Glycine, N,N-dimethyl-, methyl ester

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  • Identifiers

    CAS number
    7148-06-3

    Molecular formula
    C5H11NO2

    SMILES
    CN(C)CC(=O)OC

    Safety labels

    Flammable
    Flammable

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Fruity 84.46%
    Sweet 37.77%
    Cheesy 35.86%
    Ethereal 33.32%
    Grape 29.35%
    Tropical 29.14%
    Buttery 27.81%
    Pineapple 26.94%
    Winey 25.19%
    Ripe 24.86%

     

    Flavor
    Fruity 84.78%
    Pineapple 36.61%
    Tropical 35.3%
    Berry 32.36%
    Cheese 29.93%
    Sweet 29.86%
    Fatty 27.24%
    Green 26.49%
    Ripe 26.19%
    Grape 26.12%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    0.2

    pKa est.
    7.59 (neutral)

    Molecular weight
    117.15 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    142°C

    Flash point

    • 44.68 ˚C est.

  • Synonyms

    • N,N-Dimethylglycine methyl ester
    • 7148-06-3
    • Glycine, N,N-dimethyl-, methyl ester
    • Methyl (dimethylamino)acetate
    • BRN 1744788
    • DTXSID60221693
    • NSC 29651
    • 3-04-00-01125 (Beilstein Handbook Reference)
    • RefChem:663699
    • DTXCID90144184
    • Glycine, N,Ndimethyl, methyl ester
    • 678-389-7
    • methyl 2-(dimethylamino)acetate
    • methyl n,n-dimethylglycinate
    • MFCD00059303
    • Methyl (dimethylamino) acetate
    • NSC-29651
    • N,N-Dimethyl-glycine methyl ester
    • dimethylglycine methyl ester
    • (CH3)2NCH2COOCH3
    • methyl 2-dimethylaminoacetate
    • SCHEMBL196772
    • SCHEMBL385800
    • methyl2-(dimethylamino)acetate
    • Dimethylaminoessigsauremethylester
    • LRZFEBJUJIQVDQ-UHFFFAOYSA-
    • GDE26H4628
    • Glycine,N-dimethyl-, methyl ester
    • N,N-Dimethyl glycine methyl ester
    • NSC29651
    • AKOS003961597
    • (Dimethylamino)acetic acid methyl ester
    • GS-5488
    • HY-W141886
    • N pound notN-Dimethylglycine Methyl Ester
    • SY006226
    • CS-0201680
    • D0257
    • H10578
    • F513639
    • InChI=1/C5H11NO2/c1-6(2)4-5(7)8-3/h4H2,1-3H3
    • 7148-06-3

  • Applications

    Glycine, N,N-dimethyl-, methyl ester, CAS 7148-06-3 is primarily used as an intermediate in organic synthesis for glycine derivatives and N,N-dialkylglycine compounds; it serves as a precursor for pharmaceutical and agrochemical syntheses; it can function as a protecting-group precursor for amino acids in peptide synthesis and as a building block in cosmetic ingredient design; in industrial contexts it may be used as a solvent or diluent in processing and as a feedstock for specialty polymers or plastics, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 98.64
    methanol 305.48
    isopropanol 42.49
    water 286.67
    ethyl acetate 12.28
    n-propanol 59.54
    acetone 16.37
    n-butanol 28.56
    acetonitrile 25.98
    DMF 90.87
    toluene 1.87
    isobutanol 32.4
    1,4-dioxane 30.11
    methyl acetate 27.77
    THF 30.26
    2-butanone 15.13
    n-pentanol 10.19
    sec-butanol 34.8
    n-hexane 0.79
    ethylene glycol 260.39
    NMP 141.11
    cyclohexane 1.55
    DMSO 53.38
    n-butyl acetate 10.07
    n-octanol 12.85
    chloroform 79.39
    n-propyl acetate 6.58
    acetic acid 520.38
    dichloromethane 56.68
    cyclohexanone 28.08
    propylene glycol 208.35
    isopropyl acetate 5.41
    DMAc 91.71
    2-ethoxyethanol 38.24
    isopentanol 11.6
    n-heptane 1.48
    ethyl formate 30.15
    1,2-dichloroethane 18.76
    n-hexanol 20.64
    2-methoxyethanol 141.28
    isobutyl acetate 4.52
    tetrachloromethane 15.15
    n-pentyl acetate 7.87
    transcutol 61.71
    n-heptanol 14.82
    ethylbenzene 2.16
    MIBK 3.81
    2-propoxyethanol 51.93
    tert-butanol 35.66
    MTBE 6.65
    2-butoxyethanol 32.66
    propionic acid 163.84
    o-xylene 4.22
    formic acid 560.15
    diethyl ether 3.98
    m-xylene 2.44
    p-xylene 3.41
    chlorobenzene 8.94
    dimethyl carbonate 11.91
    n-octane 0.76
    formamide 234.66
    cyclopentanone 36.58
    2-pentanone 5.87
    anisole 6.92
    cyclopentyl methyl ether 10.64
    gamma-butyrolactone 80.84
    1-methoxy-2-propanol 66.18
    pyridine 22.77
    3-pentanone 7.32
    furfural 104.12
    n-dodecane 0.78
    diethylene glycol 97.64
    diisopropyl ether 1.17
    tert-amyl alcohol 35.2
    acetylacetone 11.71
    n-hexadecane 0.8
    acetophenone 13.49
    methyl propionate 20.15
    isopentyl acetate 9.54
    trichloroethylene 67.65
    n-nonanol 11.24
    cyclohexanol 29.48
    benzyl alcohol 18.09
    2-ethylhexanol 11.59
    isooctanol 11.28
    dipropyl ether 4.25
    1,2-dichlorobenzene 15.79
    ethyl lactate 22.66
    propylene carbonate 51.21
    n-methylformamide 111.7
    2-pentanol 11.24
    n-pentane 0.95
    1-propoxy-2-propanol 31.96
    1-methoxy-2-propyl acetate 16.86
    2-(2-methoxypropoxy) propanol 40.24
    mesitylene 2.14
    ε-caprolactone 41.95
    p-cymene 5.07
    epichlorohydrin 44.62
    1,1,1-trichloroethane 20.14
    2-aminoethanol 239.19
    morpholine-4-carbaldehyde 105.8
    sulfolane 120.33
    2,2,4-trimethylpentane 1.33
    2-methyltetrahydrofuran 20.01
    n-hexyl acetate 14.0
    isooctane 0.56
    2-(2-butoxyethoxy)ethanol 39.98
    sec-butyl acetate 3.92
    tert-butyl acetate 6.49
    decalin 1.29
    glycerin 346.54
    diglyme 48.41
    acrylic acid 225.87
    isopropyl myristate 5.25
    n-butyric acid 82.67
    acetyl acetate 14.5
    di(2-ethylhexyl) phthalate 16.23
    ethyl propionate 7.7
    nitromethane 207.14
    1,2-diethoxyethane 5.52
    benzonitrile 16.49
    trioctyl phosphate 10.16
    1-bromopropane 6.09
    gamma-valerolactone 71.56
    n-decanol 8.73
    triethyl phosphate 11.49
    4-methyl-2-pentanol 5.51
    propionitrile 18.9
    vinylene carbonate 59.92
    1,1,2-trichlorotrifluoroethane 176.33
    DMS 19.1
    cumene 2.98
    2-octanol 8.54
    2-hexanone 4.68
    octyl acetate 9.25
    limonene 7.13
    1,2-dimethoxyethane 23.29
    ethyl orthosilicate 9.46
    tributyl phosphate 11.29
    diacetone alcohol 23.2
    N,N-dimethylaniline 8.87
    acrylonitrile 41.36
    aniline 15.3
    1,3-propanediol 131.64
    bromobenzene 6.02
    dibromomethane 27.6
    1,1,2,2-tetrachloroethane 60.93
    2-methyl-cyclohexyl acetate 14.36
    tetrabutyl urea 15.2
    diisobutyl methanol 5.94
    2-phenylethanol 23.22
    styrene 2.22
    dioctyl adipate 12.1
    dimethyl sulfate 35.37
    ethyl butyrate 8.09
    methyl lactate 52.66
    butyl lactate 22.24
    diethyl carbonate 8.52
    propanediol butyl ether 52.08
    triethyl orthoformate 8.49
    p-tert-butyltoluene 5.38
    methyl 4-tert-butylbenzoate 26.88
    morpholine 45.6
    tert-butylamine 16.66
    n-dodecanol 6.84
    dimethoxymethane 20.25
    ethylene carbonate 35.53
    cyrene 53.06
    2-ethoxyethyl acetate 13.12
    2-ethylhexyl acetate 7.98
    1,2,4-trichlorobenzene 25.6
    4-methylpyridine 14.06
    dibutyl ether 3.46
    2,6-dimethyl-4-heptanol 5.94
    DEF 18.64
    dimethyl isosorbide 48.83
    tetrachloroethylene 53.15
    eugenol 35.72
    triacetin 27.41
    span 80 45.29
    1,4-butanediol 39.65
    1,1-dichloroethane 17.54
    2-methyl-1-pentanol 7.4
    methyl formate 78.64
    2-methyl-1-butanol 19.21
    n-decane 1.09
    butyronitrile 11.04
    3,7-dimethyl-1-octanol 11.09
    1-chlorooctane 4.35
    1-chlorotetradecane 2.15
    n-nonane 1.0
    undecane 0.9
    tert-butylcyclohexane 1.5
    cyclooctane 0.59
    cyclopentanol 49.94
    tetrahydropyran 13.28
    tert-amyl methyl ether 7.63
    2,5,8-trioxanonane 45.26
    1-hexene 1.86
    2-isopropoxyethanol 17.86
    2,2,2-trifluoroethanol 241.23
    methyl butyrate 11.46

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction