HY-B2208
    • NSC72097
    • Tox21_113462
    • EBC-26155
    • SBB058788
    • AKOS009075810
    • DB11323
    • Salicylic Acid-(2-Hydroxyethyl) Ester
    • CAS-87-28-5
    • NCGC00159379-02
    • NCGC00159379-04
    • DA-69794
    • FE170932
    • SY032913
    • E0113
    • NS00013719
    • Salicylic acid, 2-hydroxyethyl ester (8CI)
    • ST51037997
    • EN300-22340
    • HYDROXYETHYL SALICYLATE [EP MONOGRAPH]
    • D01557
    • E78954
    • SBI-0654048.0001
    • Ethylene glycol monosalicylate, >=98.0% (GC)
    • Q117422
    • SR-01000944719
    • SR-01000944719-1
    • BRD-K41866823-001-01-3
    • Hydroxyethyl salicylate, European Pharmacopoeia (EP) Reference Standard
    • InChI=1/C9H10O4/c10-5-6-13-9(12)7-3-1-2-4-8(7)11/h1-4,10-11H,5-6H2
    • 87-28-5

  • Applications

    Glycol Salicylate is used as a solvent and plasticizer for nitrocellulose-based coatings, inks, and adhesives in industrial manufacturing; it also serves as a solvent and fixative in fragrance formulations; in cosmetics and personal care, it acts as a solvent and emollient; and in the polymer and plastics field, it is used as a processing aid and additive in resin and adhesive formulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 268.03
    methanol 445.59
    isopropanol 186.04
    water 1.55
    ethyl acetate 59.35
    n-propanol 154.46
    acetone 221.28
    n-butanol 124.95
    acetonitrile 76.52
    DMF 1056.55
    toluene 8.48
    isobutanol 83.06
    1,4-dioxane 165.55
    methyl acetate 100.24
    THF 325.12
    2-butanone 117.67
    n-pentanol 81.33
    sec-butanol 116.12
    n-hexane 0.71
    ethylene glycol 196.27
    NMP 439.46
    cyclohexane 1.75
    DMSO 1769.37
    n-butyl acetate 40.85
    n-octanol 33.93
    chloroform 26.25
    n-propyl acetate 47.63
    acetic acid 196.44
    dichloromethane 41.25
    cyclohexanone 137.86
    propylene glycol 175.89
    isopropyl acetate 30.41
    DMAc 632.56
    2-ethoxyethanol 209.23
    isopentanol 89.26
    n-heptane 1.04
    ethyl formate 74.41
    1,2-dichloroethane 61.36
    n-hexanol 57.14
    2-methoxyethanol 518.62
    isobutyl acetate 20.8
    tetrachloromethane 3.58
    n-pentyl acetate 22.11
    transcutol 289.23
    n-heptanol 29.68
    ethylbenzene 9.12
    MIBK 46.28
    2-propoxyethanol 124.39
    tert-butanol 257.53
    MTBE 51.99
    2-butoxyethanol 73.55
    propionic acid 113.16
    o-xylene 11.52
    formic acid 179.38
    diethyl ether 31.52
    m-xylene 10.29
    p-xylene 10.57
    chlorobenzene 16.44
    dimethyl carbonate 55.57
    n-octane 0.62
    formamide 400.08
    cyclopentanone 203.09
    2-pentanone 83.03
    anisole 44.38
    cyclopentyl methyl ether 64.36
    gamma-butyrolactone 246.3
    1-methoxy-2-propanol 294.7
    pyridine 77.79
    3-pentanone 46.35
    furfural 194.52
    n-dodecane 1.09
    diethylene glycol 191.68
    diisopropyl ether 8.14
    tert-amyl alcohol 150.87
    acetylacetone 104.67
    n-hexadecane 1.22
    acetophenone 59.27
    methyl propionate 87.36
    isopentyl acetate 35.63
    trichloroethylene 94.18
    n-nonanol 28.61
    cyclohexanol 84.14
    benzyl alcohol 66.44
    2-ethylhexanol 28.94
    isooctanol 23.94
    dipropyl ether 15.78
    1,2-dichlorobenzene 20.39
    ethyl lactate 56.86
    propylene carbonate 99.62
    n-methylformamide 405.38
    2-pentanol 67.53
    n-pentane 0.78
    1-propoxy-2-propanol 78.05
    1-methoxy-2-propyl acetate 56.16
    2-(2-methoxypropoxy) propanol 79.21
    mesitylene 7.72
    ε-caprolactone 114.18
    p-cymene 9.5
    epichlorohydrin 227.66
    1,1,1-trichloroethane 19.57
    2-aminoethanol 267.98
    morpholine-4-carbaldehyde 285.71
    sulfolane 449.41
    2,2,4-trimethylpentane 1.46
    2-methyltetrahydrofuran 127.22
    n-hexyl acetate 39.7
    isooctane 1.11
    2-(2-butoxyethoxy)ethanol 109.84
    sec-butyl acetate 23.07
    tert-butyl acetate 44.03
    decalin 1.91
    glycerin 282.61
    diglyme 195.32
    acrylic acid 117.21
    isopropyl myristate 15.97
    n-butyric acid 107.47
    acetyl acetate 35.05
    di(2-ethylhexyl) phthalate 23.03
    ethyl propionate 38.01
    nitromethane 370.12
    1,2-diethoxyethane 43.4
    benzonitrile 49.74
    trioctyl phosphate 18.89
    1-bromopropane 15.1
    gamma-valerolactone 231.37
    n-decanol 21.79
    triethyl phosphate 24.08
    4-methyl-2-pentanol 33.84
    propionitrile 60.7
    vinylene carbonate 80.82
    1,1,2-trichlorotrifluoroethane 206.02
    DMS 40.95
    cumene 8.46
    2-octanol 18.54
    2-hexanone 52.24
    octyl acetate 23.1
    limonene 13.99
    1,2-dimethoxyethane 242.46
    ethyl orthosilicate 20.05
    tributyl phosphate 20.52
    diacetone alcohol 126.08
    N,N-dimethylaniline 37.15
    acrylonitrile 107.96
    aniline 41.78
    1,3-propanediol 287.93
    bromobenzene 11.03
    dibromomethane 21.71
    1,1,2,2-tetrachloroethane 83.73
    2-methyl-cyclohexyl acetate 31.03
    tetrabutyl urea 35.3
    diisobutyl methanol 17.01
    2-phenylethanol 49.82
    styrene 10.95
    dioctyl adipate 30.29
    dimethyl sulfate 132.51
    ethyl butyrate 30.76
    methyl lactate 112.74
    butyl lactate 38.15
    diethyl carbonate 25.23
    propanediol butyl ether 89.81
    triethyl orthoformate 23.92
    p-tert-butyltoluene 9.23
    methyl 4-tert-butylbenzoate 50.01
    morpholine 262.59
    tert-butylamine 72.85
    n-dodecanol 16.32
    dimethoxymethane 249.01
    ethylene carbonate 62.13
    cyrene 96.8
    2-ethoxyethyl acetate 37.75
    2-ethylhexyl acetate 23.81
    1,2,4-trichlorobenzene 30.77
    4-methylpyridine 65.69
    dibutyl ether 17.64
    2,6-dimethyl-4-heptanol 17.01
    DEF 162.43
    dimethyl isosorbide 102.23
    tetrachloroethylene 43.26
    eugenol 59.55
    triacetin 45.88
    span 80 58.32
    1,4-butanediol 102.87
    1,1-dichloroethane 26.39
    2-methyl-1-pentanol 58.51
    methyl formate 221.17
    2-methyl-1-butanol 78.1
    n-decane 1.45
    butyronitrile 57.8
    3,7-dimethyl-1-octanol 29.48
    1-chlorooctane 9.12
    1-chlorotetradecane 4.15
    n-nonane 1.17
    undecane 1.23
    tert-butylcyclohexane 1.71
    cyclooctane 0.73
    cyclopentanol 109.02
    tetrahydropyran 83.78
    tert-amyl methyl ether 44.38
    2,5,8-trioxanonane 139.71
    1-hexene 5.26
    2-isopropoxyethanol 102.52
    2,2,2-trifluoroethanol 79.54
    methyl butyrate 66.17

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction