Glycol monoacetate

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  • Identifiers

    CAS number
    542-59-6

    Molecular formula
    C4H8O3

    SMILES
    CC(=O)OCCO

    Safety labels

    Corrosive
    Corrosive

  • Odor profile

    Fragrance
    Fruity 59.6%
    Ethereal 59.57%
    Sweet 40.99%
    Alcoholic 38.49%
    Winey 36.7%
    Caramellic 34.63%
    Solvent 31.98%
    Sharp 30.76%
    Rummy 29.89%
    Pungent 28.42%

     

    Flavor
    Fruity 76.51%
    Bitter 60.33%
    Sweet 54.36%
    Ethereal 38.95%
    Green 38.84%
    Fruit 38.4%
    Tropical 34.59%
    Sharp 32.8%
    Banana 31.75%
    Musty 30.85%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -0.6

    pKa est.
    8.15 (weak base)

    Molecular weight
    104.1 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderate

    Boiling point

    • 358 to 360 °F at 760 mmHg (NTP, 1992)

    Flash point

    • 78.81 ˚C est.
    • 215 °F (NTP, 1992)

    Solubility expt.

    • greater than or equal to 100 mg/mL at 70 °F (NTP, 1992)

  • Synonyms

    • 2-Hydroxyethyl acetate
    • 542-59-6
    • Ethylene glycol monoacetate
    • 2-Acetoxyethanol
    • Glycol monoacetate
    • beta-Hydroxyethyl acetate
    • I49SK86R9L
    • NSC-9234
    • ETHYLENEDIOL MONOACETATE
    • MONOACETYL ETHYLENE GLYCOL
    • DTXSID10862156
    • RefChem:596626
    • DTXCID60810960
    • 208-821-8
    • Acetic acid 2-hydroxyethyl ester
    • 1,2-Ethanediol, monoacetate
    • Ethylenediol, monoacetate
    • Ethylene glycol, monoacetate
    • NSC 9234
    • .beta.-Hydroxyethyl acetate
    • MFCD00002864
    • Glycol, monoacetate
    • 1,2-Ethanediol, 1-acetate
    • 2-Hydroxyethylester kyseliny octove
    • Ethylene glycol, acetate
    • 51901-33-8
    • 65071-98-9
    • 2-hydroxyethylacetate
    • Laneth-9 acetate
    • Laneth-10 acetate
    • 1,2-Ethanediol,acetate
    • EINECS 208-821-8
    • 1,2-Ethanediol, acetate
    • BRN 1743114
    • UNII-I49SK86R9L
    • Glykolmonoacetat
    • AI3-15367
    • CCRIS 2692
    • 2-Hydroxyethylester kyseliny octove [Czech]
    • Glycol-monoacetin
    • EINECS 257-506-1
    • ethyleneglycol monoacetate
    • WLN: Q2OV1
    • SCHEMBL27796
    • SCHEMBL341633
    • SCHEMBL5826341
    • SCHEMBL9765601
    • SCHEMBL10388971
    • HXDLWJWIAHWIKI-UHFFFAOYSA-
    • NSC9234
    • 2-Hydroxyethyl acetate(Technical)
    • acetic acid 2-hydroxy-ethyl ester
    • 2-Hydroxyethyl acetate, AldrichCPR
    • AAA54259
    • 2-Hydroxyethyl ester of acetic acid
    • AKOS006227954
    • ETHYLENE GLYCOL MONOACETATE [MI]
    • SY009391
    • DB-089204
    • A1059
    • CS-0154995
    • NS00013807
    • EN300-97513
    • D88371
    • F046708
    • Q27280417
    • InChI=1/C4H8O3/c1-4(6)7-3-2-5/h5H,2-3H2,1H3
    • 65071-98-9

  • Applications

    Glycol monoacetate (CAS 542-59-6) is primarily used as a solvent in coatings, inks, and industrial cleaning formulations; it also acts as a lightweight plasticizer for certain polymers and resins; serves as an intermediate in chemical syntheses and can function as a solvent or carrier for fragrance materials in perfumery and personal care products; additionally, it is used as a solvent in adhesive formulations and in industrial cleaning and electronics-related cleaning applications.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 303.57
    methanol 610.99
    isopropanol 199.61
    water 394.98
    ethyl acetate 84.0
    n-propanol 186.14
    acetone 236.96
    n-butanol 129.61
    acetonitrile 263.53
    DMF 1163.46
    toluene 17.37
    isobutanol 116.48
    1,4-dioxane 177.02
    methyl acetate 126.84
    THF 194.81
    2-butanone 118.06
    n-pentanol 75.42
    sec-butanol 128.53
    n-hexane 6.52
    ethylene glycol 301.85
    NMP 563.11
    cyclohexane 4.41
    DMSO 1012.1
    n-butyl acetate 28.12
    n-octanol 35.0
    chloroform 80.1
    n-propyl acetate 36.69
    acetic acid 369.9
    dichloromethane 140.92
    cyclohexanone 114.66
    propylene glycol 208.97
    isopropyl acetate 39.27
    DMAc 792.01
    2-ethoxyethanol 245.76
    isopentanol 89.54
    n-heptane 4.56
    ethyl formate 183.34
    1,2-dichloroethane 98.51
    n-hexanol 44.28
    2-methoxyethanol 533.79
    isobutyl acetate 19.7
    tetrachloromethane 17.54
    n-pentyl acetate 22.57
    transcutol 235.32
    n-heptanol 23.77
    ethylbenzene 12.4
    MIBK 41.69
    2-propoxyethanol 132.29
    tert-butanol 200.49
    MTBE 84.13
    2-butoxyethanol 66.92
    propionic acid 180.42
    o-xylene 22.65
    formic acid 601.32
    diethyl ether 59.92
    m-xylene 17.45
    p-xylene 16.86
    chlorobenzene 30.8
    dimethyl carbonate 57.0
    n-octane 2.48
    formamide 536.11
    cyclopentanone 180.06
    2-pentanone 80.08
    anisole 53.06
    cyclopentyl methyl ether 63.82
    gamma-butyrolactone 266.89
    1-methoxy-2-propanol 261.68
    pyridine 95.04
    3-pentanone 55.88
    furfural 350.36
    n-dodecane 2.84
    diethylene glycol 206.67
    diisopropyl ether 13.63
    tert-amyl alcohol 145.18
    acetylacetone 106.19
    n-hexadecane 3.02
    acetophenone 53.86
    methyl propionate 88.67
    isopentyl acetate 26.66
    trichloroethylene 123.24
    n-nonanol 29.68
    cyclohexanol 72.49
    benzyl alcohol 70.39
    2-ethylhexanol 24.21
    isooctanol 19.75
    dipropyl ether 23.09
    1,2-dichlorobenzene 37.39
    ethyl lactate 51.05
    propylene carbonate 116.01
    n-methylformamide 551.2
    2-pentanol 60.63
    n-pentane 7.03
    1-propoxy-2-propanol 71.77
    1-methoxy-2-propyl acetate 43.45
    2-(2-methoxypropoxy) propanol 90.03
    mesitylene 12.48
    ε-caprolactone 113.5
    p-cymene 11.63
    epichlorohydrin 232.27
    1,1,1-trichloroethane 46.6
    2-aminoethanol 335.33
    morpholine-4-carbaldehyde 484.38
    sulfolane 370.19
    2,2,4-trimethylpentane 5.04
    2-methyltetrahydrofuran 111.43
    n-hexyl acetate 38.42
    isooctane 2.88
    2-(2-butoxyethoxy)ethanol 96.89
    sec-butyl acetate 21.8
    tert-butyl acetate 40.25
    decalin 4.62
    glycerin 371.58
    diglyme 185.67
    acrylic acid 206.6
    isopropyl myristate 17.76
    n-butyric acid 153.63
    acetyl acetate 56.55
    di(2-ethylhexyl) phthalate 28.41
    ethyl propionate 42.83
    nitromethane 596.57
    1,2-diethoxyethane 46.95
    benzonitrile 71.74
    trioctyl phosphate 19.49
    1-bromopropane 43.76
    gamma-valerolactone 335.61
    n-decanol 21.98
    triethyl phosphate 26.52
    4-methyl-2-pentanol 32.23
    propionitrile 136.33
    vinylene carbonate 126.72
    1,1,2-trichlorotrifluoroethane 228.57
    DMS 40.96
    cumene 12.51
    2-octanol 18.84
    2-hexanone 40.66
    octyl acetate 23.48
    limonene 16.98
    1,2-dimethoxyethane 336.36
    ethyl orthosilicate 24.2
    tributyl phosphate 23.68
    diacetone alcohol 88.15
    N,N-dimethylaniline 51.39
    acrylonitrile 203.82
    aniline 61.98
    1,3-propanediol 290.51
    bromobenzene 22.75
    dibromomethane 69.69
    1,1,2,2-tetrachloroethane 96.92
    2-methyl-cyclohexyl acetate 25.66
    tetrabutyl urea 40.39
    diisobutyl methanol 17.42
    2-phenylethanol 38.14
    styrene 15.92
    dioctyl adipate 32.84
    dimethyl sulfate 157.69
    ethyl butyrate 29.76
    methyl lactate 113.16
    butyl lactate 35.17
    diethyl carbonate 24.95
    propanediol butyl ether 85.45
    triethyl orthoformate 26.02
    p-tert-butyltoluene 11.61
    methyl 4-tert-butylbenzoate 55.84
    morpholine 221.17
    tert-butylamine 104.85
    n-dodecanol 17.09
    dimethoxymethane 246.85
    ethylene carbonate 93.44
    cyrene 93.91
    2-ethoxyethyl acetate 37.46
    2-ethylhexyl acetate 19.9
    1,2,4-trichlorobenzene 43.89
    4-methylpyridine 115.05
    dibutyl ether 23.77
    2,6-dimethyl-4-heptanol 17.42
    DEF 195.66
    dimethyl isosorbide 111.43
    tetrachloroethylene 65.5
    eugenol 67.82
    triacetin 53.68
    span 80 60.99
    1,4-butanediol 129.05
    1,1-dichloroethane 65.95
    2-methyl-1-pentanol 61.28
    methyl formate 379.82
    2-methyl-1-butanol 90.91
    n-decane 4.17
    butyronitrile 121.86
    3,7-dimethyl-1-octanol 32.59
    1-chlorooctane 14.69
    1-chlorotetradecane 7.09
    n-nonane 4.06
    undecane 3.29
    tert-butylcyclohexane 5.13
    cyclooctane 2.25
    cyclopentanol 109.51
    tetrahydropyran 75.71
    tert-amyl methyl ether 66.12
    2,5,8-trioxanonane 144.99
    1-hexene 17.87
    2-isopropoxyethanol 111.03
    2,2,2-trifluoroethanol 194.43
    methyl butyrate 67.9

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction